CN111170946A - 一种奥美沙坦中间体的合成方法 - Google Patents
一种奥美沙坦中间体的合成方法 Download PDFInfo
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- CN111170946A CN111170946A CN202010180497.5A CN202010180497A CN111170946A CN 111170946 A CN111170946 A CN 111170946A CN 202010180497 A CN202010180497 A CN 202010180497A CN 111170946 A CN111170946 A CN 111170946A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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Priority Applications (1)
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CN202010180497.5A CN111170946B (zh) | 2020-03-16 | 2020-03-16 | 一种奥美沙坦中间体的合成方法 |
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CN202010180497.5A CN111170946B (zh) | 2020-03-16 | 2020-03-16 | 一种奥美沙坦中间体的合成方法 |
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CN111170946A true CN111170946A (zh) | 2020-05-19 |
CN111170946B CN111170946B (zh) | 2022-02-11 |
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CN202010180497.5A Active CN111170946B (zh) | 2020-03-16 | 2020-03-16 | 一种奥美沙坦中间体的合成方法 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060258727A1 (en) * | 2005-01-03 | 2006-11-16 | Lilach Hedvati | Olmesartan medoxomil with reduced levels of impurities |
CN1976926A (zh) * | 2004-09-02 | 2007-06-06 | 特瓦制药工业有限公司 | 奥美沙坦酯的制备 |
CN102070533A (zh) * | 2011-01-27 | 2011-05-25 | 上海科胜药物研发有限公司 | 一种合成4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的新方法 |
CN104356069A (zh) * | 2014-11-18 | 2015-02-18 | 黄冈鲁班药业有限公司 | 高纯度奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用 |
CN104402873A (zh) * | 2014-12-02 | 2015-03-11 | 千辉药业(安徽)有限责任公司 | 一种奥美沙坦酯中间体的制备方法 |
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2020
- 2020-03-16 CN CN202010180497.5A patent/CN111170946B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1976926A (zh) * | 2004-09-02 | 2007-06-06 | 特瓦制药工业有限公司 | 奥美沙坦酯的制备 |
US20060258727A1 (en) * | 2005-01-03 | 2006-11-16 | Lilach Hedvati | Olmesartan medoxomil with reduced levels of impurities |
CN102070533A (zh) * | 2011-01-27 | 2011-05-25 | 上海科胜药物研发有限公司 | 一种合成4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的新方法 |
CN104356069A (zh) * | 2014-11-18 | 2015-02-18 | 黄冈鲁班药业有限公司 | 高纯度奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用 |
CN104402873A (zh) * | 2014-12-02 | 2015-03-11 | 千辉药业(安徽)有限责任公司 | 一种奥美沙坦酯中间体的制备方法 |
Non-Patent Citations (1)
Title |
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虞心红等: ""抗高血压新药奥美沙坦的合成"", 《华东理工大学学报(自然科学版)》 * |
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Denomination of invention: A synthetic method of olmesartan intermediate Effective date of registration: 20220507 Granted publication date: 20220211 Pledgee: Zhejiang Taizhou Jiaojiang Rural Commercial Bank Co.,Ltd. Zhang'an sub branch Pledgor: ZHEJIANG HUAZHOU PHARMACEUTICALS Co.,Ltd. Registration number: Y2022330000658 |
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Effective date of registration: 20230117 Address after: 318000, No. 35, Donghai Fifth Avenue, Linhai Park, Chemical Raw Material Drug Base, Taizhou City, Zhejiang Province Patentee after: Zhejiang Huayang Pharmaceutical Co.,Ltd. Address before: 318017 Xiayang Industrial Zone, Zhang'an street, Jiaojiang District, Taizhou City, Zhejiang Province Patentee before: ZHEJIANG HUAZHOU PHARMACEUTICALS Co.,Ltd. |