JP2007527406A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007527406A5 JP2007527406A5 JP2006526305A JP2006526305A JP2007527406A5 JP 2007527406 A5 JP2007527406 A5 JP 2007527406A5 JP 2006526305 A JP2006526305 A JP 2006526305A JP 2006526305 A JP2006526305 A JP 2006526305A JP 2007527406 A5 JP2007527406 A5 JP 2007527406A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- godan
- binding
- hmgb
- piece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50256803P | 2003-09-11 | 2003-09-11 | |
| US60/502,568 | 2003-09-11 | ||
| PCT/US2004/029527 WO2005026209A2 (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibodies against hmgb1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011118559A Division JP5513441B2 (ja) | 2003-09-11 | 2011-05-27 | Hmgb1に対するモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007527406A JP2007527406A (ja) | 2007-09-27 |
| JP2007527406A5 true JP2007527406A5 (https=) | 2007-11-08 |
| JP4792392B2 JP4792392B2 (ja) | 2011-10-12 |
Family
ID=34312406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526305A Expired - Fee Related JP4792392B2 (ja) | 2003-09-11 | 2004-09-10 | Hmgb1に対するモノクローナル抗体 |
| JP2011118559A Expired - Fee Related JP5513441B2 (ja) | 2003-09-11 | 2011-05-27 | Hmgb1に対するモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011118559A Expired - Fee Related JP5513441B2 (ja) | 2003-09-11 | 2011-05-27 | Hmgb1に対するモノクローナル抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7288250B2 (https=) |
| EP (1) | EP1668035A2 (https=) |
| JP (2) | JP4792392B2 (https=) |
| CN (1) | CN1878793A (https=) |
| AU (1) | AU2004272607B2 (https=) |
| CA (2) | CA2882022A1 (https=) |
| WO (1) | WO2005026209A2 (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) † | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| US7807157B2 (en) * | 2004-02-20 | 2010-10-05 | Intellect Neurosciences Inc. | Monoclonal antibodies and use thereof |
| US20080305120A1 (en) * | 2004-06-17 | 2008-12-11 | Medimmune, Inc. | Immunogenic Compositions Comprising Hmgb 1 Polypeptides |
| EP1771565B1 (en) | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| WO2007001422A2 (en) * | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| AU2005313971B2 (en) * | 2004-12-08 | 2011-10-13 | Immunomedics, Inc. | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
| WO2006124477A2 (en) * | 2005-05-13 | 2006-11-23 | The Feinstein Institute For Medical Research | Combination therapy with inhibitors of hmgb and caspase for the treatment of inflammatory diseases |
| EP1899376A2 (en) | 2005-06-16 | 2008-03-19 | The Feinstein Institute for Medical Research | Antibodies against hmgb1 and fragments thereof |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
| JP3876325B1 (ja) * | 2005-10-24 | 2007-01-31 | 国立大学法人 岡山大学 | 脳梗塞抑制剤 |
| US20100172909A1 (en) * | 2005-10-24 | 2010-07-08 | Masahiro Nishibori | Cerebral edema suppressant |
| WO2007076200A2 (en) * | 2005-11-28 | 2007-07-05 | Medimmune, Inc. | Antagonists of hmgb1 and/or rage and methods of use thereof |
| JP3882090B1 (ja) * | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | 脳血管攣縮抑制剤 |
| CN1850863B (zh) * | 2006-05-23 | 2012-07-04 | 中国科学院生物物理研究所 | 针对自身抗原和/或种属间高度保守抗原的抗体及其制备方法 |
| JP4982739B2 (ja) * | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | ポリグルタミン病の予防・治療剤 |
| US20090297546A1 (en) * | 2006-12-20 | 2009-12-03 | Shino-Test Corporation | Avian-derived antibody capable of binding specifically to human hmgb1, immunological determination method for human hmgb1, and immunological determination reagent for human hmgb1 |
| WO2008099917A1 (ja) * | 2007-02-15 | 2008-08-21 | Fukuoka University | 抗hmgb-1抗体を含む臓器移植拒絶抑制剤 |
| JP5225109B2 (ja) * | 2007-02-15 | 2013-07-03 | 国立大学法人 熊本大学 | ヒトhmgb−1に特異的に結合する抗体を有効成分として含有する治療剤 |
| US20100216977A1 (en) | 2007-02-15 | 2010-08-26 | Kyushu University, National University Corporation | Therapeutic agent for interstitial pulmonary disease comprising anti-hmgb-1 antibody |
| ITMI20080799A1 (it) * | 2008-04-30 | 2009-11-01 | Areta Internat S R L | Anticorpi monoclonali amti hmga1 procedimento per la loro preparazione e loro impiego per la determinazione quantitativa di hmga1 |
| JP5676253B2 (ja) | 2008-04-30 | 2015-02-25 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| PT2329266E (pt) * | 2008-09-11 | 2016-06-07 | Pasteur Institut | Monitorização e inibição da infecção pelo vírus da imunodeficiência humana mediante modulação do desencadeamento dependente de hmgb1 da replicação e persistência do vih-1 |
| CN101798347B (zh) * | 2009-03-03 | 2012-05-30 | 中国科学院生物物理研究所 | 抗高迁移率族蛋白b1的单克隆抗体 |
| CN101891817B (zh) * | 2009-03-03 | 2012-11-07 | 中国科学院生物物理研究所 | 抗高迁移率族蛋白b-1的单克隆抗体及其应用 |
| WO2010129917A2 (en) * | 2009-05-08 | 2010-11-11 | Vaccinex, Inc. | Anti-cd100 antibodies and methods for using the same |
| EP2455469A4 (en) | 2009-07-16 | 2013-03-13 | Nec Software Ltd | FOR BINDING TO HMGB1 ABLE NUCLEIC ACID MOLECULE AND USE THEREOF |
| JP2011095014A (ja) * | 2009-10-27 | 2011-05-12 | Canon Inc | 免疫学的測定方法及び免疫学的測定キット |
| JP5865703B2 (ja) | 2009-10-28 | 2016-02-17 | 株式会社ジェノミックス | 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤 |
| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| CN102770456B (zh) | 2009-12-04 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| ES2413437T3 (es) | 2010-03-10 | 2013-07-16 | Institut Pasteur | HMGB1 y anticuerpos anti-HMGB1 en pacientes infectados por VIH especialmente con trastornos neurológicos |
| US8999349B2 (en) * | 2010-07-27 | 2015-04-07 | The Regents Of The University Of California | HMGB1-derived peptides enhance immune response to antigens |
| CN102375064A (zh) * | 2010-08-26 | 2012-03-14 | 杭州华得森生物技术有限公司 | 用酶联免疫法检测人体中hmga2含量的体外诊断试剂盒 |
| JP6154135B2 (ja) * | 2010-12-03 | 2017-06-28 | 国立大学法人 岡山大学 | 外傷性神経障害治療剤 |
| EP2694548B1 (en) * | 2011-04-05 | 2015-12-02 | Dia.pro Diagnostic Bioprobes S.r.l. | Hmgb1 specific monoclonal antibodies |
| PT3358011T (pt) * | 2011-04-26 | 2020-04-23 | Univ Osaka | Péptido para induzir a regeneração de um tecido e a sua utilização |
| US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| WO2012170742A2 (en) * | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| EP2756002A4 (en) * | 2011-09-16 | 2015-04-08 | Univ Texas | COMPOSITIONS AND METHODS RELATED TO THE REPAIR OF DNA DAMAGES |
| AU2012322721B2 (en) | 2011-10-11 | 2016-05-05 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability |
| GB2504139B (en) * | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| WO2013091903A1 (en) * | 2011-12-22 | 2013-06-27 | Novo Nordisk A/S | Anti-crac channel antibodies |
| US9822170B2 (en) | 2012-02-22 | 2017-11-21 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| CN102924577B (zh) * | 2012-11-28 | 2014-03-26 | 扬州大学 | 鸡高迁移率族蛋白b1抗原多肽和抗鸡高迁移率族蛋白b1单克隆抗体 |
| CA2897914A1 (en) * | 2013-01-28 | 2014-07-31 | Evec Inc. | Humanized anti-hmgb1 antibody or antigen-binding fragment thereof |
| US9840555B2 (en) | 2013-11-04 | 2017-12-12 | Li-Te Chin | Method for producing human monoclonal antibodies that binds to at least one part of HMGB1 |
| ES2811274T3 (es) | 2014-04-18 | 2021-03-11 | Univ Leland Stanford Junior | Anticuerpos monoclonales humanizados y quiméricos para CD99 |
| KR101689540B1 (ko) * | 2014-07-04 | 2016-12-27 | 한양대학교 산학협력단 | 세포 이식 거부반응 억제용 약제학적 조성물 |
| KR20180054639A (ko) * | 2015-08-28 | 2018-05-24 | 알렉터 엘엘씨 | 항-siglec-7 항체 및 이의 사용 방법 |
| KR102767638B1 (ko) | 2016-05-03 | 2025-02-20 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법 |
| US20190284259A1 (en) * | 2016-07-22 | 2019-09-19 | Georgia State University Research Foundation | Monoclonal Antibodies to B Virus And Their Use For Identification Of B Virus Specific Reactive Peptides |
| WO2018030405A1 (ja) | 2016-08-09 | 2018-02-15 | 国立大学法人東京医科歯科大学 | Hmgb1に対する抗体、及びそれを含有するアルツハイマー病を治療又は予防するための組成物 |
| AU2017332367B2 (en) * | 2016-09-21 | 2021-12-23 | Stephen H. Thorne | High mobility group box i mutant |
| US11174310B2 (en) | 2016-10-26 | 2021-11-16 | Fuso Pharmaceutical Industries, Ltd. | Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement |
| EP3556378B1 (en) | 2017-01-27 | 2025-03-12 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| WO2019048040A1 (en) * | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| EP3703723A4 (en) | 2017-10-31 | 2021-12-15 | KaliVir Immunotherapeutics, Inc. | ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION |
| CN111868231B (zh) | 2017-12-01 | 2024-05-31 | 斯特姆里姆有限公司 | 外胚层间充质干细胞及其产生方法 |
| CN111542335A (zh) | 2017-12-01 | 2020-08-14 | 斯特姆里姆有限公司 | 炎症性肠病的治疗药 |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| CN119841953A (zh) | 2018-06-08 | 2025-04-18 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| AU2019370276A1 (en) | 2018-10-30 | 2021-06-10 | Board Of Regents, The University Of Texas System | Anti-CD79b antibodies and chimeric antigen receptors and methods of use thereof |
| CN109957015A (zh) * | 2019-04-01 | 2019-07-02 | 中国人民解放军海军军医大学国家肝癌科学中心 | 一种hmgb1封闭性抗体的制备方法及其应用 |
| JP2022534406A (ja) * | 2019-05-27 | 2022-07-29 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | タウの立体配座特異的エピトープ、それらに対する抗体、およびそれらに関連する方法 |
| EP3875118A4 (en) * | 2019-12-18 | 2022-04-27 | National University Corporation Okayama University | USE OF ANTIBODY-DRUG CONJUGATES AND ANTIBODIES FOR DRUG DELIVERY |
| CN115297932A (zh) * | 2020-03-31 | 2022-11-04 | 弗莱德哈钦森癌症中心 | 抗cd33抗体和其用途 |
| EP4142778A4 (en) * | 2020-04-30 | 2024-06-05 | Board of Regents, The University of Texas System | ANTI-CD79B ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF |
| JP2023529557A (ja) * | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗enpp1抗体の阻害 |
| EP4178626A4 (en) * | 2020-07-13 | 2024-08-14 | University of Southern California | Universal car-nk cell targeting various epitopes of hiv-1 gp160 |
| TW202227621A (zh) | 2020-11-19 | 2022-07-16 | 美商凱立凡爾免疫治療股份有限公司 | 重塑腫瘤微環境的溶瘤免疫療法 |
| CN113151186B (zh) * | 2021-02-04 | 2022-02-18 | 上海交通大学 | 抗人cd271的单克隆抗体及用途 |
| BR112023022681A2 (pt) | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
| CN113203857B (zh) * | 2021-05-06 | 2021-12-31 | 上海奕检医学检验实验室有限公司 | 一种肿瘤诊断试剂盒 |
| CN119095615A (zh) * | 2022-01-11 | 2024-12-06 | 得克萨斯系统大学评议会 | 抗cd94抗体和嵌合抗原受体及其使用方法 |
| KR102788660B1 (ko) * | 2022-03-25 | 2025-03-28 | 부산대학교 산학협력단 | 신규한 hmgb1 유래 펩타이드 및 이의 용도 |
| CN119775409B (zh) * | 2025-03-05 | 2025-07-11 | 深圳真实生物医药科技有限公司 | 靶向sost的抗体及其用途 |
| CN119775408B (zh) * | 2025-03-12 | 2025-05-30 | 武汉伊莱瑞特生物科技股份有限公司 | 抗猴高迁移率族蛋白b1单克隆抗体、酶联免疫检测试剂盒及其应用 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6468A (en) * | 1849-05-22 | ruteyen | ||
| US4678772A (en) | 1983-02-28 | 1987-07-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions containing glycyrrhizin |
| JPS6032714A (ja) | 1983-08-01 | 1985-02-19 | Teijin Ltd | 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物 |
| US5585344A (en) | 1984-03-19 | 1996-12-17 | The Rockefeller University | Liver-derived receptors for advanced glycosylation endproducts and uses thereof |
| JPS62166897A (ja) | 1986-01-20 | 1987-07-23 | Toyo Soda Mfg Co Ltd | 核内非ヒストン蛋白質に対するモノクロ−ナル抗体 |
| JPS63135351A (ja) | 1986-11-28 | 1988-06-07 | Sanwa Kagaku Kenkyusho Co Ltd | グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JP2998287B2 (ja) | 1991-03-13 | 2000-01-11 | 千寿製薬株式会社 | グリチルレチン酸誘導体 |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| IT1253431B (it) | 1991-12-02 | 1995-08-08 | Valetudo S R L | Preparati farmaceutici per uso topico destinati al trattamento della psoriasi e della dermatite atopica |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| IT1254321B (it) | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale. |
| GB9217316D0 (en) * | 1992-08-14 | 1992-09-30 | Ludwig Inst Cancer Res | Schwann cell mitogenic factor,its preparation and use |
| EP0727487A1 (en) | 1995-02-17 | 1996-08-21 | K.U. Leuven Research & Development | Multiple-tumor aberrant growth genes |
| JP3472048B2 (ja) | 1995-10-09 | 2003-12-02 | 鐘淵化学工業株式会社 | 自己免疫疾患の診断薬 |
| US6323329B1 (en) | 1995-12-21 | 2001-11-27 | Jorn Bullerdiek | Nucleic acid sequences of genes encoding high mobility group proteins |
| DE19548122A1 (de) | 1995-12-21 | 1997-06-26 | Joern Prof Dr Bullerdiek | Nukleinsäuresequenzen von Genen der High Mobility Group Proteine sowie Verwendungen derselben |
| US5864018A (en) | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| US6171779B1 (en) | 1996-07-12 | 2001-01-09 | University Of Medicine & Dentistry Of New Jersey | HMGI proteins in cancer |
| US6720472B2 (en) | 1996-07-12 | 2004-04-13 | University Of Medicine And Dentistry Of New Jersey | HMGI proteins in cancer and obesity |
| DE69737870T2 (de) | 1996-07-17 | 2008-02-07 | Kaneka Corp. | Medikamente für die diagnostik von autoimmunerkrankungen |
| US7258857B2 (en) | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| ES2331622T3 (es) | 1997-05-07 | 2010-01-11 | Schering Corporation | Proteinas receptoras humanas similares a toll, reactivos y metodos relacionados. |
| US20030032090A1 (en) | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| IT1291366B1 (it) | 1997-05-14 | 1999-01-07 | Angelini Ricerche Spa | Composizione farmaceutica antivirale comprendente acido glicirrizico ed almeno una proteina dotata di attivita' antivirale |
| PT1887014E (pt) | 1997-10-17 | 2010-07-05 | Genentech Inc | Homëlogos de toll humana |
| US20030027260A1 (en) | 1997-10-17 | 2003-02-06 | Genentech, Inc. | Human Toll homologues |
| ES2137125B1 (es) | 1997-11-18 | 2000-08-16 | Vinyals S A Lab Dr | La utilizacion de la sal de zinc del acido glicirretico en preparados contra el acne y las composiciones que contienen dicha sal. |
| US6783961B1 (en) | 1999-02-26 | 2004-08-31 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| IT1299583B1 (it) | 1998-05-19 | 2000-03-16 | Vander Way Limited | Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica |
| AU765719B2 (en) | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| US7151082B2 (en) * | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6177077B1 (en) | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| TWI221082B (en) | 1999-04-14 | 2004-09-21 | Sumitomo Chemical Co | Pesticidal compositions |
| AU5320700A (en) | 1999-06-04 | 2000-12-28 | Millennium Pharmaceuticals, Inc. | Novel toll molecules and uses therefor |
| US6794132B2 (en) * | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| US7572466B1 (en) * | 1999-10-13 | 2009-08-11 | Health Research, Inc. | Oral immunology using plant product containing a non-enteric pathogen antigen |
| GB9927332D0 (en) | 1999-11-18 | 2000-01-12 | Leiv Eiriksson Nyfotek As | Novel antibody and uses thereof |
| US6677321B1 (en) | 1999-12-09 | 2004-01-13 | Bruce Levin | Methods and compositions for treatment of inflammatory disease |
| GB0001704D0 (en) | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| CA2404511A1 (en) | 2000-03-31 | 2001-10-04 | Mochida Pharmaceutical Co., Ltd. | Tlr/cd14 binding inhibitor |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| NZ534666A (en) | 2000-05-25 | 2006-01-27 | Schering Corp | Mammalian DNAX Toll-like receptor protein, DTLR9, antibodies and medicaments made therefrom and use in treating immunological disorders |
| US7423177B2 (en) | 2001-03-05 | 2008-09-09 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| GB0015325D0 (en) | 2000-06-22 | 2000-08-16 | Danionics As | Electrochemical cells |
| CA2439852A1 (en) | 2001-03-02 | 2002-09-12 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
| CN1235583C (zh) | 2001-03-05 | 2006-01-11 | 特兰斯泰克制药公司 | 用作治疗剂的苯并咪唑衍生物 |
| EP1379230A4 (en) | 2001-03-15 | 2009-01-21 | Univ Pittsburgh | METHOD OF USE OF PYRUVATE AND / OR ITS DERIVATIVES FOR TREATING CYTOKINE-ORGANIZED INFLAMMABLE CONDITIONS |
| US7754217B2 (en) * | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| WO2002090520A2 (en) | 2001-05-09 | 2002-11-14 | Yale University | Toll/interleukin-1 receptor adaptor protein (tirap) |
| MXPA03009995A (es) | 2001-05-09 | 2004-06-30 | Univ Michigan | Uso de composiciones para tratar rosacea. |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| CN100447154C (zh) * | 2001-05-15 | 2008-12-31 | 费因斯坦医学研究学院 | 利用hmg片段作为抗炎症试剂 |
| JP4823465B2 (ja) | 2001-07-13 | 2011-11-24 | 株式会社シノテスト | ヒトhmg−1に特異的に結合する抗体並びにこの抗体を用いるヒトhmg−1の免疫学的測定方法及び免疫学的測定試薬 |
| US20030032674A1 (en) | 2001-08-13 | 2003-02-13 | Hwang Daniel H. | Use of unsaturated fatty acids to treat severe inflammatory diseases |
| JP2005501917A (ja) | 2001-09-07 | 2005-01-20 | ザ トラスティーズ オブ ボストン ユニバーシティ | 免疫複合体関連疾患を処置するための方法および組成物 |
| JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長cDNA |
| EP1293566A1 (en) * | 2001-09-17 | 2003-03-19 | Societe Des Produits Nestle S.A. | A soluble toll-like receptor |
| AU2002364607A1 (en) | 2001-12-28 | 2003-07-24 | The Burnham Institute | Novel ligand involved in the transmigration of leukocytes . |
| DK1482931T3 (da) | 2002-03-05 | 2011-12-19 | Transtech Pharma Inc | Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE |
| AU2003228099A1 (en) | 2002-07-03 | 2004-01-23 | Centro Cardiologico Monzino S.P.A.-Irccs | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
| GB0226251D0 (en) | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
| US20040141948A1 (en) * | 2002-11-20 | 2004-07-22 | Critical Therapeutics, Inc. | Use of HMGB fragments as anti-inflammatory agents |
| JP2006510619A (ja) | 2002-11-20 | 2006-03-30 | クリティカル セラピューティクス,インコーポレイテッド | 抗炎症剤としてのhmgb断片の使用 |
| US20060121047A1 (en) | 2002-11-20 | 2006-06-08 | Tracey Kevin J | Use of hmgb polypetides for increasing immune responses |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) * | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| WO2005034952A2 (en) | 2003-10-07 | 2005-04-21 | The Feinstein Institute For Medical Research | Isoxazole and isothiazole compounds useful in the treatment of inflammation |
| US20080305120A1 (en) | 2004-06-17 | 2008-12-11 | Medimmune, Inc. | Immunogenic Compositions Comprising Hmgb 1 Polypeptides |
| JP2008507505A (ja) * | 2004-07-20 | 2008-03-13 | プロヴィンシア・イタリアーナ・デッラ・コングレガチォーネ・フィリ・デッリマコラータ・コンセチォーネ−イスティトゥト・デルモパティコ・デッリマコラータ−アイ・アール・シー・シー・エス | 創傷治癒のためのhmgb1の使用 |
| EP1771565B1 (en) | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| GEP20105110B (en) | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| JP5622351B2 (ja) | 2004-09-03 | 2014-11-12 | クレアビリス・セラピューティクス・エスピーエー | プロテアーゼ抵抗性ヒトおよび非ヒトHMGB1Box−A変異体、ならびにそれらの治療/診断への使用 |
| WO2007001422A2 (en) | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| WO2007011606A2 (en) | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| EP1957534A1 (en) | 2005-11-09 | 2008-08-20 | Pharmexa A/S | Therapeutic vaccines targeting hmgb1 |
| WO2007076200A2 (en) | 2005-11-28 | 2007-07-05 | Medimmune, Inc. | Antagonists of hmgb1 and/or rage and methods of use thereof |
| JP2010502224A (ja) * | 2006-09-08 | 2010-01-28 | アボット・ラボラトリーズ | インターロイキン13結合タンパク質 |
| US8173405B2 (en) | 2006-12-13 | 2012-05-08 | William Marsh Rice University | Nerolidol, terpene, and terpene deriviative synthesis |
| US20100249038A1 (en) | 2007-06-12 | 2010-09-30 | Board Of Regents, University Of Texas System | Antagonists of the receptor for advanced glycation end-products (rage) |
-
2004
- 2004-09-10 AU AU2004272607A patent/AU2004272607B2/en not_active Ceased
- 2004-09-10 JP JP2006526305A patent/JP4792392B2/ja not_active Expired - Fee Related
- 2004-09-10 CA CA2882022A patent/CA2882022A1/en not_active Abandoned
- 2004-09-10 EP EP04788671A patent/EP1668035A2/en not_active Withdrawn
- 2004-09-10 WO PCT/US2004/029527 patent/WO2005026209A2/en not_active Ceased
- 2004-09-10 US US10/938,992 patent/US7288250B2/en not_active Expired - Fee Related
- 2004-09-10 CA CA2538763A patent/CA2538763C/en not_active Expired - Fee Related
- 2004-09-10 CN CNA2004800332177A patent/CN1878793A/zh active Pending
-
2007
- 2007-09-20 US US11/903,129 patent/US7632500B2/en not_active Expired - Lifetime
- 2007-10-15 US US11/974,923 patent/US20090148453A1/en not_active Abandoned
-
2010
- 2010-10-04 US US12/897,453 patent/US8846047B2/en not_active Expired - Fee Related
-
2011
- 2011-05-27 JP JP2011118559A patent/JP5513441B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007527406A5 (https=) | ||
| AU2021201506B2 (en) | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains | |
| TWI679211B (zh) | 抗il-33抗體和彼之組成物、方法及用途 | |
| JP7848133B2 (ja) | ヒトIL-4Rαにおける特異的エピトープとの抗体結合及び抗体の適用 | |
| US9469689B2 (en) | Therapeutic DLL4 binding proteins | |
| CN103261223B (zh) | 人制瘤素m抗体及使用方法 | |
| JP2009517057A5 (https=) | ||
| JP2010502183A5 (https=) | ||
| TW201124427A (en) | IL-1 binding proteins | |
| RU2011149334A (ru) | Анти-il-17f антитела и способы их применения | |
| RU2008126242A (ru) | Антитела против глобуломера а бета, их антигенсвязывающие части, соответствующие гибридомы, нуклеиновые кислоты, векторы, клетки-хозяева, способы получения указанных антител, композиции, содержащие указанные антитела, применения указанных антител и способы использования указанных антител | |
| JP2024156657A5 (https=) | ||
| US20200369774A1 (en) | Il-6r antibody and antigen binding fragment thereof and medical use | |
| CN114667296B (zh) | 一种双特异性抗体及其用途 | |
| JP2005528914A5 (https=) | ||
| US20110223176A1 (en) | Basigin binding proteins | |
| EP2944654A1 (en) | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains | |
| RU2007118670A (ru) | Ангиопоэтин-2-специфические связывающие агенты | |
| JP2017524362A5 (https=) | ||
| CN109721656B (zh) | 靶向rankl的治疗性抗体 | |
| JP2005535562A5 (https=) | ||
| US20150344568A1 (en) | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains | |
| CN117279944A (zh) | 干细胞因子抗体及其使用方法 | |
| CN117098777A (zh) | 一种tslp抗原结合蛋白及其应用 | |
| JP2021515597A5 (https=) |