JP2007514472A5 - - Google Patents
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- JP2007514472A5 JP2007514472A5 JP2006541689A JP2006541689A JP2007514472A5 JP 2007514472 A5 JP2007514472 A5 JP 2007514472A5 JP 2006541689 A JP2006541689 A JP 2006541689A JP 2006541689 A JP2006541689 A JP 2006541689A JP 2007514472 A5 JP2007514472 A5 JP 2007514472A5
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- JP
- Japan
- Prior art keywords
- inhibitor
- antagonist
- derivative
- inhibitors
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003112 inhibitor Substances 0.000 claims 44
- 239000003795 chemical substances by application Substances 0.000 claims 36
- 239000005557 antagonist Substances 0.000 claims 20
- -1 vinca alkaloid Chemical compound 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- 230000005764 inhibitory process Effects 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 12
- 230000015572 biosynthetic process Effects 0.000 claims 12
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 10
- 229940043355 kinase inhibitor Drugs 0.000 claims 10
- 108020004414 DNA Proteins 0.000 claims 8
- 229940122803 Vinca alkaloid Drugs 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 8
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 8
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 8
- 238000003786 synthesis reaction Methods 0.000 claims 8
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 8
- HDZZVAMISRMYHH-UHFFFAOYSA-N 9beta-Ribofuranosyl-7-deazaadenin Natural products C1=CC=2C(N)=NC=NC=2N1C1OC(CO)C(O)C1O HDZZVAMISRMYHH-UHFFFAOYSA-N 0.000 claims 6
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 6
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 claims 6
- 229940123034 Heat shock protein 90 antagonist Drugs 0.000 claims 6
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 6
- 229940121375 antifungal agent Drugs 0.000 claims 6
- 239000003429 antifungal agent Substances 0.000 claims 6
- 239000011612 calcitriol Substances 0.000 claims 6
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 6
- 229960004679 doxorubicin Drugs 0.000 claims 6
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 6
- 210000002744 extracellular matrix Anatomy 0.000 claims 6
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 claims 6
- 229960001156 mitoxantrone Drugs 0.000 claims 6
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 6
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims 6
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 6
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 6
- 229960001592 paclitaxel Drugs 0.000 claims 6
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 6
- 229960005330 pimecrolimus Drugs 0.000 claims 6
- 229960001237 podophyllotoxin Drugs 0.000 claims 6
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims 6
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 150000003212 purines Chemical class 0.000 claims 6
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 6
- 229960002930 sirolimus Drugs 0.000 claims 6
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 6
- 229960003048 vinblastine Drugs 0.000 claims 6
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 6
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 4
- DOEWDSDBFRHVAP-KRXBUXKQSA-N (E)-3-tosylacrylonitrile Chemical compound CC1=CC=C(S(=O)(=O)\C=C\C#N)C=C1 DOEWDSDBFRHVAP-KRXBUXKQSA-N 0.000 claims 4
- AWSUSADYFDCYML-KUPUPYBPSA-N (z)-7-[(1s,5r)-5-[(e)-oct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid Chemical compound CCCCCC\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O AWSUSADYFDCYML-KUPUPYBPSA-N 0.000 claims 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 4
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
- 102100035904 Caspase-1 Human genes 0.000 claims 4
- 108090000426 Caspase-1 Proteins 0.000 claims 4
- 101710088194 Dehydrogenase Proteins 0.000 claims 4
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 claims 4
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims 4
- 229940122331 Fibrinogen antagonist Drugs 0.000 claims 4
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 4
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 claims 4
- 101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 claims 4
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 4
- 229940122696 MAP kinase inhibitor Drugs 0.000 claims 4
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 4
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 4
- QHKYPYXTTXKZST-UHFFFAOYSA-N SB-202190 Chemical compound C1=CC(O)=CC=C1C1=NC(C=2C=CC(F)=CC=2)=C(C=2C=CN=CC=2)N1 QHKYPYXTTXKZST-UHFFFAOYSA-N 0.000 claims 4
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 4
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 4
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 4
- 229940123237 Taxane Drugs 0.000 claims 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 4
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 4
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 4
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 4
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 4
- 239000003146 anticoagulant agent Substances 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 229960003668 docetaxel Drugs 0.000 claims 4
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims 4
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims 4
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 4
- 229960005420 etoposide Drugs 0.000 claims 4
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 4
- 231100000782 microtubule inhibitor Toxicity 0.000 claims 4
- 230000005012 migration Effects 0.000 claims 4
- 238000013508 migration Methods 0.000 claims 4
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 claims 4
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229960000951 mycophenolic acid Drugs 0.000 claims 4
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 4
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 4
- 229960003171 plicamycin Drugs 0.000 claims 4
- 229950010131 puromycin Drugs 0.000 claims 4
- 230000037390 scarring Effects 0.000 claims 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 4
- 229960002855 simvastatin Drugs 0.000 claims 4
- 210000004872 soft tissue Anatomy 0.000 claims 4
- 229960001967 tacrolimus Drugs 0.000 claims 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 4
- HDZZVAMISRMYHH-KCGFPETGSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O HDZZVAMISRMYHH-KCGFPETGSA-N 0.000 claims 4
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 4
- 229960004528 vincristine Drugs 0.000 claims 4
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 4
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 4
- 229950009819 zotarolimus Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- YKJYKKNCCRKFSL-RDBSUJKOSA-N (-)-anisomycin Chemical compound C1=CC(OC)=CC=C1C[C@@H]1[C@H](OC(C)=O)[C@@H](O)CN1 YKJYKKNCCRKFSL-RDBSUJKOSA-N 0.000 claims 2
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 2
- SCVHJVCATBPIHN-SJCJKPOMSA-N (3s)-3-[[(2s)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Chemical compound N([C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)COC=1C(=C(F)C=C(F)C=1F)F)C(=O)C(=O)NC1=CC=CC=C1C(C)(C)C SCVHJVCATBPIHN-SJCJKPOMSA-N 0.000 claims 2
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
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Claims (26)
- 軟組織移植片および瘢痕抑制化剤または瘢痕抑制化剤を含む組成物のいずれかを備える装置であって、該薬剤が装置と装置移植先である宿主との間での瘢痕化を阻害する、装置。
- 移植片が審美インプラントまたは再建のための移植片である、請求項1に記載の装置。
- 前記軟組織移植片が、胸移植片、顔面移植片、顎移植片、頤移植片、鼻移植片、唇移植片、頬移植片、胸筋移植片、臀部移植片、および自家組織移植片から選択される、請求項1または2に記載の装置。
- 前記薬剤が、組織の再生の低下;炎症の阻害;繊維症の阻害;装置と装置移植先である宿主の間の癒着の阻害;血管形成の阻害;結合組織細胞の移動の阻害;結合組織細胞の増殖の阻害;繊維芽細胞の移動の阻害;繊維芽細胞の増殖の阻害;細胞外基質の生成の阻害;細胞外基質の破壊の促進;細胞外基質の蓄積の阻害;組織の再造形の阻害;および装置を囲む繊維性結合組織の被膜形成の阻害のうちの1つを示す、請求項1〜3のいずれか1項に記載の装置。
- 前記薬剤が、パクリタキセル、タキサン、ドセタキセル、ミトキサントロン、ドキソルビシン、エポチロンB、エトポシド、血管形成阻害剤、TAXOTERE、ツベルシジン、ビンカアルカロイド、ビンクリスチン、ビンブラスチン、ゲルダナマイシン、シンバスタチン、タクロリムス、シロリムス、エバロリムス、ハロフギノン、ミコフェノール酸、ミトラマイシン、ピメクロリムス、1−α−25ジヒドロキシビタミンD 3 、Bay11−7082、SB202190、ABT−578、およびスルコニゾールから選択される、請求項1〜3のいずれか1項に記載の装置。
- 前記薬剤が、ミトキサントロン、ラパマイシン、エバロリムス、ピメクロリムス、パクリタキセル、GW8510、ドキソルビシン、ゲルダナマイシン、ブレオマイシン、ハロフギノン、塩酸エピルビシン、トポテメイ、タモキシフェン、エタニダゾール、ゲムシタビン、ミトラマイシン、ダウノルビシン、クロモマイシンA 3 、ビノレルビン、イダルビシン、ノガラマイシン、17−DMAG、エポチロン、ビンブラスチン、ビンクリスチン、シタラビン、アニソマイシン、CNI−1493、17−AAG、クロルプロマジン、ポドフィロトキシン、セラストロール、LY290181、ヘキシレン・グリコール、重水、グリシンエチルエステル、エチレングリコールビス−(スクシンイミジルコハク酸塩)、ツベルシジン、エピチロン、オキサリプラチン、クロモマイシンA 3 、1−α−25ジヒドロキシビタミンD 3 、エピルビシン、ミコフェノール酸、モフェチル、SKF 86002、15−デオキシプロスタグランジンJ2、ファスカピリシン、IDN−6556、レスベラトロール、SP600125、Bay−58−2667、15−デオキシプロスタグランジンJ2、BXT−51072、ロバスタチン、クラドリビン、サイトカラシンA、ピューロマイシン、イトラコナゾール、D−マンノース−6−リン酸塩、ゲムフィブロジル、シプロフィブラート、ベザフィブラート、ピューロマイシン、L(−)−ペリリルアルコール、およびアナシタビンから選択される、請求項1〜3のいずれか1項に記載の装置。
- 前記薬剤が、タキサン、血管形成阻害剤、5−リポキシゲナーゼ阻害剤または拮抗薬、ケモカイン受容体の拮抗薬、C−Cケモカイン受容体1、C−Cケモカイン受容体3、C−Cケモカイン受容体5、細胞周期阻害剤、微小管阻害剤、パクリタキセル、ドセタキセル、パクリタキセルの類似体または誘導体、ビンカアルカロイド、ビンカアルカロイドがビンブラスチンであるビンカアルカロイド、カンプトセシンかその類似体または誘導体、ポドフィロトキシン、ポドフィロトキシンがエトポシドかその類似体または誘導体であるポドフィロトキシン、アントラサイクリン、アントラサイクリンがドキソルビシンかその類似体または誘導体であるアントラサイクリン、アントラサイクリンがミトキサントロンかその類似体または誘導体であるアントラサイクリン、白金化合物、ニトロソウレア、ニトロイミダゾール、葉酸拮抗薬、シチジン類似体、ピリミジン類似体、フルオロピリミジン類似体、プリン類似体、プリン類似体がツベルシジンであるプリン類似体、ナイトロジェンマスタードかその類似体または誘導体、ヒドロキシウレア、マイトマイシンかその類似体または誘導体、スルホン酸アルキル、ベンズアミドかその類似体または誘導体、ニコチンアミドかその類似体または誘導体、ハロゲン化糖かその類似体または誘導体、DNAアルキル化剤、微小管阻害剤、トポイソメラーゼ阻害剤、DNA分裂剤、代謝拮抗薬、アデノシンデアミナーゼを阻害する薬剤、プリン環合成を阻害する薬剤、ヌクレオチド転換阻害剤、ヒドロ葉酸の還元を阻害する薬剤、チミジン一リン酸を抑止する薬剤、DNA障害を生じる薬剤、DNA挿入剤、RNA合成阻害剤、ピリミジン合成阻害剤、リボヌクレオチドの合成または機能を阻害する薬剤、チミジン一リン酸の合成または機能を阻害する薬剤、DNA合成を阻害する薬剤、DNA付加体形成を生じる薬剤、タンパク質合成を阻害する薬剤、微小管の機能を阻害する薬剤、サイクリン依存性タンパク質キナーゼ阻害剤、上皮細胞増殖因子キナーゼ阻害剤、エラスターゼ阻害剤、Xa因子阻害剤、ファルネシルトランスフェラーゼ阻害剤、フィブリノゲン拮抗薬、グアニル酸シクラーゼ刺激物、熱ショックタンパク質90拮抗薬、熱ショックタンパク質90拮抗薬がゲルダナマイシンかその類似体または誘導体である熱ショックタンパク質90拮抗薬、グアニル酸シクラーゼ刺激物、ヒドロキシメチルグルタリル補酵素Aレダクターゼ(HMGCoAレダクターゼ)阻害剤、HMGCoAレダクターゼ阻害剤がシンバスタチンかその類似体または誘導体であるHMGCoAレダクターゼ阻害剤、ヒドロオロチン酸デヒドロゲナーゼ阻害剤、IκBキナーゼ2(IKK2)阻害剤、IL−1拮抗剤、インターロイキン−1β−変換酵素(ICE)拮抗薬、IL−1R関連キナーゼ(IRAK)拮抗薬、IL−4作動薬、免疫調整剤、シロリムスかその類似体または誘導体、エバロリムスかその類似体または誘導体、タクロリムスかその類似体または誘導体、バイオリムスかその類似体または誘導体、トレスペリムスかその類似体または誘導体、オーラノフィンかその類似体または誘導体、27−0−デメチルラパマイシンかその類似体または誘導体、グスペリムスかその類似体または誘導体、ピメクロリムスかその類似体または誘導体、ABT−578かその類似体または誘導体、イノシン一リン酸デヒドロゲナーゼ(IMPDH)阻害剤、IMPDH阻害剤がミコノフェール酸かその類似体または誘導体であるIMPDH阻害剤、IMPDH阻害剤が1−α−25ジヒドロキシビタミンD 3 かその類似体または誘導体であるIMPDH阻害剤、ロイコトリエン阻害剤、単球遊走促進因子−1(MCP−1)拮抗薬、マトリクスメタロプロテイナーゼ(MMP)阻害剤、NF−κB阻害剤、NF−κB阻害剤がBay11−7082であるNF−κB阻害剤、酸化窒素(NO)拮抗薬、p38マイトジェン活性化タンパク質(MAP)キナーゼ阻害剤、p38MAPキナーゼ阻害剤がSB 202190であるp38 MAPキナーゼ阻害剤、ホスホジエステラーゼ阻害剤、トランスフォーミング増殖因子(TGF)β阻害剤、トロンボキサンA2拮抗薬、腫瘍壊死因子α(TNFα)拮抗薬、TNF−α変換酵素(TACE)阻害剤、チロシンキナーゼ阻害剤、ビトロネクチン阻害剤、繊維芽細胞増殖因子阻害剤、タンパク質キナーゼ阻害剤、血小板由来増殖因子(PDGF)受容体キナーゼ阻害剤、内皮増殖因子受容体キナーゼ阻害剤、レチノイン酸受容体拮抗薬、フィブリノゲン拮抗薬、抗真菌剤、抗真菌剤がスルコナゾールである抗真菌剤、ビスフォスフォネート、ホスホリパーゼA1阻害剤、ヒスタミンH1/H2/H3受容体拮抗薬、マクロライド系抗生物質、GPIIb/IIIa受容体拮抗薬、エンドセリン受容体拮抗薬、ペルオキシソーム増殖剤応答性受容体の作動薬、エストロゲン受容体薬、ソマストスタチン類似体、ニューロキニン1拮抗薬、ニューロキニン3拮抗薬、ニューロキニン拮抗薬、VLA−4(very late antigen−4)拮抗薬、破骨細胞阻害剤、DNAトポイソメラーゼATP加水分解阻害剤、アンギオテンシンI変換酵素阻害剤、アンギオテンシンII拮抗薬、エンケファリナーゼ阻害剤、ペルオキシソーム増殖剤応答性受容体γ作動薬インシュリン増感剤、タンパク質キナーゼC阻害剤、CXCR3阻害剤、Itk阻害剤、細胞質型ホスホリパーゼA 2 α阻害剤、ペルオキシソーム増殖剤応答性受容体(PPAR)作動薬、アポトーシス作動薬、免疫抑制剤、Erb阻害剤、リポコルチン作動薬、血管細胞接着分子−1(VCAM−1)拮抗薬、コラーゲン拮抗薬、α2インテグリン拮抗薬、TNFα阻害剤、酸化窒素阻害剤、カテプシン阻害剤、およびエポチロンBから選択される、請求項1〜3のいずれか1項に記載の装置。
- 第二の薬学的に活性な薬剤をさらに含む、請求項1〜3のいずれか1項に記載の装置。
- 前記第二の薬学的に活性な薬剤が、抗血栓剤、抗血小板薬、抗増殖剤、抗炎症薬、抗腫瘍剤、抗生物質、または抗菌性剤である、請求項8に記載の装置。
- 感染、炎症、または血栓を阻害する薬剤をさらに含む、請求項1〜3のいずれか1項に記載の装置。
- 前記組成物が、ポリマーをさらに含む、請求項1〜3のいずれか1項に記載の装置。
- 前記ポリマーが、生分解性である、請求項11に記載の装置。
- 前記ポリマーが、非生分解性である、請求項11に記載の装置。
- 装置を作製する方法であって、該方法は、軟組織移植片および瘢痕抑制化剤または瘢痕抑制化剤を含む組成物のいずれかを組み合わせる工程を包含し、該薬剤が装置と装置移植先である宿主との間での瘢痕化を阻害する、方法。
- 移植片が審美インプラントまたは再建のための移植片である、請求項14に記載の方法。
- 前記軟組織移植片が、胸移植片、顔面移植片、顎移植片、頤移植片、鼻移植片、唇移植片、頬移植片、胸筋移植片、臀部移植片、および自家組織移植片から選択される、請求項14または15に記載の方法。
- 前記薬剤が、組織の再生の低下;炎症の阻害;繊維症の阻害;装置と装置移植先である宿主の間の癒着の阻害;血管形成の阻害;結合組織細胞の移動の阻害;結合組織細胞の増殖の阻害;繊維芽細胞の移動の阻害;繊維芽細胞の増殖の阻害;細胞外基質の生成の阻害;細胞外基質の破壊の促進;細胞外基質の蓄積の阻害;組織の再造形の阻害;および装置を囲む繊維性結合組織の被膜形成の阻害のうちの1つを示す、請求項14〜16のいずれか1項に記載の方法。
- 前記薬剤が、パクリタキセル、タキサン、ドセタキセル、ミトキサントロン、ドキソルビシン、エポチロンB、エトポシド、血管形成阻害剤、TAXOTERE、ツベルシジン、ビンカアルカロイド、ビンクリスチン、ビンブラスチン、ゲルダナマイシン、シンバスタチン、タクロリムス、シロリムス、エバロリムス、ハロフギノン、ミコフェノール酸、ミトラマイシン、ピメクロリムス、1−α−25ジヒドロキシビタミンD 3 、Bay11−7082、SB202190、ABT−578、およびスルコニゾールから選択される、請求項14〜16のいずれか1項に記載の方法。
- 前記薬剤が、ミトキサントロン、ラパマイシン、エバロリムス、ピメクロリムス、パクリタキセル、GW8510、ドキソルビシン、ゲルダナマイシン、ブレオマイシン、ハロフギノン、塩酸エピルビシン、トポテメイ、タモキシフェン、エタニダゾール、ゲムシタビン、ミトラマイシン、ダウノルビシン、クロモマイシンA 3 、ビノレルビン、イダルビシン、ノガラマイシン、17−DMAG、エポチロン、ビンブラスチン、ビンクリスチン、シタラビン、アニソマイシン、CNI−1493、17−AAG、クロルプロマジン、ポドフィロトキシン、セラストロール、LY290181、ヘキシレン・グリコール、重水、グリシンエチルエステル、エチレングリコールビス−(スクシンイミジルコハク酸塩)、ツベルシジン、エピチロン、オキサリプラチン、クロモマイシンA 3 、1−α−25ジヒドロキシビタミンD 3 、エピルビシン、ミコフェノール酸、モフェチル、SKF 86002、15−デオキシプロスタグランジンJ2、ファスカピリシン、IDN−6556、レスベラトロール、SP600125、Bay−58−2667、15−デオキシプロスタグランジンJ2、BXT−51072、ロバスタチン、クラドリビン、サイトカラシンA、ピューロマイシン、イトラコナゾール、D−マンノース−6−リン酸塩、ゲムフィブロジル、シプロフィブラート、ベザフィブラート、ピューロマイシン、L(−)−ペリリルアルコール、およびアナシタビンから選択される、請求項14〜16のいずれか1項に記載の方法。
- 前記薬剤が、タキサン、血管形成阻害剤、5−リポキシゲナーゼ阻害剤または拮抗薬、ケモカイン受容体の拮抗薬、C−Cケモカイン受容体1、C−Cケモカイン受容体3、C−Cケモカイン受容体5、細胞周期阻害剤、微小管阻害剤、パクリタキセル、ドセタキセル、パクリタキセルの類似体または誘導体、ビンカアルカロイド、ビンカアルカロイドがビンブラスチンであるビンカアルカロイド、カンプトセシンかその類似体または誘導体、ポドフィロトキシン、ポドフィロトキシンがエトポシドかその類似体または誘導体であるポドフィロトキシン、アントラサイクリン、アントラサイクリンがドキソルビシンかその類似体または誘導体であるアントラサイクリン、アントラサイクリンがミトキサントロンかその類似体または誘導体であるアントラサイクリン、白金化合物、ニトロソウレア、ニトロイミダゾール、葉酸拮抗薬、シチジン類似体、ピリミジン類似体、フルオロピリミジン類似体、プリン類似体、プリン類似体がツベルシジンであるプリン類似体、ナイトロジェンマスタードかその類似体または誘導体、ヒドロキシウレア、マイトマイシンかその類似体または誘導体、スルホン酸アルキル、ベンズアミドかその類似体または誘導体、ニコチンアミドかその類似体または誘導体、ハロゲン化糖かその類似体または誘導体、DNAアルキル化剤、微小管阻害剤、トポイソメラーゼ阻害剤、DNA分裂剤、代謝拮抗薬、アデノシンデアミナーゼを阻害する薬剤、プリン環合成を阻害する薬剤、ヌクレオチド転換阻害剤、ヒドロ葉酸の還元を阻害する薬剤、チミジン一リン酸を抑止する薬剤、DNA障害を生じる薬剤、DNA挿入剤、RNA合成阻害剤、ピリミジン合成阻害剤、リボヌクレオチドの合成または機能を阻害する薬剤、チミジン一リン酸の合成または機能を阻害する薬剤、DNA合成を阻害する薬剤、DNA付加体形成を生じる薬剤、タンパク質合成を阻害する薬剤、微小管の機能を阻害する薬剤、サイクリン依存性タンパク質キナーゼ阻害剤、上皮細胞増殖因子キナーゼ阻害剤、エラスターゼ阻害剤、Xa因子阻害剤、ファルネシルトランスフェラーゼ阻害剤、フィブリノゲン拮抗薬、グアニル酸シクラーゼ刺激物、熱ショックタンパク質90拮抗薬、熱ショックタンパク質90拮抗薬がゲルダナマイシンかその類似体または誘導体である熱ショックタンパク質90拮抗薬、グアニル酸シクラーゼ刺激物、ヒドロキシメチルグルタリル補酵素Aレダクターゼ(HMGCoAレダクターゼ)阻害剤、HMGCoAレダクターゼ阻害剤がシンバスタチンかその類似体または誘導体であるHMGCoAレダクターゼ阻害剤、ヒドロオロチン酸デヒドロゲナーゼ阻害剤、IκBキナーゼ2(IKK2)阻害剤、IL−1拮抗剤、インターロイキン−1β−変換酵素(ICE)拮抗薬、IL−1R関連キナーゼ(IRAK)拮抗薬、IL−4作動薬、免疫調整剤、シロリムスかその類似体または誘導体、エバロリムスかその類似体または誘導体、タクロリムスかその類似体または誘導体、バイオリムスかその類似体または誘導体、トレスペリムスかその類似体または誘導体、オーラノフィンかその類似体または誘導体、27−0−デメチルラパマイシンかその類似体または誘導体、グスペリムスかその類似体または誘導体、ピメクロリムスかその類似体または誘導体、ABT−578かその類似体または誘導体、イノシン一リン酸デヒドロゲナーゼ(IMPDH)阻害剤、IMPDH阻害剤がミコノフェール酸かその類似体または誘導体であるIMPDH阻害剤、IMPDH阻害剤が1−α−25ジヒドロキシビタミンD 3 かその類似体または誘導体であるIMPDH阻害剤、ロイコトリエン阻害剤、単球遊走促進因子−1(MCP−1)拮抗薬、マトリクスメタロプロテイナーゼ(MMP)阻害剤、NF−κB阻害剤、NF−κB阻害剤がBay11−7082であるNF−κB阻害剤、酸化窒素(NO)拮抗薬、p38マイトジェン活性化タンパク質(MAP)キナーゼ阻害剤、p38MAPキナーゼ阻害剤がSB 202190であるp38 MAPキナーゼ阻害剤、ホスホジエステラーゼ阻害剤、トランスフォーミング増殖因子(TGF)β阻害剤、トロンボキサンA2拮抗薬、腫瘍壊死因子α(TNFα)拮抗薬、TNF−α変換酵素(TACE)阻害剤、チロシンキナーゼ阻害剤、ビトロネクチン阻害剤、繊維芽細胞増殖因子阻害剤、タンパク質キナーゼ阻害剤、血小板由来増殖因子(PDGF)受容体キナーゼ阻害剤、内皮増殖因子受容体キナーゼ阻害剤、レチノイン酸受容体拮抗薬、フィブリノゲン拮抗薬、抗真菌剤、抗真菌剤がスルコナゾールである抗真菌剤、ビスフォスフォネート、ホスホリパーゼA1阻害剤、ヒスタミンH1/H2/H3受容体拮抗薬、マクロライド系抗生物質、GPIIb/IIIa受容体拮抗薬、エンドセリン受容体拮抗薬、ペルオキシソーム増殖剤応答性受容体の作動薬、エストロゲン受容体薬、ソマストスタチン類似体、ニューロキニン1拮抗薬、ニューロキニン3拮抗薬、ニューロキニン拮抗薬、VLA−4(very late antigen−4)拮抗薬、破骨細胞阻害剤、DNAトポイソメラーゼATP加水分解阻害剤、アンギオテンシンI変換酵素阻害剤、アンギオテンシンII拮抗薬、エンケファリナーゼ阻害剤、ペルオキシソーム増殖剤応答性受容体γ作動薬インシュリン増感剤、タンパク質キナーゼC阻害剤、CXCR3阻害剤、Itk阻害剤、細胞質型ホスホリパーゼA 2 α阻害剤、ペルオキシソーム増殖剤応答性受容体(PPAR)作動薬、アポトーシス作動薬、免疫抑制剤、Erb阻害剤、リポコルチン作動薬、血管細胞接着分子−1(VCAM−1)拮抗薬、コラーゲン拮抗薬、α2インテグリン拮抗薬、TNFα阻害剤、酸化窒素阻害剤、カテプシン阻害剤、およびエポチロンBから選択される、請求項14〜16のいずれか1項に記載の方法。
- 前記装置が、第二の薬学的に活性な薬剤をさらに含む、請求項14〜16のいずれか1項に記載の方法。
- 前記第二の薬学的に活性な薬剤が、抗血栓剤、抗血小板薬、抗増殖剤、抗炎症薬、抗腫瘍剤、抗生物質、または抗菌性剤である、請求項21に記載の装置。
- 前記装置が、感染、炎症、または血栓を阻害する薬剤をさらに含む、請求項14〜16のいずれか1項に記載の方法。
- 前記組成物が、ポリマーをさらに含む、請求項14〜16のいずれか1項に記載の方法。
- 前記ポリマーが、生分解性である、請求項24に記載の方法。
- 前記ポリマーが、非生分解性である、請求項24に記載の方法。
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2004
- 2004-11-22 AU AU2004293463A patent/AU2004293463A1/en not_active Abandoned
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- 2004-11-22 US US10/996,353 patent/US20050152941A1/en not_active Abandoned
- 2004-11-22 WO PCT/US2004/039346 patent/WO2005051232A2/en active Application Filing
- 2004-11-22 CA CA002536242A patent/CA2536242A1/en not_active Abandoned
- 2004-11-22 US US10/996,352 patent/US20050158356A1/en not_active Abandoned
- 2004-11-22 EP EP04811760A patent/EP1687043A2/en not_active Withdrawn
- 2004-11-22 JP JP2006541669A patent/JP2007513650A/ja active Pending
- 2004-11-22 WO PCT/US2004/039099 patent/WO2005051451A2/en not_active Application Discontinuation
- 2004-11-22 WO PCT/US2004/039465 patent/WO2005051444A2/en not_active Application Discontinuation
- 2004-11-22 US US10/996,355 patent/US20050149157A1/en not_active Abandoned
- 2004-11-22 CA CA002536188A patent/CA2536188A1/en not_active Abandoned
- 2004-11-22 EP EP04817879A patent/EP1685085A2/en not_active Withdrawn
- 2004-11-22 WO PCT/US2004/039183 patent/WO2005051483A2/en active Application Filing
- 2004-11-22 WO PCT/US2004/039353 patent/WO2006055008A2/en active Application Filing
- 2004-11-22 AU AU2004293030A patent/AU2004293030A1/en not_active Abandoned
- 2004-11-22 WO PCT/US2004/039387 patent/WO2005051871A2/en not_active Application Discontinuation
- 2004-11-22 JP JP2006541598A patent/JP2007516742A/ja active Pending
- 2004-11-22 AU AU2004293075A patent/AU2004293075A1/en not_active Abandoned
- 2004-11-22 EP EP04812062A patent/EP1687041A2/en not_active Withdrawn
- 2004-11-22 JP JP2006541689A patent/JP2007514472A/ja not_active Withdrawn
- 2004-11-26 US US10/998,350 patent/US20050187600A1/en not_active Abandoned
- 2004-11-26 US US10/998,351 patent/US20050209665A1/en not_active Abandoned
- 2004-11-30 US US11/001,415 patent/US20050181007A1/en not_active Abandoned
- 2004-12-01 US US11/001,787 patent/US20050181009A1/en not_active Abandoned
- 2004-12-01 US US11/001,416 patent/US20050142162A1/en not_active Abandoned
- 2004-12-01 US US11/001,789 patent/US20050181010A1/en not_active Abandoned
- 2004-12-02 US US11/004,672 patent/US20050175664A1/en not_active Abandoned
- 2004-12-02 US US11/004,671 patent/US20050169960A1/en not_active Abandoned
- 2004-12-02 US US11/004,675 patent/US20050169961A1/en not_active Abandoned
- 2004-12-07 US US11/006,891 patent/US20050182468A1/en not_active Abandoned
- 2004-12-07 US US11/006,901 patent/US20050181005A1/en not_active Abandoned
- 2004-12-07 US US11/006,890 patent/US20050182450A1/en not_active Abandoned
- 2004-12-07 US US11/006,884 patent/US20050182467A1/en not_active Abandoned
- 2004-12-07 US US11/006,887 patent/US20050152945A1/en not_active Abandoned
- 2004-12-07 US US11/006,897 patent/US20050186239A1/en not_active Abandoned
- 2004-12-07 US US11/007,837 patent/US20050182469A1/en not_active Abandoned
- 2004-12-07 US US11/006,881 patent/US20050152944A1/en not_active Abandoned
- 2004-12-07 US US11/006,898 patent/US20050192647A1/en not_active Abandoned
- 2004-12-07 US US11/006,910 patent/US20060282123A1/en not_active Abandoned
- 2004-12-07 US US11/006,880 patent/US20050186245A1/en not_active Abandoned
- 2004-12-07 US US11/006,903 patent/US20050152947A1/en not_active Abandoned
- 2004-12-07 US US11/006,885 patent/US20050209666A1/en not_active Abandoned
- 2004-12-07 US US11/007,838 patent/US20050152948A1/en not_active Abandoned
- 2004-12-07 US US11/006,892 patent/US20050187639A1/en not_active Abandoned
- 2004-12-07 US US11/006,882 patent/US20050154374A1/en not_active Abandoned
- 2004-12-07 US US11/006,894 patent/US20050152946A1/en not_active Abandoned
- 2004-12-07 US US11/006,883 patent/US20050186246A1/en not_active Abandoned
- 2004-12-07 US US11/006,909 patent/US20050203635A1/en not_active Abandoned
- 2004-12-07 US US11/006,906 patent/US20050182496A1/en not_active Abandoned
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2009
- 2009-04-16 US US12/425,316 patent/US20090214652A1/en not_active Abandoned
- 2009-05-11 US US12/464,012 patent/US20100092536A1/en not_active Abandoned
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2010
- 2010-02-10 US US12/703,679 patent/US20100268288A1/en not_active Abandoned
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