CN1976926A - 奥美沙坦酯的制备 - Google Patents

奥美沙坦酯的制备 Download PDF

Info

Publication number
CN1976926A
CN1976926A CNA2005800219037A CN200580021903A CN1976926A CN 1976926 A CN1976926 A CN 1976926A CN A2005800219037 A CNA2005800219037 A CN A2005800219037A CN 200580021903 A CN200580021903 A CN 200580021903A CN 1976926 A CN1976926 A CN 1976926A
Authority
CN
China
Prior art keywords
acid
water
olmesartan medoxomil
olmesartan
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800219037A
Other languages
English (en)
Chinese (zh)
Inventor
L·赫德瓦蒂
G·皮拉斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CN1976926A publication Critical patent/CN1976926A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2005800219037A 2004-09-02 2005-09-02 奥美沙坦酯的制备 Pending CN1976926A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60643704P 2004-09-02 2004-09-02
US60/606,437 2004-09-02

Publications (1)

Publication Number Publication Date
CN1976926A true CN1976926A (zh) 2007-06-06

Family

ID=35462159

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005800219037A Pending CN1976926A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的制备
CNA2005800262573A Pending CN1993355A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的纯化方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005800262573A Pending CN1993355A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的纯化方法

Country Status (7)

Country Link
US (1) US7528258B2 (enExample)
EP (1) EP1706401A1 (enExample)
JP (1) JP4511550B2 (enExample)
CN (2) CN1976926A (enExample)
CA (1) CA2573800A1 (enExample)
IL (1) IL181549A0 (enExample)
WO (1) WO2006029056A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102414200A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 奥美沙坦酯的制备方法
CN102414201A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 新型溶剂化物晶体
CN102459243A (zh) * 2009-05-20 2012-05-16 兰贝克赛实验室有限公司 奥美沙坦酯制造工艺
US8592474B2 (en) 2007-08-08 2013-11-26 Lek Pharmaceuticals D.D. Process for the preparation or purification of olmesartan medoxomil
WO2014036686A1 (zh) * 2012-09-04 2014-03-13 上海迪赛诺化学制药有限公司 奥美沙坦酯的制备方法
US8735598B2 (en) 2008-06-09 2014-05-27 Daiichi Sankyo Company, Limited Method for producing 1-biphenylmethylimidazole compound
CN111170946A (zh) * 2020-03-16 2020-05-19 浙江华洲药业有限公司 一种奥美沙坦中间体的合成方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281800A1 (en) * 2005-04-12 2006-12-14 Glenmark Pharmaceuticals Limited Polymorphic form of olmesartan and process for its preparation
EP1816131A1 (en) * 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
EP1910343B1 (en) * 2005-07-29 2014-10-29 Krka Process for the preparation of olmesartan medoxomil
EP2022790A1 (en) * 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. A process for the preparation or purification of olmesartan medoxomil
WO2011014611A2 (en) * 2009-07-30 2011-02-03 Dr. Reddy's Laboratories Ltd. Preparation of olmesartan medoxomil
WO2011013096A1 (en) * 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
EP2409710A1 (en) 2010-06-29 2012-01-25 NanotecMARIN GmbH Injectable material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis
EP2409682A1 (en) 2010-07-19 2012-01-25 Werner E. G. MÜLLER Hydroxyapatite-binding nano- and microparticles for caries prophylaxis and reduction of dental hypersensitivity
KR101266224B1 (ko) 2010-09-02 2013-05-21 일동제약주식회사 트리틸 올메사르탄 메독소밀의 개선된 제조방법
CZ2010785A3 (cs) * 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
AR083523A1 (es) 2010-10-29 2013-03-06 Interquim Sa Procedimiento de obtencion del olmesartan medoxomilo
EP2489346A1 (en) 2011-01-26 2012-08-22 NanotecMARIN GmbH Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases
EP2739619B1 (en) 2011-08-05 2015-09-16 Lupin Limited Process for the preparation of olmesartan medoxomil
CN102558161B (zh) * 2011-12-07 2016-07-06 浙江华海药业股份有限公司 一种采用丙酮与水混合液精制奥美沙坦酯的工艺
CN102584804B (zh) * 2011-12-13 2016-05-18 浙江华海药业股份有限公司 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
CN108658954A (zh) * 2018-06-12 2018-10-16 广州小桔生物科技有限公司 一种高纯度奥美沙坦酯的精制方法
CN109761966A (zh) * 2019-01-30 2019-05-17 浙江省食品药品检验研究院 一种奥美沙坦酯晶体及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
DE3634717A1 (de) * 1986-10-11 1988-04-14 Dynamit Nobel Ag Verfahren zur herstellung von 5-methyltetrazol
US4870188A (en) 1987-04-16 1989-09-26 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
US5656650A (en) * 1990-12-14 1997-08-12 Smithkline Beecham Corp. Angiotensin II receptor blocking compositions
IE914572A1 (en) * 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5591762A (en) * 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
FI112942B3 (fi) * 1991-02-21 2012-03-13 Daiichi Sankyo Co Ltd Menetelmä kohonneen verenpaineen hoitoon ja ennaltaehkäisyyn käyttökelpoisten 4'-(1H-imidatsol-1-yylimetyyli)-1,1' -bifenyylijohdannaisten valmistamiseksi
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist
JPH06298683A (ja) 1993-04-15 1994-10-25 Sankyo Co Ltd 光反応による４−（２−置換）フェニルベンジルブロミド類の製造法
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
JPH0753489A (ja) 1993-06-11 1995-02-28 Sankyo Co Ltd ビフェニルカルボキサミド誘導体の製造法
US5412102A (en) 1994-05-27 1995-05-02 Syntex (U.S.A.) Inc. Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid
JP2928982B2 (ja) * 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
JPH08325248A (ja) 1995-05-26 1996-12-10 Chugoku Kayaku Kk テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
JP3671266B2 (ja) * 1996-03-21 2005-07-13 東洋化成工業株式会社 ５−置換テトラゾール類の製造方法
GB9613470D0 (en) 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
IT1291551B1 (it) * 1997-04-11 1999-01-11 Luso Farmaco Inst Processo per la preparazione di composti 4-bromometil bifenilici
FR2771090B1 (fr) * 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
JP4185182B2 (ja) 1998-04-08 2008-11-26 第一三共株式会社 イミダゾール誘導体の製造方法
JP4260241B2 (ja) 1998-04-21 2009-04-30 第一三共株式会社 イミダゾール誘導体の製造法
US6271418B1 (en) * 2000-02-22 2001-08-07 Nippon Kayaku Co., Ltd. Process for preparing (hetero) aromatic substituted benzene derivatives
CN1265788C (zh) * 2000-11-21 2006-07-26 三共株式会社 药物组合物
PT1535901E (pt) * 2002-06-12 2008-04-10 Sumitomo Chemical Co Processo para a produção de 4'-bromometil-2-cianobifenilo
CN1271068C (zh) 2003-03-25 2006-08-23 上海医药工业研究院 一种奥美沙坦酯的制备方法
ITMI20032338A1 (it) 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592474B2 (en) 2007-08-08 2013-11-26 Lek Pharmaceuticals D.D. Process for the preparation or purification of olmesartan medoxomil
US8735598B2 (en) 2008-06-09 2014-05-27 Daiichi Sankyo Company, Limited Method for producing 1-biphenylmethylimidazole compound
CN102414200A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 奥美沙坦酯的制备方法
CN102414201A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 新型溶剂化物晶体
US8859600B2 (en) 2009-04-28 2014-10-14 Daiichi Sankyo Company, Limited Acetone solvate crystals of trityl olmesartan medoxomil
CN102414200B (zh) * 2009-04-28 2014-12-17 第一三共株式会社 奥美沙坦酯的制备方法
US8933241B2 (en) 2009-04-28 2015-01-13 Daiichi Sankyo Company, Limited Method for producing olmesartan medoxomil
CN102414201B (zh) * 2009-04-28 2015-10-14 第一三共株式会社 溶剂化物晶体
CN102459243A (zh) * 2009-05-20 2012-05-16 兰贝克赛实验室有限公司 奥美沙坦酯制造工艺
WO2014036686A1 (zh) * 2012-09-04 2014-03-13 上海迪赛诺化学制药有限公司 奥美沙坦酯的制备方法
CN111170946A (zh) * 2020-03-16 2020-05-19 浙江华洲药业有限公司 一种奥美沙坦中间体的合成方法
CN111170946B (zh) * 2020-03-16 2022-02-11 浙江华洲药业有限公司 一种奥美沙坦中间体的合成方法

Also Published As

Publication number Publication date
IL181549A0 (en) 2007-07-04
JP2007509992A (ja) 2007-04-19
CN1993355A (zh) 2007-07-04
JP4511550B2 (ja) 2010-07-28
CA2573800A1 (en) 2006-03-16
EP1706401A1 (en) 2006-10-04
WO2006029056A1 (en) 2006-03-16
US7528258B2 (en) 2009-05-05
US20060069141A1 (en) 2006-03-30

Similar Documents

Publication Publication Date Title
CN1976926A (zh) 奥美沙坦酯的制备
CN101778842B (zh) 制备或纯化奥美沙坦酯的方法
KR101090325B1 (ko) 고순도 올메사탄 메독소밀의 제조방법
CA2575177A1 (en) Purification of olmesartan medoxomil
CN1204125C (zh) 坎地沙坦酯的合成新路线
CN1271068C (zh) 一种奥美沙坦酯的制备方法
WO2011036674A1 (en) A new process for the preparation of olmesartan medoxomil
CN1257902C (zh) 西洛他唑的生产方法
US7880015B2 (en) Process for the preparation of angiotensin II antagonist
US20130190506A1 (en) Process for olmesartan medoxomil
US20120184750A1 (en) Process for the preparation of olmesartan medoxomil
CN1096296A (zh) 制备叶酸的方法
CN1922145A (zh) 制备瑞巴派特的改进的方法
CN1129570C (zh) 在常压下从α,α－二甲基苯乙腈制备α,α－二甲基苯乙酸的方法
CN1628096A (zh) 制备1－(巯基甲基)－环丙烷乙酸的方法
JP2010077077A (ja) Ｎ−ペンタノイル−ｎ−［２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−イルメチル］−ｌ−バリンの製造方法
CN1832931A (zh) 制备苯基四唑衍生物的方法
WO2017209035A1 (ja) ビフェニルベンズイミダゾール誘導体の製造方法
JP4508670B2 (ja) 高純度アダマンタントリオール類の製造方法
US8981110B2 (en) Process for the preparation of olmesartan medoxomil
CN1774440A (zh) 苯并噁庚因－11－亚哌啶化合物及其制造方法
WO2001056985A1 (en) Process for cyclizing optically active 4-amino-2-halogenobutyric acids
CN1756743A (zh) 制备弗克芬得的方法
JP2002053568A (ja) アミドチアゾール酢酸誘導体の製造方法
JP2018203693A (ja) 脱トリチル化物を製造する方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication