IT1291551B1 - Processo per la preparazione di composti 4-bromometil bifenilici - Google Patents

Processo per la preparazione di composti 4-bromometil bifenilici

Info

Publication number
IT1291551B1
IT1291551B1 IT97MI000846A ITMI970846A IT1291551B1 IT 1291551 B1 IT1291551 B1 IT 1291551B1 IT 97MI000846 A IT97MI000846 A IT 97MI000846A IT MI970846 A ITMI970846 A IT MI970846A IT 1291551 B1 IT1291551 B1 IT 1291551B1
Authority
IT
Italy
Prior art keywords
bromomethl
preparation
biphenyl compounds
biphenyl
compounds
Prior art date
Application number
IT97MI000846A
Other languages
English (en)
Inventor
Aldo Salimbeni
Renato Canevotti
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to IT97MI000846A priority Critical patent/IT1291551B1/it
Priority to PCT/EP1998/001992 priority patent/WO1998046562A1/en
Priority to ES98913755T priority patent/ES2183340T3/es
Priority to DE69807859T priority patent/DE69807859T2/de
Priority to AU68328/98A priority patent/AU6832898A/en
Priority to EP98913755A priority patent/EP0973729B1/en
Priority to US09/402,667 priority patent/US6111114A/en
Priority to JP54343398A priority patent/JP2001518904A/ja
Publication of ITMI970846A1 publication Critical patent/ITMI970846A1/it
Application granted granted Critical
Publication of IT1291551B1 publication Critical patent/IT1291551B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
IT97MI000846A 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici IT1291551B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (it) 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici
PCT/EP1998/001992 WO1998046562A1 (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds
ES98913755T ES2183340T3 (es) 1997-04-11 1998-04-06 Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo.
DE69807859T DE69807859T2 (de) 1997-04-11 1998-04-06 Verfahren zur herstellung von 4-bromomethyl diphenyl verbindungen
AU68328/98A AU6832898A (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds
EP98913755A EP0973729B1 (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds
US09/402,667 US6111114A (en) 1997-04-11 1998-04-06 Process for the preparation of 4-bromomethyl diphenyl compounds
JP54343398A JP2001518904A (ja) 1997-04-11 1998-04-06 ４−ブロモメチルジフェニル化合物の調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (it) 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici

Publications (2)

Publication Number Publication Date
ITMI970846A1 ITMI970846A1 (it) 1998-10-11
IT1291551B1 true IT1291551B1 (it) 1999-01-11

Family

ID=11376859

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000846A IT1291551B1 (it) 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici

Country Status (8)

Country Link
US (1) US6111114A (it)
EP (1) EP0973729B1 (it)
JP (1) JP2001518904A (it)
AU (1) AU6832898A (it)
DE (1) DE69807859T2 (it)
ES (1) ES2183340T3 (it)
IT (1) IT1291551B1 (it)
WO (1) WO1998046562A1 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771090B1 (fr) * 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
DK1535901T3 (da) 2002-06-12 2008-04-07 Sumitomo Chemical Co Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl
JP4537678B2 (ja) * 2003-09-04 2010-09-01 住友化学株式会社 ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法
WO2006029056A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries Ltd. Preparation of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CA2575177A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries Ltd. Purification of olmesartan medoxomil
CN101039917A (zh) * 2004-10-15 2007-09-19 特瓦制药工业有限公司 制备替米沙坦的方法
CN101094849A (zh) * 2004-12-30 2007-12-26 特瓦制药工业有限公司 在ph高于2.5的情况下制备奥美沙坦酯的方法
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
KR20090108739A (ko) * 2005-01-03 2009-10-16 테바 파마슈티컬 인더스트리즈 리미티드 불순물의 양이 감소된 올메사탄 메독소밀
EP1871764A1 (en) * 2005-04-01 2008-01-02 LEK Pharmaceuticals D.D. A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
CN108947870B (zh) * 2018-07-23 2021-03-19 湖北宇阳药业有限公司 一种溴代沙坦联苯的制备方法
CN112010831A (zh) * 2020-09-08 2020-12-01 上海生农生化制品股份有限公司 一种绿色高效的苯醚缩酮溴化合成方法
CN112898182A (zh) * 2021-03-11 2021-06-04 安徽云帆药业有限公司 一种制备4`-溴甲基-2-氰基联苯的合成方法
CN112851549A (zh) * 2021-03-11 2021-05-28 安徽云帆药业有限公司 一种溴化钠套用实验方法
CN114426501A (zh) * 2021-12-23 2022-05-03 山东艾孚特科技有限公司 基于水相反应的溴代沙坦联苯的制备方法
CN114436833A (zh) * 2021-12-27 2022-05-06 南京红太阳医药研究院有限公司 一种替米沙坦关键中间体4′-甲基联苯-2-羧酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688657B2 (ja) * 1989-02-23 1997-12-10 三光化学工業株式会社 芳香核に結合するメチル基の臭素化方法
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
ES2092737T3 (es) * 1992-10-29 1996-12-01 Hoechst Ag Procedimiento para la preparacion de compuestos bromometil-aromaticos.

Also Published As

Publication number Publication date
ES2183340T3 (es) 2003-03-16
AU6832898A (en) 1998-11-11
US6111114A (en) 2000-08-29
DE69807859T2 (de) 2003-05-22
JP2001518904A (ja) 2001-10-16
ITMI970846A1 (it) 1998-10-11
WO1998046562A1 (en) 1998-10-22
EP0973729B1 (en) 2002-09-11
EP0973729A1 (en) 2000-01-26
DE69807859D1 (de) 2002-10-17

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