ATE337017T1 - Positionelle isomeren von pegyliertem interferon alpha 2a - Google Patents

Positionelle isomeren von pegyliertem interferon alpha 2a

Info

Publication number
ATE337017T1
ATE337017T1 AT03789020T AT03789020T ATE337017T1 AT E337017 T1 ATE337017 T1 AT E337017T1 AT 03789020 T AT03789020 T AT 03789020T AT 03789020 T AT03789020 T AT 03789020T AT E337017 T1 ATE337017 T1 AT E337017T1
Authority
AT
Austria
Prior art keywords
interferon alpha
pegylated interferon
positional isomers
isomers
positional
Prior art date
Application number
AT03789020T
Other languages
English (en)
Inventor
Doris Brugger
Stefan Foser
Alfred Schacher
Karl Weyer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE337017T1 publication Critical patent/ATE337017T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03789020T 2002-11-15 2003-11-10 Positionelle isomeren von pegyliertem interferon alpha 2a ATE337017T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02025585 2002-11-15

Publications (1)

Publication Number Publication Date
ATE337017T1 true ATE337017T1 (de) 2006-09-15

Family

ID=32319537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789020T ATE337017T1 (de) 2002-11-15 2003-11-10 Positionelle isomeren von pegyliertem interferon alpha 2a

Country Status (23)

Country Link
US (1) US20040223950A1 (de)
EP (1) EP1562634B1 (de)
JP (1) JP4279258B2 (de)
KR (1) KR20050065677A (de)
CN (1) CN1323722C (de)
AR (1) AR042039A1 (de)
AT (1) ATE337017T1 (de)
AU (1) AU2003293668A1 (de)
BR (1) BR0316227A (de)
CA (1) CA2503594C (de)
DE (1) DE60307881T2 (de)
ES (1) ES2270152T3 (de)
GT (1) GT200300244A (de)
MX (1) MXPA05005178A (de)
NO (1) NO20052310L (de)
PA (1) PA8587801A1 (de)
PE (1) PE20040834A1 (de)
PL (1) PL376883A1 (de)
RU (1) RU2005118752A (de)
TW (1) TW200413404A (de)
UY (1) UY28080A1 (de)
WO (1) WO2004045648A1 (de)
ZA (1) ZA200503756B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005118998A (ru) * 2002-11-18 2006-01-27 Максиджен, Инк. (Us) Полипептиды и конъюгаты альфа-интерферона
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
NZ548256A (en) 2004-02-02 2010-02-26 Ambrx Inc Modified human four helical bundle polypeptides and their uses
BRPI0511196A (pt) * 2004-05-19 2007-12-04 Maxygen Inc polipeptìdeo isolado ou recombinante, conjugado, composição, célula hospedeira, vetor, métodos para preparar um polipeptìdeo, para preparar um conjugado, para reduzir o número de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna hcv, dna hbv e rna hiv no soro de um paciente infectado com hcv, hbv e hiv, e, uso do polipeptìdeo, do conjugado ou da composição
JP2008545393A (ja) 2005-05-18 2008-12-18 マキシジェン， インコーポレイテッド 進歩したインターフェロンαポリペプチド
US7695710B2 (en) 2005-06-20 2010-04-13 Pepgen Corporation Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
EP1901777A2 (de) * 2005-06-20 2008-03-26 Pepgen Corporation Lang zirkulierende chimären mit niedriger toxizität von humanen interferon-alpha-analoga und interferon tau
CN101002944B (zh) * 2006-01-17 2012-07-25 中国科学院过程工程研究所 支链聚乙二醇-干扰素结合物及其制备方法
AR078117A1 (es) * 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
DK2196475T3 (da) * 2007-09-04 2012-09-17 Biosteed Gene Expression Tech Co Ltd Interferon alfa 2a, som er modificeret med polyethylenglycol, fremgangsmåde til syntese deraf samt anvendelse deraf
CA2698173C (en) * 2007-09-04 2015-02-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha 2b modified by polyethylene glycol, the preparation and use thereof
BRPI0822530B1 (pt) * 2008-04-03 2022-03-22 Biosteed Gene Expression Tech. Co., Ltd Método de preparação de um hormônio de crescimento humano glicolado por polietileno (modificado por peg), hormônio do crescimento humano modificado por peg de menor peso molecular aparente e seu uso, preparação de hormônio do crescimento humano modificado por peg de menor peso molecular aparente e seu método de preparação e composição
CN102014965B (zh) 2008-04-29 2015-11-25 阿森迪斯药物生长障碍股份有限公司 Peg化的重组人生长激素化合物
EP2113256A1 (de) 2008-04-29 2009-11-04 Ascendis Pharma AS Pegylierte rhGH-Verbindungen
DE102009009344B4 (de) * 2009-02-05 2018-01-04 Helmholtz-Zentrum Dresden - Rossendorf E.V. Verfahren und Anordnung zur Reinigung des Reaktionsgemisches bei der Herstellung von Radiopharmaka
EP2412730B1 (de) * 2009-03-27 2014-09-10 JW Pharmaceutical Corporation Mit interferon-alpha- (ifn-alpha-) kondensiertes protein mit ifn-alpha und cytoplasmic transduction peptide (ctp)
CN101514229B (zh) * 2009-04-03 2012-05-09 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物
LT2512450T (lt) 2009-12-15 2018-04-25 Ascendis Pharma Endocrinology Division A/S Sausa augimo hormono kompozicija, laikinai prijungta prie polimero nešiklio
KR102608645B1 (ko) 2014-11-18 2023-12-01 아센디스 파마 엔도크리놀로지 디비전 에이/에스 신규한 중합체성 hGH 프로드러그
SI3220892T1 (sl) 2014-11-21 2022-01-31 Ascendis Pharma Endocrinology Division A/S Oblike odmerjanja dolgotrajno delujočega rastnega hormona
CN106749608B (zh) * 2015-11-18 2021-10-15 石药集团中奇制药技术（石家庄）有限公司 干扰素α缀合物
AU2020233198B2 (en) 2019-03-04 2025-05-15 Ascendis Pharma Endocrinology Division A/S Long-acting growth hormone dosage forms with superior efficacy to daily somatropin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
MXPA05002476A (es) * 2002-09-05 2005-10-19 Gi Company Inc Asialo-interferones modificados y sus usos.

Also Published As

Publication number Publication date
US20040223950A1 (en) 2004-11-11
EP1562634B1 (de) 2006-08-23
NO20052310D0 (no) 2005-05-11
RU2005118752A (ru) 2006-02-10
DE60307881T2 (de) 2007-03-08
MXPA05005178A (es) 2005-07-22
PE20040834A1 (es) 2004-11-17
PA8587801A1 (es) 2004-09-16
UY28080A1 (es) 2004-05-31
CN1711109A (zh) 2005-12-21
CA2503594C (en) 2011-05-10
JP4279258B2 (ja) 2009-06-17
CN1323722C (zh) 2007-07-04
ZA200503756B (en) 2008-02-27
JP2006515571A (ja) 2006-06-01
KR20050065677A (ko) 2005-06-29
DE60307881D1 (de) 2006-10-05
NO20052310L (no) 2005-08-09
GT200300244A (es) 2004-06-03
TW200413404A (en) 2004-08-01
CA2503594A1 (en) 2004-06-03
WO2004045648A1 (en) 2004-06-03
PL376883A1 (pl) 2006-01-09
BR0316227A (pt) 2005-10-04
ES2270152T3 (es) 2007-04-01
AR042039A1 (es) 2005-06-08
EP1562634A1 (de) 2005-08-17
AU2003293668A1 (en) 2004-06-15

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