IT1291551B1 - PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS - Google Patents

PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS

Info

Publication number
IT1291551B1
IT1291551B1 IT97MI000846A ITMI970846A IT1291551B1 IT 1291551 B1 IT1291551 B1 IT 1291551B1 IT 97MI000846 A IT97MI000846 A IT 97MI000846A IT MI970846 A ITMI970846 A IT MI970846A IT 1291551 B1 IT1291551 B1 IT 1291551B1
Authority
IT
Italy
Prior art keywords
bromomethl
preparation
biphenyl compounds
biphenyl
compounds
Prior art date
Application number
IT97MI000846A
Other languages
Italian (it)
Inventor
Aldo Salimbeni
Renato Canevotti
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to IT97MI000846A priority Critical patent/IT1291551B1/en
Priority to PCT/EP1998/001992 priority patent/WO1998046562A1/en
Priority to US09/402,667 priority patent/US6111114A/en
Priority to EP98913755A priority patent/EP0973729B1/en
Priority to JP54343398A priority patent/JP2001518904A/en
Priority to ES98913755T priority patent/ES2183340T3/en
Priority to DE69807859T priority patent/DE69807859T2/en
Priority to AU68328/98A priority patent/AU6832898A/en
Publication of ITMI970846A1 publication Critical patent/ITMI970846A1/en
Application granted granted Critical
Publication of IT1291551B1 publication Critical patent/IT1291551B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
IT97MI000846A 1997-04-11 1997-04-11 PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS IT1291551B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (en) 1997-04-11 1997-04-11 PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS
PCT/EP1998/001992 WO1998046562A1 (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds
US09/402,667 US6111114A (en) 1997-04-11 1998-04-06 Process for the preparation of 4-bromomethyl diphenyl compounds
EP98913755A EP0973729B1 (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds
JP54343398A JP2001518904A (en) 1997-04-11 1998-04-06 Method for preparing 4-bromomethyldiphenyl compound
ES98913755T ES2183340T3 (en) 1997-04-11 1998-04-06 PROCEDURE FOR THE PREPARATION OF COMPOUNDS OF 4-BROMOMETIL-BIFENILO.
DE69807859T DE69807859T2 (en) 1997-04-11 1998-04-06 METHOD FOR PRODUCING 4-BROMOMETHYL DIPHENYL COMPOUNDS
AU68328/98A AU6832898A (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (en) 1997-04-11 1997-04-11 PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS

Publications (2)

Publication Number Publication Date
ITMI970846A1 ITMI970846A1 (en) 1998-10-11
IT1291551B1 true IT1291551B1 (en) 1999-01-11

Family

ID=11376859

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000846A IT1291551B1 (en) 1997-04-11 1997-04-11 PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS

Country Status (8)

Country Link
US (1) US6111114A (en)
EP (1) EP0973729B1 (en)
JP (1) JP2001518904A (en)
AU (1) AU6832898A (en)
DE (1) DE69807859T2 (en)
ES (1) ES2183340T3 (en)
IT (1) IT1291551B1 (en)
WO (1) WO1998046562A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771090B1 (en) * 1997-11-17 2000-02-04 Sanofi Sa PROCESS FOR THE PREPARATION OF BROMOMETHYL-BIPHENYL DERIVATIVES
DE19757995A1 (en) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Process for the preparation of aromatic bromomethyl compounds
JPWO2003106406A1 (en) * 2002-06-12 2005-10-13 住友化学株式会社 Method for producing 4'-bromomethyl-2-cyanobiphenyl
JP4537678B2 (en) * 2003-09-04 2010-09-01 住友化学株式会社 2 '-(1H-tetrazol-5-yl) biphenyl-4-carbaldehyde crystal and method for producing the same
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CN1976926A (en) * 2004-09-02 2007-06-06 特瓦制药工业有限公司 Preparation of olmesartan medoxomil
KR20090102883A (en) * 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 Purification of olmesartan medoxomil
KR20070061583A (en) * 2004-10-15 2007-06-13 테바 파마슈티컬 인더스트리즈 리미티드 Process for preparing telmisartan
CN101094849A (en) * 2004-12-30 2007-12-26 特瓦制药工业有限公司 Process for preparing olmesartan medoxomil at ph higher than 2.5
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
CA2592160A1 (en) * 2005-01-03 2006-07-13 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
EP1871764A1 (en) 2005-04-01 2008-01-02 LEK Pharmaceuticals D.D. A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
CN108947870B (en) * 2018-07-23 2021-03-19 湖北宇阳药业有限公司 Preparation method of bromosartanbiphenyl
CN112010831A (en) * 2020-09-08 2020-12-01 上海生农生化制品股份有限公司 Green and efficient phenyl ether ketal bromination synthesis method
CN112851549A (en) * 2021-03-11 2021-05-28 安徽云帆药业有限公司 Experiment method for sodium bromide application
CN112898182A (en) * 2021-03-11 2021-06-04 安徽云帆药业有限公司 Synthetic method for preparing 4' -bromomethyl-2-cyanobiphenyl
CN114426501A (en) * 2021-12-23 2022-05-03 山东艾孚特科技有限公司 Preparation method of bromosartanbiphenyl based on aqueous phase reaction
CN114436833A (en) * 2021-12-27 2022-05-06 南京红太阳医药研究院有限公司 Preparation method of telmisartan key intermediate 4' -methylbiphenyl-2-carboxylic ester

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688657B2 (en) * 1989-02-23 1997-12-10 三光化学工業株式会社 Method for bromination of methyl group bonded to aromatic nucleus
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
EP0595150B1 (en) * 1992-10-29 1996-07-31 Hoechst Aktiengesellschaft Process for the preparation of aromatic bromomethylcompounds

Also Published As

Publication number Publication date
DE69807859T2 (en) 2003-05-22
US6111114A (en) 2000-08-29
EP0973729A1 (en) 2000-01-26
ITMI970846A1 (en) 1998-10-11
AU6832898A (en) 1998-11-11
JP2001518904A (en) 2001-10-16
WO1998046562A1 (en) 1998-10-22
ES2183340T3 (en) 2003-03-16
EP0973729B1 (en) 2002-09-11
DE69807859D1 (en) 2002-10-17

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