JP2006523718A - チロナミン誘導体およびチロナミンアナログならびにこれらを使用する方法 - Google Patents

チロナミン誘導体およびチロナミンアナログならびにこれらを使用する方法 Download PDF

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JP2006523718A
JP2006523718A JP2006513092A JP2006513092A JP2006523718A JP 2006523718 A JP2006523718 A JP 2006523718A JP 2006513092 A JP2006513092 A JP 2006513092A JP 2006513092 A JP2006513092 A JP 2006513092A JP 2006523718 A JP2006523718 A JP 2006523718A
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lower alkyl
substituents
compound
aryl
conh
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トーマス エス． スカンラン，
マシュー イー． ハート，
デービッド ケー． グランディー，
ジェイムス アール． ブンゾウ，
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THE REGENTS OF THE UNIVERSITY OF CARIFORNIA
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THE REGENTS OF THE UNIVERSITY OF CARIFORNIA
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
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    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
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JP2006513092A 2003-04-18 2004-04-19 チロナミン誘導体およびチロナミンアナログならびにこれらを使用する方法 Pending JP2006523718A (ja)

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US10/418,399 US6979750B1 (en) 2003-04-18 2003-04-18 Thyronamine derivatives and analogs and methods of use thereof
US10/825,881 US7321065B2 (en) 2003-04-18 2004-04-16 Thyronamine derivatives and analogs and methods of use thereof
PCT/US2004/011893 WO2004093800A2 (en) 2003-04-18 2004-04-19 Thyronamine derivatives and analogs and methods of use thereof

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
EP1735268B1 (en) 2004-03-15 2012-02-15 Eli Lilly And Company Opioid receptor antagonists
WO2007059039A1 (en) * 2005-11-11 2007-05-24 Oregon Health & Science University Thyroxine derivatives for preconditioning against stroke
WO2008005407A2 (en) * 2006-07-03 2008-01-10 Fred Hutchinson Cancer Research Center Trace amine-associated receptors in the olfactory epithelium
GB0725214D0 (en) * 2007-12-24 2008-02-06 Karobio Ab Pharmaceutical compounds
EP2098226A1 (de) * 2008-03-06 2009-09-09 Forschungsverbund Berlin e.V. AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten
TWI449533B (zh) * 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗
KR101112731B1 (ko) * 2009-11-02 2012-03-13 연세대학교 산학협력단 3-아이오도타이로나민의 제조방법
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CN102464618B (zh) 2010-11-03 2014-07-23 中国中化股份有限公司 吡唑酰胺类化合物及其应用
US20140288077A1 (en) * 2011-07-05 2014-09-25 St. Jude Children's Research Hospital Substituted 4-phenoxyphenol analogs as modulators of proliferating cell nuclear antigen activity
WO2014063642A1 (zh) 2012-10-25 2014-05-01 中国中化股份有限公司 取代嘧啶类化合物及其用途
CN103772369B (zh) 2012-10-25 2016-12-21 沈阳中化农药化工研发有限公司 胡椒乙胺类化合物及其用途
WO2015151068A1 (en) * 2014-04-03 2015-10-08 Universita' Di Pisa Synthetic analogues of 3-iodothyronamine (t1am) and uses thereof
WO2016108572A2 (ko) * 2014-12-30 2016-07-07 연세대학교 산학협력단 콜레스테롤 관련 질환의 예방 및 치료용 조성물
KR101755255B1 (ko) 2015-04-30 2017-07-07 연세대학교 원주산학협력단 저대사 유도용 조성물, 저대사 유도방법 및 그 기술을 이용한 어류 운송방법
US11974970B2 (en) 2015-06-29 2024-05-07 University Industry Foundation, Yonsei University Wonju Campus Muscular atrophy-inducing agent using hypometabolism-inducing substance T1AM, and use thereof in treating muscular hypertrophy
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WO2017003177A1 (ko) * 2015-06-29 2017-01-05 연세대학교 원주산학협력단 저대사 유도물질 t1am을 이용한 근위축 유도제 및 이의 근비대증 치료 용도
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CA3130371A1 (en) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Novel thyromimetics

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118942A (en) * 1961-02-10 1964-01-21 Wisconsin Alumni Res Found alpha-methyl-iodothyronamines
DE2514630A1 (de) * 1974-04-03 1975-10-09 Roussel Uclaf Thyronamin-derivate, herstellungsverfahren dafuer und pharmazeutische zusammensetzungen
FR2291743A1 (fr) * 1974-11-21 1976-06-18 Roussel Uclaf Nouveau derive de la thyronamine et ses sels, leur procede de preparation et leur application comme medicaments
JPS559096A (en) * 1978-07-03 1980-01-22 Lilly Co Eli Phenethanol amines
JPS5984849A (ja) * 1982-09-22 1984-05-16 バイエル・アクチエンゲゼルシヤフト 成長促進性フエニルエチルアミン誘導体類
JPH0543536A (ja) * 1991-08-13 1993-02-23 Dainippon Jochugiku Co Ltd 新規アミジン誘導体、及びこれを含有する殺虫、殺ダニ剤
JPH06329535A (ja) * 1993-03-26 1994-11-29 Taisho Pharmaceut Co Ltd シグマ受容体拮抗薬
JPH06511259A (ja) * 1992-04-09 1994-12-15 ゼネカ　リミテッド 治療用アミン
JPH0959230A (ja) * 1995-06-14 1997-03-04 Taisho Pharmaceut Co Ltd 光学活性置換フェニルアルキルアミン誘導体
JPH11508241A (ja) * 1995-06-07 1999-07-21 カロ バイオ エービー 甲状腺ホルモンまたは甲状腺ホルモン様化合物に関する新規な使用
JPH11302235A (ja) * 1998-04-15 1999-11-02 Taisho Pharmaceut Co Ltd フェノキシアルキルアミン誘導体
JP2001500152A (ja) * 1996-09-16 2001-01-09 ナイコメッド・アマーシャム・ピーエルシー 標識化エラスターゼ・インヒビター
WO2001068609A1 (en) * 2000-03-14 2001-09-20 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivatives
JP2002503721A (ja) * 1998-02-21 2002-02-05 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換イソインドロンおよび医薬におけるサイクリックｇｍｐ調節剤としてのそれらの使用
US20020032238A1 (en) * 2000-07-08 2002-03-14 Henning Priepke Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments
JP2002513387A (ja) * 1996-09-05 2002-05-08 イーライ・リリー・アンド・カンパニー 選択的β▲下３▼アドレナリン作動性アゴニスト
WO2002051838A1 (en) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists
JP2002539115A (ja) * 1999-03-10 2002-11-19 ビオヴィトルム・アクチボラゲット タンパク質チロシンホスファターゼ阻害剤
WO2003086396A1 (fr) * 2002-04-02 2003-10-23 Tsumura & Co. Inhibiteur de phosphodiesterase iv contenant un derive de pyridylacrylamide
WO2003106462A1 (en) * 2002-06-14 2003-12-24 Pfizer Inc. Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
WO2004020415A1 (en) * 2002-08-27 2004-03-11 Astrazeneca Ab 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12.

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4252951A (en) * 1979-10-09 1981-02-24 Eli Lilly And Company Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) * 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4634666A (en) * 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) * 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5871907A (en) * 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
US5858657A (en) * 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
DE4210569A1 (de) * 1992-03-31 1993-10-07 Hoechst Ag Verwendung von substituierten µ-Hydroxyethylaminen als fungizide Wirkstoffe
CA2150262C (en) * 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US5914241A (en) 1993-01-19 1999-06-22 Biosite Diagnostics, Inc. Assays and kits for detecting analytes in the presence of cross-reacting substances
US5914349A (en) * 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
AU5727798A (en) 1996-12-23 1998-07-17 Texas A & M University, The Anti-amyloidogenic agents
US5965375A (en) 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
JP2003500431A (ja) 1999-06-01 2003-01-07 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター 毛髪の損失を治療する方法
AU6936500A (en) * 1999-08-24 2001-03-19 Regents Of The University Of California, The Non-quinoline inhibitors of malaria parasites
WO2001056989A2 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
AU2002230057A1 (en) 2001-01-29 2002-08-12 Insight Strategy And Marketing Ltd Diphenyl ether derivatives and their uses as heparanase inhibitors
FR2826571B1 (fr) 2001-06-29 2005-10-07 Oreal Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles
US6951884B2 (en) 2002-06-12 2005-10-04 Hoffmann-La Roche Inc. Fluorobenzamides and uses thereof
US7321065B2 (en) 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds

Patent Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118942A (en) * 1961-02-10 1964-01-21 Wisconsin Alumni Res Found alpha-methyl-iodothyronamines
DE2514630A1 (de) * 1974-04-03 1975-10-09 Roussel Uclaf Thyronamin-derivate, herstellungsverfahren dafuer und pharmazeutische zusammensetzungen
FR2291743A1 (fr) * 1974-11-21 1976-06-18 Roussel Uclaf Nouveau derive de la thyronamine et ses sels, leur procede de preparation et leur application comme medicaments
JPS559096A (en) * 1978-07-03 1980-01-22 Lilly Co Eli Phenethanol amines
JPS5984849A (ja) * 1982-09-22 1984-05-16 バイエル・アクチエンゲゼルシヤフト 成長促進性フエニルエチルアミン誘導体類
JPH0543536A (ja) * 1991-08-13 1993-02-23 Dainippon Jochugiku Co Ltd 新規アミジン誘導体、及びこれを含有する殺虫、殺ダニ剤
JPH06511259A (ja) * 1992-04-09 1994-12-15 ゼネカ　リミテッド 治療用アミン
JPH06329535A (ja) * 1993-03-26 1994-11-29 Taisho Pharmaceut Co Ltd シグマ受容体拮抗薬
JPH11508241A (ja) * 1995-06-07 1999-07-21 カロ バイオ エービー 甲状腺ホルモンまたは甲状腺ホルモン様化合物に関する新規な使用
JPH0959230A (ja) * 1995-06-14 1997-03-04 Taisho Pharmaceut Co Ltd 光学活性置換フェニルアルキルアミン誘導体
JP2002513387A (ja) * 1996-09-05 2002-05-08 イーライ・リリー・アンド・カンパニー 選択的β▲下３▼アドレナリン作動性アゴニスト
JP2001500152A (ja) * 1996-09-16 2001-01-09 ナイコメッド・アマーシャム・ピーエルシー 標識化エラスターゼ・インヒビター
JP2002503721A (ja) * 1998-02-21 2002-02-05 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換イソインドロンおよび医薬におけるサイクリックｇｍｐ調節剤としてのそれらの使用
JPH11302235A (ja) * 1998-04-15 1999-11-02 Taisho Pharmaceut Co Ltd フェノキシアルキルアミン誘導体
JP2002539115A (ja) * 1999-03-10 2002-11-19 ビオヴィトルム・アクチボラゲット タンパク質チロシンホスファターゼ阻害剤
WO2001068609A1 (en) * 2000-03-14 2001-09-20 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivatives
US20020032238A1 (en) * 2000-07-08 2002-03-14 Henning Priepke Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments
WO2002051838A1 (en) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists
WO2003086396A1 (fr) * 2002-04-02 2003-10-23 Tsumura & Co. Inhibiteur de phosphodiesterase iv contenant un derive de pyridylacrylamide
WO2003106462A1 (en) * 2002-06-14 2003-12-24 Pfizer Inc. Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
WO2004020415A1 (en) * 2002-08-27 2004-03-11 Astrazeneca Ab 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12.

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US7355079B2 (en) 2008-04-08
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