JP2017524362A5 - - Google Patents

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Publication number
JP2017524362A5
JP2017524362A5 JP2017505099A JP2017505099A JP2017524362A5 JP 2017524362 A5 JP2017524362 A5 JP 2017524362A5 JP 2017505099 A JP2017505099 A JP 2017505099A JP 2017505099 A JP2017505099 A JP 2017505099A JP 2017524362 A5 JP2017524362 A5 JP 2017524362A5
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JP
Japan
Prior art keywords
antibody
binding fragment
seq
αklotho
cdr
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JP2017505099A
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English (en)
Japanese (ja)
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JP2017524362A (ja
JP6612324B2 (ja
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Priority claimed from PCT/CA2015/050728 external-priority patent/WO2016015162A1/en
Publication of JP2017524362A publication Critical patent/JP2017524362A/ja
Publication of JP2017524362A5 publication Critical patent/JP2017524362A5/ja
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Publication of JP6612324B2 publication Critical patent/JP6612324B2/ja
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JP2017505099A 2014-07-31 2015-07-31 αＫｌｏｔｈｏに対して高親和性を有する抗体 Expired - Fee Related JP6612324B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031477P 2014-07-31 2014-07-31
US62/031,477 2014-07-31
PCT/CA2015/050728 WO2016015162A1 (en) 2014-07-31 2015-07-31 ANTIBODIES WITH HIGH AFFINITY FOR αKLOTHO

Publications (3)

Publication Number Publication Date
JP2017524362A JP2017524362A (ja) 2017-08-31
JP2017524362A5 true JP2017524362A5 (https=) 2018-09-06
JP6612324B2 JP6612324B2 (ja) 2019-11-27

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Family Applications (1)

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JP2017505099A Expired - Fee Related JP6612324B2 (ja) 2014-07-31 2015-07-31 αＫｌｏｔｈｏに対して高親和性を有する抗体

Country Status (5)

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US (2) US10228374B2 (https=)
EP (1) EP3174986A4 (https=)
JP (1) JP6612324B2 (https=)
CA (1) CA2955039C (https=)
WO (1) WO2016015162A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10663474B2 (en) 2016-02-03 2020-05-26 The Governing Council Of The University Of Toronto Antibodies which specifically bind αKlotho polypeptide
CN110248674B (zh) * 2016-09-07 2021-10-26 萨辛生命科学有限公司 针对vegf的合成抗体及其用途
US11026625B2 (en) 2017-08-08 2021-06-08 Fresenius Medical Care Holdings, Inc. Systems and methods for treating and estimating progression of chronic kidney disease
CA3101100A1 (en) * 2017-12-06 2019-06-13 Klotho Therapeutics, Inc. Products and methods for assessing and increasing klotho protein levels
AU2018395249B2 (en) 2017-12-29 2025-10-16 Yale University Anti-renalase antibodies for the treatment and prevention of diseases and disorders
WO2019133665A2 (en) * 2017-12-29 2019-07-04 Yale University Methods for measuring renalase
WO2020047505A1 (en) * 2018-08-30 2020-03-05 The Uab Research Foundation Production and detection of bioactive soluble klotho protein
CN117805395A (zh) * 2023-12-29 2024-04-02 上海药明合联生物技术有限公司 一种比较抗体偶联药物和抗体的亲和力的方法及其应用
CN120943965B (zh) * 2025-10-16 2026-02-06 广东医科大学附属医院 一种αKL蛋白抗体及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US20150337037A1 (en) 2012-06-05 2015-11-26 Msm Protein Technologies Human monoclonal antibodies against human chemokine receptor ccr6
CN107614020A (zh) 2015-03-18 2018-01-19 免疫生化公司 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物
US10663474B2 (en) 2016-02-03 2020-05-26 The Governing Council Of The University Of Toronto Antibodies which specifically bind αKlotho polypeptide

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