PE20060426A1 - DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa - Google Patents
DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfaInfo
- Publication number
- PE20060426A1 PE20060426A1 PE2005000615A PE2005000615A PE20060426A1 PE 20060426 A1 PE20060426 A1 PE 20060426A1 PE 2005000615 A PE2005000615 A PE 2005000615A PE 2005000615 A PE2005000615 A PE 2005000615A PE 20060426 A1 PE20060426 A1 PE 20060426A1
- Authority
- PE
- Peru
- Prior art keywords
- tace
- alkyl
- mmps
- adams
- inhibitors
- Prior art date
Links
- BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 title abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 title 1
- 102000029791 ADAM Human genes 0.000 title 1
- 108091022885 ADAM Proteins 0.000 title 1
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 title 1
- 101000777461 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 17 Proteins 0.000 title 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
- 150000003892 tartrate salts Chemical class 0.000 title 1
- -1 PIPERIDINYL Chemical class 0.000 abstract 9
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
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| DE1123468B (de) | 1955-01-22 | 1962-02-08 | Hermann Leinfelder | Verfahren zur Herstellung wasserloeslicher, poly-N-quaternaerer, die Diffusion in Geweben erhoehender Substanzen |
| US5618842A (en) * | 1991-12-31 | 1997-04-08 | Lifegroup S.P.A. | N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin |
| US6228869B1 (en) * | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| FR2762315B1 (fr) | 1997-04-22 | 1999-05-28 | Logeais Labor Jacques | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
| ATE260251T1 (de) * | 1999-08-18 | 2004-03-15 | Warner Lambert Co | Hydroxamsäurederivate als matrix- metalloproteinase-inhibitoren |
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| US20070167426A1 (en) * | 2004-06-02 | 2007-07-19 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| US7553864B2 (en) * | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
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- 2005-06-01 WO PCT/US2005/019131 patent/WO2005121130A2/en not_active Ceased
- 2005-06-01 KR KR1020067026812A patent/KR20070103671A/ko not_active Withdrawn
- 2005-06-01 AU AU2005252201A patent/AU2005252201A1/en not_active Abandoned
- 2005-06-01 MX MXPA06014054A patent/MXPA06014054A/es unknown
- 2005-06-01 CA CA002569111A patent/CA2569111A1/en not_active Abandoned
- 2005-06-01 AR ARP050102245A patent/AR051172A1/es not_active Application Discontinuation
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- 2005-06-01 JP JP2007515501A patent/JP2008501691A/ja not_active Withdrawn
- 2005-06-01 TW TW094117942A patent/TW200612911A/zh unknown
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2009
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| US7652020B2 (en) | 2010-01-26 |
| MXPA06014054A (es) | 2007-01-31 |
| US20060252778A1 (en) | 2006-11-09 |
| WO2005121130A3 (en) | 2006-07-20 |
| ZA200610055B (en) | 2009-05-27 |
| EP1773821A2 (en) | 2007-04-18 |
| CA2569111A1 (en) | 2005-12-22 |
| WO2005121130A2 (en) | 2005-12-22 |
| AR051172A1 (es) | 2006-12-27 |
| US20100145048A1 (en) | 2010-06-10 |
| AU2005252201A1 (en) | 2005-12-22 |
| KR20070103671A (ko) | 2007-10-24 |
| TW200612911A (en) | 2006-05-01 |
| JP2008501691A (ja) | 2008-01-24 |
| CN101027295A (zh) | 2007-08-29 |
| US8039467B2 (en) | 2011-10-18 |
| IL179674A0 (en) | 2007-05-15 |
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