JP2007504446A5 - - Google Patents

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JP2007504446A5
JP2007504446A5 JP2006524942A JP2006524942A JP2007504446A5 JP 2007504446 A5 JP2007504446 A5 JP 2007504446A5 JP 2006524942 A JP2006524942 A JP 2006524942A JP 2006524942 A JP2006524942 A JP 2006524942A JP 2007504446 A5 JP2007504446 A5 JP 2007504446A5
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reservoir
integrated structure
sorting
inlet
fluid
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JP2006524942A
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JP2007504446A (ja
JP4533382B2 (ja
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Priority claimed from PCT/US2004/028213 external-priority patent/WO2005022147A1/en
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Publication of JP2007504446A5 publication Critical patent/JP2007504446A5/ja
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Claims (10)

  1. カートリッジ、チップおよび蓋を含むマイクロ流体分析およびソーティング用の一体化された構造物であって、
    該カートリッジは、
    光学ウィンドウ、
    少なくとも:
    試料貯留部、
    流体貯留部、
    廃棄物貯留部、および
    標的収集貯留部
    を含む複数の貯留部を含み、
    該チップは、少なくとも:
    試料入口チャネル、ここに細胞入口チャネルは試料貯留部に流体的に結合しており、
    1またはそれを超える流体入口チャネル、ここに該流体入口チャネルは該流体貯留部に流体的に結合しており、
    検出領域、
    分岐したソーティング領域、および
    少なくとも廃棄チャネルおよび標的チャネルを含む少なくとも2の出口チャネルを含み、ここに該廃棄チャネルは該廃棄物貯留部に流体的に結合し、該標的チャネルは該標的収集貯留部に結合しており、
    ここに、該チップは光学ウィンドウに隣接して配置されており、
    該蓋は、少なくとも:
    圧力式圧力出入口、該出入口は入口を有し、該試料貯留部および該流体貯留部のうちの少なくとも1に結合しており、および
    該圧力式圧力出入口の入口と該試料貯留部および該流体貯留部のうちの少なくとも1との間に配置されたフィルタを含む、
    ことを特徴とする該一体化された構造物。
  2. 該試料貯留部が、円錐形、先細りであって、またはさらに細胞付着を最小限化する材料からなるインサートを含む、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  3. 該蓋が、試料貯留部、標的収集貯留部、廃棄物貯留部および1またはそれを超える流体貯留部よりなる群のための独立した圧力式圧力出入口を含む、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  4. 該蓋が、貯留部に対する光学アクセスを提供する、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  5. 該蓋が、カートリッジに結合したスナップ−オン付属物を含む、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  6. 該フィルタが、以下の特性:気体透過性および流体不透過性、のうちの1またはそれを超えるものを有する、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  7. 該流体入口チャネルおよび該流体出口チャネルが異なる幅を有する、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  8. 接着剤が該チップと該カートリッジとの間に配置されている、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  9. さらに、該蓋とカートリッジとの間にガスケットを含む、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
  10. 該チップおよびカートリッジが2の別の構造物を含む、請求項1記載のマイクロ流体分析およびソーティング用の一体化された構造物。
JP2006524942A 2003-08-28 2004-08-27 マイクロ流体分析およびソーティング用の一体化された構造物 Expired - Fee Related JP4533382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49929403P 2003-08-28 2003-08-28
US57489704P 2004-05-26 2004-05-26
PCT/US2004/028213 WO2005022147A1 (en) 2003-08-28 2004-08-27 Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network

Publications (3)

Publication Number Publication Date
JP2007504446A JP2007504446A (ja) 2007-03-01
JP2007504446A5 true JP2007504446A5 (ja) 2007-10-11
JP4533382B2 JP4533382B2 (ja) 2010-09-01

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JP2006524942A Expired - Fee Related JP4533382B2 (ja) 2003-08-28 2004-08-27 マイクロ流体分析およびソーティング用の一体化された構造物

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US (2) US7745221B2 (ja)
EP (1) EP1668355A4 (ja)
JP (1) JP4533382B2 (ja)
CN (1) CN1860363B (ja)
AU (1) AU2004269406B2 (ja)
CA (1) CA2536360C (ja)
WO (1) WO2005022147A1 (ja)

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