DE69807859D1 - Verfahren zur herstellung von 4-bromomethyl diphenyl verbindungen - Google Patents

Verfahren zur herstellung von 4-bromomethyl diphenyl verbindungen

Info

Publication number
DE69807859D1
DE69807859D1 DE69807859T DE69807859T DE69807859D1 DE 69807859 D1 DE69807859 D1 DE 69807859D1 DE 69807859 T DE69807859 T DE 69807859T DE 69807859 T DE69807859 T DE 69807859T DE 69807859 D1 DE69807859 D1 DE 69807859D1
Authority
DE
Germany
Prior art keywords
producing
diphenyl compounds
bromomethyl
bromomethyl diphenyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69807859T
Other languages
English (en)
Other versions
DE69807859T2 (de
Inventor
Aldo Salimbeni
Renato Canevotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Publication of DE69807859D1 publication Critical patent/DE69807859D1/de
Application granted granted Critical
Publication of DE69807859T2 publication Critical patent/DE69807859T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69807859T 1997-04-11 1998-04-06 Verfahren zur herstellung von 4-bromomethyl diphenyl verbindungen Expired - Fee Related DE69807859T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (it) 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici
PCT/EP1998/001992 WO1998046562A1 (en) 1997-04-11 1998-04-06 A process for the preparation of 4-bromomethyl diphenyl compounds

Publications (2)

Publication Number Publication Date
DE69807859D1 true DE69807859D1 (de) 2002-10-17
DE69807859T2 DE69807859T2 (de) 2003-05-22

Family

ID=11376859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69807859T Expired - Fee Related DE69807859T2 (de) 1997-04-11 1998-04-06 Verfahren zur herstellung von 4-bromomethyl diphenyl verbindungen

Country Status (8)

Country Link
US (1) US6111114A (de)
EP (1) EP0973729B1 (de)
JP (1) JP2001518904A (de)
AU (1) AU6832898A (de)
DE (1) DE69807859T2 (de)
ES (1) ES2183340T3 (de)
IT (1) IT1291551B1 (de)
WO (1) WO1998046562A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771090B1 (fr) * 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
PT1535901E (pt) * 2002-06-12 2008-04-10 Sumitomo Chemical Co Processo para a produção de 4'-bromometil-2-cianobifenilo
JP4537678B2 (ja) * 2003-09-04 2010-09-01 住友化学株式会社 ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
JP4437141B2 (ja) * 2004-09-02 2010-03-24 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの精製法
JP4511550B2 (ja) * 2004-09-02 2010-07-28 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの調製法
KR20080112424A (ko) * 2004-10-15 2008-12-24 테바 파마슈티컬 인더스트리즈 리미티드 텔미사르탄의 제조 방법
EP1716138A1 (de) * 2004-12-30 2006-11-02 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von olmesartan-medoxomil bei einem ph-wert von über 2,5
WO2006073519A1 (en) * 2005-01-03 2006-07-13 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
EP1871764A1 (de) * 2005-04-01 2008-01-02 LEK Pharmaceuticals D.D. Synthese von 4-brommethyl-2'-formylbiphenyl und 4-brommethyl-2'-hydroxymethylbiphenyl und deren verwendung bei der herstellung von angiotensin-ii-antagonisten
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
CN108947870B (zh) * 2018-07-23 2021-03-19 湖北宇阳药业有限公司 一种溴代沙坦联苯的制备方法
CN112010831A (zh) * 2020-09-08 2020-12-01 上海生农生化制品股份有限公司 一种绿色高效的苯醚缩酮溴化合成方法
CN112898182A (zh) * 2021-03-11 2021-06-04 安徽云帆药业有限公司 一种制备4`-溴甲基-2-氰基联苯的合成方法
CN112851549A (zh) * 2021-03-11 2021-05-28 安徽云帆药业有限公司 一种溴化钠套用实验方法
CN114426501A (zh) * 2021-12-23 2022-05-03 山东艾孚特科技有限公司 基于水相反应的溴代沙坦联苯的制备方法
CN114436833A (zh) * 2021-12-27 2022-05-06 南京红太阳医药研究院有限公司 一种替米沙坦关键中间体4′-甲基联苯-2-羧酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688657B2 (ja) * 1989-02-23 1997-12-10 三光化学工業株式会社 芳香核に結合するメチル基の臭素化方法
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
EP0595150B1 (de) * 1992-10-29 1996-07-31 Hoechst Aktiengesellschaft Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen

Also Published As

Publication number Publication date
ITMI970846A1 (it) 1998-10-11
AU6832898A (en) 1998-11-11
WO1998046562A1 (en) 1998-10-22
ES2183340T3 (es) 2003-03-16
JP2001518904A (ja) 2001-10-16
DE69807859T2 (de) 2003-05-22
EP0973729B1 (de) 2002-09-11
IT1291551B1 (it) 1999-01-11
EP0973729A1 (de) 2000-01-26
US6111114A (en) 2000-08-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee