ECSP056025A - Compuestos glp-1 unidos a polietilenglicol - Google Patents
Compuestos glp-1 unidos a polietilenglicolInfo
- Publication number
- ECSP056025A ECSP056025A EC2005006025A ECSP056025A ECSP056025A EC SP056025 A ECSP056025 A EC SP056025A EC 2005006025 A EC2005006025 A EC 2005006025A EC SP056025 A ECSP056025 A EC SP056025A EC SP056025 A ECSP056025 A EC SP056025A
- Authority
- EC
- Ecuador
- Prior art keywords
- glp
- compounds
- polyethylene glycol
- less
- peg
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención descrita en este documento proporciona compuestos GLP-1 unidos covalentemente a una o más moléculas de polietilenglicol (PEG), o un derivado del mismo donde cada PEG está unido a un aminoácido Cys o Lys o al carboxi terminal del péptido, dando como resultado compuestos GLP-1 PEGilados con una semivida de eliminación de al menos una hora, preferiblemente al menos 3, 5, 7, 10, 15, 20 horas y más preferiblemente al menos 24 horas. Los compuestos GLP-1 PEGilados de la presente invención tienen preferiblemente un valor de eliminación de 200 ml/h/kg o menos, más preferiblemente 180, 150, 120, 100, 80, 60 ml/h/kg o menos y mucho más preferiblemente menos de 50, 40 o 20 ml/h/kg.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45608103P | 2003-03-19 | 2003-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP056025A true ECSP056025A (es) | 2006-01-27 |
Family
ID=33310655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005006025A ECSP056025A (es) | 2003-03-19 | 2005-09-19 | Compuestos glp-1 unidos a polietilenglicol |
Country Status (25)
Country | Link |
---|---|
US (1) | US7557183B2 (es) |
EP (1) | EP1605897B1 (es) |
JP (1) | JP2006520818A (es) |
KR (1) | KR100733940B1 (es) |
CN (1) | CN1832959A (es) |
AU (1) | AU2004231461B2 (es) |
BR (1) | BRPI0407936A (es) |
CA (1) | CA2518336A1 (es) |
CO (1) | CO5611157A2 (es) |
CR (1) | CR7997A (es) |
CY (1) | CY1114035T1 (es) |
DK (1) | DK1605897T3 (es) |
EA (1) | EA009366B1 (es) |
EC (1) | ECSP056025A (es) |
ES (1) | ES2390270T3 (es) |
HR (1) | HRP20050683A2 (es) |
MX (1) | MXPA05009940A (es) |
NO (1) | NO20054310L (es) |
NZ (1) | NZ541534A (es) |
PL (1) | PL1605897T3 (es) |
PT (1) | PT1605897E (es) |
SI (1) | SI1605897T1 (es) |
UA (1) | UA92451C2 (es) |
WO (1) | WO2004093823A2 (es) |
ZA (1) | ZA200506881B (es) |
Families Citing this family (116)
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US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
WO2006127896A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated factor ix |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
DE602004026113D1 (de) | 2003-12-18 | 2010-04-29 | Novo Nordisk As | Glp-1-verbindungen |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
WO2006097538A1 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Extended glp-1 compounds |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド1(glp−1)受容体アンタゴニストおよびそれらの薬理学的使用方法 |
ES2350852T3 (es) * | 2005-05-13 | 2011-01-27 | Eli Lilly And Company | Compuestos glp-1 pegilados. |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
CA2627716A1 (en) * | 2005-10-26 | 2007-05-03 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
WO2007056362A2 (en) | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
US8293869B2 (en) | 2005-12-16 | 2012-10-23 | Nektar Therapeutics | Polymer conjugates of GLP-1 |
MX2008013304A (es) * | 2006-04-20 | 2008-10-27 | Amgen Inc | Compuestos de peptido 1 tipo glucagon. |
JP2009544327A (ja) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー/エス | O−結合型グリコシル化配列によるペプチドのグリコシル化 |
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JP2005508895A (ja) * | 2001-08-28 | 2005-04-07 | イーライ・リリー・アンド・カンパニー | Glp−1および基礎インスリンの予備混合物 |
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AU2003200839B2 (en) | 2002-01-08 | 2008-12-11 | Eli Lilly And Company | Extended glucagon-like peptide-1 analogs |
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2004
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- 2004-03-19 ES ES04722142T patent/ES2390270T3/es not_active Expired - Lifetime
- 2004-03-19 PT PT04722142T patent/PT1605897E/pt unknown
- 2004-03-19 EA EA200501482A patent/EA009366B1/ru not_active IP Right Cessation
- 2004-03-19 DK DK04722142.9T patent/DK1605897T3/da active
- 2004-03-19 EP EP04722142A patent/EP1605897B1/en not_active Expired - Lifetime
- 2004-03-19 CA CA002518336A patent/CA2518336A1/en not_active Abandoned
- 2004-03-19 PL PL04722142T patent/PL1605897T3/pl unknown
- 2004-03-19 MX MXPA05009940A patent/MXPA05009940A/es active IP Right Grant
- 2004-03-19 JP JP2006508916A patent/JP2006520818A/ja active Pending
- 2004-03-19 UA UAA200508688A patent/UA92451C2/ru unknown
- 2004-03-19 KR KR1020057017465A patent/KR100733940B1/ko not_active IP Right Cessation
- 2004-03-19 SI SI200431937T patent/SI1605897T1/sl unknown
- 2004-03-19 NZ NZ541534A patent/NZ541534A/en not_active IP Right Cessation
- 2004-03-19 CN CNA2004800074368A patent/CN1832959A/zh active Pending
- 2004-03-19 AU AU2004231461A patent/AU2004231461B2/en not_active Ceased
- 2004-03-19 US US10/548,328 patent/US7557183B2/en not_active Expired - Fee Related
- 2004-03-19 BR BRPI0407936-1A patent/BRPI0407936A/pt not_active IP Right Cessation
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2005
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- 2005-09-13 CO CO05092631A patent/CO5611157A2/es unknown
- 2005-09-19 EC EC2005006025A patent/ECSP056025A/es unknown
- 2005-09-19 CR CR7997A patent/CR7997A/es unknown
- 2005-09-19 NO NO20054310A patent/NO20054310L/no not_active Application Discontinuation
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2012
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CR7997A (es) | 2008-11-28 |
NO20054310D0 (no) | 2005-09-19 |
ZA200506881B (en) | 2006-11-29 |
EA200501482A1 (ru) | 2006-06-30 |
EP1605897A4 (en) | 2010-08-04 |
EP1605897A2 (en) | 2005-12-21 |
BRPI0407936A (pt) | 2006-02-21 |
WO2004093823A2 (en) | 2004-11-04 |
US20080113905A1 (en) | 2008-05-15 |
UA92451C2 (en) | 2010-11-10 |
SI1605897T1 (sl) | 2012-11-30 |
MXPA05009940A (es) | 2005-12-05 |
NZ541534A (en) | 2008-05-30 |
HRP20050683A2 (en) | 2006-07-31 |
CN1832959A (zh) | 2006-09-13 |
CO5611157A2 (es) | 2006-02-28 |
ES2390270T3 (es) | 2012-11-08 |
US7557183B2 (en) | 2009-07-07 |
AU2004231461A1 (en) | 2004-11-04 |
KR100733940B1 (ko) | 2007-06-29 |
EP1605897B1 (en) | 2012-07-25 |
NO20054310L (no) | 2005-11-16 |
KR20050111386A (ko) | 2005-11-24 |
PT1605897E (pt) | 2012-09-10 |
AU2004231461B2 (en) | 2009-11-12 |
JP2006520818A (ja) | 2006-09-14 |
PL1605897T3 (pl) | 2012-12-31 |
WO2004093823A3 (en) | 2005-12-22 |
DK1605897T3 (da) | 2012-08-20 |
CA2518336A1 (en) | 2004-11-04 |
CY1114035T1 (el) | 2016-07-27 |
EA009366B1 (ru) | 2007-12-28 |
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