CA2573800A1 - Preparation of olmesartan medoxomil - Google Patents

Preparation of olmesartan medoxomil Download PDF

Info

Publication number
CA2573800A1
CA2573800A1 CA002573800A CA2573800A CA2573800A1 CA 2573800 A1 CA2573800 A1 CA 2573800A1 CA 002573800 A CA002573800 A CA 002573800A CA 2573800 A CA2573800 A CA 2573800A CA 2573800 A1 CA2573800 A1 CA 2573800A1
Authority
CA
Canada
Prior art keywords
olmesartan medoxomil
acid
water
solution
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002573800A
Other languages
English (en)
French (fr)
Inventor
Lilach Hedvati
Gideon Pilarsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2573800A1 publication Critical patent/CA2573800A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002573800A 2004-09-02 2005-09-02 Preparation of olmesartan medoxomil Abandoned CA2573800A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60643704P 2004-09-02 2004-09-02
US60/606,437 2004-09-02
PCT/US2005/031481 WO2006029056A1 (en) 2004-09-02 2005-09-02 Preparation of olmesartan medoxomil

Publications (1)

Publication Number Publication Date
CA2573800A1 true CA2573800A1 (en) 2006-03-16

Family

ID=35462159

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002573800A Abandoned CA2573800A1 (en) 2004-09-02 2005-09-02 Preparation of olmesartan medoxomil

Country Status (7)

Country Link
US (1) US7528258B2 (enExample)
EP (1) EP1706401A1 (enExample)
JP (1) JP4511550B2 (enExample)
CN (2) CN1993355A (enExample)
CA (1) CA2573800A1 (enExample)
IL (1) IL181549A0 (enExample)
WO (1) WO2006029056A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281800A1 (en) * 2005-04-12 2006-12-14 Glenmark Pharmaceuticals Limited Polymorphic form of olmesartan and process for its preparation
EA014026B1 (ru) * 2005-07-29 2010-08-30 Крка, Товарна Здравил, Д.Д., Ново Место Способ получения олмесартан медоксомила
EP1816131A1 (en) * 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
EP2022790A1 (en) * 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. A process for the preparation or purification of olmesartan medoxomil
CA2707365A1 (en) 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil
KR101630885B1 (ko) 2008-06-09 2016-06-15 다이이찌 산쿄 가부시키가이샤 1-비페닐메틸이미다졸 화합물의 제조 방법
ES2527686T3 (es) * 2009-04-28 2015-01-28 Daiichi Sankyo Company, Limited Procedimiento de producción de olmesartán medoxomil
CA2760031C (en) 2009-04-28 2015-03-10 Daiichi Sankyo Company, Limited Acetone solvate crystals of trityl olmesartan medoxomil
WO2010134052A1 (en) 2009-05-20 2010-11-25 Ranbaxy Laboratories Limited Process for the preparation of olmesartan medoxomil
WO2011014611A2 (en) * 2009-07-30 2011-02-03 Dr. Reddy's Laboratories Ltd. Preparation of olmesartan medoxomil
CA2769704A1 (en) * 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
EP2409710A1 (en) 2010-06-29 2012-01-25 NanotecMARIN GmbH Injectable material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis
EP2409682A1 (en) 2010-07-19 2012-01-25 Werner E. G. MÜLLER Hydroxyapatite-binding nano- and microparticles for caries prophylaxis and reduction of dental hypersensitivity
KR101266224B1 (ko) 2010-09-02 2013-05-21 일동제약주식회사 트리틸 올메사르탄 메독소밀의 개선된 제조방법
CZ2010785A3 (cs) 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
AR083523A1 (es) 2010-10-29 2013-03-06 Interquim Sa Procedimiento de obtencion del olmesartan medoxomilo
EP2489346A1 (en) 2011-01-26 2012-08-22 NanotecMARIN GmbH Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases
EP2739619B1 (en) 2011-08-05 2015-09-16 Lupin Limited Process for the preparation of olmesartan medoxomil
CN102558161B (zh) * 2011-12-07 2016-07-06 浙江华海药业股份有限公司 一种采用丙酮与水混合液精制奥美沙坦酯的工艺
CN102584804B (zh) * 2011-12-13 2016-05-18 浙江华海药业股份有限公司 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
WO2014036686A1 (zh) * 2012-09-04 2014-03-13 上海迪赛诺化学制药有限公司 奥美沙坦酯的制备方法
CN108658954A (zh) * 2018-06-12 2018-10-16 广州小桔生物科技有限公司 一种高纯度奥美沙坦酯的精制方法
CN109761966A (zh) * 2019-01-30 2019-05-17 浙江省食品药品检验研究院 一种奥美沙坦酯晶体及其制备方法
CN111170946B (zh) * 2020-03-16 2022-02-11 浙江华洲药业有限公司 一种奥美沙坦中间体的合成方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
DE3634717A1 (de) 1986-10-11 1988-04-14 Dynamit Nobel Ag Verfahren zur herstellung von 5-methyltetrazol
US4870188A (en) 1987-04-16 1989-09-26 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
DE4036706A1 (de) 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
US5656650A (en) 1990-12-14 1997-08-12 Smithkline Beecham Corp. Angiotensin II receptor blocking compositions
IE914572A1 (en) 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US5616599A (en) 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CA2229000C (en) * 1991-02-21 2002-04-09 Sankyo Company, Limited 1-biphenylimidazole derivatives, their preparation and their therapeutic use
US5252753A (en) 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5310928A (en) 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5264447A (en) 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist
JPH06298683A (ja) 1993-04-15 1994-10-25 Sankyo Co Ltd 光反応による４−（２−置換）フェニルベンジルブロミド類の製造法
US5721263A (en) 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
JPH0753489A (ja) 1993-06-11 1995-02-28 Sankyo Co Ltd ビフェニルカルボキサミド誘導体の製造法
US5412102A (en) 1994-05-27 1995-05-02 Syntex (U.S.A.) Inc. Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid
JP2928982B2 (ja) 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
JPH08325248A (ja) 1995-05-26 1996-12-10 Chugoku Kayaku Kk テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法
US5994348A (en) 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
JP3671266B2 (ja) 1996-03-21 2005-07-13 東洋化成工業株式会社 ５−置換テトラゾール類の製造方法
GB9613470D0 (en) 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
IT1291551B1 (it) 1997-04-11 1999-01-11 Luso Farmaco Inst Processo per la preparazione di composti 4-bromometil bifenilici
FR2771090B1 (fr) 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
JP4185182B2 (ja) 1998-04-08 2008-11-26 第一三共株式会社 イミダゾール誘導体の製造方法
JP4260241B2 (ja) 1998-04-21 2009-04-30 第一三共株式会社 イミダゾール誘導体の製造法
US6271418B1 (en) 2000-02-22 2001-08-07 Nippon Kayaku Co., Ltd. Process for preparing (hetero) aromatic substituted benzene derivatives
EP1595540A1 (en) 2000-11-21 2005-11-16 Sankyo Company Limited Composition containing an angiotensin II receptor antagonist and a diuretic and its use for the treatment of hypertension
DK1535901T3 (da) 2002-06-12 2008-04-07 Sumitomo Chemical Co Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl
CN1271068C (zh) 2003-03-25 2006-08-23 上海医药工业研究院 一种奥美沙坦酯的制备方法
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.

Also Published As

Publication number Publication date
IL181549A0 (en) 2007-07-04
US20060069141A1 (en) 2006-03-30
CN1993355A (zh) 2007-07-04
EP1706401A1 (en) 2006-10-04
CN1976926A (zh) 2007-06-06
JP2007509992A (ja) 2007-04-19
JP4511550B2 (ja) 2010-07-28
WO2006029056A1 (en) 2006-03-16
US7528258B2 (en) 2009-05-05

Similar Documents

Publication Publication Date Title
CA2573800A1 (en) Preparation of olmesartan medoxomil
KR101090325B1 (ko) 고순도 올메사탄 메독소밀의 제조방법
CA2707334C (en) A process for the preparation or purification of olmesartan medoxomil
CA2575177A1 (en) Purification of olmesartan medoxomil
CN105622595A (zh) 一种阿奇沙坦酯钾盐及其中间体新的制备方法
WO2011036674A1 (en) A new process for the preparation of olmesartan medoxomil
US7880015B2 (en) Process for the preparation of angiotensin II antagonist
US20130190506A1 (en) Process for olmesartan medoxomil
US20120184750A1 (en) Process for the preparation of olmesartan medoxomil
EP2016073B1 (en) Process for the preparation of pure irbesartan
KR100662110B1 (ko) 테트라졸 유도체의 제조방법
CA2591694A1 (en) Process for preparing olmesartan medoxomil at ph higher than 2.5
KR101009404B1 (ko) (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법
EP2022790A1 (en) A process for the preparation or purification of olmesartan medoxomil
KR101009383B1 (ko) 고순도의2-부틸-3-[[2'-(1에이취-테트라졸-5-일)[1,1'-비페닐]-4-일]메틸]-1,3-디아자스피로[4.4]논-1-엔-4-온 화합물의제조방법
KR101257272B1 (ko) 탈보호화 반응을 이용한 고혈압 치료용 비페닐테트라졸 화합물의 제조방법
CN101712682A (zh) 他索沙坦的合成方法

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued