KR101009404B1 - (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 - Google Patents
(에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 Download PDFInfo
- Publication number
- KR101009404B1 KR101009404B1 KR1020080040396A KR20080040396A KR101009404B1 KR 101009404 B1 KR101009404 B1 KR 101009404B1 KR 1020080040396 A KR1020080040396 A KR 1020080040396A KR 20080040396 A KR20080040396 A KR 20080040396A KR 101009404 B1 KR101009404 B1 KR 101009404B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- pentanoyl
- carboxy
- tetrazol
- formula
- Prior art date
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- ACWBQPMHZXGDFX-QFIPXVFZSA-N CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O)=O Chemical compound CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O)=O ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
- 0 CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1C#N)[C@](*)C(C)C)=O Chemical compound CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1C#N)[C@](*)C(C)C)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
- 하기 화학식 3으로 표시되는 화합물로부터 피리딘 용매 중에서 하기 화학식 1로 표시되는 (S)-N-(1-카르복시-2-메틸-프로-1-필)-N-펜타노일-N-[2′-(1H-테트라졸-5-일)비페닐-4-일-메틸]아민 화합물의 제조방법에 있어서,알칼리금속아지드와 화학식 3으로 표시되는 화합물을 염화아연의 존재하에 피리딘 용매 중에서 직접 반응시켜 반응생성물을 제조하고, 상기 반응생성물을 디클로로메탄과 이소프로판올 혼합액에 용해시킨 후 아세톤으로 결정화시킴을 특징으로 하는 하기 화학식 1로 표시되는 (S)-N-(1-카르복시-2-메틸-프로-1-필)-N-펜타노일-N-[2′-(1H-테트라졸-5-일)비페닐-4-일-메틸]아민 화합물의 제조방법.<화학식 1><화학식 3>
- 제 1 항에 있어서, 알칼리금속아지드는 리튬아지드, 소디움아지드, 칼륨아지드, 세륨아지드 중에서 선택되는 어느 하나인 것을 특징으로 하는 화학식 1로 표시되는 (S)-N-(1-카르복시-2-메틸-프로-1-필)-N-펜타노일-N-[2'-(1H-테트라졸-5-일)비페닐-4-일-메틸]아민 화합물의 제조방법.
Priority Applications (1)
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KR1020080040396A KR101009404B1 (ko) | 2008-04-30 | 2008-04-30 | (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 |
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KR1020080040396A KR101009404B1 (ko) | 2008-04-30 | 2008-04-30 | (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 |
Publications (2)
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KR20090114649A KR20090114649A (ko) | 2009-11-04 |
KR101009404B1 true KR101009404B1 (ko) | 2011-01-19 |
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KR1020080040396A KR101009404B1 (ko) | 2008-04-30 | 2008-04-30 | (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102822151B (zh) * | 2010-04-07 | 2015-03-18 | 新梅斯托克公司 | 用于制备缬沙坦的改进的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003089417A1 (en) | 2002-04-15 | 2003-10-30 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2’-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan) |
KR100662110B1 (ko) * | 2005-10-14 | 2006-12-27 | 켐젠주식회사 | 테트라졸 유도체의 제조방법 |
WO2007032019A2 (en) * | 2005-08-22 | 2007-03-22 | Alembic Limited | Process for preparing valsartan |
KR20070089487A (ko) * | 2006-02-28 | 2007-08-31 | 동아제약주식회사 | 안지오텐신 ⅱ 길항제의 제조방법 |
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- 2008-04-30 KR KR1020080040396A patent/KR101009404B1/ko active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003089417A1 (en) | 2002-04-15 | 2003-10-30 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2’-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan) |
WO2007032019A2 (en) * | 2005-08-22 | 2007-03-22 | Alembic Limited | Process for preparing valsartan |
KR100662110B1 (ko) * | 2005-10-14 | 2006-12-27 | 켐젠주식회사 | 테트라졸 유도체의 제조방법 |
KR20070089487A (ko) * | 2006-02-28 | 2007-08-31 | 동아제약주식회사 | 안지오텐신 ⅱ 길항제의 제조방법 |
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