|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
CA2522345A1
(en)
|
2003-04-09 |
2004-11-18 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
JP2007537141A
(ja)
|
2003-12-18 |
2007-12-20 |
ノボ ノルディスク アクティーゼルスカブ |
新規なglp−1化合物
|
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
|
EP1814573B1
(en)
|
2004-10-29 |
2016-03-09 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
CA2593682C
(en)
|
2005-01-10 |
2016-03-22 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
|
TWI376234B
(en)
|
2005-02-01 |
2012-11-11 |
Msd Oss Bv |
Conjugates of a polypeptide and an oligosaccharide
|
|
TWI362392B
(en)
|
2005-03-18 |
2012-04-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
|
ES2484796T3
(es)
|
2005-03-18 |
2014-08-12 |
Novo Nordisk A/S |
Compuestos de GLP-1 extendidos
|
|
US9187546B2
(en)
|
2005-04-08 |
2015-11-17 |
Novo Nordisk A/S |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
CA2607566A1
(en)
*
|
2005-05-06 |
2006-11-16 |
Bayer Pharmaceuticals Corporation |
Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
|
|
SI1881850T1
(sl)
*
|
2005-05-13 |
2011-01-31 |
Lilly Co Eli |
Glp-1 pegilirane spojine
|
|
US20080255026A1
(en)
|
2005-05-25 |
2008-10-16 |
Glycopegylated Factor 1X |
Glycopegylated Factor Ix
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
KR101057284B1
(ko)
*
|
2005-10-26 |
2011-08-16 |
일라이 릴리 앤드 캄파니 |
선택적 vpac2 수용체 펩티드 작동제
|
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
|
CA2913805A1
(en)
|
2005-11-07 |
2007-05-18 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
WO2007075534A2
(en)
*
|
2005-12-16 |
2007-07-05 |
Nektar Therapeutics Al, Corporation |
Polymer conjugates of glp-1
|
|
EP2007804B1
(en)
*
|
2006-04-20 |
2014-06-18 |
Amgen, Inc |
Glp-1 compounds
|
|
CN101516388B
(zh)
|
2006-07-21 |
2012-10-31 |
诺和诺德公司 |
通过o-联糖基化序列的肽的糖基化
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
CN101125207B
(zh)
|
2006-11-14 |
2012-09-05 |
上海华谊生物技术有限公司 |
带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途
|
|
US8617531B2
(en)
*
|
2006-12-14 |
2013-12-31 |
Bolder Biotechnology, Inc. |
Methods of making proteins and peptides containing a single free cysteine
|
|
JP2008169195A
(ja)
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
|
CN101578102B
(zh)
*
|
2007-01-05 |
2013-07-17 |
印第安纳大学研究及科技有限公司 |
在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物
|
|
NZ578948A
(en)
|
2007-02-15 |
2012-03-30 |
Univ Indiana Res & Tech Corp |
Glucagon/glp-1 receptor co-agonists
|
|
EP2144923B1
(en)
|
2007-04-03 |
2013-02-13 |
BioGeneriX AG |
Methods of treatment using glycopegylated g-csf
|
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
|
BRPI0813139A8
(pt)
|
2007-06-19 |
2019-01-29 |
Glytech Inc |
peptídeo glp-1 com adição de cadeia oligossacarídea
|
|
EP2190872B1
(en)
*
|
2007-09-05 |
2018-03-14 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
|
US20100261637A1
(en)
|
2007-09-05 |
2010-10-14 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
US20100292133A1
(en)
|
2007-09-05 |
2010-11-18 |
Novo Nordisk A/S |
Truncated glp-1 derivaties and their therapeutical use
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
CA2707861A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
US20110065633A1
(en)
|
2008-01-30 |
2011-03-17 |
Indiana University Research And Technology Corporation |
Ester-based peptide prodrugs
|
|
US20130189239A1
(en)
|
2008-02-27 |
2013-07-25 |
Novo Nordisk A/S |
Conjugated Factor VIII Molecules
|
|
TWI541023B
(zh)
|
2008-06-17 |
2016-07-11 |
印第安納大學科技研究公司 |
在生理ph緩衝液中呈現增強之溶解度及穩定性之升糖激素類似物
|
|
ES2558842T3
(es)
*
|
2008-06-17 |
2016-02-09 |
Indiana University Research And Technology Corporation |
Agonistas mixtos a base de GIP para el tratamiento de trastornos metabólicos y obesidad
|
|
CA2728284C
(en)
|
2008-06-17 |
2019-09-10 |
Richard D. Dimarchi |
Glucagon/glp-1 receptor co-agonists
|
|
IT1392655B1
(it)
*
|
2008-11-20 |
2012-03-16 |
Bio Ker S R L |
Site-specific monoconjugated insulinotropic glp-1 peptides.
|
|
US8697632B2
(en)
|
2008-12-19 |
2014-04-15 |
Indiana University Research And Technology Corporation |
Amide based insulin prodrugs
|
|
JP2012512898A
(ja)
*
|
2008-12-19 |
2012-06-07 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
ジペプチド結合薬用剤
|
|
EP2376097A4
(en)
|
2008-12-19 |
2012-10-03 |
Univ Indiana Res & Tech Corp |
PEPTIDE PRODRUGS OF AMIDE-BASED GLUCAGON SUPERFAMILY
|
|
JP5789515B2
(ja)
|
2008-12-19 |
2015-10-07 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン類似体
|
|
JP5759976B2
(ja)
*
|
2009-03-20 |
2015-08-05 |
ハンミ・サイエンス・カンパニー・リミテッド |
位置特異的な生理活性ポリペプチド結合体の調製方法
|
|
CN101870728A
(zh)
*
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
WO2010148089A1
(en)
|
2009-06-16 |
2010-12-23 |
Indiana University Research And Technology Corporation |
Gip receptor-active glucagon compounds
|
|
CA2778890A1
(en)
|
2009-10-30 |
2011-05-05 |
Otsuka Chemical Co., Ltd. |
Glycosylated form of antigenic glp-1 analogue
|
|
US20120329711A1
(en)
|
2009-12-16 |
2012-12-27 |
Nordisk A/S |
Glp-1 receptor agonist compounds with a modified n-terminus
|
|
WO2011075393A2
(en)
|
2009-12-18 |
2011-06-23 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
KR20120123443A
(ko)
|
2010-01-27 |
2012-11-08 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
대사 장애 및 비만 치료용 글루카곤 길항제-gip 항진제 콘쥬게이트
|
|
RU2012153753A
(ru)
|
2010-05-13 |
2014-06-20 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептиды глюкагонового суперсемейства, обладающие активностью в отношении сопряженных с g-белком рецепторов
|
|
ES2661228T3
(es)
|
2010-05-13 |
2018-03-28 |
Indiana University Research And Technology Corporation |
Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona
|
|
WO2011143788A1
(en)
*
|
2010-05-17 |
2011-11-24 |
Zhejiang Beta Pharma Inc. |
Novel glucagon like peptide analogs, composition, and method of use
|
|
JP5969469B2
(ja)
|
2010-06-16 |
2016-08-17 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト
|
|
CA2803164C
(en)
|
2010-06-24 |
2018-08-21 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
|
US8778872B2
(en)
|
2010-06-24 |
2014-07-15 |
Indiana University Research And Technology Corporation |
Amide based glucagon superfamily peptide prodrugs
|
|
CN102397558B
(zh)
*
|
2010-09-09 |
2013-08-14 |
中国人民解放军军事医学科学院毒物药物研究所 |
Exendin-4类似物的定位聚乙二醇化修饰物及其用途
|
|
WO2012054822A1
(en)
|
2010-10-22 |
2012-04-26 |
Nektar Therapeutics |
Pharmacologically active polymer-glp-1 conjugates
|
|
CN105748402B
(zh)
|
2010-11-24 |
2022-06-03 |
杜雷科特公司 |
生物可降解的药物递送组合物
|
|
MX377589B
(es)
|
2010-12-16 |
2025-03-10 |
Novo Nordisk As |
Composiciones sólidas que comprenden agonista de glp-1 y sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico.
|
|
NZ612297A
(en)
|
2010-12-22 |
2015-10-30 |
Univ Indiana Res & Tech Corp |
Glucagon analogs exhibiting gip receptor activity
|
|
CN102718858B
(zh)
*
|
2011-03-29 |
2014-07-02 |
天津药物研究院 |
胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
|
|
CN106928341B
(zh)
*
|
2011-03-30 |
2021-06-01 |
上海仁会生物制药股份有限公司 |
定点单取代聚乙二醇化Exendin类似物及其制备方法
|
|
AU2012241894B2
(en)
|
2011-04-12 |
2015-12-03 |
Novo Nordisk A/S |
Double-acylated GLP-1 derivatives
|
|
CN102180963B
(zh)
*
|
2011-04-22 |
2014-06-25 |
中国药科大学 |
胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN102766204B
(zh)
*
|
2011-05-05 |
2014-10-15 |
天津药物研究院 |
胰高血糖素样肽-1突变体多肽及其制备方法和其应用
|
|
CN102786590A
(zh)
*
|
2011-05-19 |
2012-11-21 |
江苏豪森药业股份有限公司 |
分枝型peg修饰的glp-1类似物及其可药用盐
|
|
JP6184404B2
(ja)
|
2011-06-22 |
2017-08-23 |
インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション |
グルカゴン/glp−1レセプターコアゴニスト
|
|
CN103857408B
(zh)
|
2011-06-22 |
2017-04-12 |
印第安那大学科技研究公司 |
胰高血糖素/glp‑1受体协同激动剂
|
|
CN102321170B
(zh)
*
|
2011-09-14 |
2013-11-13 |
深圳翰宇药业股份有限公司 |
利拉鲁肽变构体及其缀合物
|
|
BR112014007124A2
(pt)
|
2011-11-17 |
2017-06-13 |
Univ Indiana Res & Tech Corp |
superfamília de peptídeos gluxagon que exibem atividade no receptor glicocorticóide
|
|
TW201334791A
(zh)
|
2011-11-23 |
2013-09-01 |
杜瑞克公司 |
輻射滅菌之可生物降解之藥物遞送組合物
|
|
CN104114183A
(zh)
|
2011-12-20 |
2014-10-22 |
印第安纳大学研究及科技有限公司 |
用于治疗糖尿病的基于ctp的胰岛素类似物
|
|
ES2715308T3
(es)
|
2012-03-22 |
2019-06-03 |
Novo Nordisk As |
Composiciones que comprenden un agente de suministro y su preparación
|
|
KR102072202B1
(ko)
|
2012-03-22 |
2020-01-31 |
노보 노르디스크 에이/에스 |
Glp-1 펩티드의 조성물 및 그것의 제조
|
|
EP2851429B1
(en)
|
2012-05-18 |
2019-07-24 |
Adda Biotech Inc. |
Protein and protein conjugate for diabetes treatment, and applications thereof
|
|
WO2013189988A1
(en)
|
2012-06-20 |
2013-12-27 |
Novo Nordisk A/S |
Tablet formulation comprising a peptide and a delivery agent
|
|
ES2602486T3
(es)
|
2012-06-21 |
2017-02-21 |
Indiana University Research And Technology Corporation |
Análogos de glucagón que muestran actividad de receptor de GIP
|
|
CN108383902A
(zh)
|
2012-09-26 |
2018-08-10 |
印第安纳大学研究及科技有限公司 |
胰岛素类似物二聚体
|
|
CN103087177A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
一类长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087179A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087175A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
新型长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087176A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087178A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
JP6538645B2
(ja)
|
2013-03-14 |
2019-07-03 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン‐インクレチン複合物
|
|
RS58039B1
(sr)
|
2013-05-02 |
2019-02-28 |
Novo Nordisk As |
Oralno doziranje glp-1 jedinjenja
|
|
AU2014283221A1
(en)
|
2013-06-20 |
2015-12-03 |
Novo Nordisk A/S |
GLP-1 derivatives and uses thereof
|
|
JP6139712B2
(ja)
|
2013-07-04 |
2017-05-31 |
ノヴォ ノルディスク アー/エス |
Glp−1様ペプチドの誘導体及びその使用
|
|
WO2015081891A1
(en)
|
2013-12-06 |
2015-06-11 |
Baikang (Suzhou) Co., Ltd |
Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
|
|
WO2015088990A1
(en)
|
2013-12-09 |
2015-06-18 |
Durect Corporation |
Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
|
|
CN108271356A
(zh)
|
2014-09-24 |
2018-07-10 |
印第安纳大学研究及科技有限公司 |
肠降血糖素-胰岛素缀合物
|
|
EP3197912B1
(en)
|
2014-09-24 |
2023-01-04 |
Indiana University Research & Technology Corporation |
Lipidated amide-based insulin prodrugs
|
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
|
JP6730278B2
(ja)
|
2014-11-27 |
2020-07-29 |
ノヴォ ノルディスク アー/エス |
Glp−1誘導体及びその使用
|
|
US20160151511A1
(en)
|
2014-12-02 |
2016-06-02 |
Antriabio, Inc. |
Proteins and protein conjugates with increased hydrophobicity
|
|
EP3233898A1
(en)
|
2014-12-17 |
2017-10-25 |
Novo Nordisk A/S |
Glp-1 derivatives and uses thereof
|
|
KR102291020B1
(ko)
|
2014-12-30 |
2021-08-20 |
한미약품 주식회사 |
안정성이 증가된 글루카곤 유도체
|
|
WO2016196017A1
(en)
|
2015-06-04 |
2016-12-08 |
Antriabio, Inc. |
Amine pegylation methods for the preparation of site-specific protein conjugates
|
|
FI3322437T3
(fi)
|
2015-06-30 |
2024-02-20 |
Hanmi Pharmaceutical Co Ltd |
Glukagonijohdannainen ja sen pitkävaikutteisen konjugaatin käsittävä koostumus
|
|
JP6712323B2
(ja)
*
|
2015-12-31 |
2020-06-17 |
ハンミ ファーマシューティカル カンパニー リミテッド |
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|
|
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(zh)
*
|
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|
|
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(zh)
|
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|
|
AR114353A1
(es)
|
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2020-08-26 |
Novo Nordisk As |
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|
|
EP3891176B1
(en)
|
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|
|
WO2020214012A1
(ko)
*
|
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|
|
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(ko)
*
|
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|
|
US20210187077A1
(en)
*
|
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|
|
US12233115B2
(en)
|
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|