BR112015030948A2 - Derivados de glp-1 e usos dos mesmos - Google Patents

Derivados de glp-1 e usos dos mesmos

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Publication number
BR112015030948A2
BR112015030948A2 BR112015030948A BR112015030948A BR112015030948A2 BR 112015030948 A2 BR112015030948 A2 BR 112015030948A2 BR 112015030948 A BR112015030948 A BR 112015030948A BR 112015030948 A BR112015030948 A BR 112015030948A BR 112015030948 A2 BR112015030948 A2 BR 112015030948A2
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derivatives
glp
linker
analogue
relates
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BR112015030948A
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English (en)
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Reedtz-Runge Steffen
Sauerberg Per
Kofoed Jacob
Pettersson Ingrid
Wenzel Tornoe Christian
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Novo Nordisk As
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Publication of BR112015030948A2 publication Critical patent/BR112015030948A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Abstract

DERIVADOS DE GLP-1 E USOS DOS MESMOS. A presente invenção refere-se a um derivado de um análogo de GLP-1, opcionalmente C-terminalmente estendido, cujo derivado compreende uma primeira e uma segunda porção de prolongamento na forma de um radical de diácido C20 ou C22, um ligador ramificado de bis-amino, e um primeiro e um segundo outro ligador cada compreendendo um elemento ligador tipo OEG; em que estes elementos são interconectados por meio de ligações de amida e ligados a um resíduo Lys do análogo de GLP-1. A invenção também se refere aos produtos intermediários na forma de novos análogos de GLP-1 incorporados nos derivados da invenção, bem como composições farmacêuticas e usos médicos dos derivados. Os derivados têm meias-vidas muito longas, ao mesmo tempo em que, mantendo uma potência satisfatória, os torna potencialmente adequados para administração uma vez ao mês.
BR112015030948A 2013-06-20 2014-06-19 Derivados de glp-1 e usos dos mesmos BR112015030948A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13173068 2013-06-20
US201361841995P 2013-07-02 2013-07-02
EP13175092 2013-07-04
US201361845647P 2013-07-12 2013-07-12
PCT/EP2014/062952 WO2014202727A1 (en) 2013-06-20 2014-06-19 Glp-1 derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BR112015030948A2 true BR112015030948A2 (pt) 2017-09-19

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Country Status (11)

Country Link
US (1) US10195255B2 (pt)
EP (1) EP3010546B1 (pt)
JP (1) JP6475233B2 (pt)
KR (1) KR20160021183A (pt)
CN (1) CN105377306B (pt)
AU (1) AU2014283221A1 (pt)
BR (1) BR112015030948A2 (pt)
CA (1) CA2915922A1 (pt)
ES (1) ES2646538T3 (pt)
MX (1) MX2015016564A (pt)
WO (1) WO2014202727A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2915922A1 (en) 2013-06-20 2014-12-24 Novo Nordisk A/S Glp-1 derivatives and uses thereof
EP3226906B1 (en) 2014-11-27 2019-06-12 Novo Nordisk A/S Glp-1 derivatives and uses thereof
WO2016097108A1 (en) * 2014-12-17 2016-06-23 Novo Nordisk A/S Glp-1 derivatives and uses thereof
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
LT3393496T (lt) 2015-12-23 2023-12-11 The Johns Hopkins University Ilgo veikimo glp-1r agonistas, kaip neurologinių ir neurodegeneracinių būklių terapija
CN106928343A (zh) * 2015-12-30 2017-07-07 深圳翰宇药业股份有限公司 索玛鲁肽的制备方法
EP3423481B1 (en) 2016-03-03 2020-10-07 Novo Nordisk A/S Glp-1 derivatives and uses thereof
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018113340A1 (zh) * 2016-12-20 2018-06-28 中国药科大学 多肽p11及其用途
DK3774862T3 (da) 2018-04-05 2022-09-05 Sun Pharmaceutical Ind Ltd Nye GLP-1-analoger
WO2019243502A1 (en) * 2018-06-21 2019-12-26 Novo Nordisk A/S Novel compounds for treatment of obesity
CN113226351A (zh) 2018-10-22 2021-08-06 詹森药业有限公司 胰高血糖素样肽1(glp1)-生长分化因子15(gdf15)融合蛋白及其用途
WO2020118843A1 (zh) * 2018-12-12 2020-06-18 四川利通科创生物医药科技有限公司 一种glp-1突变体及其制备方法和用途
CN110590934B (zh) * 2019-09-25 2020-12-08 北京乐普医药科技有限公司 一种glp-1化合物
CN111253475B (zh) * 2020-02-18 2021-03-09 江苏诺泰澳赛诺生物制药股份有限公司 Glp-1激动多肽化合物及其盐与合成方法及用途
CN115925995A (zh) 2020-09-30 2023-04-07 北京质肽生物医药科技有限公司 多肽缀合物和使用方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1060191B1 (en) 1998-02-27 2010-04-28 Novo Nordisk A/S Derivatives of glp-1 analogs
ES2315226T3 (es) 1999-03-17 2009-04-01 Novo Nordisk A/S Metodo de acilacion de peptidos y proteinas.
AU1269501A (en) 1999-11-12 2001-05-30 Novo Nordisk A/S Use of glp-1 agonists for the inhibition of beta cell degeneration
GB0020551D0 (en) 2000-08-22 2000-10-11 Birkett David Sprinkler system
WO2003058203A2 (en) * 2002-01-08 2003-07-17 Eli Lilly And Company Extended glucagon-like peptide-1 analogs
KR100733940B1 (ko) 2003-03-19 2007-06-29 일라이 릴리 앤드 캄파니 폴리에틸렌 글리콜이 연결된 ｇｌｐ-1 화합물
SE525666C2 (sv) * 2003-07-07 2005-03-29 Atlas Copco Tools Ab Metod för kvalitetssäkring av skruvförbandsåtdragning
WO2005027978A2 (en) 2003-09-19 2005-03-31 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
CN100444898C (zh) * 2003-09-19 2008-12-24 诺沃挪第克公司 治疗肽的清蛋白结合型衍生物
WO2006037810A2 (en) 2004-10-07 2006-04-13 Novo Nordisk A/S Protracted glp-1 compounds
TWI362392B (en) * 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
MX2007011307A (es) 2005-03-18 2007-10-08 Novo Nordisk As Compuestos de glp-1 extendidos.
KR101011081B1 (ko) 2005-05-13 2011-01-25 일라이 릴리 앤드 캄파니 Ｐｅｇ화된 ｇｌｐ-1 화합물
CN101868476B (zh) * 2007-09-05 2015-02-25 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途
JP5606314B2 (ja) * 2007-09-05 2014-10-15 ノボ・ノルデイスク・エー／エス Ａ−ｂ−ｃ−ｄ−で誘導体化されたペプチドとその治療用途
WO2010142665A1 (en) 2009-06-11 2010-12-16 Novo Nordisk A/S Glp-1 and fgf21 combinations for treatment of diabetes type 2
KR101817607B1 (ko) * 2009-12-16 2018-01-11 노보 노르디스크 에이/에스 이중 아실화된 ｇｌｐ―１ 유도체
US20130143798A1 (en) 2010-03-26 2013-06-06 Novo Nordisk A/S Novel glucagon analogues
US20130137645A1 (en) 2010-07-19 2013-05-30 Mary S. Rosendahl Modified peptides and proteins
CN105601729A (zh) 2010-11-09 2016-05-25 诺沃—诺迪斯克有限公司 双-酰化的glp-1衍生物
CN103458920B (zh) * 2010-12-22 2016-07-06 印第安那大学科技研究公司 表现出gip受体活性的胰高血糖素类似物
ES2612278T3 (es) 2011-04-12 2017-05-16 Novo Nordisk A/S Derivados de GLP-1 doble-acilados
US20140220134A1 (en) 2011-06-24 2014-08-07 Astrazeneca Pharamceuticals LP Method for treating diabetes with extended release formulation of glp-1 receptor agonists
JP6352806B2 (ja) 2011-09-23 2018-07-04 ノヴォ ノルディスク アー／エス 新規のグルカゴン類似体
WO2013167454A1 (en) 2012-05-08 2013-11-14 Novo Nordisk A/S Double-acylated glp-1 derivatives
CA2915922A1 (en) 2013-06-20 2014-12-24 Novo Nordisk A/S Glp-1 derivatives and uses thereof
US9498534B2 (en) 2013-07-04 2016-11-22 Novo Nordisk A/S Derivatives of GLP-1 like peptides, and uses thereof
EP3226906B1 (en) 2014-11-27 2019-06-12 Novo Nordisk A/S Glp-1 derivatives and uses thereof
WO2016097108A1 (en) 2014-12-17 2016-06-23 Novo Nordisk A/S Glp-1 derivatives and uses thereof

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WO2014202727A1 (en) 2014-12-24
MX2015016564A (es) 2016-04-15
CN105377306A (zh) 2016-03-02
AU2014283221A1 (en) 2015-12-03
ES2646538T3 (es) 2017-12-14
US20160143998A1 (en) 2016-05-26
US10195255B2 (en) 2019-02-05
CA2915922A1 (en) 2014-12-24
JP6475233B2 (ja) 2019-02-27
JP2016523243A (ja) 2016-08-08
EP3010546A1 (en) 2016-04-27
KR20160021183A (ko) 2016-02-24
CN105377306B (zh) 2020-03-17

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