JP2008212150A5 - - Google Patents

Download PDF

Info

Publication number
JP2008212150A5
JP2008212150A5 JP2008040781A JP2008040781A JP2008212150A5 JP 2008212150 A5 JP2008212150 A5 JP 2008212150A5 JP 2008040781 A JP2008040781 A JP 2008040781A JP 2008040781 A JP2008040781 A JP 2008040781A JP 2008212150 A5 JP2008212150 A5 JP 2008212150A5
Authority
JP
Japan
Prior art keywords
cells
culture medium
endoderm
hps
cell culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008040781A
Other languages
English (en)
Japanese (ja)
Other versions
JP4917559B2 (ja
JP2008212150A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2008212150A publication Critical patent/JP2008212150A/ja
Publication of JP2008212150A5 publication Critical patent/JP2008212150A5/ja
Application granted granted Critical
Publication of JP4917559B2 publication Critical patent/JP4917559B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2008040781A 2001-12-07 2008-02-22 ヒト胚幹細胞由来の膵島細胞 Expired - Lifetime JP4917559B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33888501P 2001-12-07 2001-12-07
US60/338,885 2001-12-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2003551271A Division JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011258931A Division JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Publications (3)

Publication Number Publication Date
JP2008212150A JP2008212150A (ja) 2008-09-18
JP2008212150A5 true JP2008212150A5 (enExample) 2010-04-15
JP4917559B2 JP4917559B2 (ja) 2012-04-18

Family

ID=23326555

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003551271A Expired - Lifetime JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞
JP2008040781A Expired - Lifetime JP4917559B2 (ja) 2001-12-07 2008-02-22 ヒト胚幹細胞由来の膵島細胞
JP2011258931A Expired - Lifetime JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2003551271A Expired - Lifetime JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011258931A Expired - Lifetime JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Country Status (10)

Country Link
US (8) US7033831B2 (enExample)
EP (2) EP1463798A4 (enExample)
JP (3) JP4666567B2 (enExample)
KR (2) KR101008868B1 (enExample)
CN (2) CN101240262A (enExample)
AU (3) AU2002364143B2 (enExample)
CA (2) CA2470539C (enExample)
GB (2) GB2399823B (enExample)
IL (3) IL162131A0 (enExample)
WO (1) WO2003050249A2 (enExample)

Families Citing this family (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558952B1 (en) * 1992-12-14 2003-05-06 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
WO2003048336A2 (en) * 2001-12-04 2003-06-12 Organogenesis Inc. Cultured cells from pancreatic islets
US7033831B2 (en) * 2001-12-07 2006-04-25 Geron Corporation Islet cells from human embryonic stem cells
CA2473115A1 (en) * 2002-01-09 2003-07-24 Japan Science And Technology Agency Remedy for dysmnesia
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
AU2003210959A1 (en) * 2002-02-12 2003-09-04 Cornell Research Foundation, Inc. Identification and high-yield isolation of human pancreatic islet progenitor and stem cells
CA2487058C (en) 2002-05-17 2015-04-14 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
CA2494134A1 (en) * 2002-05-24 2003-12-04 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US20040002447A1 (en) * 2002-06-04 2004-01-01 Regents Of The University Of California Induction of insulin expression
JP2006506386A (ja) * 2002-10-22 2006-02-23 ワラタ ファーマシューティカルズ, インコーポレイテッド 糖尿病の処置
HUE028026T2 (en) 2002-12-16 2016-11-28 Technion Res & Dev Foundation Breeding system free of native cells, free of foreign matter for human embryonic stem cells
WO2004069172A2 (en) * 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
JP5426073B2 (ja) 2003-05-08 2014-02-26 セルアーティス アーベー ヒト胚盤胞由来幹細胞(hBS細胞)のフィーダー支持からフィーダーなしの培養系への効率的な移送方法
AU2004241380A1 (en) * 2003-05-20 2004-12-02 Riken Preparation of endodermal stem cells
ES2584428T3 (es) * 2003-06-20 2016-09-27 Axiogenesis Ag Modelado de tejidos en un sistema de células madre embrionarias (ES)
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US20060223177A1 (en) 2003-06-27 2006-10-05 Ethicon Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
ES2552226T3 (es) 2003-06-27 2015-11-26 DePuy Synthes Products, Inc. Reparación y regeneración de cartílago y hueso utilizando células derivadas posparto
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
EP1668119A2 (en) * 2003-09-15 2006-06-14 Ramot at Tel Aviv University Ltd. Insulin-producing bone marrow derived cells and methods of generating and using same
JP2007522796A (ja) * 2003-11-07 2007-08-16 ユニヴァーシティ オブ フロリダ リサーチ ファウンデーション,インク. 神経前駆細胞の培養と分化
AU2013200203B2 (en) * 2003-12-23 2014-11-20 Viacyte, Inc. Definitive endoderm
US8586357B2 (en) * 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
MXPA06007252A (es) * 2003-12-23 2007-01-23 Cythera Inc Endodermo definitivo.
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
WO2005071066A1 (en) * 2004-01-23 2005-08-04 Board Of Regents, The University Of Texas System Methods and compositions for preparing pancreatic insulin secreting cells
US20090155218A1 (en) * 2004-03-10 2009-06-18 Alberto Hayek Compositions and methods for growth of embryonic stem cells
US7585672B2 (en) * 2004-04-01 2009-09-08 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
NZ550605A (en) * 2004-04-27 2009-08-28 Cythera Inc Cell culture comprising human PDX1-positive foregut endoderm cells
EP2377922B1 (en) * 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
AU2005245965B2 (en) * 2004-05-21 2010-12-16 Wicell Research Institute, Inc. Feeder independent extended culture of embryonic stem cells
WO2006001471A1 (ja) * 2004-06-29 2006-01-05 The University Of Tokyo グルコース応答性インスリン分泌を促進するための医薬組成物
AU2011203583B2 (en) * 2004-07-09 2013-03-07 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
EP3505622A1 (en) * 2004-07-09 2019-07-03 Viacyte, Inc. Preprimitive streak and mesendoderm cells
GB2431165B (en) 2004-07-13 2009-04-01 Geron Corp Medium for growing human embryonic stem cells
CA2576872C (en) * 2004-08-13 2013-11-12 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
EP1797171A1 (en) * 2004-09-29 2007-06-20 Cellartis AB Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hbs)
AU2005294200A1 (en) * 2004-10-08 2006-04-20 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
WO2006040763A2 (en) * 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
CA2592435C (en) 2004-12-23 2017-03-28 DePuy Synthes Products, Inc. Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
WO2006071911A2 (en) * 2004-12-23 2006-07-06 Cythera, Inc. Expansion of definitive endoderm cells
AU2006203990B2 (en) * 2005-01-07 2011-08-11 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
CA2613812A1 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
CN100425694C (zh) * 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
EP1728873A1 (en) 2005-05-30 2006-12-06 DeveloGen Aktiengesellschaft Use of an insulinoma cell for identifying pancreatic beta-cell mitogens
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
CN101484575B (zh) * 2005-06-08 2013-10-02 森托科尔公司 用于眼变性的细胞疗法
CA2613369C (en) 2005-06-22 2020-11-10 Geron Corporation Suspension culture of human embryonic stem cells
WO2007026353A2 (en) 2005-08-29 2007-03-08 Technion Research & Development Foundation Ltd. Media for culturing stem cells
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
US8865763B2 (en) 2005-10-14 2014-10-21 Alltech, Inc. Methods and compositions for altering cell function
US8871715B2 (en) 2005-10-14 2014-10-28 Alltech, Inc. Use of selenium compounds, especially selenium yeasts for altering cognitive function
JP2009511061A (ja) * 2005-10-14 2009-03-19 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 膵臓表現型を有する細胞への非胚性幹細胞の分化
CN102764279B (zh) * 2005-10-14 2015-04-01 全面技术公司 改变细胞功能的方法和组合物
ES2743202T3 (es) 2005-10-27 2020-02-18 Viacyte Inc Endodermo de intestino proximal dorsal y ventral que expresa PDX1
AU2012202481B2 (en) * 2005-10-27 2015-07-02 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
JP5289970B2 (ja) * 2005-12-16 2013-09-11 エシコン・インコーポレイテッド 組織適合性不適合な移植における逆免疫反応を抑制するための組成物および方法
AU2006327073B2 (en) * 2005-12-19 2012-08-30 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
EP1979050B1 (en) * 2005-12-28 2017-04-19 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
AU2016213746A1 (en) * 2006-03-02 2016-08-25 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AU2024201016B2 (en) * 2006-03-02 2024-10-24 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
EP1999253B1 (en) * 2006-03-02 2019-05-22 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
EP2021462B1 (en) * 2006-04-28 2019-01-09 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US7989204B2 (en) * 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
CA2650561C (en) * 2006-05-02 2014-02-25 Wisconsin Alumni Research Foundation Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
US20090298169A1 (en) * 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
WO2007143117A2 (en) * 2006-06-02 2007-12-13 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8874380B2 (en) 2010-12-09 2014-10-28 Rutgers, The State University Of New Jersey Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs
AU2007277364B2 (en) * 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
PT2733203T (pt) 2006-08-02 2019-01-23 Technion Res & Dev Foundation Métodos de expansão de células estminais embrionárias numa cultura de suspensão
KR100885854B1 (ko) 2006-09-08 2009-02-26 고려대학교 산학협력단 인간배아 줄기세포로부터 췌장전구세포로의 분화유도 방법
WO2008048647A1 (en) * 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
WO2008063675A2 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
US20100034775A1 (en) * 2006-12-20 2010-02-11 Shenzhen Well. D Genetic Engineering Co., Ltd. RECOMBINANT ADENOVIRUS COMPRISING RECOMBINANT khp53 GENE AND THE PREPARATION METHOD AND USES THEREOF
US9029147B2 (en) * 2007-06-15 2015-05-12 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101555824B1 (ko) 2007-07-18 2015-09-25 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
US8481316B2 (en) * 2007-07-19 2013-07-09 Agency For Science, Technology And Research Method for differentiating embryonic stem cells into cells expressing AQP-1
PL2584034T3 (pl) 2007-07-31 2018-03-30 Lifescan, Inc. Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
CA2701435C (en) * 2007-10-05 2017-06-20 Ethicon, Inc. Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
DK2209888T3 (da) * 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
US8198083B1 (en) 2007-10-31 2012-06-12 William Gunter Loudon Organotypic slices of the central nervous system
CA3123528C (en) 2007-11-27 2026-01-13 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
BR122017025207B1 (pt) 2008-02-21 2021-03-16 Centocor Ortho Biotech Inc superfície que faz parte de um recipiente ou matriz destinada para uso em uma cultura de células ou análises, desprovida de uma camada de células alimentadoras e desprovida de uma camada adsorvente
WO2009124213A2 (en) * 2008-04-02 2009-10-08 The Trustees Of Columbia University In The City Of New York Dental stem cell differentiation
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
WO2009137844A2 (en) 2008-05-09 2009-11-12 Vistagen Therapeutics, Inc. Pancreatic endocrine progenitor cells derived from pluripotent stem cells
KR20110051166A (ko) 2008-05-22 2011-05-17 베스타 테라퓨틱스 인코포레이티드 포유동물의 전구 세포를 인슐린 생성 이자섬 세포로 분화시키는 방법
WO2009147400A1 (en) * 2008-06-05 2009-12-10 Iti Scotland Limited Stem cell culture media and methods
EP2318516A1 (en) * 2008-06-30 2011-05-11 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
US20100015711A1 (en) 2008-06-30 2010-01-21 Janet Davis Differentiation of Pluripotent Stem Cells
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
KR101025880B1 (ko) * 2008-10-23 2011-03-30 공희숙 성체 줄기세포를 이용한 인슐린 분비세포로의 분화 유도방법
BRPI0919885A2 (pt) 2008-10-31 2015-08-11 Centocor Ortho Biotech Inc Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática
CA2742267C (en) * 2008-10-31 2019-06-04 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
CA2907326A1 (en) * 2008-11-04 2010-05-14 Chad Green Stem cell aggregate suspension compositions and methods for differentiation thereof
ES2932850T3 (es) 2008-11-14 2023-01-27 Viacyte Inc Encapsulación de células pancreáticas derivadas de células madre pluripotentes humanas
AU2009316583B2 (en) 2008-11-20 2016-04-21 Janssen Biotech, Inc. Methods and compositions for cell attachment and cultivation on planar substrates
US20100124781A1 (en) 2008-11-20 2010-05-20 Shelley Nelson Pluripotent Stem Cell Culture on Micro-Carriers
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CN107028983A (zh) 2008-12-19 2017-08-11 德普伊新特斯产品有限责任公司 肺部疾病和病症的治疗
PL3441458T3 (pl) * 2009-02-03 2023-11-06 Koninklijke Nederlandse Akademie Van Wetenschappen Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste
WO2010091241A2 (en) 2009-02-06 2010-08-12 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
US8722034B2 (en) * 2009-03-26 2014-05-13 Depuy Synthes Products Llc hUTC as therapy for Alzheimer's disease
WO2010143572A1 (ja) * 2009-06-12 2010-12-16 オリンパス株式会社 被検体情報分析装置及び被検体情報分析方法
SG176957A1 (en) 2009-06-25 2012-02-28 Geron Corp Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes
WO2010151733A1 (en) * 2009-06-25 2010-12-29 The Trustees Of Columbia University In The City Of New York Dental stem cell reprogramming
WO2011005326A1 (en) 2009-07-09 2011-01-13 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
BR112012001480A2 (pt) 2009-07-20 2015-09-01 Janssen Biotech Inc Diferenciação de células-tronco embriônicas humanas
CA2768644A1 (en) * 2009-07-20 2011-01-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
JP5819826B2 (ja) * 2009-07-20 2015-11-24 ヤンセン バイオテツク,インコーポレーテツド ヒト胚性幹細胞の分化
ES2665006T3 (es) * 2009-10-29 2018-04-24 Janssen Biotech, Inc. Células madre pluripotentes
EP4166652A1 (en) 2009-11-12 2023-04-19 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
CA2784415C (en) 2009-12-23 2019-06-18 Jean Xu Differentiation of human embryonic stem cells
US9133439B2 (en) * 2009-12-23 2015-09-15 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US8932853B2 (en) 2009-12-29 2015-01-13 Takeda Pharmaceutical Company Limited Method for manufacturing pancreatic-hormone-producing cells
WO2011109279A2 (en) 2010-03-01 2011-09-09 Centocor Ortho Biotech Inc. Methods for purifying cells derived from pluripotent stem cells
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US9752125B2 (en) * 2010-05-12 2017-09-05 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
JP2013530699A (ja) 2010-06-15 2013-08-01 セルラー ダイナミクス インターナショナル, インコーポレイテッド 生物学的応答の調査のための既製の幹細胞モデルの概要
WO2012018933A2 (en) 2010-08-04 2012-02-09 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
CN103154240B (zh) * 2010-08-09 2016-09-07 武田药品工业株式会社 制备胰腺激素产生细胞的方法
KR20130100122A (ko) 2010-08-12 2013-09-09 얀센 바이오테크 인코포레이티드 췌장 내분비 전구 세포를 이용한 당뇨병의 치료
PH12013500349A1 (en) 2010-08-31 2022-03-30 Janssen Biotech Inc Differentiation of pluripotent stem cells
CN108517310B (zh) 2010-08-31 2022-02-15 詹森生物科技公司 人胚胎干细胞的分化
CA2809300A1 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
EP2630232A4 (en) 2010-10-22 2014-04-02 Biotime Inc METHOD FOR MODIFYING TRANSCRIPTIONAL REGULATORY NETWORKS IN STEM CELLS
US10000739B2 (en) * 2010-10-28 2018-06-19 National University Corporation Kumamoto University Method and culture medium for improving pluripotent stem cell differentiation inducing efficiency
CN109536438A (zh) 2010-11-15 2019-03-29 艾克塞利瑞提德生物技术公司 由人类滋养层干细胞生成神经干细胞
EP2652125B1 (en) 2010-12-15 2017-04-26 Kadimastem Ltd. Insulin producing cells derived from pluripotent stem cells
US20190194607A1 (en) 2011-01-31 2019-06-27 Dnavec Corporation Highly functional liver cells derived from pluripotent stem cells, method for producing same, and method for testing metabolism/toxicity of drug
EP2691512B1 (en) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
EP2723852B1 (en) 2011-06-21 2021-11-17 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013049375A2 (en) * 2011-09-28 2013-04-04 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating beta cell proliferation
WO2013055397A1 (en) 2011-10-14 2013-04-18 Children's Medical Center Corporation Inhibition and enhancement of reprogramming by chromatin modifying enzymes
KR102203056B1 (ko) * 2011-12-22 2021-01-14 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
JP6301263B2 (ja) 2011-12-23 2018-03-28 デピュイ・シンセス・プロダクツ・インコーポレイテッド ヒト臍帯組織由来細胞の検出
KR20140131999A (ko) 2012-03-07 2014-11-14 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 증폭 및 유지를 위한 한정 배지
JP6084605B2 (ja) 2012-04-27 2017-02-22 日野自動車株式会社 バーナー、および、フィルター再生装置
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
IN2014DN10053A (enExample) * 2012-04-30 2015-08-14 Univ Health Network
AR090970A1 (es) 2012-05-07 2014-12-17 Janssen Biotech Inc Diferenciacion de celulas madre humanas embrionarias en endodermo pancreatico
KR20160027219A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
KR102667288B1 (ko) * 2012-06-08 2024-05-17 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
JP5979452B2 (ja) * 2012-06-11 2016-08-24 国立大学法人北海道大学 多能性幹細胞の選別方法
GB201216796D0 (en) * 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
ES3015228T3 (en) 2012-09-25 2025-04-30 Univ Yale Differentiation of human ips cells to human alveolar type ii via definitive endoderm
CN113604423B (zh) 2012-11-30 2025-06-03 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
RU2768963C2 (ru) 2012-12-31 2022-03-25 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
WO2014106141A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
WO2014105546A1 (en) * 2012-12-31 2014-07-03 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
CA2902857C (en) 2013-02-27 2022-11-29 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
KR102232650B1 (ko) 2013-06-11 2021-03-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
BR112015031253B1 (pt) 2013-06-13 2021-09-28 Orgenesis Ltd. Método para produção de uma população de células transdiferenciada
WO2014201431A1 (en) 2013-06-14 2014-12-18 Massachusetts Institute Of Technology Articles and methods for stem cell differentiation
GB201317869D0 (en) 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
US9988605B2 (en) 2013-12-11 2018-06-05 Korea Advanced Institute Of Science And Technology Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells
BR112016013623B1 (pt) * 2013-12-16 2023-03-21 Fresenius Medical Care Deutschland Gmbh Método de preparação de uma estrutura de célula esferoide semelhante à ilhota pancreática cultivada artificialmente, e uso de uma estrutura de célula esferoide
US9804692B2 (en) * 2014-03-28 2017-10-31 Samsung Display Co., Ltd. System and method for generating haptic feedback in stylus
CA2945393C (en) 2014-04-24 2021-03-23 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
EP3954759A1 (en) * 2014-05-16 2022-02-16 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2016043666A1 (en) * 2014-09-19 2016-03-24 Agency For Science, Technology And Research Differentiation of hepatocyte-like cells from stem cells
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
CA2970935A1 (en) 2014-12-19 2016-06-23 Janssen Biotech, Inc. Suspension culturing of pluripotent stem cells
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
CA3020905A1 (en) 2016-04-14 2017-10-19 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
EP3591040A4 (en) 2017-03-03 2020-11-11 Kyoto University METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
CN111565707A (zh) 2017-06-14 2020-08-21 森玛治疗公司 用于递送治疗物的装置和方法
EP3692139B1 (en) 2017-10-03 2024-11-06 SDF BioPharma Inc. Treating diabetes with genetically modified beta cells
JP2020536529A (ja) 2017-10-10 2020-12-17 チルドレンズ ホスピタル メディカル センター 食道組織および/または臓器組成物およびそれを作製する方法
AU2018370029B2 (en) 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
EP3826652B1 (en) 2018-07-26 2026-02-25 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
WO2020033879A1 (en) 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
EP3849568A4 (en) 2018-09-12 2022-06-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
US12529694B2 (en) 2019-05-16 2026-01-20 Brown University Human in vitro cardiotoxicity model
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN112852627A (zh) * 2019-11-28 2021-05-28 中国科学院大连化学物理研究所 一种基于多器官芯片的多能干细胞来源人肝和胰岛共培养的方法
CN113106054B (zh) * 2020-01-13 2022-10-14 青岛瑞思德生物科技有限公司 一种将间充质干细胞诱导分化为胰岛细胞的诱导剂
US12188051B2 (en) 2020-05-27 2025-01-07 The Regents Of The University Of Michigan Compositions and methods for obtaining vascularized human intestinal organoid tissue, and related uses thereof
US12504423B2 (en) 2020-10-16 2025-12-23 Brown University Human in vitro cardiotoxicity model
US12076437B2 (en) 2021-07-12 2024-09-03 Brown University Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
GB8604497D0 (en) 1986-02-24 1986-04-03 Connaught Lab Separation of islets of langerhans
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
DK0605428T5 (da) * 1991-06-24 2003-01-06 Hcell Technology Inc Hormonsecernerende pancreasceller opretholdt i langtidskultur
US5425764A (en) * 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
WO1994023572A1 (en) 1993-04-08 1994-10-27 Human Cell Cultures, Inc. Cell culturing method and medium
FR2710654B1 (fr) * 1993-09-30 1995-12-22 Maryam Asfari Nouvelles lignées de cellules sécrétrices d'insuline, leurs procédés d'obtention par voie de manipulation génétique et leur utilisation chez des sujets diabétiques sous forme protégée.
US5834308A (en) * 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5849989A (en) * 1994-10-07 1998-12-15 Ontogeny, Inc. Insulin promoter factor, and uses related thereto
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5679565A (en) 1995-04-10 1997-10-21 The Regents Of The University Of California Method of preserving pancreatic islets
AU6496996A (en) * 1996-02-23 1997-09-10 Circle Biomedical, Inc. Novel artificial pancreas
US5869243A (en) 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
EP0841396B2 (en) 1996-10-01 2012-04-11 Geron Corporation Human telomerase catalytic subunit
AU5734998A (en) 1997-01-10 1998-08-03 Life Technologies, Inc. Embryonic stem cell serum replacement
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US5935852A (en) * 1997-07-03 1999-08-10 Genetics Institute, Inc. DNA molecules encoding mammalian cerberus-like proteins
CA2307807C (en) 1997-10-23 2008-09-02 Andrea G. Bodnar Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000047721A2 (en) 1999-02-10 2000-08-17 Ontogeny, Inc. Methods of inducing insulin positive progenitor cells
AU780794B2 (en) * 1999-02-10 2005-04-14 Es Cell International Pte Ltd Pancreatic progenitor cells, methods and uses related thereto
US6946293B1 (en) * 1999-02-10 2005-09-20 Es Cell International Pte Ltd. Progenitor cells, methods and uses related thereto
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
WO2000078929A1 (en) 1999-06-23 2000-12-28 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
ATE514772T1 (de) 1999-08-05 2011-07-15 Abt Holding Co Multipotente erwachsene stammzellen und verfahren zu deren isolierung
AU7445800A (en) 1999-09-27 2001-04-30 Chugai Seiyaku Kabushiki Kaisha Method of prolonging normal cell life span
EP1257282A4 (en) * 1999-12-06 2003-05-02 Gen Hospital Corp PANCREATIC STEM CELLS AND THEIR USE IN TRANSPLANTATION
CA2397292A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Cell production
US6610535B1 (en) * 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
WO2002059278A2 (en) 2001-01-24 2002-08-01 The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services Differentiation of stem cells to pancreatic endocrine cells
WO2002074946A2 (en) 2001-02-26 2002-09-26 Novo Nordisk A/S Method for generating insulin-secreting cells suitable for transplantation
EP1373498A2 (en) 2001-03-21 2004-01-02 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
US7202080B2 (en) * 2001-03-29 2007-04-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
WO2002086107A2 (en) * 2001-04-19 2002-10-31 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for differentiating stem cells into insulin-producing cells
EP1393066A4 (en) 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
WO2002096203A1 (en) 2001-05-25 2002-12-05 Cythera, Inc. Stem cell differentiation
EP1298201A1 (en) * 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
GB2398079B (en) 2001-11-09 2006-05-31 Es Cell Int Pte Ltd Characterization and isolation of subsets of human embryonic stem cells (HES) and cells associated or derived therefrom
US7033831B2 (en) * 2001-12-07 2006-04-25 Geron Corporation Islet cells from human embryonic stem cells
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
CA2487058C (en) 2002-05-17 2015-04-14 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
BR0311360A (pt) 2002-05-28 2006-06-06 Becton Dickinson Co métodos para expansão e transdiferenciação in vitro de células acinares pancreáticas humanas em células produtoras de insulina
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
MXPA06007252A (es) 2003-12-23 2007-01-23 Cythera Inc Endodermo definitivo.
CA2613812A1 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
WO2007075807A2 (en) 2005-12-20 2007-07-05 Es Cell International Pte Ltd. Methods for the directed differentiation of embryonic stem cell
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells

Similar Documents

Publication Publication Date Title
JP2008212150A5 (enExample)
RU2011124900A (ru) Культура плюрипотентных стволовых клеток на микроносителях
EP2896690A3 (en) Use of RNA for reprogramming somatic cells
JP2017500013A5 (enExample)
WO2008036447A3 (en) Pluripotent stem cell culture
SE0850111L (sv) Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen
WO2007115337A8 (en) Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
WO2007077217A3 (en) Oligopeptide-free cell culture media
SI1646715T1 (sl) Pridobivanje poksvirusov z adherentnimi ali ne adherentnimi linijami ptičjih celic
EP2727998A3 (en) Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells
JP2005501554A5 (enExample)
JP2008525039A5 (enExample)
RU2016121409A (ru) Суспендирование и кластеризация плюрипотентных стволовых клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
WO2008148105A8 (en) Endometrial stem cells and methods of making and using same
EP2408903A4 (en) PLURIPOTENTE AND MULTIPOTENTE CELL CULTURE ON MICROWAVES
WO2015054526A3 (en) Methods of mammalian retinal stem cell production and applications
WO2008101001A3 (en) Three dimensional cell culture construct and apparatus for its making
WO2007030469A3 (en) Transplantable cell growth niche and related compositions and methods
WO2007149182A3 (en) Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2006070370A3 (en) Stem cells culture systems
WO2011119507A3 (en) Method of altering the differentiative state of a cell and compositions thereof
MY157524A (en) Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a muc1 or muc1* ligand
WO2008084401A3 (en) Composition and method for enabling proliferation of pluripotent stem cells
JP2015165823A5 (enExample)
WO2008056173A8 (en) Pluripotent cells from the mammalian late epiblast layer