|
US7504509B2
(en)
|
2003-12-19 |
2009-03-17 |
Plexxikon, Inc. |
Compounds and methods for development of Ret modulators
|
|
WO2005066145A1
(en)
|
2004-01-06 |
2005-07-21 |
Novo Nordisk A/S |
Heteroaryl-ureas and their use as glucokinase activators
|
|
EP1708697A4
(en)
*
|
2004-01-30 |
2007-11-28 |
Smithkline Beecham Corp |
CHEMICAL COMPOUNDS
|
|
EP2332940B1
(en)
|
2004-03-30 |
2012-10-31 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of JAK and other protein kinases
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
MXPA06014415A
(es)
|
2004-06-24 |
2007-02-19 |
Shionogi & Co |
Compuestos de sulfonamida.
|
|
WO2006004984A1
(en)
*
|
2004-06-30 |
2006-01-12 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of protein kinases
|
|
MX2007000092A
(es)
*
|
2004-06-30 |
2007-03-07 |
Vertex Pharma |
Azaindoles utiles como inhibidores de proteinas cinasas.
|
|
AU2005272815A1
(en)
*
|
2004-08-13 |
2006-02-23 |
Genentech, Inc. |
Thiazole based inhibitors of ATP-utilizing enzymes
|
|
CN101098872B
(zh)
*
|
2004-11-22 |
2012-09-05 |
沃泰克斯药物股份有限公司 |
可用作蛋白激酶抑制剂的吡咯并吡嗪和吡唑并吡嗪
|
|
EP1864971A4
(en)
*
|
2005-03-31 |
2010-02-10 |
Takeda Pharmaceutical |
PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES
|
|
NZ564065A
(en)
*
|
2005-05-20 |
2011-03-31 |
Vertex Pharma |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
BRPI0613591A2
(pt)
|
2005-07-08 |
2011-01-18 |
Novo Nordisk As |
ativadores de dicicloalquil uréia glicocinase
|
|
EP2377856A1
(en)
|
2005-07-14 |
2011-10-19 |
Novo Nordisk A/S |
Urea glucokinase activators
|
|
WO2007026920A2
(en)
|
2005-09-02 |
2007-03-08 |
Astellas Pharma Inc. |
Amide derivatives as rock inhibitors
|
|
US7592461B2
(en)
|
2005-12-21 |
2009-09-22 |
Bristol-Myers Squibb Company |
Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
|
|
EP1968568A4
(en)
*
|
2005-12-22 |
2011-04-13 |
Glaxosmithkline Llc |
HEMMER OF NUTS ACTIVITY
|
|
CN102532134A
(zh)
|
2006-01-17 |
2012-07-04 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的吖吲哚类
|
|
WO2007082808A2
(en)
*
|
2006-01-18 |
2007-07-26 |
F. Hoffmann-La Roche Ag |
Thiazoles as 11 beta-hsd1 inhibitors
|
|
EP1989205B1
(en)
*
|
2006-01-23 |
2012-06-13 |
Vertex Pharmceuticals Incorporated |
Thiophene-carboxamides useful as inhibitors of protein kinases
|
|
US20100004277A1
(en)
*
|
2006-01-26 |
2010-01-07 |
Foldrx Pharmaceuticals, Inc. |
Compounds and methods for modulating protein trafficking
|
|
CA2648250A1
(en)
*
|
2006-04-05 |
2007-10-18 |
Vertex Pharmaceuticals Incorporated |
Deazapurines useful as inhibitors of janus kinases
|
|
US7829590B2
(en)
|
2006-04-13 |
2010-11-09 |
Guy Brenchley |
Thiophene-carboxamides useful as inhibitors of protein kinases
|
|
AU2007267986A1
(en)
|
2006-05-23 |
2007-12-06 |
Vertex Pharmaceuticals Incorporated |
Thiophene-carboxamides useful as inhibitors of protein kinases
|
|
JP2009538305A
(ja)
*
|
2006-05-23 |
2009-11-05 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド
|
|
FR2907120B1
(fr)
|
2006-10-12 |
2013-01-11 |
Sanofi Aventis |
Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
EP2124951B1
(en)
|
2006-12-21 |
2014-05-21 |
Vertex Pharmaceuticals Inc. |
5-cyan0-4- (pyrrolo[2, 3b]pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
WO2008084044A1
(en)
|
2007-01-11 |
2008-07-17 |
Novo Nordisk A/S |
Urea glucokinase activators
|
|
GB0702259D0
(en)
*
|
2007-02-06 |
2007-03-14 |
Eisai London Res Lab Ltd |
7-azaindole derivatives
|
|
WO2008112297A2
(en)
*
|
2007-03-13 |
2008-09-18 |
Yale University |
Methods of treating cancer by interfering with igf-i receptor signaling
|
|
SG183036A1
(en)
|
2007-07-17 |
2012-08-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP5657252B2
(ja)
|
2007-08-29 |
2015-01-21 |
千寿製薬株式会社 |
角膜内皮細胞接着促進剤
|
|
CL2009001152A1
(es)
|
2008-05-13 |
2009-10-16 |
Array Biopharma Inc |
Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa.
|
|
EP2303277A4
(en)
*
|
2008-06-26 |
2011-08-17 |
Glaxosmithkline Llc |
HAMMER OF ACT ACTIVITY
|
|
WO2009158374A2
(en)
*
|
2008-06-26 |
2009-12-30 |
Smithkline Beecham Corporation |
Inhibitors of akt activity
|
|
GB0812648D0
(en)
*
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
TW201006832A
(en)
*
|
2008-07-15 |
2010-02-16 |
Novartis Ag |
Organic compounds
|
|
JP2011529066A
(ja)
*
|
2008-07-23 |
2011-12-01 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
三環式ピラゾロピリジンキナーゼ阻害剤
|
|
KR20110039563A
(ko)
|
2008-07-23 |
2011-04-19 |
버텍스 파마슈티칼스 인코포레이티드 |
피라졸로피리딘 키나제 억제제
|
|
AU2009274023A1
(en)
|
2008-07-23 |
2010-01-28 |
Vertex Pharmaceuticals Incorporated |
Tri-cyclic pyrazolopyridine kinase inhibitors
|
|
EP2321318A1
(en)
*
|
2008-07-23 |
2011-05-18 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridine kinase inhibitors
|
|
DE102008038221A1
(de)
|
2008-08-18 |
2010-02-25 |
Merck Patent Gmbh |
7-Azaindolderivate
|
|
EP2403860B1
(en)
*
|
2009-03-04 |
2015-11-04 |
IDENIX Pharmaceuticals, Inc. |
Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
|
|
AU2010232670B2
(en)
|
2009-04-03 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
|
|
EP2427464A1
(en)
|
2009-05-06 |
2012-03-14 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridines
|
|
KR101903354B1
(ko)
|
2009-06-17 |
2018-10-04 |
버텍스 파마슈티칼스 인코포레이티드 |
인플루엔자 바이러스 복제의 억제제
|
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
CN102066372B
(zh)
|
2009-08-24 |
2014-09-17 |
苏州爱斯鹏药物研发有限责任公司 |
含脲基的5,6元杂芳双环化合物作为激酶抑制剂
|
|
MX2012005284A
(es)
|
2009-11-06 |
2012-06-28 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
|
|
DE102009058280A1
(de)
*
|
2009-12-14 |
2011-06-16 |
Merck Patent Gmbh |
Thiazolderivate
|
|
WO2011094290A1
(en)
|
2010-01-27 |
2011-08-04 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyrimidine kinase inhibitors
|
|
JP5769733B2
(ja)
|
2010-01-27 |
2015-08-26 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
ピラゾロピリジンキナーゼ阻害剤
|
|
MX2012008641A
(es)
|
2010-01-27 |
2012-11-23 |
Vertex Pharma |
Inhibidores de cinasas de pirazolopirazinas.
|
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
|
AR081331A1
(es)
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
|
US9133123B2
(en)
|
2010-04-23 |
2015-09-15 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
|
US8877794B2
(en)
*
|
2010-08-13 |
2014-11-04 |
Abbott Laboratories |
Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
|
|
EP2651940A1
(en)
|
2010-12-16 |
2013-10-23 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
KR101911972B1
(ko)
|
2011-02-07 |
2018-10-25 |
플렉시콘 인코퍼레이티드 |
키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
US8759380B2
(en)
|
2011-04-22 |
2014-06-24 |
Cytokinetics, Inc. |
Certain heterocycles, compositions thereof, and methods for their use
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
DE102011083283A1
(de)
*
|
2011-09-23 |
2013-03-28 |
Beiersdorf Ag |
Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen
|
|
LT2788472T
(lt)
|
2011-12-06 |
2019-04-10 |
Astellas Institute For Regenerative Medicine |
Kryptingos diferenciacijos būdas, skirtas ragenos endotelio ląstelių gamybai
|
|
ES2917222T3
(es)
|
2011-12-28 |
2022-07-07 |
Kyoto Prefectural Public Univ Corp |
Normalización del cultivo de células endoteliales de la córnea
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
JP6225178B2
(ja)
*
|
2012-05-31 |
2017-11-01 |
フェネックス ファーマシューティカルス アーゲー |
オーファン核内受容体RORγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体
|
|
CA2878054C
(en)
|
2012-06-29 |
2018-09-11 |
Pfizer Inc. |
Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
|
|
WO2014177699A1
(en)
*
|
2013-05-03 |
2014-11-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Rhoa (rock) inhibitors for the treatment of enflammatory bowel disease
|
|
WO2015016371A1
(ja)
|
2013-07-30 |
2015-02-05 |
京都府公立大学法人 |
角膜内皮細胞マーカー
|
|
ES2847755T3
(es)
|
2013-10-31 |
2021-08-03 |
Kyoto Prefectural Public Univ Corp |
Fármaco terapéutico que comprende un inhibidor de la señal de TGF-beta para enfermedades relacionadas con la muerte celular del retículo endoplásmico en el endotelio corneal
|
|
ES2684755T3
(es)
|
2013-11-13 |
2018-10-04 |
Vertex Pharmaceuticals Incorporated |
Métodos para preparar inhibidores de la replicación de virus de la gripe
|
|
DK3068776T3
(da)
|
2013-11-13 |
2019-07-29 |
Vertex Pharma |
Inhibitorer af replikation af influenzavira
|
|
MX2016006915A
(es)
|
2013-11-27 |
2017-01-23 |
Kyoto Prefectural Public Univ Corp |
Aplicacion de laminina a cultivo de celulas endoteliales de la cornea.
|
|
JP6487921B2
(ja)
|
2013-12-17 |
2019-03-20 |
ファイザー・インク |
LRRK2阻害薬としての新規の3,4−二置換−1H−ピロロ[2,3−b]ピリジンおよび4,5−二置換−7H−ピロロ[2,3−c]ピリダジン
|
|
AU2015215582B2
(en)
|
2014-02-04 |
2016-10-13 |
Taiho Pharmaceutical Co., Ltd. |
Azaindole derivative
|
|
WO2016026078A1
(en)
*
|
2014-08-19 |
2016-02-25 |
Changzhou Jiekai Pharmatech Co., Ltd. |
Heterocyclic compounds as erk inhibitors
|
|
AU2015315177A1
(en)
*
|
2014-09-10 |
2017-03-16 |
Epizyme, Inc. |
Substituted pyrrolidine carboxamide compounds
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
WO2016183116A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
|
WO2017046675A1
(en)
|
2015-09-14 |
2017-03-23 |
Pfizer Inc. |
Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors
|
|
EP4088719A1
(en)
|
2015-10-13 |
2022-11-16 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
|
|
US12048761B2
(en)
|
2015-10-13 |
2024-07-30 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
|
|
ES2947826T3
(es)
|
2016-02-15 |
2023-08-21 |
Kyoto Prefectural Public Univ Corp |
Célula endotelial corneal funcional humana y aplicación de la misma
|
|
CN108203433B
(zh)
*
|
2016-12-16 |
2020-07-03 |
成都先导药物开发股份有限公司 |
一种rock抑制剂及其应用
|
|
CN108948002A
(zh)
*
|
2017-05-19 |
2018-12-07 |
厦门大学 |
五元并六元氮杂芳环类化合物、其制备方法、药用组合物及其应用
|
|
ES2841951T3
(es)
*
|
2018-04-17 |
2021-07-12 |
Univ Masarykova |
Propanamidas sustituidas como inhibidores de nucleasas
|
|
CA3093025A1
(en)
|
2018-06-12 |
2019-12-19 |
Vtv Therapeutics Llc |
Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
|
|
US20210207088A1
(en)
|
2018-08-31 |
2021-07-08 |
The Doshisha |
Composition and method for preserving or culturing ocular cells
|
|
KR102797964B1
(ko)
|
2018-10-02 |
2025-04-22 |
학교법인 도시샤 |
각막 내피 세포를 보존하기 위한 방법 및 용기
|
|
SG11202104404XA
(en)
*
|
2018-11-16 |
2021-05-28 |
California Inst Of Techn |
Erk inhibitors and uses thereof
|
|
CN114040760B
(zh)
|
2018-12-31 |
2025-05-09 |
拜欧米富士恩公司 |
Menin-mll相互作用的不可逆抑制剂
|
|
WO2020142559A1
(en)
|
2018-12-31 |
2020-07-09 |
Biomea Fusion, Llc |
Inhibitors of menin-mll interaction
|
|
WO2021064141A1
(en)
*
|
2019-10-02 |
2021-04-08 |
Tolremo Therapeutics Ag |
Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b
|
|
WO2021167840A1
(en)
|
2020-02-18 |
2021-08-26 |
Vtv Therapeutics Llc |
Sulfoxide and sulfone glucokinase activators and methods of use thereof
|
|
CN115427551A
(zh)
|
2020-02-27 |
2022-12-02 |
京都府公立大学法人 |
人功能性角膜内皮细胞及其应用
|
|
MX2022015525A
(es)
|
2020-06-08 |
2023-03-23 |
Vtv Therapeutics Llc |
Sales o co-cristales del acido {2-[3-ciclohexil-3-(trans-4-propoxi ciclohexil)ureido]tiazol-5-ilsulfanil}acetico y usos de los mismos.
|
|
CA3179059A1
(en)
*
|
2020-06-09 |
2021-12-16 |
Anima Biotech Inc. |
Collagen 1 translation inhibitors and methods of use thereof
|
|
CA3216719A1
(en)
|
2021-05-03 |
2022-11-10 |
Astellas Institute For Regenerative Medicine |
Methods of generating mature corneal endothelial cells
|
|
US12251385B2
(en)
|
2021-08-11 |
2025-03-18 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-MLL interaction for diabetes mellitus
|
|
WO2023022912A1
(en)
|
2021-08-20 |
2023-02-23 |
Biomea Fusion, Inc. |
Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer
|
|
KR20240110954A
(ko)
|
2021-11-11 |
2024-07-16 |
학교법인 도시샤 |
각막 내피 세포의 냉동보존 제제 및 상기 냉동보존 제제를 생산하기 위한 방법
|
|
WO2024155719A1
(en)
|
2023-01-18 |
2024-07-25 |
Biomea Fusion, Inc. |
Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2- pyridinecarboxamide as a covalentinhibitor of menin-mll interaction
|
|
CN116768881B
(zh)
*
|
2023-06-30 |
2025-09-09 |
郑州大学 |
4-(3-吲哚基)-1,3-噻唑类化合物及其制备方法和应用
|
|
WO2025224050A1
(en)
|
2024-04-22 |
2025-10-30 |
Institut National de la Santé et de la Recherche Médicale |
Methods of treatment of patients suffering from hypomelanosis of ito
|