MA34517B1 - Promédicaments comprenant un conjugué exendine-lieur - Google Patents
Promédicaments comprenant un conjugué exendine-lieurInfo
- Publication number
- MA34517B1 MA34517B1 MA35722A MA35722A MA34517B1 MA 34517 B1 MA34517 B1 MA 34517B1 MA 35722 A MA35722 A MA 35722A MA 35722 A MA35722 A MA 35722A MA 34517 B1 MA34517 B1 MA 34517B1
- Authority
- MA
- Morocco
- Prior art keywords
- fragment
- conjugate
- prodrugs
- relief
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
CETTE INVENTION CONCERNE UN PROMÉDICAMENT OU UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI COMPRENANT UN CONJUGUÉ EXENDINE-LIEUR D-L, D REPRÉSENTANT UN FRAGMENT D'EXENDINE ; ET -L, UN FRAGMENT LIEUR BIOLOGIQUEMENT NON ACTIF -L1 REPRÉSENTÉ PAR LA FORMULE (I). DANS LA FORMULE (I), LA LIGNE EN POINTILLÉS INDIQUE LA LIAISON À L'UN DES GROUPES AMINÉS DU FRAGMENT EXENDINE PAR FORMATION D'UNE LIAISON AMIDE. CETTE INVENTION CONCERNE, EN OUTRE, DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT LESDITS PROMÉDICAMENTS AINSI QUE LEUR UTILISATION EN TANT QUE MÉDICAMENT POUR TRAITER OU PRÉVENIR LES MALADIES OU LES TROUBLES QUI PEUVENT ÊTRE TRAITÉS PAR L'EXENDINE
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10177327A EP2438930A1 (fr) | 2010-09-17 | 2010-09-17 | Promédicaments comprenant un conjugué de liaison d'exendine |
PCT/EP2011/066097 WO2012035139A1 (fr) | 2010-09-17 | 2011-09-16 | Promédicaments comprenant un conjugué exendine-lieur |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34517B1 true MA34517B1 (fr) | 2013-09-02 |
Family
ID=43446651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35722A MA34517B1 (fr) | 2010-09-17 | 2011-09-16 | Promédicaments comprenant un conjugué exendine-lieur |
Country Status (29)
Country | Link |
---|---|
US (1) | US9133276B2 (fr) |
EP (2) | EP2438930A1 (fr) |
JP (1) | JP5932796B2 (fr) |
KR (1) | KR20130106820A (fr) |
CN (1) | CN103237561B (fr) |
AR (1) | AR082995A1 (fr) |
AU (1) | AU2011303823B2 (fr) |
BR (1) | BR112013006340A2 (fr) |
CA (1) | CA2811352C (fr) |
CL (1) | CL2013000716A1 (fr) |
CO (1) | CO6690765A2 (fr) |
CY (1) | CY1122226T1 (fr) |
DK (1) | DK2616102T3 (fr) |
ES (1) | ES2733734T3 (fr) |
HR (1) | HRP20191128T1 (fr) |
HU (1) | HUE044079T2 (fr) |
IL (1) | IL225127A (fr) |
LT (1) | LT2616102T (fr) |
MA (1) | MA34517B1 (fr) |
MX (1) | MX348983B (fr) |
MY (1) | MY158974A (fr) |
NZ (1) | NZ608387A (fr) |
PL (1) | PL2616102T3 (fr) |
PT (1) | PT2616102T (fr) |
RU (1) | RU2593774C2 (fr) |
SG (1) | SG188197A1 (fr) |
SI (1) | SI2616102T1 (fr) |
UY (1) | UY33605A (fr) |
WO (1) | WO2012035139A1 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2824093C (fr) * | 2004-03-23 | 2016-10-25 | Complex Biosystems Gmbh | Liant de promedicament |
US8906847B2 (en) * | 2008-02-01 | 2014-12-09 | Ascendis Pharma A/S | Prodrug comprising a drug linker conjugate |
SI2459220T1 (sl) * | 2009-07-31 | 2020-12-31 | Ascendis Pharma A/S | Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola |
JP5738291B2 (ja) | 2009-07-31 | 2015-06-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリンリンカー複合体を含むプロドラッグ |
UA108475C2 (uk) | 2009-07-31 | 2015-05-12 | Санофі-Авентіс Дойчланд Гмбх | Композиція інсуліну тривалої дії |
EP2438930A1 (fr) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
SG11201400815TA (en) * | 2011-10-12 | 2014-09-26 | Ascendis Pharma Ophthalmology Division As | Prevention and treatment of ocular conditions |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
AR094180A1 (es) | 2012-12-21 | 2015-07-15 | Sanofi Sa | Derivados de exendina-4 |
WO2015081891A1 (fr) * | 2013-12-06 | 2015-06-11 | Baikang (Suzhou) Co., Ltd | Pro-fragments bioréversibles pour médicaments contenant de l'azote et de l'hydroxyle |
EP3080152A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Analogues peptidiques de l'exendine 4 non acylés |
EP3080150B1 (fr) | 2013-12-13 | 2018-08-01 | Sanofi | Analogues peptidiques d'exendine-4 en tant qu'agonistes du récepteur gip/glp-1 double |
EP3080149A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Agonistes mixtes des récepteurs du glp-1/glucagon |
WO2015086729A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Agonistes mixtes des récepteurs glp-1/gip |
CN104945499B (zh) * | 2014-03-31 | 2019-12-10 | 博瑞生物医药(苏州)股份有限公司 | 结构修饰的glp-1类似物及其制备方法 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
CN106554403B (zh) * | 2015-09-25 | 2021-08-31 | 博瑞生物医药(苏州)股份有限公司 | 艾塞那肽修饰物及其用途 |
RU2747316C2 (ru) | 2016-03-01 | 2021-05-04 | Асцендис Фарма Боун Дизизис А/С | Пролекарства pth |
JP7085535B2 (ja) | 2016-09-29 | 2022-06-16 | アセンディス ファーマ ボーン ディジージズ エー/エス | ピーク対トラフ比が小さいpth化合物 |
EP4275677A3 (fr) | 2016-09-29 | 2024-01-10 | Ascendis Pharma Bone Diseases A/S | Schéma posologique pour composé pth à libération controlée |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
DK3335695T3 (da) * | 2016-12-15 | 2020-04-20 | Upm Kymmene Corp | Fremgangsmåde til frysetørring af hydrogel omfattende nanofibrillær cellulose, frysetørret medicinsk hydrogel omfattende nanofibrillær cellulose og hydrogel omfattende nanofibrillær cellulose |
KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
UY38249A (es) | 2018-05-30 | 2019-12-31 | Sanofi Sa | Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico |
WO2020061244A2 (fr) * | 2018-09-19 | 2020-03-26 | Georgia Tech Research Corporation | Promédicament activé par protéase bactérienne à auto-dosage |
US20230082544A1 (en) | 2020-02-18 | 2023-03-16 | Novo Nordisk A/S | Pharmaceutical formulations |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
WO1990007522A1 (fr) | 1988-12-23 | 1990-07-12 | Novo Nordisk A/S | Analogues d'insuline humaine |
NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
US5634943A (en) | 1990-07-12 | 1997-06-03 | University Of Miami | Injectable polyethylene oxide gel implant and method for production |
AU673160B2 (en) | 1992-02-28 | 1996-10-31 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
DE19626762A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Enzymatisch spaltbare Linker für Festphasensynthesen |
US20020064546A1 (en) | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
PT958296E (pt) | 1996-12-31 | 2003-11-28 | Reddys Lab Ltd Dr | Compostos heterociclicos processo para a sua preparacao composicoes farmaceuticas contendo-os e sua utilizacao no tratamento da diabetes e doencas relacionadas |
DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
DE69838916T2 (de) | 1997-11-14 | 2008-12-18 | Amylin Pharmaceuticals, Inc., San Diego | Neuartige exendin agonisten |
JP2001523688A (ja) | 1997-11-14 | 2001-11-27 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 新規エキセンジン・アゴニスト化合物 |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
EP1037649B1 (fr) | 1997-12-17 | 2009-09-30 | Enzon, Inc. | Prodrogues polymeriques d'agents bioactifs contenant amine ou hydroxy |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
WO1999034833A1 (fr) | 1998-01-07 | 1999-07-15 | Shearwater Polymers, Incorporated | Acrylates de polyethyleneglycol heterobifonctionnel degradables, et gels et conjugues derives de ces acrylates |
ES2291017T3 (es) | 1998-02-13 | 2008-02-16 | Amylin Pharmaceuticals, Inc. | Efectos inotropicos y diureticos de la exendina y glp-1. |
EP1117444A2 (fr) | 1998-10-09 | 2001-07-25 | The University Of Michigan | Hydrogels et supports polymeres solubles dans l'eau pour administration de medicaments |
JP2002531217A (ja) | 1998-12-04 | 2002-09-24 | チャンドラシェカー ピー. パサック, | 生体適合性架橋ポリマー |
NZ512663A (en) * | 1999-01-14 | 2004-05-28 | Amylin Pharmaceuticals Inc | Novel exendin agonist formulations and methods of administration thereof |
EP2311895B1 (fr) | 1999-02-01 | 2017-04-12 | Eidgenössische Technische Hochschule Zürich | Biomatériaux formés par réaction d'addition nucléophile à des groupes non saturés conjugués |
DK1105409T3 (da) | 1999-05-17 | 2006-07-03 | Conjuchem Inc | Beskyttelse af endogene terapeutiske peptider fra peptidaseaktivitet ved konjugering med blodkomponenter |
US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
AU1249001A (en) | 1999-06-11 | 2001-01-31 | Nektar Therapeutics Al, Corporation | Hydrogels derived from chitosan and poly(ethylene glycol) or related polymers |
US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
JP2003520810A (ja) | 2000-01-28 | 2003-07-08 | インファイムド セラピューティクス インコーポレイテッド | 徐放性タンパク質ポリマー |
US6884778B2 (en) | 2000-04-14 | 2005-04-26 | William Marsh Rice University | Biocompatible macromers |
US7291673B2 (en) | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
JP4841066B2 (ja) | 2000-09-01 | 2011-12-21 | ライスユニバーシティ | 酸化窒素生成ヒドロゲル物質 |
US6537569B2 (en) | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
EP1243276A1 (fr) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Prodrogues activables à séparateurs allongés et multiples |
WO2002085419A2 (fr) | 2001-04-23 | 2002-10-31 | Wisconsin Alumni Research Foundation | Hydrogels modifies bifonctionnels |
MXPA03010649A (es) | 2001-05-21 | 2005-10-05 | Nektar Therapeutics | Administracion pulmonar de insulina modificada quimicamente. |
DE60132094T3 (de) | 2001-10-26 | 2012-02-02 | Octoplus Polyactive Sciences B.V. | Verfahren zur Herstellung von gereinigten Partikeln |
US6960298B2 (en) | 2001-12-10 | 2005-11-01 | Nanogen, Inc. | Mesoporous permeation layers for use on active electronic matrix devices |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
AU2003226166A1 (en) | 2002-04-04 | 2003-10-20 | Enzon, Inc. | Polymeric acyl derivatives of indoles |
DE10221457A1 (de) | 2002-05-15 | 2003-11-27 | Behr Gmbh & Co | Wärmeübertrager und Verfahren zu seiner Herstellung |
EP1531868A2 (fr) | 2002-06-03 | 2005-05-25 | Alnis Biosciences, Inc. | Agents therapeutiques contenant des nano-polymeres |
US20050164201A1 (en) | 2002-06-10 | 2005-07-28 | Harvey Diane M. | Isolated nucleic acid molecule encoding a novel centromere-associated motor protein, and uses therof |
US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
AU2003282624A1 (en) | 2002-11-14 | 2004-06-03 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
ES2512499T3 (es) | 2003-04-08 | 2014-10-24 | Yeda Research And Development Co., Ltd. | Fármacos pegilados reversibles |
EP1525890A1 (fr) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Complexes protéine-protéophore |
CA2824093C (fr) | 2004-03-23 | 2016-10-25 | Complex Biosystems Gmbh | Liant de promedicament |
EP1586334A1 (fr) | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugés avec PEG |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
JPWO2006038462A1 (ja) | 2004-10-01 | 2008-05-15 | 国立大学法人九州大学 | 新規ステロイド産生細胞 |
DE102004051715A1 (de) | 2004-10-23 | 2005-06-30 | Clariant Gmbh | Flüssigwaschmittel enthaltend Farbfixiermittel |
US20060115865A1 (en) | 2004-10-25 | 2006-06-01 | Anlong Ouyang | Lamotrigine analogs |
US7678551B2 (en) | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
US7407117B2 (en) | 2004-10-28 | 2008-08-05 | Meadwestvaco Calmar, Inc. | Liquid sprayer assembly |
JP2006163996A (ja) | 2004-12-09 | 2006-06-22 | Evolium Sas | 行動履歴に基づくプッシュ型の情報提供システム |
JP2008526846A (ja) | 2005-01-05 | 2008-07-24 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 鎮痛性結合体 |
KR100665672B1 (ko) | 2005-04-13 | 2007-01-09 | 성균관대학교산학협력단 | 새로운 온도 및 pH 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔 |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
US8039432B2 (en) | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
JP2009523494A (ja) | 2006-01-12 | 2009-06-25 | ヒストジェニックス コーポレイション | 破壊された靱帯又は腱の修復及び再構築のための、及び靱帯及び腱の損傷の処置のための方法 |
DE602006007679D1 (de) | 2006-03-31 | 2009-08-20 | Sony Deutschland Gmbh | Verfahren zur Herstellung eines vernetzten Polymer-Gels |
WO2007140312A2 (fr) | 2006-05-25 | 2007-12-06 | The General Hospital Corporation | Agents anti-réticulation et procédés permettant de bloquer la réticulation de préparations d'hydrogel injectables |
JP5550338B2 (ja) | 2006-07-31 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | ペグ化持続型インスリン |
WO2008034122A2 (fr) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Segments de liaison biodégradables à base d'ester encombré pour distribution d'oligonuclotides |
WO2008097581A1 (fr) * | 2007-02-06 | 2008-08-14 | Incept, Llc | Polymérisation avec précipitation de protéines pour élution dans une solution physiologique |
US20080220047A1 (en) | 2007-03-05 | 2008-09-11 | Sawhney Amarpreet S | Low-swelling biocompatible hydrogels |
WO2008116913A2 (fr) | 2007-03-28 | 2008-10-02 | Novo Nordisk A/S | Composés peptidiques à pégylation biodégradable transitoire |
ES2733276T3 (es) | 2007-04-13 | 2019-11-28 | Kuros Biosurgery Ag | Sellante polimérico para tejidos |
US9353170B2 (en) | 2007-06-08 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Long-acting transient polymer conjugates of exendin |
EP2170945A1 (fr) | 2007-07-16 | 2010-04-07 | Novo Nordisk A/S | Analogues pegylés de l'insuline, stabilisés vis-à-vis des protéases |
DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
US8906847B2 (en) | 2008-02-01 | 2014-12-09 | Ascendis Pharma A/S | Prodrug comprising a drug linker conjugate |
EP2247645B1 (fr) | 2008-02-13 | 2017-12-06 | Hyperbranch Medical Technology, Inc. | Hydrogels à base de polyalkylèneimines réticulées à taux de dégradation ajustable |
CN102014625A (zh) | 2008-04-28 | 2011-04-13 | 佐吉尼克斯股份有限公司 | 用于治疗偏头痛的新制剂 |
LT3050576T (lt) | 2008-04-29 | 2021-07-12 | Ascendis Pharma Endocrinology Division A/S | Pegiliuoti rekombinantinio žmogaus augimo hormono junginiai |
CN102413843A (zh) | 2009-03-05 | 2012-04-11 | 阿森迪斯药物股份有限公司 | 干扰素α载体前药 |
UA108475C2 (uk) | 2009-07-31 | 2015-05-12 | Санофі-Авентіс Дойчланд Гмбх | Композиція інсуліну тривалої дії |
JP5738291B2 (ja) | 2009-07-31 | 2015-06-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリンリンカー複合体を含むプロドラッグ |
SI2459220T1 (sl) | 2009-07-31 | 2020-12-31 | Ascendis Pharma A/S | Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola |
BR112012010249A2 (pt) | 2009-10-29 | 2015-09-22 | Ascendis Pharma As | esterilização de hidrógeis biodegradáveis |
EP2438930A1 (fr) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
-
2010
- 2010-09-17 EP EP10177327A patent/EP2438930A1/fr not_active Ceased
-
2011
- 2011-09-15 UY UY0001033605A patent/UY33605A/es not_active Application Discontinuation
- 2011-09-15 AR ARP110103361A patent/AR082995A1/es unknown
- 2011-09-16 RU RU2013117441/15A patent/RU2593774C2/ru not_active IP Right Cessation
- 2011-09-16 US US13/822,170 patent/US9133276B2/en not_active Expired - Fee Related
- 2011-09-16 LT LTEP11757861.7T patent/LT2616102T/lt unknown
- 2011-09-16 DK DK11757861.7T patent/DK2616102T3/da active
- 2011-09-16 SG SG2013009881A patent/SG188197A1/en unknown
- 2011-09-16 KR KR1020137006762A patent/KR20130106820A/ko not_active Application Discontinuation
- 2011-09-16 CN CN201180055486.3A patent/CN103237561B/zh not_active Expired - Fee Related
- 2011-09-16 ES ES11757861T patent/ES2733734T3/es active Active
- 2011-09-16 PT PT11757861T patent/PT2616102T/pt unknown
- 2011-09-16 PL PL11757861T patent/PL2616102T3/pl unknown
- 2011-09-16 HU HUE11757861A patent/HUE044079T2/hu unknown
- 2011-09-16 AU AU2011303823A patent/AU2011303823B2/en not_active Ceased
- 2011-09-16 MY MYPI2013000439A patent/MY158974A/en unknown
- 2011-09-16 WO PCT/EP2011/066097 patent/WO2012035139A1/fr active Application Filing
- 2011-09-16 SI SI201131744T patent/SI2616102T1/sl unknown
- 2011-09-16 MX MX2013002822A patent/MX348983B/es active IP Right Grant
- 2011-09-16 JP JP2013528685A patent/JP5932796B2/ja not_active Expired - Fee Related
- 2011-09-16 BR BR112013006340-8A patent/BR112013006340A2/pt not_active Application Discontinuation
- 2011-09-16 NZ NZ60838711A patent/NZ608387A/en not_active IP Right Cessation
- 2011-09-16 MA MA35722A patent/MA34517B1/fr unknown
- 2011-09-16 CA CA2811352A patent/CA2811352C/fr not_active Expired - Fee Related
- 2011-09-16 EP EP11757861.7A patent/EP2616102B1/fr active Active
-
2013
- 2013-03-10 IL IL225127A patent/IL225127A/en not_active IP Right Cessation
- 2013-03-13 CO CO13050270A patent/CO6690765A2/es unknown
- 2013-03-15 CL CL2013000716A patent/CL2013000716A1/es unknown
-
2019
- 2019-06-19 HR HRP20191128TT patent/HRP20191128T1/hr unknown
- 2019-07-30 CY CY20191100811T patent/CY1122226T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA34517B1 (fr) | Promédicaments comprenant un conjugué exendine-lieur | |
MA33467B1 (fr) | Promédicaments comprenant un conjugué insuline-lieur | |
MA35271B1 (fr) | Antagonistes de trpm8 et leur utilisation dans des traitements | |
MA34083B1 (fr) | Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques | |
MA41932B1 (fr) | Méthodes de traitement ou de prévention de migraines | |
WO2010115843A3 (fr) | Composition pharmaceutique | |
WO2012080729A3 (fr) | Inhibiteurs de caséine kinase 1δ (ck1δ) | |
EA201100062A1 (ru) | Соединения и способы модулирования рецепторов, связанных с белком g | |
MA34721B1 (fr) | Acides carboxyliques 1-benzylcycloalkyle substitués et leur utilisation | |
TN2012000231A1 (en) | Quinoline amide m1 receptor positive allosteric modulators | |
EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
MA34969B1 (fr) | Composes et compositions en tant qu inibiteurs de trk | |
MA46665B1 (fr) | Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y | |
MA47392A1 (fr) | Bis-octahydrophénanthrène carboxamides et leurs conjugués protéiques | |
WO2009106980A3 (fr) | Dérivés d'indazole | |
WO2008002621A3 (fr) | Effecteurs allostériques positifs du récepteur m1 à base de quinolone à substitution benzyle | |
EA201170624A1 (ru) | Изоникотинамидные антагонисты рецепторов орексинов | |
MA33295B1 (fr) | Nouvelle formulation de diclofénac | |
MA35513B1 (fr) | Compositions pharmaceutiques comprenant 40 - o - ( 2 - hydroxy) éthyl - rapamycine | |
DE602007010781D1 (de) | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid-derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration | |
WO2011026125A3 (fr) | Compositions pharmaceutiques à rétention gastrique permettant une libération immédiate et prolongée d'acétaminophène | |
MA38349A1 (fr) | Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) | |
MA39359A1 (fr) | Composés d'isoindolinone utilisés comme modulateurs de gpr119 pour le traitement du diabète, de l'obésité et de troubles associés | |
UA96447C2 (ru) | Полиморфные формы (2s)-(4e)-n-метил-5-[3-(5-изопропоксипиридин)ил]-4-пентен-2-амина для лечения расстройств центральной нервной системы | |
WO2008097924A3 (fr) | Compositions pharmaceutiques comprenant des analogues du dextrométhorphane pour le traitement de troubles neurologiques |