|
US7638513B2
(en)
|
2004-06-02 |
2009-12-29 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US20070167426A1
(en)
*
|
2004-06-02 |
2007-07-19 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders and microbial diseases
|
|
PE20060426A1
(es)
*
|
2004-06-02 |
2006-06-28 |
Schering Corp |
DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa
|
|
CN101282962A
(zh)
*
|
2005-08-12 |
2008-10-08 |
先灵公司 |
用于治疗炎性疾病的化合物
|
|
WO2007038215A1
(en)
|
2005-09-22 |
2007-04-05 |
Incyte Corporation |
Tetracyclic inhibitors of janus kinases
|
|
JP2009520689A
(ja)
|
2005-12-01 |
2009-05-28 |
シェーリング コーポレイション |
炎症障害および微生物性疾患を処置するための化合物
|
|
HUE028588T2
(hu)
|
2005-12-13 |
2016-12-28 |
Incyte Holdings Corp |
Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
|
|
ES2415863T3
(es)
|
2006-12-22 |
2013-07-29 |
Incyte Corporation |
Heterociclos sustituidos como inhibidores de Janus Quinasas
|
|
CN101209976B
(zh)
*
|
2006-12-29 |
2012-01-11 |
中国人民解放军军事医学科学院毒物药物研究所 |
取代的酒石酸衍生物及其用于制备β-分泌酶抑制剂的用途
|
|
CA2686926C
(en)
*
|
2007-05-14 |
2016-01-05 |
Sk Holdings Co., Ltd. |
Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
|
|
EP2740731B1
(en)
|
2007-06-13 |
2016-03-23 |
Incyte Holdings Corporation |
Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
MY165582A
(en)
|
2008-03-11 |
2018-04-05 |
Incyte Holdings Corp |
Azetidine and cyclobutane derivatives as jak inhibitors
|
|
AU2009263037B2
(en)
*
|
2008-06-26 |
2011-10-06 |
Amgen Inc. |
Alkynyl alcohols as kinase inhibitors
|
|
JP5535931B2
(ja)
*
|
2008-10-27 |
2014-07-02 |
武田薬品工業株式会社 |
二環性化合物
|
|
AU2009322342A1
(en)
*
|
2008-12-05 |
2011-06-30 |
Merck Sharp & Dohme Corp. |
Morpholinone compounds as factor IXa inhibitors
|
|
US8987242B2
(en)
|
2008-12-05 |
2015-03-24 |
Merck Sharp & Dohme Corp. |
Morpholinone compounds as factor IXA inhibitors
|
|
TW201038559A
(en)
*
|
2009-04-09 |
2010-11-01 |
Bristol Myers Squibb Co |
Hepatitis C virus inhibitors
|
|
BRPI1012108B8
(pt)
|
2009-05-22 |
2021-05-25 |
Incyte Corp |
composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
|
|
NZ596479A
(en)
|
2009-05-22 |
2014-01-31 |
Incyte Corp |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
EP2272846A1
(de)
|
2009-06-23 |
2011-01-12 |
Bayer CropScience AG |
Thiazolylpiperidin Derivate als Fungizide
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
EA021478B1
(ru)
|
2009-10-09 |
2015-06-30 |
Инсайт Корпорейшн |
ГИДРОКСИЛЬНЫЕ, КЕТО И ГЛЮКУРОНИДНЫЕ ПРОИЗВОДНЫЕ 3-(4-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1Н-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА
|
|
MY159958A
(en)
|
2009-12-18 |
2017-02-15 |
Idenix Pharmaceuticals Inc |
5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
|
|
CN102127061B
(zh)
*
|
2010-01-15 |
2016-02-17 |
浙江华海药业股份有限公司 |
一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法
|
|
CA2792508C
(en)
|
2010-03-10 |
2018-01-16 |
Incyte Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
CN102190647A
(zh)
*
|
2010-03-12 |
2011-09-21 |
浙江海翔药业股份有限公司 |
一种奈比洛尔的中间体的制备方法
|
|
EA202091303A3
(ru)
|
2010-05-21 |
2021-05-31 |
Инсайт Холдингс Корпорейшн |
Композиция ингибитора jak для местного применения
|
|
ES2536415T3
(es)
|
2010-11-19 |
2015-05-25 |
Incyte Corporation |
Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
WO2012112847A1
(en)
|
2011-02-18 |
2012-08-23 |
Novartis Pharma Ag |
mTOR/JAK INHIBITOR COMBINATION THERAPY
|
|
BR112013021638A2
(pt)
*
|
2011-02-25 |
2016-08-02 |
Irm Llc |
"compostos inibidores de trk, seu uso e composições que os compreendem"
|
|
US9133187B2
(en)
|
2011-02-28 |
2015-09-15 |
Array Biopharma Inc. |
Serine/threonine kinase inhibitors
|
|
US20120252721A1
(en)
*
|
2011-03-31 |
2012-10-04 |
Idenix Pharmaceuticals, Inc. |
Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
|
|
US8691807B2
(en)
|
2011-06-20 |
2014-04-08 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
|
|
WO2013023119A1
(en)
|
2011-08-10 |
2013-02-14 |
Novartis Pharma Ag |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
GB201117313D0
(en)
|
2011-10-07 |
2011-11-16 |
Gt Biolog Ltd |
Bacterium for use in medicine
|
|
US9708276B2
(en)
|
2011-10-12 |
2017-07-18 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
|
|
US10130635B2
(en)
|
2012-05-04 |
2018-11-20 |
Rhizen Pharmaceuticals Sa |
Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
|
|
JP6290186B2
(ja)
*
|
2012-05-04 |
2018-03-07 |
ライゼン・ファーマシューティカルズ・エスアー |
光学的に純粋で置換基を有していてもよい２−（１−ヒドロキシ−アルキル）クロメン−４−オン誘導体の調製方法および医薬品調製におけるそれらの使用
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
CA2876689C
(en)
|
2012-06-13 |
2022-04-26 |
Incyte Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
CA2882410A1
(en)
|
2012-09-19 |
2014-03-27 |
Novartis Ag |
Dihydropyrrolidino-pyrimidines as kinase inhibitors
|
|
KR102242077B1
(ko)
|
2012-11-15 |
2021-04-20 |
인사이트 홀딩스 코포레이션 |
룩솔리티니브의 서방성 제형
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
EP3489239B1
(en)
|
2013-03-06 |
2021-09-15 |
Incyte Holdings Corporation |
Processes and intermediates for making a jak inhibitor
|
|
GB201306536D0
(en)
|
2013-04-10 |
2013-05-22 |
Gt Biolog Ltd |
Polypeptide and immune modulation
|
|
PH12015502383B1
(en)
|
2013-04-19 |
2023-02-03 |
Incyte Holdings Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
MX376856B
(es)
|
2013-08-07 |
2025-03-07 |
Incyte Holdings Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
|
|
CA2924527C
(en)
*
|
2013-09-20 |
2022-07-12 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Compounds for treating prostate cancer
|
|
US20160257657A1
(en)
|
2013-09-20 |
2016-09-08 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
|
|
CN103772233B
(zh)
*
|
2014-01-06 |
2015-06-10 |
华东师范大学 |
一种含多氟烷基五元环状硝酮衍生物及其制备方法
|
|
WO2015172196A1
(en)
*
|
2014-05-13 |
2015-11-19 |
Monash University |
Heterocyclic compounds and use of same
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
DK3193901T3
(en)
|
2014-12-23 |
2018-05-28 |
4D Pharma Res Ltd |
PIRIN POLYPEPTIDE AND IMMUNMODULATION
|
|
PE20171138A1
(es)
|
2014-12-23 |
2017-08-09 |
4D Pharma Res Ltd |
Modulacion inmunitaria
|
|
CA2976790C
(en)
|
2015-02-20 |
2024-02-27 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
US9580423B2
(en)
|
2015-02-20 |
2017-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
CN104894013B
(zh)
*
|
2015-05-19 |
2018-04-20 |
辽宁师范大学 |
七鳃鳗口腔腺寄生菌株lj1、分泌蛋白、分离方法及用途
|
|
EP3662917A1
(en)
|
2015-06-15 |
2020-06-10 |
4D Pharma Research Limited |
Compositions comprising bacterial strains
|
|
MA41010B1
(fr)
|
2015-06-15 |
2020-01-31 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
LT3360559T
(lt)
|
2015-06-15 |
2019-12-27 |
4D Pharma Research Limited |
Kompozicijos, apimančios bakterijų kamienus
|
|
PE20180243A1
(es)
|
2015-06-15 |
2018-01-31 |
4D Pharma Res Ltd |
Composiciones que comprenden cepas bacterianas
|
|
MA41060B1
(fr)
|
2015-06-15 |
2019-11-29 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
GB201520497D0
(en)
|
2015-11-20 |
2016-01-06 |
4D Pharma Res Ltd |
Compositions comprising bacterial strains
|
|
MA41013A
(fr)
|
2015-11-20 |
2017-08-30 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
GB201612191D0
(en)
|
2016-07-13 |
2016-08-24 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
MX373290B
(es)
|
2016-03-04 |
2020-06-18 |
4D Pharma Plc |
Composiciones que comprenden cepas bacterianas.
|
|
US10980806B2
(en)
|
2016-03-24 |
2021-04-20 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
|
|
TWI802545B
(zh)
|
2016-07-13 |
2023-05-21 |
英商４Ｄ製藥有限公司 |
包含細菌菌株之組合物
|
|
CN108017571A
(zh)
*
|
2016-10-29 |
2018-05-11 |
浙江九洲药物科技有限公司 |
一种取代异吲哚啉化合物的制备方法
|
|
EP3539963A4
(en)
*
|
2016-11-11 |
2020-05-13 |
Hepo Pharmaceutical Co., Ltd. |
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE
|
|
GB201621123D0
(en)
|
2016-12-12 |
2017-01-25 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
MA48940A
(fr)
|
2017-05-22 |
2020-04-08 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
MA41708A
(fr)
|
2017-05-24 |
2020-04-08 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
TWI767013B
(zh)
|
2017-06-14 |
2022-06-11 |
英商4D製藥研究有限公司 |
包含細菌品系之組成物
|
|
PL3638271T3
(pl)
|
2017-06-14 |
2021-03-22 |
4D Pharma Research Limited |
Kompozycje zawierające szczepy bakteryjne
|
|
JP2020523326A
(ja)
|
2017-06-14 |
2020-08-06 |
フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ |
細菌株を含む組成物
|
|
WO2019060613A2
(en)
*
|
2017-09-22 |
2019-03-28 |
John Mansell |
COMPOSITIONS AND METHODS FOR TREATING SEPSIS-RELATED DISORDERS
|
|
CN107474006A
(zh)
*
|
2017-09-25 |
2017-12-15 |
上海馨远医药科技有限公司 |
一种5‑溴异二氢吲哚盐酸盐的制备方法
|
|
TW201924683A
(zh)
|
2017-12-08 |
2019-07-01 |
美商英塞特公司 |
用於治療骨髓增生性贅瘤的低劑量組合療法
|
|
MD3746429T2
(ro)
|
2018-01-30 |
2022-08-31 |
Incyte Corp |
Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onă)
|
|
KR20260080448A
(ko)
|
2018-03-30 |
2026-06-02 |
인사이트 코포레이션 |
Jak 억제제를 사용하는 화농성 한선염의 치료
|
|
KR102956194B1
(ko)
|
2018-05-04 |
2026-04-23 |
인사이트 코포레이션 |
Fgfr 억제제의 염
|
|
RS66310B1
(sr)
|
2018-05-04 |
2025-01-31 |
Incyte Corp |
Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
|
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
|
WO2021007269A1
(en)
|
2019-07-09 |
2021-01-14 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
GEP20247679B
(en)
|
2019-10-14 |
2024-10-10 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
WO2021113479A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
MX2022006691A
(es)
|
2019-12-04 |
2022-09-19 |
Incyte Corp |
Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
EP4192828A1
(en)
|
2020-08-04 |
2023-06-14 |
Nura Bio, Inc. |
Substituted pyridine derivatives as sarm1 inhibitors
|
|
WO2022060812A1
(en)
|
2020-09-16 |
2022-03-24 |
Nura Bio, Inc. |
Substituted pyridine derivatives as sarm1 inhibitors
|
|
CN112479936A
(zh)
*
|
2020-12-16 |
2021-03-12 |
怀化学院 |
一种苯偶酰衍生物硝酮的制备方法
|
|
CN117157278A
(zh)
*
|
2021-03-23 |
2023-12-01 |
柏奥艾奇实验室公司 |
Nlrp3炎性体的抑制剂
|
|
EP4323405A1
(en)
|
2021-04-12 |
2024-02-21 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
|
|
CN113307765A
(zh)
*
|
2021-05-24 |
2021-08-27 |
上海泰坦科技股份有限公司 |
吡啶甲胺类化合物及其制备方法
|
|
TW202313610A
(zh)
|
2021-06-09 |
2023-04-01 |
美商英塞特公司 |
作為ｆｇｆｒ抑制劑之三環雜環
|
|
CA3220274A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
KR20240041987A
(ko)
*
|
2021-07-28 |
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Sarm1 억제제로서 치환된 피리딘 유도체
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WO2024114782A1
(en)
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2022-12-01 |
2024-06-06 |
National Institute Of Biological Sciences, Beijing |
Small-molecule modulators of spike protein
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