ATE337017T1 - Positionelle isomeren von pegyliertem interferon alpha 2a - Google Patents
Positionelle isomeren von pegyliertem interferon alpha 2aInfo
- Publication number
- ATE337017T1 ATE337017T1 AT03789020T AT03789020T ATE337017T1 AT E337017 T1 ATE337017 T1 AT E337017T1 AT 03789020 T AT03789020 T AT 03789020T AT 03789020 T AT03789020 T AT 03789020T AT E337017 T1 ATE337017 T1 AT E337017T1
- Authority
- AT
- Austria
- Prior art keywords
- interferon alpha
- pegylated interferon
- positional isomers
- isomers
- positional
- Prior art date
Links
- 102000006992 Interferon-alpha Human genes 0.000 title 1
- 108010047761 Interferon-alpha Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02025585 | 2002-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337017T1 true ATE337017T1 (de) | 2006-09-15 |
Family
ID=32319537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789020T ATE337017T1 (de) | 2002-11-15 | 2003-11-10 | Positionelle isomeren von pegyliertem interferon alpha 2a |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20040223950A1 (de) |
| EP (1) | EP1562634B1 (de) |
| JP (1) | JP4279258B2 (de) |
| KR (1) | KR20050065677A (de) |
| CN (1) | CN1323722C (de) |
| AR (1) | AR042039A1 (de) |
| AT (1) | ATE337017T1 (de) |
| AU (1) | AU2003293668A1 (de) |
| BR (1) | BR0316227A (de) |
| CA (1) | CA2503594C (de) |
| DE (1) | DE60307881T2 (de) |
| ES (1) | ES2270152T3 (de) |
| GT (1) | GT200300244A (de) |
| MX (1) | MXPA05005178A (de) |
| NO (1) | NO20052310L (de) |
| PA (1) | PA8587801A1 (de) |
| PE (1) | PE20040834A1 (de) |
| PL (1) | PL376883A1 (de) |
| RU (1) | RU2005118752A (de) |
| TW (1) | TW200413404A (de) |
| UY (1) | UY28080A1 (de) |
| WO (1) | WO2004045648A1 (de) |
| ZA (1) | ZA200503756B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| RU2005118998A (ru) * | 2002-11-18 | 2006-01-27 | Максиджен, Инк. (Us) | Полипептиды и конъюгаты альфа-интерферона |
| AU2008201682B2 (en) * | 2004-02-02 | 2011-02-24 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| WO2005113592A2 (en) | 2004-05-19 | 2005-12-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| BRPI0609809A2 (pt) | 2005-05-18 | 2011-10-11 | Maxygen Inc | polipeptìdeo isolado ou recombinante, conjugado, composição, polinucleotìdeo isolado ou recombinante, célula hospedeira, vetor, métodos para preparar o polipeptìdeo, para preparar um conjugado, para inibir replicação de um vìrus em células infectadas com o vìrus para reduzir o numero de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna de hcv no soro de um paciente infectado com hcv, para reduzir o nìvel de dna de hbv em soro de um paciente infectado com hbv e para reduzir o nìvel de rna de hiv em soro de um paciente infectado com hiv, e, uso do polipeptìdeo ou do conjugado |
| CN101257925A (zh) * | 2005-06-20 | 2008-09-03 | 派普根公司 | 人干扰素α类似物和干扰素τ的低毒长循环的嵌合体 |
| US7695710B2 (en) | 2005-06-20 | 2010-04-13 | Pepgen Corporation | Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs |
| CN101002944B (zh) * | 2006-01-17 | 2012-07-25 | 中国科学院过程工程研究所 | 支链聚乙二醇-干扰素结合物及其制备方法 |
| AR078117A1 (es) * | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
| KR101483814B1 (ko) * | 2007-09-04 | 2015-01-16 | 바이오스티드 진 익스프레션 테크. 컴파니 리미티드 | 폴리에틸렌 글리콜에 의해 변형된 인터페론 알파 2ａ, 이의 합성 방법 및 용도 |
| PT2186830E (pt) * | 2007-09-04 | 2012-06-20 | Biosteed Gene Expression Tech Co Ltd | Interferão alfa 2b modificado com polietilenoglicol e método de preparação e aplicações do mesmo |
| EP2272875B1 (de) * | 2008-04-03 | 2014-01-15 | Biosteed Gene Expression Tech. CO., LTD. | Doppelsträngiges polyethylenglykolmodifiziertes wachstumshormon, herstellungsverfahren und anwendung davon |
| EP2113256A1 (de) | 2008-04-29 | 2009-11-04 | Ascendis Pharma AS | Pegylierte rhGH-Verbindungen |
| EP2279007B1 (de) | 2008-04-29 | 2016-05-18 | Ascendis Pharma Growth Disorders Division A/S | Pegylierte rekombinante humane wachstumshormon-verbindungen |
| DE102009009344B4 (de) * | 2009-02-05 | 2018-01-04 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Verfahren und Anordnung zur Reinigung des Reaktionsgemisches bei der Herstellung von Radiopharmaka |
| JP5576928B2 (ja) * | 2009-03-27 | 2014-08-20 | ジェイダブリュ ファーマシューティカル コーポレーション | インターフェロン−アルファ及び細胞質残留性細胞膜透過ペプチドを含むＩＦＮ−α融合タンパク質 |
| CN101514229B (zh) * | 2009-04-03 | 2012-05-09 | 海南四环心脑血管药物研究院有限公司 | 人干扰素α衍生物及其聚乙二醇化修饰物 |
| ES2667025T3 (es) | 2009-12-15 | 2018-05-09 | Ascendis Pharma Endocrinology Division A/S | Composición seca de hormona de crecimiento unida transitoriamente a un portador de polímero |
| US10799563B2 (en) | 2014-11-18 | 2020-10-13 | Ascendis Pharma Endocrinology Division | Polymeric hGH prodrugs |
| ES2896971T3 (es) | 2014-11-21 | 2022-02-28 | Ascendis Pharma Endocrinology Div A/S | Formas de administración de hormona del crecimiento de acción prolongada |
| CN106749608B (zh) * | 2015-11-18 | 2021-10-15 | 石药集团中奇制药技术（石家庄）有限公司 | 干扰素α缀合物 |
| MX2021010286A (es) | 2019-03-04 | 2021-09-23 | Ascendis Pharma Endocrinology Div A/S | Formas de dosificacion de la hormona del crecimiento de accion prolongada con eficacia superior a la somatropina diaria. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| HK1079995A1 (zh) * | 2002-09-05 | 2006-04-21 | The General Hospital Corporation | 修饰的脱唾液酸-干扰素系及其应用 |
-
2003
- 2003-11-10 AU AU2003293668A patent/AU2003293668A1/en not_active Abandoned
- 2003-11-10 ES ES03789020T patent/ES2270152T3/es not_active Expired - Lifetime
- 2003-11-10 JP JP2004552547A patent/JP4279258B2/ja not_active Expired - Lifetime
- 2003-11-10 EP EP03789020A patent/EP1562634B1/de not_active Expired - Lifetime
- 2003-11-10 MX MXPA05005178A patent/MXPA05005178A/es unknown
- 2003-11-10 BR BR0316227-3A patent/BR0316227A/pt not_active Application Discontinuation
- 2003-11-10 CA CA2503594A patent/CA2503594C/en not_active Expired - Fee Related
- 2003-11-10 WO PCT/EP2003/012498 patent/WO2004045648A1/en not_active Ceased
- 2003-11-10 PL PL376883A patent/PL376883A1/pl not_active Application Discontinuation
- 2003-11-10 AT AT03789020T patent/ATE337017T1/de not_active IP Right Cessation
- 2003-11-10 RU RU2005118752/04A patent/RU2005118752A/ru not_active Application Discontinuation
- 2003-11-10 DE DE60307881T patent/DE60307881T2/de not_active Expired - Lifetime
- 2003-11-10 CN CNB2003801033411A patent/CN1323722C/zh not_active Expired - Lifetime
- 2003-11-10 KR KR1020057008685A patent/KR20050065677A/ko not_active Ceased
- 2003-11-12 PA PA20038587801A patent/PA8587801A1/es unknown
- 2003-11-12 TW TW092131686A patent/TW200413404A/zh unknown
- 2003-11-13 PE PE2003001148A patent/PE20040834A1/es not_active Application Discontinuation
- 2003-11-13 US US10/712,494 patent/US20040223950A1/en not_active Abandoned
- 2003-11-13 UY UY28080A patent/UY28080A1/es not_active Application Discontinuation
- 2003-11-13 GT GT200300244A patent/GT200300244A/es unknown
- 2003-11-13 AR ARP030104175A patent/AR042039A1/es unknown
-
2005
- 2005-05-10 ZA ZA200503756A patent/ZA200503756B/xx unknown
- 2005-05-11 NO NO20052310A patent/NO20052310L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1323722C (zh) | 2007-07-04 |
| DE60307881T2 (de) | 2007-03-08 |
| DE60307881D1 (de) | 2006-10-05 |
| RU2005118752A (ru) | 2006-02-10 |
| EP1562634A1 (de) | 2005-08-17 |
| CA2503594A1 (en) | 2004-06-03 |
| CN1711109A (zh) | 2005-12-21 |
| NO20052310L (no) | 2005-08-09 |
| JP4279258B2 (ja) | 2009-06-17 |
| US20040223950A1 (en) | 2004-11-11 |
| PL376883A1 (pl) | 2006-01-09 |
| EP1562634B1 (de) | 2006-08-23 |
| PA8587801A1 (es) | 2004-09-16 |
| PE20040834A1 (es) | 2004-11-17 |
| TW200413404A (en) | 2004-08-01 |
| NO20052310D0 (no) | 2005-05-11 |
| CA2503594C (en) | 2011-05-10 |
| MXPA05005178A (es) | 2005-07-22 |
| WO2004045648A1 (en) | 2004-06-03 |
| KR20050065677A (ko) | 2005-06-29 |
| BR0316227A (pt) | 2005-10-04 |
| AU2003293668A1 (en) | 2004-06-15 |
| GT200300244A (es) | 2004-06-03 |
| UY28080A1 (es) | 2004-05-31 |
| JP2006515571A (ja) | 2006-06-01 |
| ES2270152T3 (es) | 2007-04-01 |
| ZA200503756B (en) | 2008-02-27 |
| AR042039A1 (es) | 2005-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |