JP2007509992A5 - - Google Patents
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- Publication number
- JP2007509992A5 JP2007509992A5 JP2006538570A JP2006538570A JP2007509992A5 JP 2007509992 A5 JP2007509992 A5 JP 2007509992A5 JP 2006538570 A JP2006538570 A JP 2006538570A JP 2006538570 A JP2006538570 A JP 2006538570A JP 2007509992 A5 JP2007509992 A5 JP 2007509992A5
- Authority
- JP
- Japan
- Prior art keywords
- olmesartan medoxomil
- water
- acid
- solution
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims 9
- UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims 9
- 229960001199 olmesartan medoxomil Drugs 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 239000003960 organic solvent Substances 0.000 claims 5
- IJOPLMOXIPGJIJ-UHFFFAOYSA-N (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate Chemical compound C=1C=C(C=2C(=CC=CC=2)C=2N(N=NN=2)C(C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C IJOPLMOXIPGJIJ-UHFFFAOYSA-N 0.000 claims 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 239000002244 precipitate Substances 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- LZTRCELOJRDYMQ-UHFFFAOYSA-N triphenylmethanol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)C1=CC=CC=C1 LZTRCELOJRDYMQ-UHFFFAOYSA-N 0.000 claims 2
- WBRMIXBFMUWHHX-UHFFFAOYSA-N 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid Chemical class CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2N(N=NN=2)C(C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)C=C1 WBRMIXBFMUWHHX-UHFFFAOYSA-N 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60643704P | 2004-09-02 | 2004-09-02 | |
| PCT/US2005/031481 WO2006029056A1 (en) | 2004-09-02 | 2005-09-02 | Preparation of olmesartan medoxomil |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007509992A JP2007509992A (ja) | 2007-04-19 |
| JP2007509992A5 true JP2007509992A5 (enExample) | 2010-04-22 |
| JP4511550B2 JP4511550B2 (ja) | 2010-07-28 |
Family
ID=35462159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538570A Expired - Fee Related JP4511550B2 (ja) | 2004-09-02 | 2005-09-02 | オルメサルタンメドキソミルの調製法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7528258B2 (enExample) |
| EP (1) | EP1706401A1 (enExample) |
| JP (1) | JP4511550B2 (enExample) |
| CN (2) | CN1993355A (enExample) |
| CA (1) | CA2573800A1 (enExample) |
| IL (1) | IL181549A0 (enExample) |
| WO (1) | WO2006029056A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060281800A1 (en) * | 2005-04-12 | 2006-12-14 | Glenmark Pharmaceuticals Limited | Polymorphic form of olmesartan and process for its preparation |
| EA014026B1 (ru) * | 2005-07-29 | 2010-08-30 | Крка, Товарна Здравил, Д.Д., Ново Место | Способ получения олмесартан медоксомила |
| EP1816131A1 (en) * | 2006-02-06 | 2007-08-08 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of olmesartan medoxomil |
| EP2022790A1 (en) * | 2007-08-08 | 2009-02-11 | LEK Pharmaceuticals D.D. | A process for the preparation or purification of olmesartan medoxomil |
| CA2707365A1 (en) | 2007-08-08 | 2009-02-12 | Lek Pharmaceuticals D.D. | A process for the preparation of olmesartan medoxomil |
| KR101630885B1 (ko) | 2008-06-09 | 2016-06-15 | 다이이찌 산쿄 가부시키가이샤 | 1-비페닐메틸이미다졸 화합물의 제조 방법 |
| ES2527686T3 (es) * | 2009-04-28 | 2015-01-28 | Daiichi Sankyo Company, Limited | Procedimiento de producción de olmesartán medoxomil |
| CA2760031C (en) | 2009-04-28 | 2015-03-10 | Daiichi Sankyo Company, Limited | Acetone solvate crystals of trityl olmesartan medoxomil |
| WO2010134052A1 (en) | 2009-05-20 | 2010-11-25 | Ranbaxy Laboratories Limited | Process for the preparation of olmesartan medoxomil |
| WO2011014611A2 (en) * | 2009-07-30 | 2011-02-03 | Dr. Reddy's Laboratories Ltd. | Preparation of olmesartan medoxomil |
| CA2769704A1 (en) * | 2009-07-31 | 2011-02-03 | Ranbaxy Laboratories Limited | Polymorphic form of olmesartan medoxomil |
| EP2409710A1 (en) | 2010-06-29 | 2012-01-25 | NanotecMARIN GmbH | Injectable material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis |
| EP2409682A1 (en) | 2010-07-19 | 2012-01-25 | Werner E. G. MÜLLER | Hydroxyapatite-binding nano- and microparticles for caries prophylaxis and reduction of dental hypersensitivity |
| KR101266224B1 (ko) | 2010-09-02 | 2013-05-21 | 일동제약주식회사 | 트리틸 올메사르탄 메독소밀의 개선된 제조방법 |
| CZ2010785A3 (cs) | 2010-10-29 | 2012-05-16 | Zentiva, K.S. | Zpusob výroby olmesartanu medoxomilu |
| AR083523A1 (es) | 2010-10-29 | 2013-03-06 | Interquim Sa | Procedimiento de obtencion del olmesartan medoxomilo |
| EP2489346A1 (en) | 2011-01-26 | 2012-08-22 | NanotecMARIN GmbH | Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases |
| EP2739619B1 (en) | 2011-08-05 | 2015-09-16 | Lupin Limited | Process for the preparation of olmesartan medoxomil |
| CN102558161B (zh) * | 2011-12-07 | 2016-07-06 | 浙江华海药业股份有限公司 | 一种采用丙酮与水混合液精制奥美沙坦酯的工艺 |
| CN102584804B (zh) * | 2011-12-13 | 2016-05-18 | 浙江华海药业股份有限公司 | 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺 |
| US9034874B2 (en) | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
| WO2014036686A1 (zh) * | 2012-09-04 | 2014-03-13 | 上海迪赛诺化学制药有限公司 | 奥美沙坦酯的制备方法 |
| CN108658954A (zh) * | 2018-06-12 | 2018-10-16 | 广州小桔生物科技有限公司 | 一种高纯度奥美沙坦酯的精制方法 |
| CN109761966A (zh) * | 2019-01-30 | 2019-05-17 | 浙江省食品药品检验研究院 | 一种奥美沙坦酯晶体及其制备方法 |
| CN111170946B (zh) * | 2020-03-16 | 2022-02-11 | 浙江华洲药业有限公司 | 一种奥美沙坦中间体的合成方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| DE3634717A1 (de) | 1986-10-11 | 1988-04-14 | Dynamit Nobel Ag | Verfahren zur herstellung von 5-methyltetrazol |
| US4870188A (en) | 1987-04-16 | 1989-09-26 | Neorx Corporation | Vinyl substituted radiohalogen conjugates for protein labeling |
| US4870186A (en) * | 1987-05-22 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| DE4036706A1 (de) | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| US5656650A (en) | 1990-12-14 | 1997-08-12 | Smithkline Beecham Corp. | Angiotensin II receptor blocking compositions |
| IE914572A1 (en) | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
| US5614519A (en) | 1991-02-06 | 1997-03-25 | Karl Thomae Gmbh | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists |
| US5616599A (en) | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| CA2229000C (en) * | 1991-02-21 | 2002-04-09 | Sankyo Company, Limited | 1-biphenylimidazole derivatives, their preparation and their therapeutic use |
| US5252753A (en) | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
| US5310928A (en) | 1991-11-18 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Process for preparing biphenyltetrazole compounds |
| US5264447A (en) | 1992-09-01 | 1993-11-23 | Merck & Co., Inc. | Angiotensin II antagonist |
| JPH06298683A (ja) | 1993-04-15 | 1994-10-25 | Sankyo Co Ltd | 光反応による４−（２−置換）フェニルベンジルブロミド類の製造法 |
| US5721263A (en) | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| JPH0753489A (ja) | 1993-06-11 | 1995-02-28 | Sankyo Co Ltd | ビフェニルカルボキサミド誘導体の製造法 |
| US5412102A (en) | 1994-05-27 | 1995-05-02 | Syntex (U.S.A.) Inc. | Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid |
| JP2928982B2 (ja) | 1994-10-27 | 1999-08-03 | 住化ファインケム株式会社 | ４’−ブロモメチル−２−シアノビフェニルの製造法 |
| JPH08325248A (ja) | 1995-05-26 | 1996-12-10 | Chugoku Kayaku Kk | テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法 |
| US5994348A (en) | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
| JP3671266B2 (ja) | 1996-03-21 | 2005-07-13 | 東洋化成工業株式会社 | ５−置換テトラゾール類の製造方法 |
| GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| IT1291551B1 (it) | 1997-04-11 | 1999-01-11 | Luso Farmaco Inst | Processo per la preparazione di composti 4-bromometil bifenilici |
| FR2771090B1 (fr) | 1997-11-17 | 2000-02-04 | Sanofi Sa | Procede de preparation de derives de bromomethyl-biphenyle |
| DE19757995A1 (de) | 1997-12-29 | 1999-07-08 | Great Lakes Chem Konstanz Gmbh | Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen |
| JP4185182B2 (ja) | 1998-04-08 | 2008-11-26 | 第一三共株式会社 | イミダゾール誘導体の製造方法 |
| JP4260241B2 (ja) | 1998-04-21 | 2009-04-30 | 第一三共株式会社 | イミダゾール誘導体の製造法 |
| US6271418B1 (en) | 2000-02-22 | 2001-08-07 | Nippon Kayaku Co., Ltd. | Process for preparing (hetero) aromatic substituted benzene derivatives |
| EP1595540A1 (en) | 2000-11-21 | 2005-11-16 | Sankyo Company Limited | Composition containing an angiotensin II receptor antagonist and a diuretic and its use for the treatment of hypertension |
| DK1535901T3 (da) | 2002-06-12 | 2008-04-07 | Sumitomo Chemical Co | Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl |
| CN1271068C (zh) | 2003-03-25 | 2006-08-23 | 上海医药工业研究院 | 一种奥美沙坦酯的制备方法 |
| ITMI20032338A1 (it) * | 2003-11-28 | 2005-05-29 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Composti feniltetrazolici. |
-
2005
- 2005-09-02 CN CNA2005800262573A patent/CN1993355A/zh active Pending
- 2005-09-02 US US11/217,472 patent/US7528258B2/en not_active Expired - Fee Related
- 2005-09-02 JP JP2006538570A patent/JP4511550B2/ja not_active Expired - Fee Related
- 2005-09-02 EP EP05797758A patent/EP1706401A1/en not_active Withdrawn
- 2005-09-02 CN CNA2005800219037A patent/CN1976926A/zh active Pending
- 2005-09-02 WO PCT/US2005/031481 patent/WO2006029056A1/en not_active Ceased
- 2005-09-02 CA CA002573800A patent/CA2573800A1/en not_active Abandoned
-
2007
- 2007-02-26 IL IL181549A patent/IL181549A0/en unknown
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