|
CN1020944C
(zh)
|
1990-01-30 |
1993-05-26 |
阿图尔-费希尔股份公司费希尔厂 |
紧固件
|
|
ES2363941T3
(es)
*
|
2003-03-14 |
2011-08-19 |
Astellas Pharma Inc. |
Derivados de c-glucósido para el tratamiento de diabetes.
|
|
ES2531660T3
(es)
†
|
2003-08-01 |
2015-03-18 |
Mitsubishi Tanabe Pharma Corporation |
Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio
|
|
BRPI0508259A
(pt)
*
|
2004-03-04 |
2007-07-31 |
Kissei Pharmaceutical |
derivado heterocìclico fundido, composição medicinal contendo o mesmo, e uso medicinal do mesmo
|
|
CN103030617A
(zh)
|
2004-03-16 |
2013-04-10 |
贝林格尔.英格海姆国际有限公司 |
吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
|
|
US7393836B2
(en)
|
2004-07-06 |
2008-07-01 |
Boehringer Ingelheim International Gmbh |
D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
|
|
WO2006010557A1
(de)
*
|
2004-07-27 |
2006-02-02 |
Boehringer Ingelheim International Gmbh |
D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
WO2006035796A1
(ja)
*
|
2004-09-29 |
2006-04-06 |
Kissei Pharmaceutical Co., Ltd. |
1-(β-D-グリコピラノシル)-3-置換含窒素ヘテロ環化合物、それを含有する医薬組成物及びその医薬用途
|
|
DE602005009745D1
(de)
|
2004-12-16 |
2008-10-23 |
Boehringer Ingelheim Pharma |
Glucopyranosyl-substituierte benzen-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
|
|
TW200637869A
(en)
|
2005-01-28 |
2006-11-01 |
Chugai Pharmaceutical Co Ltd |
The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
|
|
AR053329A1
(es)
*
|
2005-01-31 |
2007-05-02 |
Tanabe Seiyaku Co |
Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
|
|
JP4496174B2
(ja)
*
|
2005-01-31 |
2010-07-07 |
田辺三菱製薬株式会社 |
医薬組成物
|
|
TWI365186B
(en)
*
|
2005-01-31 |
2012-06-01 |
Mitsubishi Tanabe Pharma Corp |
Indole derivatives
|
|
JP5264183B2
(ja)
|
2005-02-23 |
2013-08-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
グルコピラノシル置換((ヘテロ)アリールエチニル−ベンジル)−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体2(sglt2)インヒビターとしてのそれらの使用
|
|
ATE453656T1
(de)
|
2005-04-15 |
2010-01-15 |
Boehringer Ingelheim Int |
Glucopyranosyl-substituierte (heteroaryloxy- benzyl)-benzen-derivate als sglt-inhibitoren
|
|
US7723309B2
(en)
|
2005-05-03 |
2010-05-25 |
Boehringer Ingelheim International Gmbh |
Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
|
|
UA91546C2
(uk)
|
2005-05-03 |
2010-08-10 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
|
|
US7772191B2
(en)
|
2005-05-10 |
2010-08-10 |
Boehringer Ingelheim International Gmbh |
Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
|
|
TW200726755A
(en)
*
|
2005-07-07 |
2007-07-16 |
Astellas Pharma Inc |
A crystalline choline salt of an azulene derivative
|
|
AR054871A1
(es)
|
2005-07-27 |
2007-07-25 |
Boehringer Ingelheim Int |
Derivados de (hetero)cicloalquiletinil-bencil)-benceno sustituidos con glucopiranosilo, medicamentos que contienen dichos compuestos, sus uso y proceso para su fabricacion
|
|
WO2007025943A2
(en)
|
2005-08-30 |
2007-03-08 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
|
|
AU2006289093A1
(en)
|
2005-09-08 |
2007-03-15 |
Boehringer Ingelheim International Gmbh |
Crystalline forms of 1-chloro-4-(beta-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
|
|
AR056195A1
(es)
|
2005-09-15 |
2007-09-26 |
Boehringer Ingelheim Int |
Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
|
|
AR059489A1
(es)
|
2006-02-15 |
2008-04-09 |
Boehringer Ingelheim Vetmed |
Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
|
|
TWI370818B
(en)
|
2006-04-05 |
2012-08-21 |
Astellas Pharma Inc |
Cocrystal of c-glycoside derivative and l-proline
|
|
PE20080697A1
(es)
|
2006-05-03 |
2008-08-05 |
Boehringer Ingelheim Int |
Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
US7803778B2
(en)
*
|
2006-05-23 |
2010-09-28 |
Theracos, Inc. |
Glucose transport inhibitors and methods of use
|
|
TWI403516B
(zh)
*
|
2006-07-27 |
2013-08-01 |
Chugai Pharmaceutical Co Ltd |
To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes
|
|
TWI418556B
(zh)
*
|
2006-07-27 |
2013-12-11 |
Mitsubishi Tanabe Pharma Corp |
吲哚衍生物
|
|
TWI432446B
(zh)
|
2006-07-27 |
2014-04-01 |
Chugai Pharmaceutical Co Ltd |
稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用
|
|
US20080027014A1
(en)
*
|
2006-07-28 |
2008-01-31 |
Tanabe Seiyaku Co., Ltd. |
Novel SGLT inhibitors
|
|
WO2008020011A1
(en)
|
2006-08-15 |
2008-02-21 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
|
|
WO2008034859A1
(en)
*
|
2006-09-21 |
2008-03-27 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
|
|
AU2007307544A1
(en)
|
2006-10-13 |
2008-04-17 |
Chugai Seiyaku Kabushiki Kaisha |
Thioglucose spiroketal derivative and use thereof as therapeutic agent for diabetes
|
|
WO2008049923A1
(en)
|
2006-10-27 |
2008-05-02 |
Boehringer Ingelheim International Gmbh |
CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
|
|
NZ577391A
(en)
*
|
2006-12-04 |
2011-11-25 |
Janssen Pharmaceutica Nv |
Thienyl-containing glycopyranosyl derivatives as antidiabetics
|
|
UY30730A1
(es)
*
|
2006-12-04 |
2008-07-03 |
Mitsubishi Tanabe Pharma Corp |
Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
|
|
WO2008075736A1
(ja)
*
|
2006-12-21 |
2008-06-26 |
Astellas Pharma Inc. |
C-グリコシド誘導体の製造方法及びその合成中間体
|
|
US7795228B2
(en)
*
|
2006-12-28 |
2010-09-14 |
Theracos, Inc. |
Spiroheterocyclic glycosides and methods of use
|
|
EP2112928A4
(en)
*
|
2007-02-22 |
2014-01-08 |
Univ Utah Res Found |
SYNTHESIS OF NOVEL XYLOSIDES AND ITS POSSIBLE USES
|
|
JP5583003B2
(ja)
|
2007-04-02 |
2014-09-03 |
セラコス・インコーポレイテッド |
ベンジルグルコシド誘導体およびその用途
|
|
CN101679431B
(zh)
*
|
2007-04-11 |
2013-08-14 |
Msd欧斯股份有限公司 |
制备四环苯并氮杂卓的对映异构体的方法
|
|
CL2008002427A1
(es)
|
2007-08-16 |
2009-09-11 |
Boehringer Ingelheim Int |
Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
|
|
NZ583369A
(en)
|
2007-08-23 |
2011-08-26 |
Theracos Inc |
Benzylbenzene derivatives and methods of use
|
|
RS56990B1
(sr)
*
|
2007-09-10 |
2018-05-31 |
Janssen Pharmaceutica Nv |
Postupak za dobijanje jedinjenja koja su korisna kao inhibitori sglt
|
|
UA101004C2
(en)
|
2007-12-13 |
2013-02-25 |
Теракос, Инк. |
Derivatives of benzylphenylcyclohexane and use thereof
|
|
CL2008003653A1
(es)
*
|
2008-01-17 |
2010-03-05 |
Mitsubishi Tanabe Pharma Corp |
Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
|
|
ES2541141T3
(es)
*
|
2008-01-31 |
2015-07-16 |
Astellas Pharma Inc. |
Composición farmacéutica para el tratamiento de las enfermedades del hígado graso
|
|
TW201000494A
(en)
*
|
2008-02-13 |
2010-01-01 |
Sanofi Aventis |
Novel aromatic fluoroglycoside derivatives, medicaments comprising these compounds and use thereof
|
|
US8791077B2
(en)
|
2008-05-22 |
2014-07-29 |
Astrazeneca Ab |
Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
|
|
CN103910702A
(zh)
|
2008-08-22 |
2014-07-09 |
泰拉科斯有限公司 |
制备sglt2抑制剂的方法
|
|
AU2009286380B2
(en)
|
2008-08-28 |
2011-09-15 |
Pfizer Inc. |
Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
|
|
MX2011002990A
(es)
*
|
2008-09-19 |
2011-04-11 |
Novartis Ag |
Derivados de glucosido y usos de los mismos como inhibidores de sglt.
|
|
US9056850B2
(en)
*
|
2008-10-17 |
2015-06-16 |
Janssen Pharmaceutica N.V. |
Process for the preparation of compounds useful as inhibitors of SGLT
|
|
JP5685550B2
(ja)
|
2009-02-13 |
2015-03-18 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Sglt2阻害剤、dpp−iv阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
|
|
DK2396005T3
(da)
|
2009-02-13 |
2026-02-09 |
Boehringer Ingelheim Int |
Sglt2 hæmmer til at forbedre glykæmisk kontrol
|
|
CN101830876A
(zh)
*
|
2009-03-12 |
2010-09-15 |
上海恒瑞医药有限公司 |
C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用
|
|
US20110009347A1
(en)
*
|
2009-07-08 |
2011-01-13 |
Yin Liang |
Combination therapy for the treatment of diabetes
|
|
EP2451797B1
(en)
|
2009-07-10 |
2013-04-03 |
Janssen Pharmaceutica, N.V. |
CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
|
|
AU2010295722B2
(en)
|
2009-09-15 |
2015-04-16 |
Janssen Pharmaceutica, N.V. |
Use of alpha-methylglucoside (AMG) as an indicator for glucose absorption and excretion
|
|
EA020798B1
(ru)
|
2009-09-30 |
2015-01-30 |
Бёрингер Ингельхайм Интернациональ Гмбх |
СПОСОБ ПОЛУЧЕНИЯ КРИСТАЛЛИЧЕСКОЙ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА
|
|
PT2486029E
(pt)
|
2009-09-30 |
2015-10-14 |
Boehringer Ingelheim Int |
Processos para a preparação de derivados de benzil-benzeno substituídos com glucopiranosilo
|
|
UY32919A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
|
|
HUE031375T2
(en)
|
2009-10-14 |
2017-07-28 |
Janssen Pharmaceutica Nv |
Process for the preparation of compounds useful as inhibitors of sglt2
|
|
US8163704B2
(en)
|
2009-10-20 |
2012-04-24 |
Novartis Ag |
Glycoside derivatives and uses thereof
|
|
RS53827B1
(sr)
|
2009-11-02 |
2015-06-30 |
Pfizer Inc. |
Derivati dioksa-biciklo[3.2.1]oktan-2,3,4-triola
|
|
CN102115468B
(zh)
*
|
2009-12-31 |
2014-06-11 |
上海特化医药科技有限公司 |
一种2,5-二取代噻吩化合物的合成方法
|
|
CN102134226B
(zh)
|
2010-01-26 |
2013-06-12 |
天津药物研究院 |
一类苯基c-葡萄糖苷衍生物、其制备方法和用途
|
|
EP2552442A1
(en)
|
2010-03-30 |
2013-02-06 |
Boehringer Ingelheim International GmbH |
Pharmaceutical composition comprising an sglt2 inhibitor and a ppar- gamma agonist and uses thereof
|
|
CA2795513A1
(en)
|
2010-04-06 |
2011-10-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
SG10201506114UA
(en)
|
2010-05-11 |
2015-09-29 |
Janssen Pharmaceutica Nv |
Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
|
|
US20130052266A1
(en)
|
2010-05-11 |
2013-02-28 |
Mitsubishi Tanabe Pharma Corporation |
TABLETS CONTAINING A 1-(beta-D-GLUCOPYRANOSYL)-3-(PHENYLTHIENYLMETHYL)BENZENE COMPOUND
|
|
US8217183B2
(en)
|
2010-05-18 |
2012-07-10 |
Corning Incorporated |
Methods of making fused thiophenes
|
|
WO2011153712A1
(en)
|
2010-06-12 |
2011-12-15 |
Theracos, Inc. |
Crystalline form of benzylbenzene sglt2 inhibitor
|
|
EP2590631B1
(en)
|
2010-07-06 |
2016-10-26 |
Janssen Pharmaceutica NV |
Formulation for co-therapy treatment of diabetes
|
|
CN102372722A
(zh)
*
|
2010-08-10 |
2012-03-14 |
江苏恒瑞医药股份有限公司 |
C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用
|
|
US9006187B2
(en)
*
|
2010-09-10 |
2015-04-14 |
Green Cross Corporation |
Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same
|
|
EP3323818A1
(en)
|
2010-09-22 |
2018-05-23 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
WO2012041898A1
(en)
|
2010-09-29 |
2012-04-05 |
Celon Pharma Sp. Z O.O. |
Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes
|
|
CN102453026A
(zh)
*
|
2010-10-27 |
2012-05-16 |
上海艾力斯医药科技有限公司 |
C-芳基葡糖苷衍生物、制备方法及其应用
|
|
US20120283169A1
(en)
|
2010-11-08 |
2012-11-08 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
|
US20130035281A1
(en)
|
2011-02-09 |
2013-02-07 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
|
WO2012109996A1
(zh)
|
2011-02-18 |
2012-08-23 |
上海璎黎科技有限公司 |
一种芳基糖苷类化合物及其制备方法和应用
|
|
AR085689A1
(es)
|
2011-03-07 |
2013-10-23 |
Boehringer Ingelheim Int |
Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
|
|
US20140018371A1
(en)
|
2011-04-01 |
2014-01-16 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
EP2697218B1
(en)
|
2011-04-13 |
2016-05-25 |
Janssen Pharmaceutica NV |
Process for the preparation of compounds useful as inhibitors of sglt2
|
|
EP2697203B1
(en)
*
|
2011-04-13 |
2017-05-24 |
Merck Sharp & Dohme Corporation |
Mineralocorticoid receptor antagonists
|
|
JP2014510782A
(ja)
*
|
2011-04-14 |
2014-05-01 |
ノバルティス アーゲー |
グリコシド誘導体およびその使用
|
|
WO2012145361A1
(en)
|
2011-04-19 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20140038889A1
(en)
|
2011-04-22 |
2014-02-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US20140051714A1
(en)
|
2011-04-22 |
2014-02-20 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
TWI542596B
(zh)
|
2011-05-09 |
2016-07-21 |
健生藥品公司 |
(2s,3r,4r,5s,6r)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲基苯基)-6-(羥甲基)四氫-2h-哌喃-3,4,5-三醇之l-脯胺酸及檸檬酸共晶體
|
|
CA2836663A1
(en)
*
|
2011-05-20 |
2012-11-29 |
Janssen Pharmaceutica Nv |
Process for the preparation of compounds useful as inhibitors of sglt-2
|
|
JP2014516038A
(ja)
*
|
2011-05-20 |
2014-07-07 |
ヤンセン ファーマシューティカ エヌ.ベー. |
Sglt−2の阻害物質として有用な化合物の調製プロセス
|
|
ES2719656T3
(es)
*
|
2011-06-01 |
2019-07-11 |
Green Cross Corp |
Derivados de difenilmetano novedosos como inhibidores del SGLT2
|
|
BR112013031032A2
(pt)
|
2011-06-03 |
2016-11-29 |
Boehringer Ingelheim Int |
inibidores de sglt-2 para o tratamento de distúrbios metabólicos em pacientes tratados com agentes neurolépticos
|
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
CN102827122B
(zh)
*
|
2011-06-17 |
2015-01-14 |
山东轩竹医药科技有限公司 |
糖苷衍生物
|
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
WO2013061105A2
(en)
*
|
2011-10-28 |
2013-05-02 |
Debreceni Egyetem |
Glycogen phosphorylase inhibitors
|
|
US8697658B2
(en)
|
2011-12-15 |
2014-04-15 |
National Health Research Institutes |
Glycoside compounds
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
US9192617B2
(en)
|
2012-03-20 |
2015-11-24 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
|
WO2013152476A1
(en)
|
2012-04-10 |
2013-10-17 |
Theracos, Inc. |
Process for the preparation of benzylbenzene sglt2 inhibitors
|
|
CN103570671B
(zh)
*
|
2012-09-26 |
2016-03-30 |
上海天慈生物谷生物工程有限公司 |
一种降糖化合物及其制法和应用
|
|
WO2014074668A1
(en)
|
2012-11-08 |
2014-05-15 |
Arena Pharmaceuticals, Inc. |
Modulators of gpr119 and the treatment of disorders related thereto
|
|
EP2933250B1
(en)
*
|
2012-12-17 |
2017-08-09 |
Tianjin Institute Of Pharmaceutical Research |
Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
|
|
CN103910769B
(zh)
|
2012-12-31 |
2018-10-02 |
上海璎黎药业有限公司 |
葡萄糖衍生物和脯氨酸的复合物、晶体、制备方法及应用
|
|
JP6173427B2
(ja)
*
|
2013-02-26 |
2017-08-02 |
田辺三菱製薬株式会社 |
α−ハロテトラアシルグルコースの製造方法
|
|
JP6461080B2
(ja)
*
|
2013-03-11 |
2019-01-30 |
ヤンセン ファーマシューティカ エヌ.ベー. |
二重sglt1/sglt2阻害剤
|
|
EP3466431B1
(en)
|
2013-03-14 |
2023-11-15 |
MSD International GmbH |
Crystalline forms and methods for preparing sglt2 inhibitors
|
|
JP2016512817A
(ja)
|
2013-03-15 |
2016-05-09 |
ヤンセン ファーマシューティカ エヌ.ベー. |
高尿酸血症の治療におけるカナグリフロジンとプロベネシドの組合せ
|
|
PT2981269T
(pt)
|
2013-04-04 |
2023-10-10 |
Boehringer Ingelheim Vetmedica Gmbh |
Tratamento de distúrbios metabólicos em animais equinos
|
|
CA2812519A1
(en)
|
2013-04-05 |
2014-10-05 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
|
US11813275B2
(en)
|
2013-04-05 |
2023-11-14 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
|
TR201901110T4
(tr)
|
2013-04-05 |
2019-02-21 |
Boehringer Ingelheim Int |
Empagliflozinin terapötik kullanımları.
|
|
HK1213818A1
(zh)
|
2013-04-05 |
2016-07-15 |
勃林格殷格翰国际有限公司 |
依帕列净的治疗用途
|
|
EP4678242A3
(en)
|
2013-04-18 |
2026-03-18 |
Boehringer Ingelheim International GmbH |
Pharmaceutical composition, methods for treating and uses thereof
|
|
CA2911261A1
(en)
|
2013-05-08 |
2014-11-13 |
Lek Pharmaceuticals D.D. |
Novel crystalline hydrates of 1-(.beta.-d-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
|
|
US20160083374A1
(en)
|
2013-05-30 |
2016-03-24 |
Cadila Healthcare Limited |
Amorphous form of canagliflozin and process for preparing thereof
|
|
CN104418834B
(zh)
*
|
2013-08-23 |
2017-09-15 |
重庆博腾制药科技股份有限公司 |
一种抗糖尿病药物中间体的合成方法
|
|
CN105611920B
(zh)
|
2013-10-12 |
2021-07-16 |
泰拉科斯萨普有限责任公司 |
羟基-二苯甲烷衍生物的制备
|
|
CN104557894A
(zh)
*
|
2013-10-18 |
2015-04-29 |
上海信谊药厂有限公司 |
坎格列汀晶型及其制备方法
|
|
ES2969764T3
(es)
|
2013-12-17 |
2024-05-22 |
Boehringer Ingelheim Vetmedica Gmbh |
Un inhibidor de SGLT-2 para usar en el tratamiento de un trastorno metabólico en animales felinos
|
|
CN115671290A
(zh)
|
2014-01-23 |
2023-02-03 |
勃林格殷格翰动物保健有限公司 |
犬科动物中代谢紊乱的治疗
|
|
AU2015210898A1
(en)
|
2014-01-31 |
2016-07-28 |
Janssen Pharmaceutica Nv |
Methods for the treatment and prevention of renal disorders and fatty liver disorders
|
|
EP2918579A1
(en)
|
2014-03-14 |
2015-09-16 |
LEK Pharmaceuticals d.d. |
Synthesis of 2-arylmethyl-5-aryl-thiophene
|
|
US10174010B2
(en)
|
2014-03-19 |
2019-01-08 |
Hangzhou Pushai Pharmaceutical Technology Co., Ltd. |
Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof
|
|
WO2015150299A2
(en)
|
2014-04-01 |
2015-10-08 |
Boehringer Ingelheim Vetmedica Gmbh |
Treatment of metabolic disorders in equine animals
|
|
CN103936725B
(zh)
*
|
2014-04-01 |
2016-07-27 |
天津大学 |
卡格列净的c晶型及其结晶制备方法
|
|
CN105001213B
(zh)
|
2014-04-14 |
2020-08-28 |
上海迪诺医药科技有限公司 |
C-芳基糖苷衍生物、其药物组合物、制备方法及应用
|
|
EP2933255A1
(en)
|
2014-04-17 |
2015-10-21 |
LEK Pharmaceuticals d.d. |
Novel crystalline form of 1-(beta-D-glucopyranosyl)-4- methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
|
|
CN103980263B
(zh)
*
|
2014-04-17 |
2016-08-03 |
海门瑞一医药科技有限公司 |
卡格列净的合成工艺
|
|
CN103936800A
(zh)
*
|
2014-05-08 |
2014-07-23 |
安徽联创药物化学有限公司 |
1-(1-甲氧基吡喃葡糖基)-4-甲基-3-[5-(4-氟苯基)-2-噻吩基甲基]苯的制备方法
|
|
TW201623321A
(zh)
*
|
2014-05-13 |
2016-07-01 |
韓美藥品股份有限公司 |
雙環衍生物及包含其之藥學組成物
|
|
EP2947077A1
(en)
|
2014-05-19 |
2015-11-25 |
LEK Pharmaceuticals d.d. |
Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides
|
|
ES2711804T3
(es)
*
|
2014-05-27 |
2019-05-07 |
Glenmark Pharmaceuticals Ltd |
Proceso para preparación de canagliflozina
|
|
CN105319294B
(zh)
*
|
2014-06-20 |
2021-03-30 |
重庆医药工业研究院有限责任公司 |
一种分离测定卡格列净及其有关物质的方法
|
|
US20160002275A1
(en)
*
|
2014-07-03 |
2016-01-07 |
Cadila Healthcare Limited |
Process for preparation and purification of canagliflozin
|
|
CN104119324B
(zh)
*
|
2014-07-23 |
2016-03-30 |
齐鲁天和惠世制药有限公司 |
一种卡格列净的制备方法
|
|
CN104109157B
(zh)
*
|
2014-08-04 |
2016-05-25 |
山东康美乐医药科技有限公司 |
卡格列净的制备方法
|
|
EP2990029A1
(en)
|
2014-08-29 |
2016-03-02 |
Sandoz Ag |
Pharmaceutical compositions comprising Canagliflozin
|
|
WO2016035042A1
(en)
|
2014-09-05 |
2016-03-10 |
Mylan Laboratories Ltd |
Process for the preparation of canagliflozin
|
|
CN104292209A
(zh)
*
|
2014-09-11 |
2015-01-21 |
浙江丽晶化学有限公司 |
一种制备2-(4-氟苯基)噻吩(化合物v)的新方法
|
|
CZ2014634A3
(cs)
|
2014-09-16 |
2016-03-23 |
Zentiva, K.S. |
Komplexy canagliflozinu a cyklodextrinů
|
|
WO2016046150A1
(en)
|
2014-09-25 |
2016-03-31 |
Boehringer Ingelheim Vetmedica Gmbh |
Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
|
|
CN104817554A
(zh)
*
|
2014-11-10 |
2015-08-05 |
镇江新元素医药科技有限公司 |
一类葡萄糖苷衍生物及其药物组合物
|
|
CN104447907A
(zh)
*
|
2015-01-14 |
2015-03-25 |
佛山市赛维斯医药科技有限公司 |
含硝基联苯双葡萄糖苷结构化合物、其制备方法和用途
|
|
CN104447905A
(zh)
*
|
2015-01-14 |
2015-03-25 |
佛山市赛维斯医药科技有限公司 |
一种含硝基苯和双o-葡萄糖苷衍生物、其制备方法和用途
|
|
CN104478969A
(zh)
*
|
2015-01-14 |
2015-04-01 |
佛山市赛维斯医药科技有限公司 |
含烷氧苯基噻唑基的o-半乳糖苷衍生物、其制备方法和用途
|
|
CN104447906A
(zh)
*
|
2015-01-14 |
2015-03-25 |
佛山市赛维斯医药科技有限公司 |
烷氧苯基双葡萄糖苷衍生物、其制备方法和用途
|
|
CN104478968A
(zh)
*
|
2015-01-14 |
2015-04-01 |
佛山市赛维斯医药科技有限公司 |
含噻唑基的o-半乳糖苷衍生物、其制备方法和用途
|
|
CN104478962A
(zh)
*
|
2015-01-15 |
2015-04-01 |
佛山市赛维斯医药科技有限公司 |
一类卤代苯基s-葡萄糖苷衍生物、其制备方法和用途
|
|
EP3256482B1
(en)
|
2015-02-09 |
2019-11-27 |
Indoco Remedies Limited |
Process for the preparation of sglt inhibitor compounds
|
|
CN105884755B
(zh)
*
|
2015-02-14 |
2019-05-28 |
正大天晴药业集团股份有限公司 |
氘修饰的碳甙衍生物
|
|
US10308871B2
(en)
|
2015-02-19 |
2019-06-04 |
Jnc Corporation |
Liquid crystal compound having benzothiophene, liquid crystal composition and liquid crystal display device
|
|
WO2016135747A2
(en)
*
|
2015-02-27 |
2016-09-01 |
Msn Laboratories Private Limited |
Process for the preparation of amorphous (1s)-1,5-anhvdro-1-[3-[[5-(4 fluorophennyl)-2-thienyl]methvl]-4-methylphenyl]-d-glucitol and its polymorphs thereof
|
|
CN104803977A
(zh)
*
|
2015-03-03 |
2015-07-29 |
佛山市赛维斯医药科技有限公司 |
一种含四氮唑结构的ptp1b衍生物、其制备方法及用途
|
|
WO2016142950A1
(en)
*
|
2015-03-11 |
2016-09-15 |
Harman Finochem Limited |
A novel process for preparing (2s,3r,4r,5s,6r)-2-{3-[5-[4-fluoro-phenyl)- thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5- triol and its stable amorphous hemihydrate form
|
|
ES2817526T3
(es)
|
2015-05-22 |
2021-04-07 |
Janssen Pharmaceutica Nv |
Forma cristalina anhidra de (1S)-1,5-anhidro-1-[3-[[5-(4-fluorofenil)-2-tienil]metil]-4-metilfenil]-D-glucitol
|
|
CN104926803B
(zh)
*
|
2015-06-17 |
2017-12-22 |
南通常佑药业科技有限公司 |
一种新的sglt2抑制剂药物的制备方法
|
|
CZ2015435A3
(cs)
|
2015-06-25 |
2017-01-04 |
Zentiva, K.S. |
Pevné formy amorfního canagliflozinu
|
|
CN104987320A
(zh)
*
|
2015-08-03 |
2015-10-21 |
沧州那瑞化学科技有限公司 |
一种坎格列净中间体的制备方法
|
|
US20170071970A1
(en)
|
2015-09-15 |
2017-03-16 |
Janssen Pharmaceutica Nv |
Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
|
|
WO2017046730A1
(en)
|
2015-09-15 |
2017-03-23 |
Laurus Labs Private Limited |
Co-crystals of sglt2 inhibitors, process for their preparation and pharmaceutical compositions thereof
|
|
WO2017046655A1
(en)
*
|
2015-09-16 |
2017-03-23 |
Optimus Drugs (P) Ltd |
A novel process for the preparation of canagliflozin
|
|
US10370365B2
(en)
|
2015-09-16 |
2019-08-06 |
Optimus Drugs (P) Limited |
Process for the preparation of Canagliflozin
|
|
CZ2015729A3
(cs)
|
2015-10-13 |
2017-04-26 |
Zentiva, K.S. |
Příprava intermediátů pro syntézu Canagliflozinu a Dapagliflozinu
|
|
WO2017064679A1
(en)
*
|
2015-10-15 |
2017-04-20 |
Lupin Limited |
Process for the preparation of amorphous canagliflozin
|
|
CN105503845A
(zh)
*
|
2015-12-01 |
2016-04-20 |
北京普德康利医药科技发展有限公司 |
去氟卡格列净化合物及其制备方法和应用
|
|
WO2017093949A1
(en)
*
|
2015-12-04 |
2017-06-08 |
Dr. Reddy's Laboratories Limited |
Substantially pure canagliflozin
|
|
CN106892929B
(zh)
*
|
2015-12-17 |
2020-01-14 |
上海艾力斯医药科技有限公司 |
螺缩酮衍生物及其制备方法和应用
|
|
HUE049895T2
(hu)
|
2015-12-21 |
2020-11-30 |
Janssen Pharmaceutica Nv |
Kristályosítási eljárás kanagliflozin hemihidrát kristályok elõállítására
|
|
CN105541815B
(zh)
*
|
2015-12-24 |
2018-07-13 |
寿光富康制药有限公司 |
一种卡格列净的制备方法
|
|
WO2017141202A1
(en)
|
2016-02-17 |
2017-08-24 |
Lupin Limited |
Complex of sglt2 inhibitor and process for preparation thereof
|
|
CA3026756C
(en)
*
|
2016-06-17 |
2021-03-02 |
Daewoong Pharmaceutical Co., Ltd. |
Method for producing diphenylmethane derivative
|
|
WO2018020506A1
(en)
|
2016-07-25 |
2018-02-01 |
Natco Pharma Ltd |
Process for the preparation of amorphous form of canagliflozin
|
|
US20210212968A1
(en)
|
2016-10-19 |
2021-07-15 |
Boehringer Ingelheim International Gmbh |
Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof
|
|
KR20190084096A
(ko)
|
2016-11-10 |
2019-07-15 |
베링거 인겔하임 인터내셔날 게엠베하 |
약제학적 조성물, 치료 방법 및 이의 용도
|
|
CN106588898A
(zh)
|
2017-02-20 |
2017-04-26 |
浙江华海药业股份有限公司 |
一种卡格列净无定型的制备方法
|
|
US11312740B2
(en)
|
2017-05-09 |
2022-04-26 |
Piramal Pharma Limited |
Process for the preparation of SGLT2 inhibitors and intermediates thereof
|
|
TWI835735B
(zh)
|
2017-06-12 |
2024-03-21 |
比利時商健生藥品公司 |
減少或預防第ii型糖尿病患者中心血管事件之方法
|
|
CN108017612B
(zh)
*
|
2017-11-29 |
2020-06-09 |
南通常佑药业科技有限公司 |
一种坎格列净中间体的制备方法
|
|
CN111405899B
(zh)
|
2017-11-30 |
2025-05-16 |
爱杜西亚药品有限公司 |
用于治疗内皮素相关疾病的4-嘧啶磺酰胺衍生物与sglt-2抑制剂的组合
|
|
CN111989103A
(zh)
|
2018-04-17 |
2020-11-24 |
勃林格殷格翰国际有限公司 |
药物组合物、其治疗方法和用途
|
|
MA53175A
(fr)
|
2018-07-19 |
2021-05-26 |
Astrazeneca Ab |
Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci
|
|
WO2020039394A1
(en)
|
2018-08-24 |
2020-02-27 |
Novartis Ag |
New drug combinations
|
|
WO2020050361A1
(ja)
*
|
2018-09-06 |
2020-03-12 |
株式会社トクヤマ |
β-C-アリールグリコシド誘導体の製造方法
|
|
KR102812426B1
(ko)
|
2018-10-29 |
2025-05-26 |
베링거 인겔하임 인터내셔날 게엠베하 |
피리디닐 설폰아미드 유도체, 약제학적 조성물 및 이의 용도
|
|
US12213970B2
(en)
|
2018-10-29 |
2025-02-04 |
Boehringer Ingelheim International Gmbh |
Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
|
|
AU2018448511B2
(en)
|
2018-11-05 |
2025-07-03 |
Betagenon Ab |
Methods of treating diabetes in severe insulin-resistant diabetic subjects
|
|
TW202103709A
(zh)
|
2019-03-26 |
2021-02-01 |
比利時商健生藥品公司 |
用於治療患有慢性腎臟病之對象的方法
|
|
EP4064854A1
(en)
|
2019-11-28 |
2022-10-05 |
Boehringer Ingelheim Vetmedica GmbH |
Use of sglt-2 inhibitors in the drying-off of non-human mammals
|
|
CN110981851A
(zh)
*
|
2019-12-24 |
2020-04-10 |
艾希尔(深圳)药物研发有限公司 |
一种卡格列净杂质的制备方法
|
|
AU2021222297B2
(en)
|
2020-02-17 |
2026-01-22 |
Boehringer Ingelheim Vetmedica Gmbh |
Use of SGLT-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines
|
|
CA3180674A1
(en)
|
2020-04-22 |
2021-10-28 |
Bayer Aktiengesellschaft |
Combination of finerenone and a sglt2 inhibitor for the treatment and/or prevention of cardiovascular and/or renal diseases
|
|
CN116392472B
(zh)
|
2020-07-27 |
2025-06-20 |
阿斯利康(瑞典)有限公司 |
用达格列净治疗慢性肾脏病的方法
|
|
US12409186B2
(en)
|
2020-07-27 |
2025-09-09 |
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|
|
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(zh)
*
|
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|
|
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|
|
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|
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|
|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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