JP2007515942A5 - - Google Patents

Info

Publication number

JP2007515942A5

JP2007515942A5 JP2006533390A JP2006533390A JP2007515942A5 JP 2007515942 A5 JP2007515942 A5 JP 2007515942A5 JP 2006533390 A JP2006533390 A JP 2006533390A JP 2006533390 A JP2006533390 A JP 2006533390A JP 2007515942 A5 JP2007515942 A5 JP 2007515942A5

Authority

JP

Japan

Prior art keywords

gitrl

gitr

nucleic acid

fusion protein

cell

Prior art date

2004-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 53
• 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims 49
• 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 48
• 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 48
• 239000012634 fragment Substances 0.000 claims 24
• 108020001507 fusion proteins Proteins 0.000 claims 22
• 102000037865 fusion proteins Human genes 0.000 claims 22
• 150000007523 nucleic acids Chemical class 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 21
• 102000039446 nucleic acids Human genes 0.000 claims 21
• 238000000034 method Methods 0.000 claims 18
• 239000000556 agonist Substances 0.000 claims 17
• 210000003162 effector t lymphocyte Anatomy 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
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• 239000005557 antagonist Substances 0.000 claims 12
• 150000001875 compounds Chemical class 0.000 claims 10
• 230000003993 interaction Effects 0.000 claims 10
• 230000003472 neutralizing effect Effects 0.000 claims 10
• 239000000523 sample Substances 0.000 claims 10
• 230000001270 agonistic effect Effects 0.000 claims 9
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 210000001744 T-lymphocyte Anatomy 0.000 claims 8
• 150000003384 small molecules Chemical class 0.000 claims 8
• 108020004459 Small interfering RNA Proteins 0.000 claims 7
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 6
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 6
• 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 210000003289 regulatory T cell Anatomy 0.000 claims 6
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• 108090000623 proteins and genes Proteins 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 230000001629 suppression Effects 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 4
• 239000012646 vaccine adjuvant Substances 0.000 claims 4
• 229940124931 vaccine adjuvant Drugs 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 206010052779 Transplant rejections Diseases 0.000 claims 3
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• 108091034117 Oligonucleotide Proteins 0.000 claims 2
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• 230000001580 bacterial effect Effects 0.000 claims 1
• 230000000903 blocking effect Effects 0.000 claims 1
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
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• 229960005486 vaccine Drugs 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1