JP2020501598A5 - - Google Patents
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- JP2020501598A5 JP2020501598A5 JP2019536459A JP2019536459A JP2020501598A5 JP 2020501598 A5 JP2020501598 A5 JP 2020501598A5 JP 2019536459 A JP2019536459 A JP 2019536459A JP 2019536459 A JP2019536459 A JP 2019536459A JP 2020501598 A5 JP2020501598 A5 JP 2020501598A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- cdr
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 52
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 19
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000013056 classic Hodgkin lymphoma Diseases 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000006037 primary mediastinal B-cell lymphoma Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395832P | 2016-09-16 | 2016-09-16 | |
| US62/395,832 | 2016-09-16 | ||
| US201762519590P | 2017-06-14 | 2017-06-14 | |
| US62/519,590 | 2017-06-14 | ||
| PCT/US2017/050851 WO2018052818A1 (en) | 2016-09-16 | 2017-09-09 | Anti-pd-1 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501598A JP2020501598A (ja) | 2020-01-23 |
| JP2020501598A5 true JP2020501598A5 (https=) | 2020-10-22 |
| JP7072576B2 JP7072576B2 (ja) | 2022-05-20 |
Family
ID=61620151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536459A Active JP7072576B2 (ja) | 2016-09-16 | 2017-09-09 | 抗ｐｄ－１抗体 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11028173B2 (https=) |
| EP (3) | EP3512885B1 (https=) |
| JP (1) | JP7072576B2 (https=) |
| KR (1) | KR102391338B1 (https=) |
| CN (1) | CN109923126B (https=) |
| AU (1) | AU2017327828B2 (https=) |
| BR (1) | BR112019005129A2 (https=) |
| CA (1) | CA3037144A1 (https=) |
| DK (1) | DK4339615T3 (https=) |
| ES (2) | ES3055536T3 (https=) |
| FI (2) | FI4339615T3 (https=) |
| FR (1) | FR25C1022I2 (https=) |
| HR (1) | HRP20251501T1 (https=) |
| HU (2) | HUE067813T2 (https=) |
| LT (2) | LT4339615T (https=) |
| MY (1) | MY199683A (https=) |
| NL (1) | NL301362I2 (https=) |
| NO (1) | NO2026007I1 (https=) |
| PH (1) | PH12019500571A1 (https=) |
| PL (1) | PL4339615T3 (https=) |
| PT (1) | PT4339615T (https=) |
| RS (1) | RS67443B1 (https=) |
| RU (1) | RU2752832C2 (https=) |
| SI (1) | SI4339615T1 (https=) |
| SM (1) | SMT202500445T1 (https=) |
| TW (1) | TWI772326B (https=) |
| WO (1) | WO2018052818A1 (https=) |
| ZA (1) | ZA201901865B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019382505B2 (en) * | 2018-11-19 | 2026-02-05 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
| MY204342A (en) | 2019-03-25 | 2024-08-24 | Alteogen Inc | Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection |
| TWI869398B (zh) * | 2019-05-10 | 2025-01-11 | 英商拜西克爾德有限公司 | 治療癌症之方法 |
| WO2021006199A1 (ja) | 2019-07-05 | 2021-01-14 | 小野薬品工業株式会社 | Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| CN112300279A (zh) * | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| WO2021037007A1 (zh) | 2019-08-29 | 2021-03-04 | 荣昌生物制药(烟台)股份有限公司 | 抗pd-l1抗体及其应用 |
| CN110787292B (zh) * | 2020-01-06 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | 一种细胞程序性死亡受体1抗体制剂及其用途 |
| WO2021139780A1 (en) * | 2020-01-10 | 2021-07-15 | Shanghai Henlius Biotech, Inc. | Anti-tigit antibodies, multispecific antibodies comprising the same and methods of using the same |
| KR20220131279A (ko) | 2020-01-21 | 2022-09-27 | 상하이 헨리우스 바이오테크, 인크. | 항lag3단일 클론 항체 및 그 제조 방법과 응용 |
| CN113336847B (zh) * | 2021-02-03 | 2022-08-23 | 上海莱馥医疗科技有限公司 | 一种抗pd-1抗体 |
| EP4293046A4 (en) * | 2021-02-10 | 2025-03-05 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | Anti-pd-1 antibody and use thereof |
| EP4562048A1 (en) * | 2022-07-28 | 2025-06-04 | Merck Sharp & Dohme LLC | Pharmaceutical compositions of programmed death receptor 1 (pd-1) antibodies and ph20 variants or fragments thereof |
| KR20250054235A (ko) * | 2022-07-28 | 2025-04-22 | 머크 샤프 앤드 돔 엘엘씨 | 프로그램화된 사멸 수용체 1 (PD-1) 항체 및 rHuPH20 또는 그의 변이체 또는 단편의 제약 조성물 |
| WO2025140467A1 (zh) * | 2023-12-29 | 2025-07-03 | 上海复宏汉霖生物技术股份有限公司 | 稳定的高浓度抗pd-1抗体药物制剂 |
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-
2017
- 2017-09-09 WO PCT/US2017/050851 patent/WO2018052818A1/en not_active Ceased
- 2017-09-09 RS RS20251199A patent/RS67443B1/sr unknown
- 2017-09-09 FI FIEP24150762.3T patent/FI4339615T3/sv active
- 2017-09-09 SM SM20250445T patent/SMT202500445T1/it unknown
- 2017-09-09 PT PT241507623T patent/PT4339615T/pt unknown
- 2017-09-09 HR HRP20251501TT patent/HRP20251501T1/hr unknown
- 2017-09-09 LT LTEP24150762.3T patent/LT4339615T/lt unknown
- 2017-09-09 EP EP17851358.6A patent/EP3512885B1/en active Active
- 2017-09-09 CA CA3037144A patent/CA3037144A1/en active Pending
- 2017-09-09 CN CN201780056868.5A patent/CN109923126B/zh active Active
- 2017-09-09 JP JP2019536459A patent/JP7072576B2/ja active Active
- 2017-09-09 KR KR1020197010711A patent/KR102391338B1/ko active Active
- 2017-09-09 SI SI201731637T patent/SI4339615T1/sl unknown
- 2017-09-09 MY MYPI2019001409A patent/MY199683A/en unknown
- 2017-09-09 ES ES24150762T patent/ES3055536T3/es active Active
- 2017-09-09 EP EP25204711.3A patent/EP4696785A2/en active Pending
- 2017-09-09 RU RU2019107134A patent/RU2752832C2/ru active
- 2017-09-09 AU AU2017327828A patent/AU2017327828B2/en active Active
- 2017-09-09 EP EP24150762.3A patent/EP4339615B1/en active Active
- 2017-09-09 PL PL24150762.3T patent/PL4339615T3/pl unknown
- 2017-09-09 HU HUE17851358A patent/HUE067813T2/hu unknown
- 2017-09-09 BR BR112019005129-5A patent/BR112019005129A2/pt unknown
- 2017-09-09 DK DK24150762.3T patent/DK4339615T3/da active
- 2017-09-09 ES ES17851358T patent/ES2977137T3/es active Active
- 2017-09-15 TW TW106131824A patent/TWI772326B/zh active
-
2019
- 2019-03-13 US US16/352,194 patent/US11028173B2/en active Active
- 2019-03-15 PH PH12019500571A patent/PH12019500571A1/en unknown
- 2019-03-26 ZA ZA2019/01865A patent/ZA201901865B/en unknown
-
2021
- 2021-04-29 US US17/244,025 patent/US11685783B2/en active Active
-
2025
- 2025-06-02 HU HUS2500024C patent/HUS2500024I1/hu unknown
- 2025-06-03 FR FR25C1022C patent/FR25C1022I2/fr active Active
-
2026
- 2026-01-19 NL NL301362C patent/NL301362I2/nl unknown
- 2026-01-19 FI FIC20260002C patent/FIC20260002I1/fi unknown
- 2026-01-21 LT LTPA2026505C patent/LTPA2026505I1/lt unknown
- 2026-01-22 NO NO2026007C patent/NO2026007I1/no unknown
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