JP2006516038A5 - - Google Patents
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- JP2006516038A5 JP2006516038A5 JP2004526538A JP2004526538A JP2006516038A5 JP 2006516038 A5 JP2006516038 A5 JP 2006516038A5 JP 2004526538 A JP2004526538 A JP 2004526538A JP 2004526538 A JP2004526538 A JP 2004526538A JP 2006516038 A5 JP2006516038 A5 JP 2006516038A5
- Authority
- JP
- Japan
- Prior art keywords
- synthetic copolymer
- alkyl
- biopolymer
- comonomers
- comonomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001577 copolymer Polymers 0.000 claims 38
- 239000000758 substrate Substances 0.000 claims 18
- 230000001851 biosynthetic effect Effects 0.000 claims 17
- -1 methacrylic carboxylic acid Chemical class 0.000 claims 16
- 229920001222 biopolymer Polymers 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 12
- 150000003926 acrylamides Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 239000007943 implant Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 10
- 239000012867 bioactive agent Substances 0.000 claims 10
- 102000008186 Collagen Human genes 0.000 claims 9
- 108010035532 Collagen Proteins 0.000 claims 9
- 229920001436 collagen Polymers 0.000 claims 9
- 239000003125 aqueous solvent Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 102000016942 Elastin Human genes 0.000 claims 3
- 108010014258 Elastin Proteins 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 3
- 108090000288 Glycoproteins Proteins 0.000 claims 3
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 3
- 229940072056 alginate Drugs 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229940045110 chitosan Drugs 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 210000004087 cornea Anatomy 0.000 claims 3
- 229920002549 elastin Polymers 0.000 claims 3
- 229940012952 fibrinogen Drugs 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 239000000017 hydrogel Substances 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 3
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 3
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims 3
- YXMISKNUHHOXFT-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) prop-2-enoate Chemical compound C=CC(=O)ON1C(=O)CCC1=O YXMISKNUHHOXFT-UHFFFAOYSA-N 0.000 claims 2
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- 239000012964 benzotriazole Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- JMCVCHBBHPFWBF-UHFFFAOYSA-N n,n-diethyl-2-methylprop-2-enamide Chemical compound CCN(CC)C(=O)C(C)=C JMCVCHBBHPFWBF-UHFFFAOYSA-N 0.000 claims 2
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical group NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 claims 1
- WLPAQAXAZQUXBG-UHFFFAOYSA-N 1-pyrrolidin-1-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCCC1 WLPAQAXAZQUXBG-UHFFFAOYSA-N 0.000 claims 1
- BLSAPDZWVFWUTL-UHFFFAOYSA-N 2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound OS(=O)(=O)C1CC(=O)NC1=O BLSAPDZWVFWUTL-UHFFFAOYSA-N 0.000 claims 1
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 claims 1
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 claims 1
- YQIGLEFUZMIVHU-UHFFFAOYSA-N 2-methyl-n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C(C)=C YQIGLEFUZMIVHU-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000003999 initiator Substances 0.000 claims 1
- 229940102223 injectable solution Drugs 0.000 claims 1
- WFKDPJRCBCBQNT-UHFFFAOYSA-N n,2-dimethylprop-2-enamide Chemical compound CNC(=O)C(C)=C WFKDPJRCBCBQNT-UHFFFAOYSA-N 0.000 claims 1
- QRWZCJXEAOZAAW-UHFFFAOYSA-N n,n,2-trimethylprop-2-enamide Chemical compound CN(C)C(=O)C(C)=C QRWZCJXEAOZAAW-UHFFFAOYSA-N 0.000 claims 1
- SAEXFKSTXQREHP-UHFFFAOYSA-N n,n-dicyclohexylprop-2-enamide Chemical compound C1CCCCC1N(C(=O)C=C)C1CCCCC1 SAEXFKSTXQREHP-UHFFFAOYSA-N 0.000 claims 1
- LHLLNIZKYYRADT-UHFFFAOYSA-N n-cyclohexyl-n-methylprop-2-enamide Chemical compound C=CC(=O)N(C)C1CCCCC1 LHLLNIZKYYRADT-UHFFFAOYSA-N 0.000 claims 1
- PMJFVKWBSWWAKT-UHFFFAOYSA-N n-cyclohexylprop-2-enamide Chemical compound C=CC(=O)NC1CCCCC1 PMJFVKWBSWWAKT-UHFFFAOYSA-N 0.000 claims 1
- ZIWDVJPPVMGJGR-UHFFFAOYSA-N n-ethyl-2-methylprop-2-enamide Chemical compound CCNC(=O)C(C)=C ZIWDVJPPVMGJGR-UHFFFAOYSA-N 0.000 claims 1
- SWPMNMYLORDLJE-UHFFFAOYSA-N n-ethylprop-2-enamide Chemical compound CCNC(=O)C=C SWPMNMYLORDLJE-UHFFFAOYSA-N 0.000 claims 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 claims 1
- AWGZKFQMWZYCHF-UHFFFAOYSA-N n-octylprop-2-enamide Chemical compound CCCCCCCCNC(=O)C=C AWGZKFQMWZYCHF-UHFFFAOYSA-N 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229960002317 succinimide Drugs 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2397379 | 2002-08-09 | ||
| PCT/CA2003/001180 WO2004014969A1 (en) | 2002-08-09 | 2003-08-11 | Bio-synthetic matrix and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007273082A Division JP2008093451A (ja) | 2002-08-09 | 2007-10-19 | 眼用インプラント |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516038A JP2006516038A (ja) | 2006-06-15 |
| JP2006516038A5 true JP2006516038A5 (https=) | 2006-10-05 |
Family
ID=31501599
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526538A Pending JP2006516038A (ja) | 2002-08-09 | 2003-08-11 | 生合成基質およびその用法 |
| JP2007273082A Pending JP2008093451A (ja) | 2002-08-09 | 2007-10-19 | 眼用インプラント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007273082A Pending JP2008093451A (ja) | 2002-08-09 | 2007-10-19 | 眼用インプラント |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20060134050A1 (https=) |
| EP (2) | EP1741457A1 (https=) |
| JP (2) | JP2006516038A (https=) |
| KR (1) | KR101053792B1 (https=) |
| CN (1) | CN100491424C (https=) |
| AT (1) | ATE356838T1 (https=) |
| AU (1) | AU2003254674A1 (https=) |
| BR (1) | BR0313726A (https=) |
| DE (1) | DE60312525T2 (https=) |
| ES (1) | ES2283849T3 (https=) |
| MX (1) | MXPA05001570A (https=) |
| WO (1) | WO2004014969A1 (https=) |
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| EP1549255A4 (en) | 2002-09-13 | 2007-12-19 | Coopervision Inc | DEVICES AND METHOD FOR IMPROVING THE SEA THICKNESS |
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| TWI354021B (en) * | 2002-12-23 | 2011-12-11 | Alcon Inc | Compositions and methods for inhibiting protein on |
| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
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| WO2005095441A1 (ja) * | 2004-03-31 | 2005-10-13 | National Institute Of Advanced Industrial Science And Technology | 上皮系細胞増殖促進剤 |
| US20050259221A1 (en) | 2004-05-20 | 2005-11-24 | Coopervision, Inc | Corneal onlays and wavefront aberration correction to enhance vision |
| KR20070053217A (ko) * | 2004-08-13 | 2007-05-23 | 오타와 헬쓰 리서치 인스티튜트 | 시력 향상 안과용 장치 및 이와 관련된 방법 및 조성물 |
| US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
| KR101159071B1 (ko) * | 2005-01-14 | 2012-06-26 | 삼성전자주식회사 | 신규한 히드로겔 공중합체, 상기 공중합체가 코팅되어있는 기판, 상기 공중합체를 이용하여 마이크로어레이를제조하는 방법 및 그에 의하여 제조된 마이크로어레이 |
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-
2003
- 2003-08-11 DE DE60312525T patent/DE60312525T2/de not_active Expired - Lifetime
- 2003-08-11 ES ES03783866T patent/ES2283849T3/es not_active Expired - Lifetime
- 2003-08-11 CN CNB038240505A patent/CN100491424C/zh not_active Expired - Fee Related
- 2003-08-11 JP JP2004526538A patent/JP2006516038A/ja active Pending
- 2003-08-11 BR BR0313726-0A patent/BR0313726A/pt not_active IP Right Cessation
- 2003-08-11 MX MXPA05001570A patent/MXPA05001570A/es unknown
- 2003-08-11 KR KR1020057002380A patent/KR101053792B1/ko not_active Expired - Fee Related
- 2003-08-11 US US10/524,250 patent/US20060134050A1/en not_active Abandoned
- 2003-08-11 EP EP06016006A patent/EP1741457A1/en not_active Withdrawn
- 2003-08-11 WO PCT/CA2003/001180 patent/WO2004014969A1/en not_active Ceased
- 2003-08-11 EP EP03783866A patent/EP1530600B1/en not_active Expired - Lifetime
- 2003-08-11 AT AT03783866T patent/ATE356838T1/de not_active IP Right Cessation
- 2003-08-11 AU AU2003254674A patent/AU2003254674A1/en not_active Abandoned
-
2006
- 2006-06-30 US US11/479,297 patent/US20060246113A1/en not_active Abandoned
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2007
- 2007-10-19 JP JP2007273082A patent/JP2008093451A/ja active Pending
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2014
- 2014-04-11 US US14/250,652 patent/US20150071871A1/en not_active Abandoned
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