JP4792392B2 - Ｈｍｇｂ１に対するモノクローナル抗体 - Google Patents

Ｈｍｇｂ１に対するモノクローナル抗体 Download PDF

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JP4792392B2
JP4792392B2 JP2006526305A JP2006526305A JP4792392B2 JP 4792392 B2 JP4792392 B2 JP 4792392B2 JP 2006526305 A JP2006526305 A JP 2006526305A JP 2006526305 A JP2006526305 A JP 2006526305A JP 4792392 B2 JP4792392 B2 JP 4792392B2
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hmgb1
antibody
antigen
hmgb1 mab
binding fragment
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JP2007527406A (ja
JP2007527406A5 (https=
Inventor
ニューマン，ウォルター
チン，シーシン
オキーフ，テレサ
オーバル，ロバート
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コーナーストーン セラピューティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4718—Cytokine-induced proteins
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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JP2006526305A 2003-09-11 2004-09-10 Ｈｍｇｂ１に対するモノクローナル抗体 Expired - Fee Related JP4792392B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50256803P 2003-09-11 2003-09-11
US60/502,568 2003-09-11
PCT/US2004/029527 WO2005026209A2 (en) 2003-09-11 2004-09-10 Monoclonal antibodies against hmgb1

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JP2011118559A Division JP5513441B2 (ja) 2003-09-11 2011-05-27 Ｈｍｇｂ１に対するモノクローナル抗体

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JP2007527406A JP2007527406A (ja) 2007-09-27
JP2007527406A5 JP2007527406A5 (https=) 2007-11-08
JP4792392B2 true JP4792392B2 (ja) 2011-10-12

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JP2011118559A Expired - Fee Related JP5513441B2 (ja) 2003-09-11 2011-05-27 Ｈｍｇｂ１に対するモノクローナル抗体

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Country Link
US (4) US7288250B2 (https=)
EP (1) EP1668035A2 (https=)
JP (2) JP4792392B2 (https=)
CN (1) CN1878793A (https=)
AU (1) AU2004272607B2 (https=)
CA (2) CA2882022A1 (https=)
WO (1) WO2005026209A2 (https=)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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US6303321B1 (en) † 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7304034B2 (en) * 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7696169B2 (en) * 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
US7807157B2 (en) * 2004-02-20 2010-10-05 Intellect Neurosciences Inc. Monoclonal antibodies and use thereof
US20080305120A1 (en) * 2004-06-17 2008-12-11 Medimmune, Inc. Immunogenic Compositions Comprising Hmgb 1 Polypeptides
EP1771565B1 (en) 2004-07-20 2012-09-05 The Feinstein Institute for Medical Research Rage protein derivatives
WO2007001422A2 (en) * 2004-10-22 2007-01-04 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
US8129130B2 (en) 2004-10-22 2012-03-06 The Feinstein Institute For Medical Research High affinity antibodies against HMGB1 and methods of use thereof
AU2005313971B2 (en) * 2004-12-08 2011-10-13 Immunomedics, Inc. Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
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US7632500B2 (en) 2009-12-15
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WO2005026209A2 (en) 2005-03-24
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US7288250B2 (en) 2007-10-30
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US20080113385A1 (en) 2008-05-15
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