JP2020534830A5 - - Google Patents

Info

Publication number

JP2020534830A5

JP2020534830A5 JP2020516462A JP2020516462A JP2020534830A5 JP 2020534830 A5 JP2020534830 A5 JP 2020534830A5 JP 2020516462 A JP2020516462 A JP 2020516462A JP 2020516462 A JP2020516462 A JP 2020516462A JP 2020534830 A5 JP2020534830 A5 JP 2020534830A5

Authority

JP

Japan

Prior art keywords

seq

antigen

antibody

variable region

chain variable

Prior art date

2018-09-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000427 antigen Substances 0.000 claims 24
• 102000036639 antigens Human genes 0.000 claims 24
• 108091007433 antigens Proteins 0.000 claims 24
• 230000027455 binding Effects 0.000 claims 19
• 239000012634 fragment Substances 0.000 claims 19
• 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 17
• 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 17
• 238000000034 method Methods 0.000 claims 7
• 210000001744 T-lymphocyte Anatomy 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 3
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 238000000338 in vitro Methods 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000282693 Cercopithecidae Species 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000009977 dual effect Effects 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 210000000987 immune system Anatomy 0.000 claims 1
• 229910052747 lanthanoid Inorganic materials 0.000 claims 1
• 150000002602 lanthanoids Chemical class 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1