CN115991777A - 新型抗CD3ε抗体 - Google Patents

新型抗CD3ε抗体 Download PDF

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Publication number
CN115991777A
CN115991777A CN202211326811.1A CN202211326811A CN115991777A CN 115991777 A CN115991777 A CN 115991777A CN 202211326811 A CN202211326811 A CN 202211326811A CN 115991777 A CN115991777 A CN 115991777A
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China
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seq
antibody
antigen
variable region
chain variable
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Pending
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CN202211326811.1A
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English (en)
Chinese (zh)
Inventor
李竞
梅芹
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Wuxi Biologics Shanghai Co Ltd
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Wuxi Biologics Shanghai Co Ltd
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Publication of CN115991777A publication Critical patent/CN115991777A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN202211326811.1A 2017-09-21 2018-09-20 新型抗CD3ε抗体 Pending CN115991777A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/102622 2017-09-21
CN2017102622 2017-09-21
CN201880056557.3A CN111108119B (zh) 2017-09-21 2018-09-20 新型抗CD3ε抗体
PCT/CN2018/106618 WO2019057099A1 (en) 2017-09-21 2018-09-20 NOVEL ANTI-CD3EPSILON ANTIBODIES

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880056557.3A Division CN111108119B (zh) 2017-09-21 2018-09-20 新型抗CD3ε抗体

Publications (1)

Publication Number Publication Date
CN115991777A true CN115991777A (zh) 2023-04-21

Family

ID=65811028

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202211326811.1A Pending CN115991777A (zh) 2017-09-21 2018-09-20 新型抗CD3ε抗体
CN201880056557.3A Active CN111108119B (zh) 2017-09-21 2018-09-20 新型抗CD3ε抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880056557.3A Active CN111108119B (zh) 2017-09-21 2018-09-20 新型抗CD3ε抗体

Country Status (18)

Country Link
US (3) US11440962B2 (https=)
EP (1) EP3684806A4 (https=)
JP (2) JP7305624B2 (https=)
KR (2) KR20250046337A (https=)
CN (2) CN115991777A (https=)
AU (2) AU2018336519B2 (https=)
BR (1) BR112020004992A2 (https=)
CA (1) CA3074130A1 (https=)
EA (1) EA202090800A1 (https=)
IL (2) IL273393B1 (https=)
MX (1) MX2020003087A (https=)
MY (1) MY199530A (https=)
PH (1) PH12020550078A1 (https=)
SA (2) SA520411577B1 (https=)
SG (1) SG11202001358RA (https=)
TW (2) TWI820041B (https=)
WO (1) WO2019057099A1 (https=)
ZA (1) ZA202001314B (https=)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
KR102820804B1 (ko) 2017-09-22 2025-06-16 우시 바이올로직스 아일랜드 리미티드 신규한 이중특이적 cd3/cd19 폴리펩티드 복합체
AU2018334886B2 (en) 2017-09-22 2025-06-26 WuXi Biologics Ireland Limited Novel bispecific polypeptide complexes
MX2021014973A (es) * 2019-06-07 2022-04-18 Adimab Llc Anticuerpos anti-cd3 de alta afinidad y metodos para su generacion y uso.
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
AU2021236302A1 (en) 2020-03-12 2022-10-20 Immune-Onc Therapeutics, Inc. Novel anti-LILRB4 antibodies and derivative products
CN116249714A (zh) 2020-05-27 2023-06-09 詹森生物科技公司 包含cd3抗原结合结构域的蛋白质及其用途
CA3217391A1 (en) * 2020-07-27 2022-02-03 Youwei ZHU Formulation of novel bispecific anti-cd3/cd20 polypeptide complex
US11795224B2 (en) * 2021-03-24 2023-10-24 China Medical University Hospital Anti-T-cell nanobody and nucleic acid encoding sequence thereof, and uses of the same
EP4314075A4 (en) * 2021-03-24 2025-04-09 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CD3
CN115536740A (zh) * 2021-06-30 2022-12-30 苏州方德门达新药开发有限公司 介导细胞内有效滞留cd3的空间构象表位及其应用
CN115558023A (zh) * 2021-07-02 2023-01-03 安源医药科技（上海）有限公司 抗cd3抗体及其用途
CN118922442A (zh) * 2022-03-14 2024-11-08 成都盛世君联生物技术有限公司 一种抗cd3抗体及其制备方法和用途
CN115286715B (zh) * 2022-05-18 2023-05-23 上海百英生物科技股份有限公司 一种抗cd3的纳米抗体或其抗原结合部分及其制备方法
JP2026502768A (ja) * 2022-10-25 2026-01-27 アブレクシス， エルエルシー 抗ｃｄ３抗体
JP2025540716A (ja) 2022-11-24 2025-12-16 ウーシー バイオロジクス アイルランド リミテッド Ｐｓｍａ抗体およびその使用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1298020A (zh) * 1999-11-30 2001-06-06 中国医学科学院中国协和医科大学血液学研究所血液病医院 抗cd3单克隆抗体重链和轻链可变区基因及其应用
CN1984931A (zh) * 2004-06-03 2007-06-20 诺维莫尼公司 抗－cd3抗体及其使用方法
CN104098698A (zh) * 2013-04-08 2014-10-15 中国人民解放军第二军医大学 一种抗cd3抗体及其制法和应用
CN106029696A (zh) * 2013-12-17 2016-10-12 基因泰克公司 抗cd3抗体及使用方法

Family Cites Families (10)

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US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
EP1940881B1 (en) 2005-10-11 2016-11-30 Amgen Research (Munich) GmbH Compositions comprising cross-species-specific antibodies and uses thereof
RS53008B2 (sr) * 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
MX2009010611A (es) * 2007-04-03 2010-03-26 Micromet Ag Enlazadores biespecificos, especificos para especies.
US20110293619A1 (en) 2008-10-01 2011-12-01 Micromet Ag CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
WO2011109588A1 (en) * 2010-03-03 2011-09-09 Health Research Inc. Novel cd3 epsilon immunogens and antibodies
SG11201509361TA (en) 2013-05-28 2015-12-30 Numab Ag Novel antibodies
CN106459201A (zh) * 2014-05-28 2017-02-22 豪夫迈·罗氏有限公司 结合人和食蟹猴CD3ε的抗体
EP3204415B1 (en) * 2014-10-09 2020-06-17 EngMab Sàrl Bispecific antibodies against cd3epsilon and ror1
CN120988137A (zh) 2015-01-23 2025-11-21 赛诺菲 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1298020A (zh) * 1999-11-30 2001-06-06 中国医学科学院中国协和医科大学血液学研究所血液病医院 抗cd3单克隆抗体重链和轻链可变区基因及其应用
CN1984931A (zh) * 2004-06-03 2007-06-20 诺维莫尼公司 抗－cd3抗体及其使用方法
CN104098698A (zh) * 2013-04-08 2014-10-15 中国人民解放军第二军医大学 一种抗cd3抗体及其制法和应用
CN106029696A (zh) * 2013-12-17 2016-10-12 基因泰克公司 抗cd3抗体及使用方法

Non-Patent Citations (1)

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Title
袁泉 等: "CD3ε和PMA 对fas 基因转录调控作用的研究", 中国生物化学与分子生物学报, vol. 14, no. 6, 31 December 1998 (1998-12-31), pages 770 - 774 *

Also Published As

Publication number Publication date
SG11202001358RA (en) 2020-03-30
KR20250046337A (ko) 2025-04-02
EP3684806A1 (en) 2020-07-29
US20230192850A1 (en) 2023-06-22
KR102785140B1 (ko) 2025-03-25
MY199530A (en) 2023-11-03
WO2019057099A1 (en) 2019-03-28
ZA202001314B (en) 2021-08-25
SA523440043B1 (ar) 2024-02-08
CN111108119B (zh) 2022-11-15
CA3074130A1 (en) 2019-03-28
JP2023126851A (ja) 2023-09-12
US11440962B2 (en) 2022-09-13
US20200299384A1 (en) 2020-09-24
TWI820041B (zh) 2023-11-01
JP7305624B2 (ja) 2023-07-10
AU2018336519A1 (en) 2020-03-05
JP2020534830A (ja) 2020-12-03
NZ762170A (en) 2023-10-27
IL273393B1 (en) 2026-02-01
MX2020003087A (es) 2020-08-17
EP3684806A4 (en) 2021-09-22
US12485298B2 (en) 2025-12-02
TW201922787A (zh) 2019-06-16
US20260116974A1 (en) 2026-04-30
IL325604A (en) 2026-02-01
IL273393A (en) 2020-05-31
CN111108119A (zh) 2020-05-05
TW202428617A (zh) 2024-07-16
BR112020004992A2 (pt) 2020-10-06
TWI879275B (zh) 2025-04-01
KR20200055052A (ko) 2020-05-20
EA202090800A1 (ru) 2020-08-11
AU2025201457A1 (en) 2025-03-20
SA520411577B1 (ar) 2024-02-08
AU2018336519B2 (en) 2024-12-19
PH12020550078A1 (en) 2022-07-18
JP7737193B2 (ja) 2025-09-10

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