|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4444887A
(en)
*
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4474893A
(en)
*
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4714681A
(en)
*
|
1981-07-01 |
1987-12-22 |
The Board Of Reagents, The University Of Texas System Cancer Center |
Quadroma cells and trioma cells and methods for the production of same
|
|
US4647447A
(en)
*
|
1981-07-24 |
1987-03-03 |
Schering Aktiengesellschaft |
Diagnostic media
|
|
US4722848A
(en)
|
1982-12-08 |
1988-02-02 |
Health Research, Incorporated |
Method for immunizing animals with synthetically modified vaccinia virus
|
|
US4716111A
(en)
*
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4741900A
(en)
*
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US4816567A
(en)
*
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
US5807715A
(en)
*
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US4687659A
(en)
*
|
1984-11-13 |
1987-08-18 |
Salutar, Inc. |
Diamide-DTPA-paramagnetic contrast agents for MR imaging
|
|
US5019369A
(en)
|
1984-10-22 |
1991-05-28 |
Vestar, Inc. |
Method of targeting tumors in humans
|
|
US4631211A
(en)
|
1985-03-25 |
1986-12-23 |
Scripps Clinic & Research Foundation |
Means for sequential solid phase organic synthesis and methods using the same
|
|
US4690915A
(en)
|
1985-08-08 |
1987-09-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adoptive immunotherapy as a treatment modality in humans
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5081029A
(en)
|
1985-09-25 |
1992-01-14 |
Oncogen |
Methods of adoptive immunotherapy for treatment of aids
|
|
DE3689123T2
(de)
|
1985-11-01 |
1994-03-03 |
Xoma Corp |
Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
|
|
US4885363A
(en)
*
|
1987-04-24 |
1989-12-05 |
E. R. Squibb & Sons, Inc. |
1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
|
|
US5057313A
(en)
*
|
1986-02-25 |
1991-10-15 |
The Center For Molecular Medicine And Immunology |
Diagnostic and therapeutic antibody conjugates
|
|
US5225539A
(en)
*
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4946778A
(en)
*
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5019368A
(en)
*
|
1989-02-23 |
1991-05-28 |
Cancer Biologics, Inc. |
Detection of necrotic malignant tissue and associated therapy
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5258498A
(en)
*
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5489425A
(en)
*
|
1987-06-24 |
1996-02-06 |
The Dow Chemical Company |
Functionalized polyamine chelants
|
|
US4994560A
(en)
*
|
1987-06-24 |
1991-02-19 |
The Dow Chemical Company |
Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
|
|
JP3040121B2
(ja)
*
|
1988-01-12 |
2000-05-08 |
ジェネンテク，インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
US5120525A
(en)
*
|
1988-03-29 |
1992-06-09 |
Immunomedics, Inc. |
Radiolabeled antibody cytotoxic therapy of cancer
|
|
CA1341373C
(en)
*
|
1988-06-24 |
2002-07-02 |
Roberta C. Cheng |
Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
|
|
ZA894792B
(en)
*
|
1988-06-24 |
1991-04-24 |
Dow Chemical Co |
Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
|
|
US5756065A
(en)
*
|
1988-06-24 |
1998-05-26 |
The Dow Chemical Company |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
|
|
US5274119A
(en)
*
|
1988-07-01 |
1993-12-28 |
The Dow Chemical Company |
Vicinal diols
|
|
US4925648A
(en)
*
|
1988-07-29 |
1990-05-15 |
Immunomedics, Inc. |
Detection and treatment of infectious and inflammatory lesions
|
|
US5601819A
(en)
*
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US5223409A
(en)
*
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5342604A
(en)
*
|
1988-10-31 |
1994-08-30 |
The Dow Chemical Company |
Complexes possessing ortho ligating functionality
|
|
US5696239A
(en)
*
|
1988-10-31 |
1997-12-09 |
The Dow Chemical Company |
Conjugates possessing ortho ligating functionality and complexes thereof
|
|
US5530101A
(en)
*
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5766883A
(en)
*
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
|
IE63847B1
(en)
|
1989-05-05 |
1995-06-14 |
Res Dev Foundation |
A novel antibody delivery system for biological response modifiers
|
|
US5808003A
(en)
*
|
1989-05-26 |
1998-09-15 |
Perimmune Holdings, Inc. |
Polyaminocarboxylate chelators
|
|
US5413923A
(en)
*
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5166057A
(en)
|
1989-08-28 |
1992-11-24 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand rna virus expression-systems
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5780225A
(en)
*
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
AU7247191A
(en)
|
1990-01-11 |
1991-08-05 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5314995A
(en)
*
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
WO1991014438A1
(en)
|
1990-03-20 |
1991-10-03 |
The Trustees Of Columbia University In The City Of New York |
Chimeric antibodies with receptor binding ligands in place of their constant region
|
|
US5427908A
(en)
*
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5204253A
(en)
|
1990-05-29 |
1993-04-20 |
E. I. Du Pont De Nemours And Company |
Method and apparatus for introducing biological substances into living cells
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5545806A
(en)
*
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
*
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
*
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
*
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
*
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ATE158021T1
(de)
*
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5698426A
(en)
*
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
IL99552A0
(en)
|
1990-09-28 |
1992-08-18 |
Ixsys Inc |
Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
|
|
WO1992008802A1
(en)
|
1990-10-29 |
1992-05-29 |
Cetus Oncology Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
US5367080A
(en)
*
|
1990-11-08 |
1994-11-22 |
Sterling Winthrop Inc. |
Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
|
|
DE69133036T2
(de)
|
1990-11-09 |
2003-02-06 |
Stephen D. Gillies |
Cytokine immunokonjugate
|
|
CA2095633C
(en)
*
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
ATE414768T1
(de)
*
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
CA2108451A1
(en)
*
|
1991-04-26 |
1992-10-27 |
Beverley J. Randle |
Novel antibodies, and methods for their use
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
WO1992022324A1
(en)
|
1991-06-14 |
1992-12-23 |
Xoma Corporation |
Microbially-produced antibody fragments and their conjugates
|
|
US5565332A
(en)
*
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
US5428139A
(en)
*
|
1991-12-10 |
1995-06-27 |
The Dow Chemical Company |
Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
|
|
FR2686899B1
(fr)
*
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
PT627940E
(pt)
|
1992-03-05 |
2003-07-31 |
Univ Texas |
Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
|
|
US5733743A
(en)
*
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
US5505931A
(en)
*
|
1993-03-04 |
1996-04-09 |
The Dow Chemical Company |
Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
|
|
WO1994003205A1
(en)
|
1992-08-07 |
1994-02-17 |
Cytel Corporation |
Hla binding peptides and their uses
|
|
CA2141602A1
(en)
*
|
1992-08-26 |
1994-03-03 |
Philip Leder |
Use of the cytokine ip-10 as an anti-tumor agent
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
ES2156149T3
(es)
*
|
1992-12-04 |
2001-06-16 |
Medical Res Council |
Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
|
|
US5441050A
(en)
*
|
1992-12-18 |
1995-08-15 |
Neoprobe Corporation |
Radiation responsive surgical instrument
|
|
BR9406652A
(pt)
|
1993-03-05 |
1996-09-10 |
Cytel Corp |
Composição
|
|
US5679647A
(en)
|
1993-08-26 |
1997-10-21 |
The Regents Of The University Of California |
Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
|
|
US5804566A
(en)
|
1993-08-26 |
1998-09-08 |
The Regents Of The University Of California |
Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
DE69534347T2
(de)
|
1994-01-31 |
2006-05-24 |
Trustees Of Boston University, Boston |
Bibliotheken aus Polyklonalen Antikörpern
|
|
US6608182B1
(en)
|
1994-03-08 |
2003-08-19 |
Human Genome Sciences, Inc. |
Human vascular endothelial growth factor 2
|
|
US5739118A
(en)
|
1994-04-01 |
1998-04-14 |
Apollon, Inc. |
Compositions and methods for delivery of genetic material
|
|
US5516637A
(en)
*
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5736524A
(en)
|
1994-11-14 |
1998-04-07 |
Merck & Co.,. Inc. |
Polynucleotide tuberculosis vaccine
|
|
US5516717A
(en)
*
|
1995-04-19 |
1996-05-14 |
United Microelectronics Corporation |
Method for manufacturing electrostatic discharge devices
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5922687A
(en)
|
1995-05-04 |
1999-07-13 |
Board Of Trustees Of The Leland Stanford Junior University |
Intracellular delivery of nucleic acids using pressure
|
|
AUPO591797A0
(en)
*
|
1997-03-27 |
1997-04-24 |
Commonwealth Scientific And Industrial Research Organisation |
High avidity polyvalent and polyspecific reagents
|
|
GB9601081D0
(en)
|
1995-10-06 |
1996-03-20 |
Cambridge Antibody Tech |
Specific binding members for human transforming growth factor beta;materials and methods
|
|
US5972622A
(en)
*
|
1996-02-08 |
1999-10-26 |
Desjardins; Louise |
Method of detecting apoptosis using an anti-human GP46 monoclonal anti-body
|
|
DE19639601A1
(de)
|
1996-02-28 |
1997-09-04 |
Bayer Ag |
Parapockenviren, die Fremd-DNA enthalten, ihre Herstellung und ihre Verwendung in Impfstoffen
|
|
US5935801A
(en)
*
|
1996-03-29 |
1999-08-10 |
Dana-Farber Cancer Institute |
Monoclonal antibody that detects apoptotic antigen
|
|
WO1998002543A1
(fr)
|
1996-07-15 |
1998-01-22 |
Chugai Research Institute For Molecular Medicine, Inc. |
Nouveaux facteurs analogues au vegf
|
|
JP2000516090A
(ja)
|
1996-07-26 |
2000-12-05 |
スローン―ケッタリング インスティチュート フォー キャンサー リサーチ |
遺伝子的免疫化のための方法と試薬
|
|
EP1283268A3
(en)
|
1996-08-23 |
2004-01-02 |
Ludwig Institute For Cancer Research |
Recombinant vascular endothelial cell growth factor D (VEGF-D)
|
|
US5916771A
(en)
*
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
CA2722378C
(en)
|
1996-12-03 |
2015-02-03 |
Amgen Fremont Inc. |
Human antibodies that bind tnf.alpha.
|
|
US5856131A
(en)
*
|
1997-02-24 |
1999-01-05 |
Incyte Pharmaceuticals, Inc. |
Human selenoprotein
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
WO1999033869A2
(en)
|
1997-12-24 |
1999-07-08 |
Corixa Corporation |
Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
|
|
US5958660A
(en)
*
|
1997-12-31 |
1999-09-28 |
Eastman Kodak Company |
Hydrophilic colloid composition
|
|
WO1999037775A2
(en)
|
1998-01-26 |
1999-07-29 |
Genquest, Inc. |
Compositions and methods for detecting and treating breast cancer
|
|
CA2296792A1
(en)
|
1999-02-26 |
2000-08-26 |
Genset S.A. |
Expressed sequence tags and encoded human proteins
|
|
US20020052308A1
(en)
*
|
1999-03-12 |
2002-05-02 |
Rosen Craig A. |
Nucleic acids, proteins and antibodies
|
|
AU3395900A
(en)
|
1999-03-12 |
2000-10-04 |
Human Genome Sciences, Inc. |
Human lung cancer associated gene sequences and polypeptides
|
|
EP1248800A2
(en)
|
1999-11-30 |
2002-10-16 |
Corixa Corporation |
Compositions and methods for therapy and diagnosis of breast cancer
|
|
US6489101B1
(en)
*
|
1999-11-30 |
2002-12-03 |
Corixa Corporation |
Compositions and methods for therapy and diagnosis of breast cancer
|
|
EP1272636B8
(en)
*
|
2000-04-04 |
2008-10-08 |
University Of Rochester |
A gene differentially expressed in breast and bladder cancer and encoded polypeptides
|
|
US20030166277A1
(en)
*
|
2000-04-12 |
2003-09-04 |
University Of Rochester |
Targeted vaccine delivery systems
|
|
WO2002000677A1
(en)
|
2000-06-07 |
2002-01-03 |
Human Genome Sciences, Inc. |
Nucleic acids, proteins, and antibodies
|
|
AU2001297872B2
(en)
*
|
2000-11-17 |
2006-11-09 |
University Of Rochester |
In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
|
|
US20050196755A1
(en)
*
|
2000-11-17 |
2005-09-08 |
Maurice Zauderer |
In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
|
|
JP2005507659A
(ja)
*
|
2001-10-15 |
2005-03-24 |
イミューノメディクス、インコーポレイテッド |
直接ターゲッティング結合タンパク質
|
|
AU2003274463B2
(en)
*
|
2002-06-10 |
2009-10-29 |
University Of Rochester |
Gene differentially expressed in breast and bladder cancer and encoded polypeptides
|
|
CA2499501A1
(en)
|
2002-09-27 |
2004-04-08 |
Martek Biosciences Corporation |
Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
|
|
WO2005099361A2
(en)
*
|
2003-07-10 |
2005-10-27 |
Vaccinex, Inc. |
MHC CLASS I - PEPTIDE-ANTIBODY CONJUGATES WITH MODIFIED β2-MICROGLOBULIN
|
|
AU2004296184B2
(en)
*
|
2003-12-04 |
2010-12-16 |
Vaccinex, Inc. |
Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells
|
|
AU2007261247A1
(en)
*
|
2006-06-22 |
2007-12-27 |
Vaccinex, Inc. |
Anti-C35 antibodies for treating cancer
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