JP2006517197A5 - - Google Patents

Download PDF

Info

Publication number
JP2006517197A5
JP2006517197A5 JP2005505633A JP2005505633A JP2006517197A5 JP 2006517197 A5 JP2006517197 A5 JP 2006517197A5 JP 2005505633 A JP2005505633 A JP 2005505633A JP 2005505633 A JP2005505633 A JP 2005505633A JP 2006517197 A5 JP2006517197 A5 JP 2006517197A5
Authority
JP
Japan
Prior art keywords
carotenoids
carotenoid
human
ischemia
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2005505633A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006517197A (ja
JP4601549B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/023706 external-priority patent/WO2004011423A2/en
Publication of JP2006517197A publication Critical patent/JP2006517197A/ja
Publication of JP2006517197A5 publication Critical patent/JP2006517197A5/ja
Application granted granted Critical
Publication of JP4601549B2 publication Critical patent/JP4601549B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2005505633A 2002-07-29 2003-07-29 病気の抑制と改善のための構造上のカロチノイド類似体 Expired - Fee Related JP4601549B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US39919402P 2002-07-29 2002-07-29
US46797303P 2003-05-05 2003-05-05
US47283103P 2003-05-22 2003-05-22
US47374103P 2003-05-28 2003-05-28
US48530403P 2003-07-03 2003-07-03
PCT/US2003/023706 WO2004011423A2 (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010170929A Division JP5187700B2 (ja) 2002-07-29 2010-07-29 病気の抑制と改善のための構造上のカロチノイド類似体

Publications (3)

Publication Number Publication Date
JP2006517197A JP2006517197A (ja) 2006-07-20
JP2006517197A5 true JP2006517197A5 (US20050075337A1-20050407-C00120.png) 2010-09-16
JP4601549B2 JP4601549B2 (ja) 2010-12-22

Family

ID=31192475

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2005505633A Expired - Fee Related JP4601549B2 (ja) 2002-07-29 2003-07-29 病気の抑制と改善のための構造上のカロチノイド類似体
JP2010170929A Expired - Fee Related JP5187700B2 (ja) 2002-07-29 2010-07-29 病気の抑制と改善のための構造上のカロチノイド類似体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010170929A Expired - Fee Related JP5187700B2 (ja) 2002-07-29 2010-07-29 病気の抑制と改善のための構造上のカロチノイド類似体

Country Status (12)

Country Link
US (5) US7145025B2 (US20050075337A1-20050407-C00120.png)
EP (2) EP1532108B1 (US20050075337A1-20050407-C00120.png)
JP (2) JP4601549B2 (US20050075337A1-20050407-C00120.png)
KR (1) KR20050069975A (US20050075337A1-20050407-C00120.png)
CN (2) CN101845009B (US20050075337A1-20050407-C00120.png)
AU (1) AU2003256982A1 (US20050075337A1-20050407-C00120.png)
BR (1) BRPI0313155B8 (US20050075337A1-20050407-C00120.png)
CA (1) CA2495167C (US20050075337A1-20050407-C00120.png)
HK (2) HK1084380A1 (US20050075337A1-20050407-C00120.png)
MX (1) MXPA05001202A (US20050075337A1-20050407-C00120.png)
NO (1) NO20050619L (US20050075337A1-20050407-C00120.png)
WO (1) WO2004011423A2 (US20050075337A1-20050407-C00120.png)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2316618T3 (es) 2001-10-25 2009-04-16 Emory University Cateter para perfusion modificada.
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
CZ2004904A3 (cs) * 2002-02-25 2004-12-15 Diffusion Pharmaceuticals Llc Bipolární trans karotenoidní soli a jejich použití
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US20050009788A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US7375133B2 (en) * 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US7345091B2 (en) * 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US7723327B2 (en) * 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US7763649B2 (en) * 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
WO2004011423A2 (en) * 2002-07-29 2004-02-05 Hawaii Biotech, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
AU2005207029B2 (en) 2004-01-20 2011-09-01 Brigham Young University Novel sirtuin activating compounds and methods for making the same
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
WO2005102356A1 (en) * 2004-04-14 2005-11-03 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
US20060155150A1 (en) * 2004-10-01 2006-07-13 Lockwood Samuel F Methods for the synthesis of lutein
JP2007238441A (ja) * 2004-12-03 2007-09-20 Fuji Chem Ind Co Ltd アスタキサンチンを有効成分とする体脂肪減少用組成物
JP2008525468A (ja) * 2004-12-22 2008-07-17 エモリー・ユニバーシティ ポストコンディショニング臓器保護作用を増強する治療補助薬
US20060270589A1 (en) * 2005-02-22 2006-11-30 Lockwood Samuel F Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities
CN104840455A (zh) 2005-02-24 2015-08-19 扩散药品有限公司 反式类胡萝卜素、其合成、制剂和用途
EP1861109A2 (en) * 2005-03-09 2007-12-05 Cardax Pharmaceuticals, Inc. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders
EP2371967B1 (en) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production of carotenoids in oleaginous yeast and fungi
CA2611137A1 (en) * 2005-03-23 2006-09-28 Cardax Pharmaceuticals, Inc. Water-dispersible carotenoids, including analogs and derivatives
CA2610502A1 (en) * 2005-03-29 2006-10-05 Cardax Pharmaceuticals, Inc. Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
JP2006016407A (ja) * 2005-06-15 2006-01-19 Yamaha Motor Co Ltd ホスホジエステラーゼ阻害剤
JP2006016408A (ja) * 2005-06-23 2006-01-19 Yamaha Motor Co Ltd 血中中性脂肪抑制剤
US20070238793A1 (en) * 2005-12-07 2007-10-11 Lockwood Samuel F Structural carotenoid analogs or derivatives for the modulation of systemic and/or target organ redox status
JP2007153845A (ja) * 2005-12-07 2007-06-21 Yamaha Motor Co Ltd 脂肪蓄積抑制剤
US20070135521A1 (en) * 2005-12-14 2007-06-14 Yamaha Hatsudoki Kabushiki Kaisha Agent for Preventing Metabolic Syndrome
WO2007090095A2 (en) * 2006-01-27 2007-08-09 Cardax Pharmaceuticals, Inc. Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
US20080221377A1 (en) * 2006-06-16 2008-09-11 Lockwood Samuel F Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
RU2438358C2 (ru) * 2006-08-08 2012-01-10 Нестек С.А. Устойчивые и биологически доступные композиции изомеров каротиноидов для кожи и волос
EP2078092A2 (en) 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
ITMI20061874A1 (it) * 2006-09-29 2006-12-29 Rosario Ammirante Composizione per il trattamento degli stati patologici neurodegenerativi del sistema nervoso centrale ed in particolare nel morbo di parkinson
WO2008118862A1 (en) * 2007-03-23 2008-10-02 Cardax Pharmaceuticals, Inc. Carotenoid analogs and derivatives for the prevention of platelet aggregation
EP2146948A4 (en) * 2007-04-13 2010-08-04 Diffusion Pharmaceuticals Llc USE OF BIPOLAR TRANS-CAROTINOIDES AS PRE-TREATMENT AND TREATMENT OF PERIPHERAL VASCULAR DISEASE
MX2010004803A (es) * 2007-10-31 2010-09-09 Diffusion Pharmaceuticals Llc Una nueva clase de composiciones terapeuticas que mejoran la difusion de moleculas pequeñas.
JP2010270095A (ja) * 2008-05-30 2010-12-02 Yamaha Motor Co Ltd 認知行動能力向上剤
WO2010120686A2 (en) * 2009-04-13 2010-10-21 Parsons J Kellogg Methods for the diagnosis and treatment of benign prostatic hyperplasia
EP2445339B1 (en) 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
RU2569743C2 (ru) * 2009-09-11 2015-11-27 Нестек С.А. Композиции и способы усиления когнитивной функции и связанных с ней функций у животных
US8541645B2 (en) * 2009-10-22 2013-09-24 University Of Calcutta Animal model for cigarette-smoke-induced atherosclerosis and related methods
CN103124498A (zh) 2010-06-02 2013-05-29 扩散药品有限公司 双极性反式类胡萝卜素的口服制剂
WO2012017033A1 (en) * 2010-08-04 2012-02-09 Ieo-Istituto Europeo Di Oncologia S.R.L. Method of antigen loading for immunotherapy
CN102389407A (zh) * 2011-12-01 2012-03-28 滨州医学院 虾青素在制备治疗和预防肺纤维化的药品中的应用
GB201120772D0 (en) * 2011-12-02 2012-01-11 Ip Science Ltd Cocoa-based food products
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US20140045874A1 (en) * 2012-07-09 2014-02-13 Noglo Llc Prevention of alcohol reaction with dietary supplements
CN103073471B (zh) * 2013-01-30 2014-11-05 江苏省农业科学院 一种叶黄素二琥珀酸酯的超声辅助合成方法
US9482675B1 (en) * 2013-07-31 2016-11-01 University Of Kentucky Research Foundation Methods and systems for prognosis and diagnosis of brain damage
JP6183746B2 (ja) * 2013-11-13 2017-08-23 国立大学法人高知大学 遅延性アレルギー抑制剤
CA2948605C (en) * 2014-05-20 2019-12-24 Fuji Chemical Industries Co., Ltd. Carotenoid derivative, pharmaceutically acceptable salt thereof, or pharmaceutically acceptable ester or amide thereof
WO2016063278A1 (en) * 2014-10-19 2016-04-28 Shenkar College Of Engineering And Design Astaxanthin based polymer and uses thereof
US10071141B2 (en) 2015-05-08 2018-09-11 Spectral Platforms, Inc. Albumin-based non-covalent complexes and methods of use thereof
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
US9572783B1 (en) * 2015-10-08 2017-02-21 Chuen Wei Lu Use of xanthophylls for the treatment of cancers
CN105646869B (zh) * 2016-01-04 2018-01-16 中国海洋大学 一种水溶性虾青素衍生物及其制备方法
KR102489034B1 (ko) 2016-03-24 2023-01-13 디퓨젼 파마슈티컬즈 엘엘씨 암을 치료하기 위한, 화학 요법 및 방사선 요법과의 양극성 트랜스 카로티노이드의 용도
CN106748946A (zh) * 2017-02-14 2017-05-31 烟台固特丽生物科技股份有限公司 一种含水溶性虾青素作物营养液的制备方法
WO2018175346A1 (en) 2017-03-20 2018-09-27 Spectral Platforms, Inc. Spectroscopic methods to detect and characterize microorganisms
CA3098868A1 (en) * 2018-05-03 2019-11-07 L.E.A.F. Holdings Group Llc Carotenoid compositions and uses thereof
JP2021176821A (ja) * 2018-08-01 2021-11-11 アスタファーマシューティカルズ株式会社 新規カロテノイド関連誘導体、その塩又はエステル類若しくはアミド類
CN109678771A (zh) * 2018-12-28 2019-04-26 广州立达尔生物科技股份有限公司 一种叶黄素甘氨酸酯及其盐酸盐的制备方法
WO2021062237A1 (en) * 2019-09-27 2021-04-01 Cardax, Inc. Astaxanthin esters and methods of use thereof
FR3105790B1 (fr) * 2019-12-26 2022-01-14 Biophytis Composés chimiques ciblant l’œil et leur utilisation dans le traitement de maladies oculaires
CN111257466B (zh) * 2020-02-27 2022-04-01 南宁海关技术中心 一种红心鸭蛋中类胡萝卜素含量的测定方法
CN113788867B (zh) * 2021-06-30 2023-12-26 东北林业大学 一种叶黄素水溶性衍生物及其制备工艺

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH314001A (de) * 1952-12-18 1956-05-31 Hoffmann La Roche Verfahren zur Herstellung von Vitamin-A-Estern
CH420822A (de) * 1960-10-17 1966-09-15 Hoffmann La Roche Wasserdispergierbare Carotinoidzubereitung
US3354218A (en) * 1963-05-10 1967-11-21 Hoffmann La Roche Process for preparing 4-(2, 6, 6-trimethyl-4-methoxy-1-cyclohexen-1-yl)-3-buten-2-one
FR2076448A5 (US20050075337A1-20050407-C00120.png) * 1970-01-15 1971-10-15 Rhone Poulenc Sa
US3853993A (en) * 1973-05-01 1974-12-10 Univ Virginia Process for increasing oxygen diffusivity and method for treating atherosclerosis
US3788468A (en) * 1973-05-01 1974-01-29 Univ Virginia Process for increasing oxygen diffusivity
US3989757A (en) * 1973-08-29 1976-11-02 Hoffmann-La Roche Inc. Isomerizing cis-carotenoids to all-trans-carotenoids
CH609320A5 (US20050075337A1-20050407-C00120.png) * 1974-06-20 1979-02-28 Hoffmann La Roche
US3965261A (en) * 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) * 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4070460A (en) * 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4009270A (en) * 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
CH623304A5 (US20050075337A1-20050407-C00120.png) * 1975-11-30 1981-05-29 Hoffmann La Roche
US4038144A (en) * 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) * 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
JPS6053031B2 (ja) * 1978-03-31 1985-11-22 武田薬品工業株式会社 スピロ化合物およびその製造方法
US4176179A (en) * 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
DE2965093D1 (en) * 1978-06-02 1983-05-05 Hoffmann La Roche Derivatives of cyclohexene, process for their peparation, as well as their uses
EP0005748B1 (de) * 1978-06-02 1982-12-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cyclohexenderivaten sowie Zwischenprodukte in diesem Verfahren
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
EP0077439B1 (de) * 1981-10-16 1986-09-24 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cyclohexenderivaten, sowie ein neues Ausgangsprodukt und neue Zwischenprodukte in diesem Verfahren
EP0085763B1 (de) * 1982-02-09 1985-06-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cyclohexenderivaten
EP0101597B1 (de) * 1982-08-20 1988-06-22 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Astaxanthin und Zwischenprodukten in der Astaxanthin-Synthese
US4491574A (en) * 1983-03-02 1985-01-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Reduction of high dose aspirin toxicity by dietary vitamin A
DE3582439D1 (de) * 1984-01-28 1991-05-16 Roshdy Ismail Mittel zur behandlung von herzerkrankungen.
US5346488A (en) * 1985-04-08 1994-09-13 The General Hospital Corporation Laser-induced ablation of atherosclerotic plaque
US4851339A (en) * 1986-04-01 1989-07-25 Hills Christopher B Extraction of anti-mutagenic pigments from algae and vegetables
DK171297B1 (da) * 1987-03-27 1996-08-26 Hoffmann La Roche Fremgangsmåde til fremstilling af cyclohexenderivater som mellemprodukter til fremstilling af zeaxanthin samt cyclohexenderivater
US5057494A (en) * 1988-08-03 1991-10-15 Ethicon, Inc. Method for preventing tissue damage after an ischemic episode
EP0410236B1 (de) * 1989-07-25 1993-10-27 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Carotinoidpräparaten
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
CA2093008A1 (en) * 1990-10-01 1992-04-02 Charles H. Hennekens Beta-carotene and vitamin e therapy for inhibition of major vascular events
US6132790A (en) * 1991-09-06 2000-10-17 Betatene Limited Carotenoid composition
WO1993013660A1 (en) * 1992-01-06 1993-07-22 Health Maintenance Programs, Inc. Pharmaceutically active antioxydant containing composition and the method of its use to prevent and treat restenosis following angioplasty
US5221668A (en) * 1992-02-26 1993-06-22 Abbott Laboratories Nutritional product for trauma and surgery patients
US5328845A (en) * 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
IL104736A0 (en) * 1992-03-27 1993-06-10 Zeagen Inc Method for producing beta-carotene using a fungal mated culture
EP0565989B1 (de) * 1992-04-14 1997-06-25 F. Hoffmann-La Roche Ag Präparate von fettlöslichen Substanzen
US5310764A (en) * 1992-05-08 1994-05-10 Steven Baranowitz Treatment of age related macular degeneration with beta-carotene
US5612485A (en) * 1992-06-04 1997-03-18 Betatene Ltd Of Cheltenham High cis beta-carotene composition
GB9219524D0 (en) * 1992-09-15 1992-10-28 Smithkline Beecham Plc Novel composition
US5310554A (en) * 1992-10-27 1994-05-10 Natural Carotene Corporation High purity beta-carotene
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
ATE218855T1 (de) * 1993-03-22 2002-06-15 Cognis Australia Pty Ltd Wasserdispersible therapeutische carotenoid verbindungen
DE69424537T2 (de) * 1993-03-22 2001-11-15 Cognis Australien Pty Ltd Therapeutischer wirkstoff zur behandlung von melanomen
ATE193421T1 (de) * 1993-06-24 2000-06-15 Hoffmann La Roche Pigmentierung mit carotinoiden
US6218436B1 (en) * 1993-06-28 2001-04-17 The Howard Foundation Pharmaceutically active carotenoids
DE4322277A1 (de) * 1993-07-05 1995-01-12 Basf Ag Verbessertes Verfahren zur Herstellung von Astaxanthin, neue Zwischenprodukte hierfür sowie ein Verfahren zu deren Herstellung
FR2707184B1 (fr) * 1993-07-08 1995-08-11 Rhone Poulenc Nutrition Animal Procédé de préparation de sphérules contenant un principe actif alimentaire ou pharmaceutique.
US5607839A (en) * 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
JP3249867B2 (ja) * 1993-10-21 2002-01-21 株式会社クラレ アスタキサンチンの製造方法
CH685189A5 (de) * 1993-11-19 1995-04-28 Marigen Sa Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit antitumoral wirksamen Xanthophyll-Estern.
US6428816B1 (en) * 1994-04-08 2002-08-06 Cognis Australia Pty., Ltd. Carotenoid agent for inhibiting the conversion of epithelial cells to tumors
SE9401738D0 (sv) * 1994-05-19 1994-05-19 Ewos Ab Bioactive feed
JPH0873312A (ja) * 1994-09-02 1996-03-19 Noevir Co Ltd 皮膚外用剤
SE503336C2 (sv) * 1994-09-19 1996-05-28 Asta Carotene Ab Medel och sätt för att öka produktionen av/hos fjäderfän
US5527533A (en) * 1994-10-27 1996-06-18 Board Of Trustees Of The University Of Illinois Method of retarding and ameliorating central nervous system and eye damage
ATE183500T1 (de) * 1994-12-21 1999-09-15 Hoffmann La Roche Carotenoide ketone und ester
US5643943A (en) * 1994-12-23 1997-07-01 Alcon Laboratories, Inc. Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5589468A (en) * 1995-01-13 1996-12-31 Clintec Nutrition Co. Method for providing nutrition to elderly patients
CA2210957A1 (en) * 1995-02-03 1996-08-08 Basf Aktiengesellschaft The use of carotenoids for producing drugs for the treatment of dermatoses
US5532009A (en) * 1995-06-07 1996-07-02 The Procter & Gamble Company Fat substitutes containing water soluble beta-carotene
JPH08337592A (ja) * 1995-06-13 1996-12-24 Kaiyo Bio Technol Kenkyusho:Kk 新規カロテノイド
JPH0984591A (ja) * 1995-09-26 1997-03-31 Kaiyo Bio Technol Kenkyusho:Kk カロテノイド硫酸エステルおよびその製造方法
US6060511A (en) * 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
WO1997014705A1 (fr) * 1995-10-17 1997-04-24 Showa Denko K.K. Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants
JPH09124470A (ja) * 1995-10-26 1997-05-13 Suntory Ltd 抗ストレス組成物
US5854015A (en) * 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5827539A (en) * 1995-12-28 1998-10-27 Amway Corporation Dry carotenoid-oil powder and process for making same
US5837224A (en) * 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
US6232060B1 (en) * 1996-01-19 2001-05-15 Galileo Laboratories, Inc. Assay system for anti-stress agents
JPH09202730A (ja) * 1996-01-24 1997-08-05 Nippon Mektron Ltd 発ガン抑制作用剤
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
DE19609477A1 (de) * 1996-03-11 1997-09-18 Basf Ag Stabile wäßrige Solubilisate von Carotinoiden und Vitamine
DE19609476A1 (de) * 1996-03-11 1997-09-18 Basf Ag Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen
SE506191C2 (sv) * 1996-03-27 1997-11-17 Astacarotene Ab Medel och sätt för att öka produktionen av/hos däggdjur
DK0807431T3 (da) * 1996-05-14 2004-07-26 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af carotenoidpræparater
DE19637517A1 (de) * 1996-09-13 1998-03-19 Basf Ag Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen
AU7888498A (en) * 1996-12-25 1998-07-31 Designer Foods Association Ltd. Carcinogenesis inhibitors
DK1493439T3 (da) * 1997-04-02 2012-01-30 Brigham & Womens Hospital Middel til fastlæggelse af en persons risikoprofil for aterosklerotisk sygdom
US5858700A (en) * 1997-04-03 1999-01-12 Kemin Foods, Lc Process for the isolation and purification of lycopene crystals
WO1998045241A2 (en) * 1997-04-04 1998-10-15 Henkel Corporation Lutein esters having high bioavailability
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5876782A (en) * 1997-05-14 1999-03-02 Kemin Industries, Inc. Method for the conversion of xanthophylls in plant material
JPH10327865A (ja) * 1997-05-29 1998-12-15 Kirin Brewery Co Ltd カロテノイド配糖体およびその製造法
SE512531C2 (sv) * 1997-09-04 2000-03-27 Astacarotene Ab Användning av åtminstone en typ av xantofyller för framställning av ett läkemedel för profylaktisk och/eller terapeutisk förbättring av muskelfunktionsdurationen hos däggdjur och/eller behandling av muskelstörningar eller - sjukdomar hos däggdjur
US6008417A (en) 1997-10-20 1999-12-28 Roche Vitamins Inc. Process for making metabolites of lycopene
US5959138A (en) * 1997-11-25 1999-09-28 Industrial Organica S.A. De C.V. Short chain diesters and process for making the same
SE511237C2 (sv) * 1997-12-16 1999-08-30 Astacarotene Ab Användning av åtminstone en typ av xantofyller för framställning av ett humant eller verinärmedicinskt läkemedel för profylaktisk behandling av mastit hos däggdjursmammor
DE19802134A1 (de) * 1998-01-21 1999-07-22 Basf Ag Verwendung von Carotinoid-Aggregaten als Färbemittel
US6020003A (en) * 1998-02-23 2000-02-01 Basf Corporation Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6331537B1 (en) * 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
NL1010351C2 (nl) * 1998-10-19 2001-01-08 Werklust & Beheer B V Esters van caroteno´den voor gebruik in de preventie en behandeling van oogaandoeningen.
US6075058A (en) * 1998-12-12 2000-06-13 Tufts University Compositions for increased bioavailability of carotenoids
US6399105B1 (en) * 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
US6426362B1 (en) * 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
JP4491090B2 (ja) * 1999-10-08 2010-06-30 ヒガシマル醤油株式会社 アポトーシス誘導剤
EP1238068A1 (en) 1999-12-08 2002-09-11 California Institute Of Technology Directed evolution of biosynthetic and biodegration pathways
US6344214B1 (en) * 1999-12-13 2002-02-05 Cyanotech Corporation Method for retarding and ameliorating fever blisters and canker sores
US6258855B1 (en) * 2000-02-08 2001-07-10 Cyanotech Corporation Method of retarding and ameliorating carpal tunnel syndrome
AU5137901A (en) * 2000-04-06 2001-10-23 Coastside Res Method to inhibit lipoxygenase and cancer cell proliferation
US20030104090A1 (en) 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
US6579544B1 (en) * 2000-05-31 2003-06-17 Nutriex, L.L.C. Method for supplementing the diet
US20020110604A1 (en) * 2000-08-11 2002-08-15 Ashni Naturaceuticals, Inc. Composition exhibiting synergistic antioxidant activity
WO2002047493A2 (en) 2000-12-16 2002-06-20 Aventis Pharma Deutschland Gmbh Health promoting compositions
IL157106A0 (en) * 2001-02-23 2004-02-08 Barlovento Internat Novel carotenoid esters
US6984523B2 (en) 2001-08-02 2006-01-10 E.I. Du Pont De Nemours And Company Carotenoid ketolase gene
GB0119052D0 (en) * 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
CA2474208C (en) * 2002-02-06 2011-03-29 Dsm Ip Assets B.V. Astaxanthin esters
US7514107B2 (en) * 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
DE60328374D1 (de) * 2002-04-30 2009-08-27 Suntory Holdings Ltd Astaxanthin-fettsäureester mit mittlerer kettenlänge, verfahren zu dessen herstellung und zusammensetzung, die den ester enthält
US20050059659A1 (en) 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050026874A1 (en) 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US7375133B2 (en) 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7521584B2 (en) 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US20050004235A1 (en) 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050059635A1 (en) 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US7320997B2 (en) 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
WO2004011423A2 (en) 2002-07-29 2004-02-05 Hawaii Biotech, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
US20050143475A1 (en) 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US7345091B2 (en) 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050009788A1 (en) 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050049248A1 (en) 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
WO2005102356A1 (en) * 2004-04-14 2005-11-03 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
US20060155150A1 (en) * 2004-10-01 2006-07-13 Lockwood Samuel F Methods for the synthesis of lutein

Similar Documents

Publication Publication Date Title
JP2006517197A5 (US20050075337A1-20050407-C00120.png)
JP7232806B2 (ja) グルコラファニン、ミロシナーゼ、アスコルビン酸およびキノコ抽出物または粉末を含む組成物
ES2262741T3 (es) Uso de acidos grasos poliinsaturados para la prevencion de accidentes cardiovasculares importantes.
EP3628640B1 (en) Methods of making a deuterated or a non-deuterated molecule and pharmaceutical formulations for treatment
US20140005151A1 (en) Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
US5631234A (en) Method for treating ischemia-reperfusion tissue injury
JP5072856B2 (ja) 循環器官用薬
CA2083609C (en) Preventive or therapeutic agent for ischemia-reperfusion tissue injury, arrhythmia and lung injury caused by active oxygens and free radicals
US7671038B1 (en) Method of therapeautic treatments including human immunodeficiency virus (HIV) disease and other conditions in a human host by administering adenine nucleotides
CN1068517C (zh) 2(3)叔丁基-4-羟基茴香醚在制备防治组织器官损伤性疾病药物中的应用
EP3446689A1 (en) Use of isothiocyanate compounds
WO2023218364A1 (en) Anti-aging and anti-inflammatory compositions comprising nicotinamide mononucleotide and reservatrol and uses thereof
US20060258754A1 (en) Method of treating endothelial dysfunction, oxidative stress and related diseases
EP4346861A1 (en) Compositions comprising sulforaphane or a sulforaphane precursor and moringa plant components