JP2007535565A5

JP2007535565A5 -

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Publication number: JP2007535565A5
Authority: JP; Japan
Prior art keywords: phenyl; amino; butyl; tert; pyrazol
Prior art date: 2005-05-02
Legal status : Pending

Application number

JP2007511073A

Other languages

English (en)

Japanese (ja)

Other versions

JP2007535565A (ja

Filing date

2005-05-02

Publication date

2008-06-19

2005-05-02 Application filed filed Critical

2005-05-02 Priority claimed from PCT/US2005/015106 external-priority patent/WO2005110994A2/en

2007-12-06 Publication of JP2007535565A publication Critical patent/JP2007535565A/ja

2008-06-19 Publication of JP2007535565A5 publication Critical patent/JP2007535565A5/ja

Status Pending legal-status Critical Current

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-1 hydroxy, amino Chemical group 0.000 claims 142
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 38
150000001875 compounds Chemical class 0.000 claims 32
125000000217 alkyl group Chemical group 0.000 claims 25
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 23
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
208000035475 disorder Diseases 0.000 claims 20
239000003814 drug Substances 0.000 claims 20
229910052739 hydrogen Inorganic materials 0.000 claims 20
239000001257 hydrogen Substances 0.000 claims 20
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 19
230000003463 hyperproliferative effect Effects 0.000 claims 19
229940124597 therapeutic agent Drugs 0.000 claims 19
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
239000004202 carbamide Substances 0.000 claims 14
229910052736 halogen Inorganic materials 0.000 claims 14
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 12
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 12
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 11
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 11
150000002367 halogens Chemical class 0.000 claims 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 11
125000006413 ring segment Chemical group 0.000 claims 11
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 10
125000001188 haloalkyl group Chemical group 0.000 claims 10
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 9
229910052799 carbon Inorganic materials 0.000 claims 9
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 9
BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims 8
150000003839 salts Chemical class 0.000 claims 7
125000001424 substituent group Chemical group 0.000 claims 7
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 6
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
206010028980 Neoplasm Diseases 0.000 claims 6
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 6
239000000460 chlorine Substances 0.000 claims 6
229910052801 chlorine Inorganic materials 0.000 claims 6
229910052731 fluorine Inorganic materials 0.000 claims 6
239000011737 fluorine Substances 0.000 claims 6
125000002950 monocyclic group Chemical group 0.000 claims 6
229910052760 oxygen Inorganic materials 0.000 claims 6
229920006395 saturated elastomer Polymers 0.000 claims 6
229910052717 sulfur Inorganic materials 0.000 claims 6
239000002253 acid Substances 0.000 claims 5
125000003545 alkoxy group Chemical group 0.000 claims 5
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
201000011510 cancer Diseases 0.000 claims 5
150000001721 carbon Chemical group 0.000 claims 5
150000002431 hydrogen Chemical class 0.000 claims 5
239000002207 metabolite Substances 0.000 claims 5
229940002612 prodrug Drugs 0.000 claims 5
239000000651 prodrug Substances 0.000 claims 5
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
102000014150 Interferons Human genes 0.000 claims 4
108010050904 Interferons Proteins 0.000 claims 4
125000004093 cyano group Chemical group *C#N 0.000 claims 4
125000001153 fluoro group Chemical group F* 0.000 claims 4
125000005842 heteroatom Chemical group 0.000 claims 4
229940079322 interferon Drugs 0.000 claims 4
239000000203 mixture Substances 0.000 claims 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims 3
VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical group CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 claims 3
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 3
108010074604 Epoetin Alfa Proteins 0.000 claims 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
206010039491 Sarcoma Diseases 0.000 claims 3
IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 3
ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 3
239000003795 chemical substances by application Substances 0.000 claims 3
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
KIIAVHWBIPNTGI-UHFFFAOYSA-N ethoxy-methoxy-propoxy-lambda3-bromane Chemical compound COBr(OCCC)OCC KIIAVHWBIPNTGI-UHFFFAOYSA-N 0.000 claims 3
210000004392 genitalia Anatomy 0.000 claims 3
125000004438 haloalkoxy group Chemical group 0.000 claims 3
125000000623 heterocyclic group Chemical group 0.000 claims 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 3
229960004338 leuprorelin Drugs 0.000 claims 3
125000004433 nitrogen atom Chemical group N* 0.000 claims 3
125000004043 oxo group Chemical group O=* 0.000 claims 3
229960001592 paclitaxel Drugs 0.000 claims 3
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
150000003536 tetrazoles Chemical class 0.000 claims 3
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 3
UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 3
BHSOBLOBORUXMS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-methoxyethoxymethyl)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=CC(COCCOC)=CC=C1N1C(NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=CC(C(C)(C)C)=N1 BHSOBLOBORUXMS-UHFFFAOYSA-N 0.000 claims 2
JDAKOHHPPJZIIT-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-morpholin-4-ylethoxymethyl)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(COCCN4CCOCC4)=CC=3)=CC=2)=C1 JDAKOHHPPJZIIT-UHFFFAOYSA-N 0.000 claims 2
CBOWQEOQWWGGJC-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(methoxymethyl)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=CC(COC)=CC=C1N1C(NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=CC(C(C)(C)C)=N1 CBOWQEOQWWGGJC-UHFFFAOYSA-N 0.000 claims 2
PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 2
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
HQMLIDZJXVVKCW-REOHCLBHSA-N L-alaninamide Chemical compound C[C@H](N)C(N)=O HQMLIDZJXVVKCW-REOHCLBHSA-N 0.000 claims 2
XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical group IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 claims 2
108010000817 Leuprolide Proteins 0.000 claims 2
206010025323 Lymphomas Diseases 0.000 claims 2
241000124008 Mammalia Species 0.000 claims 2
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
229910019142 PO4 Inorganic materials 0.000 claims 2
229930012538 Paclitaxel Natural products 0.000 claims 2
208000000453 Skin Neoplasms Diseases 0.000 claims 2
101000655609 Streptomyces azureus Thiostrepton Proteins 0.000 claims 2
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
125000004432 carbon atom Chemical group C* 0.000 claims 2
208000006990 cholangiocarcinoma Diseases 0.000 claims 2
229960002436 cladribine Drugs 0.000 claims 2
229940026692 decadron Drugs 0.000 claims 2
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
150000002148 esters Chemical class 0.000 claims 2
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 2
229960002949 fluorouracil Drugs 0.000 claims 2
206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 claims 2
108700020746 histrelin Proteins 0.000 claims 2
229960002193 histrelin Drugs 0.000 claims 2
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
229960004768 irinotecan Drugs 0.000 claims 2
208000032839 leukemia Diseases 0.000 claims 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
229910052757 nitrogen Inorganic materials 0.000 claims 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
239000010452 phosphate Substances 0.000 claims 2
125000003226 pyrazolyl group Chemical group 0.000 claims 2
229960004622 raloxifene Drugs 0.000 claims 2
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 2
201000000849 skin cancer Diseases 0.000 claims 2
229960000303 topotecan Drugs 0.000 claims 2
XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 2
229960005026 toremifene Drugs 0.000 claims 2
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims 1
BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 claims 1
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims 1
WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 claims 1
VESKBLGTHHPZJF-QNWVGRARSA-N (2s)-2-amino-5-[[(2r)-2-amino-3-[2-[bis[bis(2-chloroethyl)amino]phosphoryloxy]ethylsulfonyl]propanoyl]-[(r)-carboxy(phenyl)methyl]amino]-5-oxopentanoic acid Chemical compound ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](N)C(=O)N(C(=O)CC[C@H](N)C(O)=O)[C@@H](C(O)=O)C1=CC=CC=C1 VESKBLGTHHPZJF-QNWVGRARSA-N 0.000 claims 1
DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims 1
DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 1
PUDHBTGHUJUUFI-SCTWWAJVSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-p Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 PUDHBTGHUJUUFI-SCTWWAJVSA-N 0.000 claims 1
FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims 1
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
YNDGYWVQJNUSSD-UHFFFAOYSA-N 1-[2-[3-(aminomethyl)phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(CN)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 YNDGYWVQJNUSSD-UHFFFAOYSA-N 0.000 claims 1
VPGDDYNTSDDCRG-UHFFFAOYSA-N 1-[2-[3-(aminomethyl)phenyl]-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(CN)C=CC=3)=CC=2)=C1 VPGDDYNTSDDCRG-UHFFFAOYSA-N 0.000 claims 1
OYNFGNITHOYLOQ-UHFFFAOYSA-N 1-[2-[3-[bis(2-hydroxyethyl)amino]phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(N(CCO)CCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 OYNFGNITHOYLOQ-UHFFFAOYSA-N 0.000 claims 1
PIHDPZBAHNDQGC-UHFFFAOYSA-N 1-[2-[4-(2-aminoethoxy)phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(OCCN)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 PIHDPZBAHNDQGC-UHFFFAOYSA-N 0.000 claims 1
ABYQNJKXDPISBM-UHFFFAOYSA-N 1-[2-[4-(2-aminoethoxy)phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(OCCN)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 ABYQNJKXDPISBM-UHFFFAOYSA-N 0.000 claims 1
COWCCUYIEUZKKW-UHFFFAOYSA-N 1-[2-[4-(2-aminoethoxy)phenyl]-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCCN)=CC=3)=CC=2)=C1 COWCCUYIEUZKKW-UHFFFAOYSA-N 0.000 claims 1
XIEXRSUZWARTBD-UHFFFAOYSA-N 1-[2-[4-(aminomethyl)phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CN)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 XIEXRSUZWARTBD-UHFFFAOYSA-N 0.000 claims 1
PLKUEIDWYBUCBR-UHFFFAOYSA-N 1-[2-[4-(aminomethyl)phenyl]-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(CN)=CC=3)=CC=2)=C1 PLKUEIDWYBUCBR-UHFFFAOYSA-N 0.000 claims 1
MBRLMCVETLGOTD-UHFFFAOYSA-N 1-[2-[4-[[bis(2-hydroxyethyl)amino]methyl]phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(CN(CCO)CCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 MBRLMCVETLGOTD-UHFFFAOYSA-N 0.000 claims 1
FNHITZCPPMBJOI-UHFFFAOYSA-N 1-[2-[4-[[bis(2-hydroxyethyl)amino]methyl]phenyl]-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CN(CCO)CCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 FNHITZCPPMBJOI-UHFFFAOYSA-N 0.000 claims 1
CKIDGOMUFOAFJV-UHFFFAOYSA-N 1-[2-[4-[[bis(2-hydroxyethyl)amino]methyl]phenyl]-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(CN(CCO)CCO)=CC=3)=CC=2)=C1 CKIDGOMUFOAFJV-UHFFFAOYSA-N 0.000 claims 1
PNBWRZYBPGIXKV-UHFFFAOYSA-N 1-[2-[4-[[bis(3-hydroxypropyl)amino]methyl]phenyl]-5-tert-butylpyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(CN(CCCO)CCCO)=CC=3)=CC=2)=C1 PNBWRZYBPGIXKV-UHFFFAOYSA-N 0.000 claims 1
OEDQSXVJMMISCX-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=CC(NCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 OEDQSXVJMMISCX-UHFFFAOYSA-N 0.000 claims 1
IJBUKGGYBXPIMW-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(NCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 IJBUKGGYBXPIMW-UHFFFAOYSA-N 0.000 claims 1
RWUDYSFVUHKYLA-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(NCCO)C=CC=3)=CC=2)=C1 RWUDYSFVUHKYLA-UHFFFAOYSA-N 0.000 claims 1
DJZBYMAJAHKOKM-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-methoxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound COCCNC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=NC=CC=3)=CC=2)=C1 DJZBYMAJAHKOKM-UHFFFAOYSA-N 0.000 claims 1
IWBWVYYWGAGKKB-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-methoxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound COCCNC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=C1 IWBWVYYWGAGKKB-UHFFFAOYSA-N 0.000 claims 1
QGGBGJMRHZXHQN-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-methoxyethylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound COCCNC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=C1 QGGBGJMRHZXHQN-UHFFFAOYSA-N 0.000 claims 1
MWOKSTPCOBTMQR-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=CC(OCCN2CCCC2)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 MWOKSTPCOBTMQR-UHFFFAOYSA-N 0.000 claims 1
QXCGHDBMHNUXHJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(OCCN2CCCC2)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 QXCGHDBMHNUXHJ-UHFFFAOYSA-N 0.000 claims 1
HQAFYXJFJKFMTA-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(OCCN4CCCC4)C=CC=3)=CC=2)=C1 HQAFYXJFJKFMTA-UHFFFAOYSA-N 0.000 claims 1
SIJBFZZBPXNCNO-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=CC(OCCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 SIJBFZZBPXNCNO-UHFFFAOYSA-N 0.000 claims 1
ZXUWSRNPQZVPLR-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(OCCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 ZXUWSRNPQZVPLR-UHFFFAOYSA-N 0.000 claims 1
WYIXXQVVUPYOHS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(OCCCO)C=CC=3)=CC=2)=C1 WYIXXQVVUPYOHS-UHFFFAOYSA-N 0.000 claims 1
NPFZFAKBGZJMSS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=CC(NCCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 NPFZFAKBGZJMSS-UHFFFAOYSA-N 0.000 claims 1
FMEAFBHPDCBPPE-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(NCCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 FMEAFBHPDCBPPE-UHFFFAOYSA-N 0.000 claims 1
JNFASIYSVGBTIU-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-hydroxypropylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(NCCCO)C=CC=3)=CC=2)=C1 JNFASIYSVGBTIU-UHFFFAOYSA-N 0.000 claims 1
NAYMLHGUYDAUST-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-morpholin-4-ylpropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=CC(OCCCN2CCOCC2)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 NAYMLHGUYDAUST-UHFFFAOYSA-N 0.000 claims 1
YPYYFEBVFYQEMI-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-morpholin-4-ylpropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(OCCCN2CCOCC2)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 YPYYFEBVFYQEMI-UHFFFAOYSA-N 0.000 claims 1
OEZYDPPLKBEWSA-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(3-morpholin-4-ylpropoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(OCCCN4CCOCC4)C=CC=3)=CC=2)=C1 OEZYDPPLKBEWSA-UHFFFAOYSA-N 0.000 claims 1
RJPRBEISRPEZIN-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-(hydroxymethyl)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(CO)C=CC=3)=CC=2)=C1 RJPRBEISRPEZIN-UHFFFAOYSA-N 0.000 claims 1
KYXFWAOOHMIRAL-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-[(2,3-dihydroxypropylamino)methyl]phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(CNCC(O)CO)C=CC=3)=CC=2)=C1 KYXFWAOOHMIRAL-UHFFFAOYSA-N 0.000 claims 1
ADNMPCMEWGGTDL-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-[(2-hydroxyethylamino)methyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=CC(CNCCO)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 ADNMPCMEWGGTDL-UHFFFAOYSA-N 0.000 claims 1
JSYLYRFZLKWXHF-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-[dimethylsulfamoyl(2-hydroxyethyl)amino]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound CN(C)S(=O)(=O)N(CCO)C1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=C1 JSYLYRFZLKWXHF-UHFFFAOYSA-N 0.000 claims 1
CHPWYSLLSXRYAU-UHFFFAOYSA-N 1-[5-tert-butyl-2-[3-[dimethylsulfamoyl(3-hydroxypropyl)amino]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound OCCCN(S(=O)(=O)N(C)C)C1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=C1 CHPWYSLLSXRYAU-UHFFFAOYSA-N 0.000 claims 1
ISUILLQIPPSBNW-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2,3-dihydroxypropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(OCC(O)CO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 ISUILLQIPPSBNW-UHFFFAOYSA-N 0.000 claims 1
JPXBUZZZPDKCER-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2,3-dihydroxypropoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCC(O)CO)=CC=3)=CC=2)=C1 JPXBUZZZPDKCER-UHFFFAOYSA-N 0.000 claims 1
GEHXQPRBADNGAJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(OCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 GEHXQPRBADNGAJ-UHFFFAOYSA-N 0.000 claims 1
QWQWXDRDMRMDDS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(OCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 QWQWXDRDMRMDDS-UHFFFAOYSA-N 0.000 claims 1
CKMADWOVUWVZFY-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCCO)=CC=3)=CC=2)=C1 CKMADWOVUWVZFY-UHFFFAOYSA-N 0.000 claims 1
BWQJCQNTODDYHP-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 BWQJCQNTODDYHP-UHFFFAOYSA-N 0.000 claims 1
JZECSHSHTIPKLH-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethyl)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(CCO)=CC=3)=CC=2)=C1 JZECSHSHTIPKLH-UHFFFAOYSA-N 0.000 claims 1
LZRTWANPIKXPGB-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(NCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 LZRTWANPIKXPGB-UHFFFAOYSA-N 0.000 claims 1
IWJVQGOSCNTJTM-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(NCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 IWJVQGOSCNTJTM-UHFFFAOYSA-N 0.000 claims 1
PYFMDJILOWLTKE-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-hydroxyethylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(NCCO)=CC=3)=CC=2)=C1 PYFMDJILOWLTKE-UHFFFAOYSA-N 0.000 claims 1
NAJIORIXSPERTD-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-methoxyethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=CC(OCCOC)=CC=C1N1C(NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=CC(C(C)(C)C)=N1 NAJIORIXSPERTD-UHFFFAOYSA-N 0.000 claims 1
FSHUUEXTJHSRTM-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-methoxyethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(NCCOC)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FSHUUEXTJHSRTM-UHFFFAOYSA-N 0.000 claims 1
YSRYOEYJFNXKLM-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-methoxyethylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=CC(NCCOC)=CC=C1N1C(NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=CC(C(C)(C)C)=N1 YSRYOEYJFNXKLM-UHFFFAOYSA-N 0.000 claims 1
NNOBAVIJDTWLOU-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-morpholin-4-yl-2-oxoethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CC(=O)N2CCOCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 NNOBAVIJDTWLOU-UHFFFAOYSA-N 0.000 claims 1
MJSHSPYDBYHGGS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-morpholin-4-ylethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCN2CCOCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 MJSHSPYDBYHGGS-UHFFFAOYSA-N 0.000 claims 1
UDOMFPPPFZOXCS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-morpholin-4-ylethylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(NCCN2CCOCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 UDOMFPPPFZOXCS-UHFFFAOYSA-N 0.000 claims 1
JJMQMWZNCNHZST-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-oxo-2-piperazin-1-ylethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CC(=O)N2CCNCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 JJMQMWZNCNHZST-UHFFFAOYSA-N 0.000 claims 1
BSPKVZSNFLDDRN-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-oxo-2-pyrrolidin-1-ylethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CC(=O)N2CCCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 BSPKVZSNFLDDRN-UHFFFAOYSA-N 0.000 claims 1
XLDPNPVNGPJRGL-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-piperazin-1-ylethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCN2CCNCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 XLDPNPVNGPJRGL-UHFFFAOYSA-N 0.000 claims 1
HHFPDBMETPOJST-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-piperidin-4-ylethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(OCCC2CCNCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 HHFPDBMETPOJST-UHFFFAOYSA-N 0.000 claims 1
DHNIQTXBUKETQP-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-piperidin-4-ylethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCCC4CCNCC4)=CC=3)=CC=2)=C1 DHNIQTXBUKETQP-UHFFFAOYSA-N 0.000 claims 1
KKPNCIBIIXJIJW-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(OCCN2CCCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 KKPNCIBIIXJIJW-UHFFFAOYSA-N 0.000 claims 1
DTQKTQIRVVJANJ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(OCCN2CCCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 DTQKTQIRVVJANJ-UHFFFAOYSA-N 0.000 claims 1
SRUJCVACIINUDZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCCN4CCCC4)=CC=3)=CC=2)=C1 SRUJCVACIINUDZ-UHFFFAOYSA-N 0.000 claims 1
CYKMPDFAJNHZLP-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(2-pyrrolidin-1-ylethyl)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCN2CCCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 CYKMPDFAJNHZLP-UHFFFAOYSA-N 0.000 claims 1
BEFXPHGMOFMGRO-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(OCCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 BEFXPHGMOFMGRO-UHFFFAOYSA-N 0.000 claims 1
IOKXXPYJWBVTRC-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(OCCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 IOKXXPYJWBVTRC-UHFFFAOYSA-N 0.000 claims 1
UDJCREBRPUSTLP-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(3-hydroxypropoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(OCCCO)=CC=3)=CC=2)=C1 UDJCREBRPUSTLP-UHFFFAOYSA-N 0.000 claims 1
IRWFZMZXGMGFEV-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(3-hydroxypropylamino)phenyl]pyrazol-3-yl]-3-(4-pyridin-3-yloxyphenyl)urea Chemical compound C=1C=C(NCCCO)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CN=C1 IRWFZMZXGMGFEV-UHFFFAOYSA-N 0.000 claims 1
CCMKXZJIDTYJCY-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(3-hydroxypropylamino)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(NCCCO)=CC=3)=CC=2)=C1 CCMKXZJIDTYJCY-UHFFFAOYSA-N 0.000 claims 1
NCGUIFLZYSXFJZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(oxolan-2-ylmethylsulfamoyl)-3-(trifluoromethoxy)phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(S(=O)(=O)NCC2OCCC2)C(OC(F)(F)F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 NCGUIFLZYSXFJZ-UHFFFAOYSA-N 0.000 claims 1
XGRCTUPHXPXFSC-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-(oxolan-2-ylmethylsulfamoyl)-3-(trifluoromethoxy)phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=C(OC(F)(F)F)C(=CC=3)S(=O)(=O)NCC3OCCC3)=CC=2)=C1 XGRCTUPHXPXFSC-UHFFFAOYSA-N 0.000 claims 1
FJZJQSMXSKSYTH-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[(2-methoxyethylamino)methyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(CNCCOC)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FJZJQSMXSKSYTH-UHFFFAOYSA-N 0.000 claims 1
MDVZQFPUAKENCZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[(2-methoxyethylamino)methyl]phenyl]pyrazol-3-yl]-3-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]urea Chemical compound C1=CC(CNCCOC)=CC=C1N1C(NC(=O)NC=2C(=CC(OC=3C=C(C)N=CC=3)=CC=2)F)=CC(C(C)(C)C)=N1 MDVZQFPUAKENCZ-UHFFFAOYSA-N 0.000 claims 1
CADFTZYMNPVRRQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[(4-hydroxy-3,3-dimethylbutyl)amino]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(NCCC(C)(CO)C)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 CADFTZYMNPVRRQ-UHFFFAOYSA-N 0.000 claims 1
QFFHSPCOWRJBTH-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[2-(2-methoxyethylamino)ethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(CCNCCOC)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 QFFHSPCOWRJBTH-UHFFFAOYSA-N 0.000 claims 1
SHOXRHCWJDTZHP-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[2-(2-morpholin-4-ylethylamino)ethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCNCCN2CCOCC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 SHOXRHCWJDTZHP-UHFFFAOYSA-N 0.000 claims 1
QAEPQYCYOULHKB-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1CN(C)CCN1C(=O)CC1=CC=C(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)C=C1 QAEPQYCYOULHKB-UHFFFAOYSA-N 0.000 claims 1
DKEDTEYIOZMUAG-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1CN(C)CCN1CCC1=CC=C(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)C=C1 DKEDTEYIOZMUAG-UHFFFAOYSA-N 0.000 claims 1
ZLYFHJZQNXEEPL-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[2-(diethylamino)ethoxy]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(OCCN(CC)CC)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 ZLYFHJZQNXEEPL-UHFFFAOYSA-N 0.000 claims 1
OKNQYBVPDCLFJN-RUZDIDTESA-N 1-[5-tert-butyl-2-[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]ethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CCN2C[C@H](O)CC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 OKNQYBVPDCLFJN-RUZDIDTESA-N 0.000 claims 1
INVIKJXXMWWVIL-DEOSSOPVSA-N 1-[5-tert-butyl-2-[4-[2-[(3s)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C=1C=C(CC(=O)N2C[C@@H](O)CC2)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 INVIKJXXMWWVIL-DEOSSOPVSA-N 0.000 claims 1
OZOJRCNJURVGPS-UHFFFAOYSA-N 1-[5-tert-butyl-2-[4-[dimethylsulfamoyl(2-hydroxyethyl)amino]phenyl]pyrazol-3-yl]-3-(4-pyridin-4-yloxyphenyl)urea Chemical compound C1=CC(N(CCO)S(=O)(=O)N(C)C)=CC=C1N1C(NC(=O)NC=2C=CC(OC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 OZOJRCNJURVGPS-UHFFFAOYSA-N 0.000 claims 1
VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
QXLQZLBNPTZMRK-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-(2,4-dimethylphenyl)prop-2-en-1-one Chemical compound CN(C)CC(=C)C(=O)C1=CC=C(C)C=C1C QXLQZLBNPTZMRK-UHFFFAOYSA-N 0.000 claims 1
NDLQHWDYAQFRBU-UHFFFAOYSA-N 2-[4-[3-tert-butyl-5-[(4-pyridin-4-yloxyphenyl)carbamoylamino]pyrazol-1-yl]phenyl]acetic acid Chemical compound C=1C=C(CC(O)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 NDLQHWDYAQFRBU-UHFFFAOYSA-N 0.000 claims 1
GCYFECCUPQKKIS-UHFFFAOYSA-N 2-[4-[3-tert-butyl-5-[[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]carbamoylamino]pyrazol-1-yl]phenyl]acetic acid Chemical compound C1=NC(C)=CC(OC=2C=C(F)C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(CC(O)=O)=CC=3)=CC=2)=C1 GCYFECCUPQKKIS-UHFFFAOYSA-N 0.000 claims 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
LGEXGKUJMFHVSY-UHFFFAOYSA-N 2-n,4-n,6-n-trimethyl-1,3,5-triazine-2,4,6-triamine Chemical compound CNC1=NC(NC)=NC(NC)=N1 LGEXGKUJMFHVSY-UHFFFAOYSA-N 0.000 claims 1
NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims 1
UZFPOOOQHWICKY-UHFFFAOYSA-N 3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(=C(C)C(C=C4N5)=N3)CCC(O)=O)=N2)C)=C(C)C(C(C)O)=C1C=C5C(C)=C4C(C)OC(C)C1=C(N2)C=C(N3)C(C)=C(C(O)C)C3=CC(C(C)=C3CCC(O)=O)=NC3=CC(C(CCC(O)=O)=C3C)=NC3=CC2=C1C UZFPOOOQHWICKY-UHFFFAOYSA-N 0.000 claims 1
ZPWKORUGOJSORB-UHFFFAOYSA-N 3-[3-tert-butyl-5-[(4-pyridin-4-yloxyphenyl)carbamoylamino]pyrazol-1-yl]-n-[[6-(trifluoromethyl)pyridin-3-yl]methyl]benzamide Chemical compound C=1C=CC(C(=O)NCC=2C=NC(=CC=2)C(F)(F)F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=NC=C1 ZPWKORUGOJSORB-UHFFFAOYSA-N 0.000 claims 1
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JP2007511073A 2004-04-30 2005-05-02 癌の治療に有用な置換ピラゾリル尿素誘導体 Pending JP2007535565A (ja)