CO6690765A2 - Profármacos que comprenden un conjugado de conector de exendina - Google Patents
Profármacos que comprenden un conjugado de conector de exendinaInfo
- Publication number
- CO6690765A2 CO6690765A2 CO13050270A CO13050270A CO6690765A2 CO 6690765 A2 CO6690765 A2 CO 6690765A2 CO 13050270 A CO13050270 A CO 13050270A CO 13050270 A CO13050270 A CO 13050270A CO 6690765 A2 CO6690765 A2 CO 6690765A2
- Authority
- CO
- Colombia
- Prior art keywords
- exendin
- prodrugs
- conjugate
- moiety
- connector conjugate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Abstract
La presente invención se refiere a un profármaco o una sal del mismo farmacéuticamente aceptable, que comprende un conjugado de exendina-conector D-L, en el que D representa un resto de exendina; y -L es un resto conector que no es biológicamente activo -Lrepresentado por la fórmula (I),en la que la línea de trazos indica la unión a uno de los grupos amino del resto de exendina formando un enlace amida. La invención se refiere además a composiciones farmacéuticas que comprenden dichos profármacos así como a su uso como un medicamento para tratar o prevenir enfermedades o trastornos que se pueden tratar mediante la exendina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10177327A EP2438930A1 (en) | 2010-09-17 | 2010-09-17 | Prodrugs comprising an exendin linker conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6690765A2 true CO6690765A2 (es) | 2013-06-17 |
Family
ID=43446651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13050270A CO6690765A2 (es) | 2010-09-17 | 2013-03-13 | Profármacos que comprenden un conjugado de conector de exendina |
Country Status (29)
Country | Link |
---|---|
US (1) | US9133276B2 (es) |
EP (2) | EP2438930A1 (es) |
JP (1) | JP5932796B2 (es) |
KR (1) | KR20130106820A (es) |
CN (1) | CN103237561B (es) |
AR (1) | AR082995A1 (es) |
AU (1) | AU2011303823B2 (es) |
BR (1) | BR112013006340A2 (es) |
CA (1) | CA2811352C (es) |
CL (1) | CL2013000716A1 (es) |
CO (1) | CO6690765A2 (es) |
CY (1) | CY1122226T1 (es) |
DK (1) | DK2616102T3 (es) |
ES (1) | ES2733734T3 (es) |
HR (1) | HRP20191128T1 (es) |
HU (1) | HUE044079T2 (es) |
IL (1) | IL225127A (es) |
LT (1) | LT2616102T (es) |
MA (1) | MA34517B1 (es) |
MX (1) | MX348983B (es) |
MY (1) | MY158974A (es) |
NZ (1) | NZ608387A (es) |
PL (1) | PL2616102T3 (es) |
PT (1) | PT2616102T (es) |
RU (1) | RU2593774C2 (es) |
SG (1) | SG188197A1 (es) |
SI (1) | SI2616102T1 (es) |
UY (1) | UY33605A (es) |
WO (1) | WO2012035139A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0507875B8 (pt) * | 2004-03-23 | 2021-05-25 | Complex Biosystems Gmbh | pró-fármaco de cascata polimérico |
SI2237799T1 (sl) * | 2008-02-01 | 2019-07-31 | Ascendis Pharma A/S | Predzdravilo, ki obsega samo-cepljiv linker |
DK2459171T3 (en) | 2009-07-31 | 2017-09-25 | Sanofi Aventis Deutschland | Long-acting insulin composition |
SI2459220T1 (sl) * | 2009-07-31 | 2020-12-31 | Ascendis Pharma A/S | Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola |
BR112012002168A2 (pt) | 2009-07-31 | 2016-05-31 | Sanofi Aventis Deutschland | profármacos compreendendo um conjugado ligador de insulina |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
AU2012322917B2 (en) * | 2011-10-12 | 2016-11-03 | Ascendis Pharma Ophthalmology Division A/S | Prevention and treatment of ocular conditions |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
AU2013366691A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 derivatives |
WO2015081891A1 (en) * | 2013-12-06 | 2015-06-11 | Baikang (Suzhou) Co., Ltd | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽-4(exendin-4)胜肽類似物 |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
CN104945499B (zh) * | 2014-03-31 | 2019-12-10 | 博瑞生物医药(苏州)股份有限公司 | 结构修饰的glp-1类似物及其制备方法 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
CN106554403B (zh) * | 2015-09-25 | 2021-08-31 | 博瑞生物医药(苏州)股份有限公司 | 艾塞那肽修饰物及其用途 |
MY196308A (en) | 2016-03-01 | 2023-03-24 | Ascendis Pharma Bone Diseases As | PTH Prodrugs |
EP4218795A3 (en) | 2016-09-29 | 2023-08-30 | Ascendis Pharma Bone Diseases A/S | Pth compounds with low peak-to-trough ratios |
AU2017336249A1 (en) | 2016-09-29 | 2019-03-21 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release PTH compound |
AR110299A1 (es) * | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
EP3335695B1 (en) * | 2016-12-15 | 2020-02-05 | UPM-Kymmene Corporation | A method for freeze-drying hydrogel comprising nanofibrillar cellulose, a freeze-dried medical hydrogel comprising nanofibrillar cellulose, and a hydrogel comprising nanofibrillar cellulose |
TWI783890B (zh) | 2017-08-24 | 2022-11-11 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
UY38249A (es) | 2018-05-30 | 2019-12-31 | Sanofi Sa | Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico |
US20220181034A1 (en) * | 2018-09-19 | 2022-06-09 | Georgia Tech Research Corporation | Self-titrating bacterial protease-activated prodrug |
KR20220143037A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 이의 용도 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
AU641631B2 (en) | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
PT93057B (pt) | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
US5634943A (en) | 1990-07-12 | 1997-06-03 | University Of Miami | Injectable polyethylene oxide gel implant and method for production |
CA2117588C (en) | 1992-02-28 | 1998-08-25 | Jeffrey A. Hubbell | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
DE19626762A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Enzymatisch spaltbare Linker für Festphasensynthesen |
US20020064546A1 (en) | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
RU2200161C2 (ru) | 1996-12-31 | 2003-03-10 | Др. Редди'З Рисерч Фаундейшн | Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение |
DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
DK1032587T4 (da) | 1997-11-14 | 2013-04-08 | Amylin Pharmaceuticals Llc | Hidtil ukendte exendinagonist-forbindelser |
JP2003522721A (ja) | 1997-11-14 | 2003-07-29 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 新規なエキセンジンアゴニスト化合物 |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
CA2312975C (en) | 1997-12-17 | 2012-08-21 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
ATE255422T1 (de) | 1998-01-07 | 2003-12-15 | Debio Rech Pharma Sa | Abbaubare, heterobifunktionelle polyethylenglykolacrylate, sowie damit herstellbare gele und konjugate |
ATE366115T1 (de) | 1998-02-13 | 2007-07-15 | Amylin Pharmaceuticals Inc | Inotropische und diuretische effekte von exendin und glp-1 |
AU6419899A (en) | 1998-10-09 | 2000-05-01 | Regents Of The University Of Michigan, The | Hydrogels and water soluble polymeric carriers for drug delivery |
WO2000033764A1 (en) | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Biocompatible crosslinked polymers |
CA2356706C (en) * | 1999-01-14 | 2014-09-30 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist formulations and methods of administration thereof |
AU773914B2 (en) | 1999-02-01 | 2004-06-10 | Eidgenossische Technische Hochschule Zurich | Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups |
EP1591453A1 (en) | 1999-05-17 | 2005-11-02 | ConjuChem Inc. | Modified peptides yy and conjugates thereof |
US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
JP2003503367A (ja) | 1999-06-11 | 2003-01-28 | シアウォーター・コーポレイション | キトサンとポリ(エチレングリコール)または関連ポリマーから得られるヒドロゲル |
US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
WO2001055360A1 (en) | 2000-01-28 | 2001-08-02 | Infimed Therapeutics, Inc. | Slow release protein polymers |
US6884778B2 (en) | 2000-04-14 | 2005-04-26 | William Marsh Rice University | Biocompatible macromers |
US7291673B2 (en) | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
JP4841066B2 (ja) | 2000-09-01 | 2011-12-21 | ライスユニバーシティ | 酸化窒素生成ヒドロゲル物質 |
US6537569B2 (en) | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
EP1423093A4 (en) | 2001-04-23 | 2005-11-30 | Wisconsin Alumni Res Found | BIFUNCTIONAL MODIFIED HYDROGEL |
AP1763A (en) | 2001-05-21 | 2007-08-02 | Nektar Therapeutics | Pulmonary administration of chemically modified insulin |
DE60132094T3 (de) | 2001-10-26 | 2012-02-02 | Octoplus Polyactive Sciences B.V. | Verfahren zur Herstellung von gereinigten Partikeln |
US6960298B2 (en) | 2001-12-10 | 2005-11-01 | Nanogen, Inc. | Mesoporous permeation layers for use on active electronic matrix devices |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
WO2003084926A2 (en) | 2002-04-04 | 2003-10-16 | Enzon, Inc. | Polymeric acyl derivatives of indoles |
DE10221457A1 (de) | 2002-05-15 | 2003-11-27 | Behr Gmbh & Co | Wärmeübertrager und Verfahren zu seiner Herstellung |
AU2003273272A1 (en) | 2002-06-03 | 2003-12-19 | Alinis Biosciences, Inc. | Therapeutic agent-containing polymeric nanoarticles |
CA2487077A1 (en) | 2002-06-10 | 2003-12-18 | Merck & Co., Inc. | Isolated nucleic acid molecule encoding a novel centromere-associated motor protein, and uses thereof |
US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
EP1560599A1 (en) | 2002-11-14 | 2005-08-10 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
SI1620118T1 (sl) | 2003-04-08 | 2014-11-28 | Yeda Research And Development Co., Ltd. | Reverzibilna pegilirana zdravila |
EP1525890A1 (en) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophore complexes |
BRPI0507875B8 (pt) | 2004-03-23 | 2021-05-25 | Complex Biosystems Gmbh | pró-fármaco de cascata polimérico |
EP1586334A1 (en) | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugates with peg |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
WO2006038462A1 (ja) | 2004-10-01 | 2006-04-13 | Kyushu University, National University Corporation | 新規ステロイド産生細胞 |
DE102004051715A1 (de) | 2004-10-23 | 2005-06-30 | Clariant Gmbh | Flüssigwaschmittel enthaltend Farbfixiermittel |
US7678551B2 (en) | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
US20060115865A1 (en) | 2004-10-25 | 2006-06-01 | Anlong Ouyang | Lamotrigine analogs |
US7407117B2 (en) | 2004-10-28 | 2008-08-05 | Meadwestvaco Calmar, Inc. | Liquid sprayer assembly |
JP2006163996A (ja) | 2004-12-09 | 2006-06-22 | Evolium Sas | 行動履歴に基づくプッシュ型の情報提供システム |
EP1838317A4 (en) | 2005-01-05 | 2012-02-29 | Univ Minnesota | ANALGESIC CONJUGATES |
KR100665672B1 (ko) | 2005-04-13 | 2007-01-09 | 성균관대학교산학협력단 | 새로운 온도 및 pH 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔 |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
US8039432B2 (en) | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
WO2007082088A2 (en) | 2006-01-12 | 2007-07-19 | Histogenics Corporation | Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries |
EP1840152B1 (en) | 2006-03-31 | 2009-07-08 | Sony Deutschland Gmbh | A method of forming a crosslinked polymer gel |
WO2007140312A2 (en) | 2006-05-25 | 2007-12-06 | The General Hospital Corporation | Anti-cross-linking agents and methods for inhibiting cross-linking of injectable hydrogel formulations |
US20090306337A1 (en) | 2006-07-31 | 2009-12-10 | Novo Nordisk A/S | Pegylated, Extended Insulins |
KR20090055623A (ko) | 2006-09-15 | 2009-06-02 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오티드 전달을 위한 방해된 에스테르 기재 생분해성 링커 |
AU2008214319A1 (en) * | 2007-02-06 | 2008-08-14 | Incept, Llc | Polymerization with precipitation of proteins for elution in physiological solution |
US20080220047A1 (en) | 2007-03-05 | 2008-09-11 | Sawhney Amarpreet S | Low-swelling biocompatible hydrogels |
WO2008116913A2 (en) | 2007-03-28 | 2008-10-02 | Novo Nordisk A/S | Peptide compounds with transient biodegradable pegylation |
EP2537539B1 (en) | 2007-04-13 | 2019-04-03 | Kuros Biosurgery AG | Polymeric Tissue Sealant |
WO2008148839A2 (en) * | 2007-06-08 | 2008-12-11 | Ascendis Pharma As | Long-acting polymeric prodrugs of exendin |
EP2170945A1 (en) | 2007-07-16 | 2010-04-07 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
SI2237799T1 (sl) | 2008-02-01 | 2019-07-31 | Ascendis Pharma A/S | Predzdravilo, ki obsega samo-cepljiv linker |
AU2009214615B2 (en) | 2008-02-13 | 2014-06-12 | Hyperbranch Medical Technology, Inc. | Crosslinked polyalkyleneimine hydrogels with tunable degradation rates |
JP2011518881A (ja) | 2008-04-28 | 2011-06-30 | ゾゲニクス インコーポレーティッド | 片頭痛の治療のための製剤 |
CA2721947C (en) | 2008-04-29 | 2016-03-08 | Ascendis Pharma As | Pegylated recombinant human growth hormone compounds |
AU2010220324A1 (en) | 2009-03-05 | 2011-09-01 | Ascendis Pharma As | Interferon alpha carrier prodrugs |
SI2459220T1 (sl) | 2009-07-31 | 2020-12-31 | Ascendis Pharma A/S | Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola |
DK2459171T3 (en) | 2009-07-31 | 2017-09-25 | Sanofi Aventis Deutschland | Long-acting insulin composition |
BR112012002168A2 (pt) | 2009-07-31 | 2016-05-31 | Sanofi Aventis Deutschland | profármacos compreendendo um conjugado ligador de insulina |
JP5893566B2 (ja) | 2009-10-29 | 2016-03-23 | アセンディス ファーマ エー/エス | 生分解性ヒドロゲルの滅菌 |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
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