TW200604168A - Azaindoles useful as inhibitors of rock and other protein kinases - Google Patents

Azaindoles useful as inhibitors of rock and other protein kinases

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Publication number
TW200604168A
TW200604168A TW094110745A TW94110745A TW200604168A TW 200604168 A TW200604168 A TW 200604168A TW 094110745 A TW094110745 A TW 094110745A TW 94110745 A TW94110745 A TW 94110745A TW 200604168 A TW200604168 A TW 200604168A
Authority
TW
Taiwan
Prior art keywords
inhibitors
protein kinases
rock
useful
azaindoles useful
Prior art date
Application number
TW094110745A
Other languages
English (en)
Chinese (zh)
Inventor
Jeremy Green
Andrew Miller
Juan-Miguel Jimenez
Craig Marhefka
Jing-Rong Cao
John J Court
Upul K Bandarage
Huai Gao
Suganthini Nanthakumar
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200604168A publication Critical patent/TW200604168A/zh

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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TW094110745A 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases TW200604168A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55904104P 2004-04-02 2004-04-02

Publications (1)

Publication Number Publication Date
TW200604168A true TW200604168A (en) 2006-02-01

Family

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Family Applications (1)

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TW094110745A TW200604168A (en) 2004-04-02 2005-04-04 Azaindoles useful as inhibitors of rock and other protein kinases

Country Status (14)

Country Link
US (1) US7514448B2 (enExample)
EP (1) EP1756108A2 (enExample)
JP (1) JP5019612B2 (enExample)
KR (1) KR20070002081A (enExample)
CN (1) CN101014597A (enExample)
AR (1) AR049333A1 (enExample)
AU (1) AU2005236002A1 (enExample)
CA (1) CA2561724A1 (enExample)
IL (1) IL178414A0 (enExample)
MX (1) MXPA06011328A (enExample)
NO (1) NO20064976L (enExample)
RU (1) RU2006138621A (enExample)
TW (1) TW200604168A (enExample)
WO (1) WO2005103050A2 (enExample)

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PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
PT1723128E (pt) 2004-01-06 2013-02-27 Novo Nordisk As Heteroaril-ureias e o seu uso como activadores da glicoquinase
JP2007519753A (ja) * 2004-01-30 2007-07-19 スミスクライン ビーチャム コーポレーション 化合物
US7507826B2 (en) 2004-03-30 2009-03-24 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
CN100528841C (zh) 2004-06-24 2009-08-19 盐野义制药株式会社 磺酰胺化合物
MX2007000092A (es) * 2004-06-30 2007-03-07 Vertex Pharma Azaindoles utiles como inhibidores de proteinas cinasas.
EP2325184A1 (en) * 2004-06-30 2011-05-25 Vertex Pharmceuticals Incorporated Azaindoles useful as inhibitors of protein kinases
MX2007001727A (es) * 2004-08-13 2007-04-20 Genentech Inc Compuestos a base de 2-amido-tiazol que exhiben actividad inhibidora de enzima que utiliza atp y composiciones y usos de los mismos.
NZ555566A (en) * 2004-11-22 2009-12-24 Vertex Pharma Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases
US20090264650A1 (en) * 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
CA2609126A1 (en) * 2005-05-20 2006-11-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
EP1904466A1 (en) 2005-07-08 2008-04-02 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
KR101446973B1 (ko) 2005-07-14 2014-10-07 트랜스테크 파르마 엘엘씨 우레아 글루코키나제 활성제
US8211919B2 (en) 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
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