TW200604168A - Azaindoles useful as inhibitors of rock and other protein kinases - Google Patents

Azaindoles useful as inhibitors of rock and other protein kinases

Info

Publication number
TW200604168A
TW200604168A TW094110745A TW94110745A TW200604168A TW 200604168 A TW200604168 A TW 200604168A TW 094110745 A TW094110745 A TW 094110745A TW 94110745 A TW94110745 A TW 94110745A TW 200604168 A TW200604168 A TW 200604168A
Authority
TW
Taiwan
Prior art keywords
inhibitors
protein kinases
rock
useful
azaindoles useful
Prior art date
Application number
TW094110745A
Other languages
English (en)
Inventor
Jeremy Green
Andrew Miller
Juan-Miguel Jimenez
Craig Marhefka
Jing-Rong Cao
John J Court
Upul K Bandarage
Huai Gao
Suganthini Nanthakumar
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200604168A publication Critical patent/TW200604168A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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TW094110745A 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases TW200604168A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55904104P 2004-04-02 2004-04-02

Publications (1)

Publication Number Publication Date
TW200604168A true TW200604168A (en) 2006-02-01

Family

ID=34983212

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094110745A TW200604168A (en) 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases

Country Status (14)

Country Link
US (1) US7514448B2 (zh)
EP (1) EP1756108A2 (zh)
JP (1) JP5019612B2 (zh)
KR (1) KR20070002081A (zh)
CN (1) CN101014597A (zh)
AR (1) AR049333A1 (zh)
AU (1) AU2005236002A1 (zh)
CA (1) CA2561724A1 (zh)
IL (1) IL178414A0 (zh)
MX (1) MXPA06011328A (zh)
NO (1) NO20064976L (zh)
RU (1) RU2006138621A (zh)
TW (1) TW200604168A (zh)
WO (1) WO2005103050A2 (zh)

Families Citing this family (96)

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WO2005066145A1 (en) 2004-01-06 2005-07-21 Novo Nordisk A/S Heteroaryl-ureas and their use as glucokinase activators
JP2007519753A (ja) * 2004-01-30 2007-07-19 スミスクライン ビーチャム コーポレーション 化合物
PL2332940T3 (pl) 2004-03-30 2013-03-29 Vertex Pharma Azaindole użyteczne jako inhibitory JAK i innych kinaz białkowych
WO2006001318A1 (ja) 2004-06-24 2006-01-05 Shionogi & Co., Ltd. スルホンアミド化合物
EP2325184A1 (en) * 2004-06-30 2011-05-25 Vertex Pharmceuticals Incorporated Azaindoles useful as inhibitors of protein kinases
MX2007000092A (es) * 2004-06-30 2007-03-07 Vertex Pharma Azaindoles utiles como inhibidores de proteinas cinasas.
ES2401138T3 (es) * 2004-08-13 2013-04-17 Genentech, Inc. Inhibidores basados en tiazol de enzimas que usan ATP
US7795259B2 (en) * 2004-11-22 2010-09-14 Vertex Pharmaceuticals Incorporated Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases
EP1864971A4 (en) * 2005-03-31 2010-02-10 Takeda Pharmaceutical PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES
RU2435769C2 (ru) * 2005-05-20 2011-12-10 Вертекс Фармасьютикалз Инкорпорейтед Пирролопиридины, полезные в качестве ингибиторов протеинкиназы
JP2009500377A (ja) 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス ジシクロアルキルウレア型グルコキナーゼ活性化剤
WO2007006814A1 (en) 2005-07-14 2007-01-18 Novo Nordisk A/S Urea glucokinase activators
KR20080040027A (ko) 2005-09-02 2008-05-07 아스테라스 세이야쿠 가부시키가이샤 Ｒｏｃｋ 억제제로서 아미드 유도체
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP1968568A4 (en) * 2005-12-22 2011-04-13 Glaxosmithkline Llc HEMMER OF NUTS ACTIVITY
TW201412738A (zh) 2006-01-17 2014-04-01 Vertex Pharma 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
CN101370796B (zh) 2006-01-18 2012-10-10 霍夫曼-拉罗奇有限公司 作为11β-HSD1抑制剂的噻唑类
WO2007087283A2 (en) * 2006-01-23 2007-08-02 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
JP2009525966A (ja) * 2006-01-26 2009-07-16 フォールドアールエックス ファーマシューティカルズ インコーポレーティッド タンパク質輸送を調節するための化合物および方法
CA2648250A1 (en) * 2006-04-05 2007-10-18 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
AU2007238698A1 (en) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
US8853244B2 (en) 2006-05-23 2014-10-07 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
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