AR042039A1 - Isomeros posicionales del ifn peg alfa 2 a - Google Patents

Isomeros posicionales del ifn peg alfa 2 a

Info

Publication number
AR042039A1
AR042039A1 ARP030104175A ARP030104175A AR042039A1 AR 042039 A1 AR042039 A1 AR 042039A1 AR P030104175 A ARP030104175 A AR P030104175A AR P030104175 A ARP030104175 A AR P030104175A AR 042039 A1 AR042039 A1 AR 042039A1
Authority
AR
Argentina
Prior art keywords
peg
lys
alfa
positional isomers
ifn
Prior art date
Application number
ARP030104175A
Other languages
English (en)
Inventor
Doris Brugger
Stefan Foser
Alfred Schcher
Karl Weyer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR042039A1 publication Critical patent/AR042039A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Isómero posicionales del interferón alfa 2S monopegilado, con un método para su aislamiento y para su uso en la fabricación de medicamentos para el tratamiento de enfermedades, especialmente para el tratamiento de enfermedades virales. Reivindicación 1:Los isómeros posicionales del interferón alfa 2S pegilado seleccionados del grupo PEG-Lys(31), PEG-Lys(49), PEG-Lys(83), PEG-Lys(112), PEG-Lys(121), PEG-Lys(131), PEG-Lys(134) y PEG-Lys(164).
ARP030104175A 2002-11-15 2003-11-13 Isomeros posicionales del ifn peg alfa 2 a AR042039A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02025585 2002-11-15

Publications (1)

Publication Number Publication Date
AR042039A1 true AR042039A1 (es) 2005-06-08

Family

ID=32319537

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104175A AR042039A1 (es) 2002-11-15 2003-11-13 Isomeros posicionales del ifn peg alfa 2 a

Country Status (23)

Country Link
US (1) US20040223950A1 (es)
EP (1) EP1562634B1 (es)
JP (1) JP4279258B2 (es)
KR (1) KR20050065677A (es)
CN (1) CN1323722C (es)
AR (1) AR042039A1 (es)
AT (1) ATE337017T1 (es)
AU (1) AU2003293668A1 (es)
BR (1) BR0316227A (es)
CA (1) CA2503594C (es)
DE (1) DE60307881T2 (es)
ES (1) ES2270152T3 (es)
GT (1) GT200300244A (es)
MX (1) MXPA05005178A (es)
NO (1) NO20052310L (es)
PA (1) PA8587801A1 (es)
PE (1) PE20040834A1 (es)
PL (1) PL376883A1 (es)
RU (1) RU2005118752A (es)
TW (1) TW200413404A (es)
UY (1) UY28080A1 (es)
WO (1) WO2004045648A1 (es)
ZA (1) ZA200503756B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
CA2504267A1 (en) * 2002-11-18 2004-06-03 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
AU2005211385B2 (en) 2004-02-02 2008-12-11 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
MXPA06013412A (es) 2004-05-19 2007-01-23 Maxygen Inc Polipeptidos de interferon-alfa y conjugados.
JP2008545393A (ja) 2005-05-18 2008-12-18 マキシジェン， インコーポレイテッド 進歩したインターフェロンαポリペプチド
US7695710B2 (en) 2005-06-20 2010-04-13 Pepgen Corporation Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
EP1901777A2 (en) * 2005-06-20 2008-03-26 Pepgen Corporation Low-toxicity, long-circulating chimeras of human interferon-alpha analogs and interferon tau
CN101002944B (zh) * 2006-01-17 2012-07-25 中国科学院过程工程研究所 支链聚乙二醇-干扰素结合物及其制备方法
AR078117A1 (es) * 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
ES2382124T3 (es) * 2007-09-04 2012-06-05 Biosteed Gene Expression Tech. Co., Ltd. Interferón alfa 2b modificado con polietilenglicol y método de preparación y aplicaciones de este
DK2196475T3 (da) * 2007-09-04 2012-09-17 Biosteed Gene Expression Tech Co Ltd Interferon alfa 2a, som er modificeret med polyethylenglycol, fremgangsmåde til syntese deraf samt anvendelse deraf
MX2010010953A (es) 2008-04-03 2011-04-21 Biosteed Gene Expression Tech Co Ltd Hormona de crecimiento modificada con glicol de polietileno de doble cadena, metodo de preparacion y aplicación del a misma.
US9272048B2 (en) 2008-04-29 2016-03-01 Ascendis Pharma Growth Disorders Division A/S PEGylated recombinant human growth hormone compounds
EP2113256A1 (en) 2008-04-29 2009-11-04 Ascendis Pharma AS PEGylated rhGH compounds
DE102009009344B4 (de) * 2009-02-05 2018-01-04 Helmholtz-Zentrum Dresden - Rossendorf E.V. Verfahren und Anordnung zur Reinigung des Reaktionsgemisches bei der Herstellung von Radiopharmaka
WO2010110503A1 (ko) * 2009-03-27 2010-09-30 주식회사 중외제약 인터페론-알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 IFN-α 융합 단백질
CN101514229B (zh) * 2009-04-03 2012-05-09 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物
CN106749608B (zh) * 2015-11-18 2021-10-15 石药集团中奇制药技术（石家庄）有限公司 干扰素α缀合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
JP2006508918A (ja) * 2002-09-05 2006-03-16 ザ ジェネラル ホスピタル コーポレーション 修飾されたアシアロインターフェロンおよびその使用

Also Published As

Publication number Publication date
DE60307881T2 (de) 2007-03-08
US20040223950A1 (en) 2004-11-11
PA8587801A1 (es) 2004-09-16
CA2503594A1 (en) 2004-06-03
ATE337017T1 (de) 2006-09-15
NO20052310D0 (no) 2005-05-11
CN1323722C (zh) 2007-07-04
EP1562634A1 (en) 2005-08-17
JP4279258B2 (ja) 2009-06-17
UY28080A1 (es) 2004-05-31
CN1711109A (zh) 2005-12-21
BR0316227A (pt) 2005-10-04
PL376883A1 (pl) 2006-01-09
MXPA05005178A (es) 2005-07-22
TW200413404A (en) 2004-08-01
DE60307881D1 (de) 2006-10-05
ES2270152T3 (es) 2007-04-01
CA2503594C (en) 2011-05-10
GT200300244A (es) 2004-06-03
NO20052310L (no) 2005-08-09
AU2003293668A1 (en) 2004-06-15
WO2004045648A1 (en) 2004-06-03
EP1562634B1 (en) 2006-08-23
KR20050065677A (ko) 2005-06-29
ZA200503756B (en) 2008-02-27
JP2006515571A (ja) 2006-06-01
PE20040834A1 (es) 2004-11-17
RU2005118752A (ru) 2006-02-10

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