ES2721172T3 - Una nueva clase de moléculas terapéuticas a base de proteínas - Google Patents
Una nueva clase de moléculas terapéuticas a base de proteínas Download PDFInfo
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- ES2721172T3 ES2721172T3 ES17164276T ES17164276T ES2721172T3 ES 2721172 T3 ES2721172 T3 ES 2721172T3 ES 17164276 T ES17164276 T ES 17164276T ES 17164276 T ES17164276 T ES 17164276T ES 2721172 T3 ES2721172 T3 ES 2721172T3
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- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 16
- 150000001413 amino acids Chemical class 0.000 abstract 15
- 102000005348 Neuraminidase Human genes 0.000 abstract 5
- 108010006232 Neuraminidase Proteins 0.000 abstract 5
- 230000003197 catalytic effect Effects 0.000 abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
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- Pulmonology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
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- Dermatology (AREA)
- Rheumatology (AREA)
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- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un método para preparar una composición farmacéutica, que comprende: (a) proporcionar una proteína de dominio catalítico de sialidasa que comprende un dominio catalítico de una sialidasa, en donde la proteína comprende una secuencia de dominio catalítico seleccionada entre: (i) la secuencia de aminoácidos expuesta en SEQ ID NO: 14, en donde dicha secuencia carece de los aminoácidos 1 a 273 de la secuencia de cualquiera de los aminoácidos expuesta en SEQ ID NO. 12; (ii) una secuencia de aminoácidos que comienza en el aminoácido 274 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12 y termina en el aminoácido 666 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12, y carece de los aminoácidos 1 a 273 y 667 a 901 de la secuencia de aminoácidos expuesta en SEQ ID NO. 12; (iii) una secuencia de aminoácidos que comienza en el aminoácido 274 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12 y termina en el aminoácido 681 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12, y carece de los aminoácidos 1 a 273 y 682 a 901 de la secuencia de aminoácidos expuesta en SEQ ID NO. 12; (iv) una secuencia de aminoácidos que comienza en el aminoácido 290 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12 y termina en el aminoácido 666 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12, y carece de los aminoácidos 1 a 289 y 667 a 901 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12; y (v) una secuencia de aminoácidos que comienza en el aminoácido 290 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12 y termina en el aminoácido 681 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12, y carece de los aminoácidos 1 a 289 y 682 a 901 de la secuencia de aminoácidos expuesta en SEQ ID NO: 12, en donde la proteína de dominio catalítico de sialidasa tiene actividad sialidasa; y (b) combinar la proteína de dominio catalítico de sialidasa con un vehículo o diluyente farmacéuticamente aceptable creando de este modo una composición farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/939,262 US7807174B2 (en) | 2002-11-22 | 2004-09-10 | Class of therapeutic protein based molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2721172T3 true ES2721172T3 (es) | 2019-07-29 |
Family
ID=36060467
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05790917.8T Active ES2554787T3 (es) | 2004-09-10 | 2005-07-21 | Una nueva clase de moléculas terapéuticas a base de proteínas |
| ES15180371.5T Active ES2626845T3 (es) | 2004-09-10 | 2005-07-21 | Una nueva clase de moléculas terapéuticas a base de proteínas |
| ES17164276T Active ES2721172T3 (es) | 2004-09-10 | 2005-07-21 | Una nueva clase de moléculas terapéuticas a base de proteínas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05790917.8T Active ES2554787T3 (es) | 2004-09-10 | 2005-07-21 | Una nueva clase de moléculas terapéuticas a base de proteínas |
| ES15180371.5T Active ES2626845T3 (es) | 2004-09-10 | 2005-07-21 | Una nueva clase de moléculas terapéuticas a base de proteínas |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7807174B2 (es) |
| EP (4) | EP1786902B1 (es) |
| JP (2) | JP4764881B2 (es) |
| KR (1) | KR20070064619A (es) |
| CN (2) | CN104017787B (es) |
| AU (1) | AU2005285461B2 (es) |
| BR (1) | BRPI0515646B8 (es) |
| CA (2) | CA2578050C (es) |
| DK (3) | DK3241898T3 (es) |
| ES (3) | ES2554787T3 (es) |
| HK (2) | HK1201562A1 (es) |
| IL (3) | IL181779A (es) |
| PT (3) | PT1786902E (es) |
| RU (1) | RU2468080C2 (es) |
| TR (1) | TR201905393T4 (es) |
| WO (1) | WO2006031291A2 (es) |
| ZA (1) | ZA200702915B (es) |
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| US20100210528A1 (en) * | 1999-03-05 | 2010-08-19 | Leland Shapiro | Compositions, methods and uses for inhibition and/or treatment of influenza infection |
| US7807174B2 (en) * | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
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| US8512710B2 (en) | 2002-11-22 | 2013-08-20 | Ansun Biopharma, Inc. | Class of therapeutic protein based molecules |
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| AU2015215955B2 (en) * | 2006-01-24 | 2016-12-01 | Ansun Biopharma, Inc. | Technology for preparation of macromolecular microspheres |
| WO2007114881A1 (en) | 2006-01-24 | 2007-10-11 | Nexbio, Inc. | Technology for preparation of macromolecular microspheres |
| US8273381B1 (en) * | 2006-04-14 | 2012-09-25 | Auburn University | Compositions for and methods of controlling olfactory responses to odorants |
| US20100143972A1 (en) * | 2006-12-14 | 2010-06-10 | Horswill Alexander R | Method of Making Cyclic Polypeptides with Inteins |
| AU2008219305B2 (en) * | 2007-02-20 | 2013-08-22 | Dsm Ip Assets B.V. | Novel sialidase |
| US8124632B2 (en) * | 2007-08-03 | 2012-02-28 | Romark Laboratories, L.C. | Alkylsulfonyl-substituted thiazolide compounds |
| JP5918124B2 (ja) | 2009-05-12 | 2016-05-18 | ロマーク ラボラトリーズ エル．シー． | ハロアルキルヘテロアリールベンズアミド化合物 |
| AU2010264479B2 (en) * | 2009-06-26 | 2017-06-01 | Romark Laboratories L.C. | Compounds and methods for treating influenza |
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| WO2011057081A1 (en) * | 2009-11-06 | 2011-05-12 | Nexbio, Inc. | Methods, compounds and compositions for treatment and prophylaxis in the respiratory tract |
| CN104203267A (zh) * | 2012-02-17 | 2014-12-10 | 安迅生物制药公司 | 用于治疗流感和副流感患者的方法、化合物和组合物 |
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| WO1998031817A2 (en) | 1997-01-14 | 1998-07-23 | Hopital Sainte-Justine | Human lysosomal sialidase and therapeutic uses thereof |
| US6251392B1 (en) * | 1997-10-20 | 2001-06-26 | Epicyte Pharmaceuticals, Inc. | Epithelial cell targeting agent |
| US6737511B1 (en) * | 1999-08-16 | 2004-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis |
| US20020025320A1 (en) * | 1999-08-20 | 2002-02-28 | Prosper Boyaka | Sialidases as mucosal adjuvants |
| CN1405562A (zh) * | 2002-10-24 | 2003-03-26 | 肖洪武 | 一种唾液酸酶测定试剂 |
| CN1729013B (zh) * | 2002-11-22 | 2012-10-03 | 耐百生物制药有限公司 | 广谱抗病毒化合物、药物制剂及其用途 |
| US7807174B2 (en) * | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
| DE10258400A1 (de) * | 2002-12-13 | 2004-06-24 | N.V. Nutricia | Trans-Sialidasen aus Trypanosoma congolense |
| WO2007114881A1 (en) * | 2006-01-24 | 2007-10-11 | Nexbio, Inc. | Technology for preparation of macromolecular microspheres |
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2004
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