JP2007332155A5 - - Google Patents
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- Publication number
- JP2007332155A5 JP2007332155A5 JP2007211802A JP2007211802A JP2007332155A5 JP 2007332155 A5 JP2007332155 A5 JP 2007332155A5 JP 2007211802 A JP2007211802 A JP 2007211802A JP 2007211802 A JP2007211802 A JP 2007211802A JP 2007332155 A5 JP2007332155 A5 JP 2007332155A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- botulinum toxin
- pharmaceutical composition
- neurotoxin
- clostridial neurotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 claims 9
- 229920001282 polysaccharide Polymers 0.000 claims 9
- 239000005017 polysaccharide Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108030001720 Bontoxilysin Proteins 0.000 claims 5
- 229940053031 botulinum toxin Drugs 0.000 claims 5
- 108010055044 Tetanus Toxin Proteins 0.000 claims 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 3
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 3
- 101710138657 Neurotoxin Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 3
- 239000002581 neurotoxin Substances 0.000 claims 3
- 231100000618 neurotoxin Toxicity 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 108010057266 Type A Botulinum Toxins Proteins 0.000 claims 2
- 229940094657 botulinum toxin type a Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 238000004925 denaturation Methods 0.000 claims 1
- 230000036425 denaturation Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50014700A | 2000-02-08 | 2000-02-08 | |
| US09/500,147 | 2000-02-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004084590A Division JP4118830B2 (ja) | 2000-02-08 | 2004-03-23 | ボツリヌス毒素医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011160451A Division JP2011251988A (ja) | 2000-02-08 | 2011-07-22 | ボツリヌス毒素医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007332155A JP2007332155A (ja) | 2007-12-27 |
| JP2007332155A5 true JP2007332155A5 (enExample) | 2008-04-17 |
| JP5080902B2 JP5080902B2 (ja) | 2012-11-21 |
Family
ID=23988236
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557580A Pending JP2003522154A (ja) | 2000-02-08 | 2001-02-05 | ボツリヌス毒素医薬組成物 |
| JP2004084590A Expired - Lifetime JP4118830B2 (ja) | 2000-02-08 | 2004-03-23 | ボツリヌス毒素医薬組成物 |
| JP2005079801A Pending JP2005179375A (ja) | 2000-02-08 | 2005-03-18 | ボツリヌス毒素医薬組成物 |
| JP2005196335A Withdrawn JP2005336201A (ja) | 2000-02-08 | 2005-07-05 | ボツリヌス毒素医薬組成物 |
| JP2007211802A Expired - Lifetime JP5080902B2 (ja) | 2000-02-08 | 2007-08-15 | ボツリヌス毒素医薬組成物 |
| JP2011160451A Pending JP2011251988A (ja) | 2000-02-08 | 2011-07-22 | ボツリヌス毒素医薬組成物 |
| JP2011233808A Pending JP2012031194A (ja) | 2000-02-08 | 2011-10-25 | ボツリヌス毒素医薬組成物 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557580A Pending JP2003522154A (ja) | 2000-02-08 | 2001-02-05 | ボツリヌス毒素医薬組成物 |
| JP2004084590A Expired - Lifetime JP4118830B2 (ja) | 2000-02-08 | 2004-03-23 | ボツリヌス毒素医薬組成物 |
| JP2005079801A Pending JP2005179375A (ja) | 2000-02-08 | 2005-03-18 | ボツリヌス毒素医薬組成物 |
| JP2005196335A Withdrawn JP2005336201A (ja) | 2000-02-08 | 2005-07-05 | ボツリヌス毒素医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011160451A Pending JP2011251988A (ja) | 2000-02-08 | 2011-07-22 | ボツリヌス毒素医薬組成物 |
| JP2011233808A Pending JP2012031194A (ja) | 2000-02-08 | 2011-10-25 | ボツリヌス毒素医薬組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20020064536A1 (enExample) |
| EP (4) | EP1586329A1 (enExample) |
| JP (7) | JP2003522154A (enExample) |
| KR (3) | KR100753765B1 (enExample) |
| CN (2) | CN1258379C (enExample) |
| AR (1) | AR027391A1 (enExample) |
| AT (2) | ATE293988T1 (enExample) |
| AU (2) | AU3331501A (enExample) |
| BR (1) | BR0108173A (enExample) |
| CA (3) | CA2400318C (enExample) |
| CY (1) | CY1108007T1 (enExample) |
| DE (2) | DE60110372T2 (enExample) |
| DK (3) | DK1514556T3 (enExample) |
| ES (3) | ES2275992T5 (enExample) |
| MX (1) | MXPA02007519A (enExample) |
| NZ (2) | NZ530779A (enExample) |
| PT (3) | PT1253932E (enExample) |
| TW (2) | TWI282739B (enExample) |
| WO (1) | WO2001058472A2 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
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| US8632785B2 (en) * | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
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| DE10035156A1 (de) * | 2000-07-19 | 2002-02-07 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Proteinkomplex als Vehikel für oral verfügbare Protein-Arzneimittel |
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| DE10149030A1 (de) * | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US7140371B2 (en) * | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
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| US7238357B2 (en) * | 2002-11-05 | 2007-07-03 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
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| ATE404175T1 (de) * | 2003-03-31 | 2008-08-15 | Alza Corp | Nicht wässrige einphasige visköse vehikel und formulierungen die diese vehikel verwenden |
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| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
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| US7160699B2 (en) | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
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| US20100266638A1 (en) | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
| US7691381B2 (en) * | 2004-04-15 | 2010-04-06 | Allergan, Inc. | Stabilized biodegradable neurotoxin implants |
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