CO5611157A2 - Compuestos glp-1 unidos a polietilenglicol - Google Patents
Compuestos glp-1 unidos a polietilenglicolInfo
- Publication number
- CO5611157A2 CO5611157A2 CO05092631A CO05092631A CO5611157A2 CO 5611157 A2 CO5611157 A2 CO 5611157A2 CO 05092631 A CO05092631 A CO 05092631A CO 05092631 A CO05092631 A CO 05092631A CO 5611157 A2 CO5611157 A2 CO 5611157A2
- Authority
- CO
- Colombia
- Prior art keywords
- glp
- compound
- lys
- amino acid
- pegylated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
1.- Un compuesto GLP-1 PEGilado que comprende un compuesto GLP-1 unido covalentemente a al menos una molécula de PEG, en el que cada PEG está unido al compuesto por un aminoácido Cys o Lys o al aminoácido carboxi terminal y en el que el compuesto GLP-1 PEGilado tiene una semivida de eliminación de al menos una hora.2.- Un compuesto GLP-1 PEGilado que comprende la secuencia de aminoácidos de GLP-1 (7-37)OH como se muestra en SEC.lD.N° 1 unido covalentemente a una molécula de PEG por 3, 2, ó 1 de los restos seleccionados entre el grupo constituido por Lys en la posición 26 y Lys en la posición 34 y Gly en la posición 37.3.- Un compuesto GLP-1 PEGilado que comprende la secuencia de aminoácidos de GLP-1 (7-36)OH como se muestra en SEC.lD.N° 2 unido covalentemente a una molécula de PEG por 3, 2 ó 1 de los restos seleccionados entre el grupo constituido por Lys en la posición 26 y Lys en la posición 34 y Arg en la posición 36.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45608103P | 2003-03-19 | 2003-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5611157A2 true CO5611157A2 (es) | 2006-02-28 |
Family
ID=33310655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO05092631A CO5611157A2 (es) | 2003-03-19 | 2005-09-13 | Compuestos glp-1 unidos a polietilenglicol |
Country Status (25)
Country | Link |
---|---|
US (1) | US7557183B2 (es) |
EP (1) | EP1605897B1 (es) |
JP (1) | JP2006520818A (es) |
KR (1) | KR100733940B1 (es) |
CN (1) | CN1832959A (es) |
AU (1) | AU2004231461B2 (es) |
BR (1) | BRPI0407936A (es) |
CA (1) | CA2518336A1 (es) |
CO (1) | CO5611157A2 (es) |
CR (1) | CR7997A (es) |
CY (1) | CY1114035T1 (es) |
DK (1) | DK1605897T3 (es) |
EA (1) | EA009366B1 (es) |
EC (1) | ECSP056025A (es) |
ES (1) | ES2390270T3 (es) |
HR (1) | HRP20050683A2 (es) |
MX (1) | MXPA05009940A (es) |
NO (1) | NO20054310L (es) |
NZ (1) | NZ541534A (es) |
PL (1) | PL1605897T3 (es) |
PT (1) | PT1605897E (es) |
SI (1) | SI1605897T1 (es) |
UA (1) | UA92451C2 (es) |
WO (1) | WO2004093823A2 (es) |
ZA (1) | ZA200506881B (es) |
Families Citing this family (116)
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RU2006120079A (ru) | 2003-12-18 | 2008-01-27 | Ново Нордиск А/С (DK) | Производные глюкагоноподобного пептида-1 (glp-1) |
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- 2004-03-19 NZ NZ541534A patent/NZ541534A/en not_active IP Right Cessation
- 2004-03-19 US US10/548,328 patent/US7557183B2/en not_active Expired - Fee Related
- 2004-03-19 WO PCT/US2004/006082 patent/WO2004093823A2/en active Application Filing
- 2004-03-19 DK DK04722142.9T patent/DK1605897T3/da active
- 2004-03-19 MX MXPA05009940A patent/MXPA05009940A/es active IP Right Grant
- 2004-03-19 CN CNA2004800074368A patent/CN1832959A/zh active Pending
- 2004-03-19 JP JP2006508916A patent/JP2006520818A/ja active Pending
- 2004-03-19 PT PT04722142T patent/PT1605897E/pt unknown
- 2004-03-19 KR KR1020057017465A patent/KR100733940B1/ko not_active IP Right Cessation
- 2004-03-19 CA CA002518336A patent/CA2518336A1/en not_active Abandoned
- 2004-03-19 UA UAA200508688A patent/UA92451C2/ru unknown
- 2004-03-19 EP EP04722142A patent/EP1605897B1/en not_active Expired - Lifetime
- 2004-03-19 EA EA200501482A patent/EA009366B1/ru not_active IP Right Cessation
- 2004-03-19 PL PL04722142T patent/PL1605897T3/pl unknown
- 2004-03-19 SI SI200431937T patent/SI1605897T1/sl unknown
- 2004-03-19 ES ES04722142T patent/ES2390270T3/es not_active Expired - Lifetime
- 2004-03-19 BR BRPI0407936-1A patent/BRPI0407936A/pt not_active IP Right Cessation
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- 2005-09-19 CR CR7997A patent/CR7997A/es unknown
- 2005-09-19 NO NO20054310A patent/NO20054310L/no not_active Application Discontinuation
- 2005-09-19 EC EC2005006025A patent/ECSP056025A/es unknown
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AU2004231461B2 (en) | 2009-11-12 |
ZA200506881B (en) | 2006-11-29 |
KR100733940B1 (ko) | 2007-06-29 |
JP2006520818A (ja) | 2006-09-14 |
CA2518336A1 (en) | 2004-11-04 |
CY1114035T1 (el) | 2016-07-27 |
EA200501482A1 (ru) | 2006-06-30 |
US20080113905A1 (en) | 2008-05-15 |
MXPA05009940A (es) | 2005-12-05 |
NZ541534A (en) | 2008-05-30 |
EA009366B1 (ru) | 2007-12-28 |
AU2004231461A1 (en) | 2004-11-04 |
EP1605897A4 (en) | 2010-08-04 |
ES2390270T3 (es) | 2012-11-08 |
WO2004093823A2 (en) | 2004-11-04 |
BRPI0407936A (pt) | 2006-02-21 |
ECSP056025A (es) | 2006-01-27 |
NO20054310D0 (no) | 2005-09-19 |
CR7997A (es) | 2008-11-28 |
NO20054310L (no) | 2005-11-16 |
PL1605897T3 (pl) | 2012-12-31 |
HRP20050683A2 (en) | 2006-07-31 |
SI1605897T1 (sl) | 2012-11-30 |
KR20050111386A (ko) | 2005-11-24 |
PT1605897E (pt) | 2012-09-10 |
EP1605897A2 (en) | 2005-12-21 |
WO2004093823A3 (en) | 2005-12-22 |
UA92451C2 (en) | 2010-11-10 |
DK1605897T3 (da) | 2012-08-20 |
EP1605897B1 (en) | 2012-07-25 |
CN1832959A (zh) | 2006-09-13 |
US7557183B2 (en) | 2009-07-07 |
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