JP2020522475A5 - - Google Patents

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Publication number
JP2020522475A5
JP2020522475A5 JP2019565224A JP2019565224A JP2020522475A5 JP 2020522475 A5 JP2020522475 A5 JP 2020522475A5 JP 2019565224 A JP2019565224 A JP 2019565224A JP 2019565224 A JP2019565224 A JP 2019565224A JP 2020522475 A5 JP2020522475 A5 JP 2020522475A5
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JP
Japan
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seq
amino acid
acid sequence
chain variable
variable region
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JP2019565224A
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English (en)
Japanese (ja)
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JP7761373B2 (ja
JP2020522475A (ja
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Priority claimed from PCT/CA2018/050634 external-priority patent/WO2018218352A1/en
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Publication of JP2020522475A5 publication Critical patent/JP2020522475A5/ja
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JP2019565224A 2017-05-30 2018-05-30 Ｔｄｐ－４３のｒｎａ認識モチーフ１（ｒｒｍ１）中のエピトープ、およびそれらに対するミスフォールディング選択的抗体 Active JP7761373B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762512647P 2017-05-30 2017-05-30
US62/512,647 2017-05-30
US201762570582P 2017-10-10 2017-10-10
US62/570,582 2017-10-10
US201762595866P 2017-12-07 2017-12-07
US62/595,866 2017-12-07
PCT/CA2018/050634 WO2018218352A1 (en) 2017-05-30 2018-05-30 Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto

Publications (3)

Publication Number Publication Date
JP2020522475A JP2020522475A (ja) 2020-07-30
JP2020522475A5 true JP2020522475A5 (https=) 2021-07-26
JP7761373B2 JP7761373B2 (ja) 2025-10-28

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ID=64454301

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Application Number Title Priority Date Filing Date
JP2019565224A Active JP7761373B2 (ja) 2017-05-30 2018-05-30 Ｔｄｐ－４３のｒｎａ認識モチーフ１（ｒｒｍ１）中のエピトープ、およびそれらに対するミスフォールディング選択的抗体

Country Status (5)

Country Link
US (2) US11214613B2 (https=)
EP (1) EP3634987A4 (https=)
JP (1) JP7761373B2 (https=)
CA (1) CA3064785A1 (https=)
WO (1) WO2018218352A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220012270A (ko) * 2019-05-23 2022-02-03 에이씨 이뮨 에스.에이. 항-tdp-43 결합 분자 및 이의 용도
CN114174515A (zh) * 2019-05-27 2022-03-11 英属哥伦比亚大学 tau中的构象特异性表位、其抗体和其相关方法
EP4041308A1 (en) 2019-10-07 2022-08-17 University of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease
EP4093426A1 (en) 2020-01-24 2022-11-30 University of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease
EP4504775A1 (en) * 2022-04-08 2025-02-12 AC Immune SA Anti-tdp-43 binding molecules
WO2025035133A1 (en) * 2023-08-10 2025-02-13 Board Of Regents, The University Of Texas System Bmp-7 antibody compositions & methods for treating cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1426381A1 (en) 1995-10-02 2004-06-09 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES An epithelial protein and DNA thereof for use in early cancer detection
US6472367B1 (en) * 1998-05-05 2002-10-29 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin mediated cell adhesion
AT506819B1 (de) * 2008-06-12 2011-06-15 Affiris Forschungs Und Entwicklungs Gmbh Vakzin zur behandlung von alzheimer-krankheit
AU2009301580B2 (en) 2008-10-06 2015-11-26 The University Of British Columbia Methods and systems for predicting misfolded protein epitopes
GB0922435D0 (en) * 2009-12-22 2010-02-03 Ucb Pharma Sa Method
EP2606058B1 (en) * 2010-07-21 2017-03-08 Eastern Virginia Medical School Peptide compounds to regulate the complement system
CA2853412C (en) 2011-10-28 2021-05-04 University Of Zurich Tdp-43 specific binding molecules
JP2016503817A (ja) * 2012-12-31 2016-02-08 ディヴェロップメント センター フォー バイオテクノロジー アンチグラニュリシン抗体及びその使用方法
WO2016053610A1 (en) 2014-10-03 2016-04-07 Academia Sinica Antibodies against pathological forms of tdp-43 and uses thereof
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
JP6952351B2 (ja) 2015-11-09 2021-10-20 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 集団座標バイアシングによりミスフォールディングタンパク質エピトープを予測するためのシステムおよび方法
US20180125920A1 (en) * 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions

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