JP2006515587A5 - - Google Patents

Download PDF

Info

Publication number
JP2006515587A5
JP2006515587A5 JP2004560041A JP2004560041A JP2006515587A5 JP 2006515587 A5 JP2006515587 A5 JP 2006515587A5 JP 2004560041 A JP2004560041 A JP 2004560041A JP 2004560041 A JP2004560041 A JP 2004560041A JP 2006515587 A5 JP2006515587 A5 JP 2006515587A5
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
composition
pharmaceutically acceptable
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004560041A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006515587A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2003/005682 external-priority patent/WO2004054563A1/en
Publication of JP2006515587A publication Critical patent/JP2006515587A/ja
Publication of JP2006515587A5 publication Critical patent/JP2006515587A5/ja
Withdrawn legal-status Critical Current

Links

JP2004560041A 2002-12-13 2003-12-03 性的不能を治療する方法 Withdrawn JP2006515587A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43349102P 2002-12-13 2002-12-13
PCT/IB2003/005682 WO2004054563A1 (en) 2002-12-13 2003-12-03 Alpha-2-delta ligand for the treatment of sexual dysfunction

Publications (2)

Publication Number Publication Date
JP2006515587A JP2006515587A (ja) 2006-06-01
JP2006515587A5 true JP2006515587A5 (enExample) 2006-10-12

Family

ID=32595199

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004560036A Pending JP2006511527A (ja) 2002-12-13 2003-12-03 種々の薬学的用途のためのα２δリガンド
JP2004560041A Withdrawn JP2006515587A (ja) 2002-12-13 2003-12-03 性的不能を治療する方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2004560036A Pending JP2006511527A (ja) 2002-12-13 2003-12-03 種々の薬学的用途のためのα２δリガンド

Country Status (15)

Country Link
US (8) US7432299B2 (enExample)
EP (2) EP1572183A1 (enExample)
JP (2) JP2006511527A (enExample)
KR (2) KR20050085537A (enExample)
CN (8) CN1726022A (enExample)
AU (3) AU2003303038B2 (enExample)
BR (2) BR0317273A (enExample)
CA (3) CA2451267A1 (enExample)
MX (2) MXPA05005665A (enExample)
MY (1) MY140525A (enExample)
NZ (2) NZ539971A (enExample)
PL (2) PL377656A1 (enExample)
TW (2) TW200412241A (enExample)
WO (3) WO2004054559A1 (enExample)
ZA (6) ZA200503861B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
US20050043345A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US20050043406A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
BRPI0414798A (pt) 2003-09-25 2006-11-21 Warner Lambert Co métodos para usar aminoácidos com afinidade para a proteìna alfa2delta
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
US8415298B2 (en) 2004-06-21 2013-04-09 The Board Of Trustees Of The Leland Stanford Junior University Of Stanford Administration of FGF2 for treamtent of anxiety
PL1791423T3 (pl) * 2004-08-02 2013-09-30 Sami Labs Ltd Kompozycje i sposoby postępowania z hiperproliferacyjnymi zaburzeniami dermatologicznymi
US7973025B2 (en) 2005-05-26 2011-07-05 Neuron Systems, Inc. Compositions and methods of treating retinal disease
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
WO2007027476A2 (en) * 2005-08-26 2007-03-08 Xenoport, Inc. Treating premature ejaculation using gabapentin and pregabalin prodrugs
DE102005050377A1 (de) * 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclische Verbindungen und ihre Verwendung
WO2008073257A1 (en) * 2006-12-08 2008-06-19 Xenoport, Inc. Use of prodrugs of gaba analogs for treating diseases
DE102007001804A1 (de) * 2007-01-12 2008-07-17 Johann Wolfgang Goethe-Universität Frankfurt am Main Verwendung von GABAB-Rezeptor selektiven Agonisten zur Behandlung entzündlicher Hauterkrankungen
WO2009055059A1 (en) * 2007-10-26 2009-04-30 The Scripps Research Institute Methods for treating substance dependence
AU2008318311B2 (en) * 2007-11-02 2014-05-15 The Board Of Trustees Of The Leland Stanford Junior University FGF9-related methods for treating anxiety
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) * 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
JP5563483B2 (ja) * 2008-01-25 2014-07-30 ゼノポート，インコーポレイティド アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2011072141A1 (en) 2009-12-11 2011-06-16 Neuron Systems, Inc. Compositions and methods for the treatment of macular degeneration
CN102432525A (zh) * 2011-10-20 2012-05-02 苏州康润医药有限公司 3-苄基-3-氮杂二环[2,1,0]己烷的实用合成方法
HK1217325A1 (zh) 2012-12-20 2017-01-06 奥尔德拉医疗公司 迫位原醇
US8992951B2 (en) * 2013-01-09 2015-03-31 Sapna Life Sciences Corporation Formulations, procedures, methods and combinations thereof for reducing or preventing the development, or the risk of development, of neuropathology as a result of trauma
SG11201505587YA (en) 2013-01-23 2015-08-28 Aldeyra Therapeutics Inc Toxic aldehyde related diseases and treatment
CA2898869A1 (en) 2013-01-25 2014-07-31 Aldeyra Therapeutics, Inc. Novel traps in the treatment of macular degeneration
CA3111682A1 (en) 2014-06-26 2015-12-30 Island Breeze Systems Ca, Llc Mdi related products and methods of use
BR112017024364A2 (pt) * 2015-05-12 2018-07-31 Cipla Europe Nv inalador, kit de inalador, método para usar um kit de inalador, método para carregar um recipiente em um inalador, método para remover um recipiente aberto a partir de um inalador após o uso, método para tratar um paciente com diabetes mellitus e uso de um medicamento em pó
AU2016311158A1 (en) 2015-08-21 2018-04-05 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
WO2017196881A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
CA3054811A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN110945014B (zh) 2017-05-26 2024-08-06 诺瓦色生物公司 电压门控钙通道缺陷亚基α2δ及其应用
MX2020003425A (es) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Tratamiento de trastornos inflamatorios.
EP3833660A4 (en) 2018-08-06 2022-05-11 Aldeyra Therapeutics, Inc. POLYMORPHIC COMPOUNDS AND THEIR USES
JP2022530967A (ja) 2019-05-02 2022-07-05 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
AU2020370758B2 (en) * 2019-10-25 2025-08-14 Kyoto University Preventative or therapeutic agent for tauopathy
CA3175856A1 (en) 2020-05-13 2021-11-18 Todd Brady Pharmaceutical formulations and uses thereof

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503059A (en) * 1950-04-04 Nxchj
US2599000A (en) * 1950-09-02 1952-06-03 Smith Kline French Lab Nu, nu-disubstituted-beta-halo-alkylamines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
NL175059C (nl) * 1974-02-23 Boehringer Mannheim Gmbh Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
FR2421888A1 (fr) * 1978-02-06 1979-11-02 Synthelabo Amides d'alkylene-diamines et leur application en therapeutique
IT1094076B (it) * 1978-04-18 1985-07-26 Acraf Cicloalchiltriazoli
JPS56110665A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
US5084479A (en) * 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
GB9117716D0 (en) * 1991-08-16 1991-10-02 Lynxvale Ltd Gaba derivatives and their therapeutic application
JP3856816B2 (ja) * 1992-05-20 2006-12-13 ノースウェスターン ユニヴァーシティ 抗発作治療用のｇａｂａ及びｌ−グルタミン酸類縁体
US5510381A (en) * 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
DK0888325T3 (da) 1996-02-07 2002-09-16 Warner Lambert Co Cykliske aminosyrer som farmaceutiske midler
WO1997033859A1 (en) 1996-03-14 1997-09-18 Warner-Lambert Company Novel bridged cyclic amino acids as pharmaceutical agents
AU734173B2 (en) 1996-03-14 2001-06-07 Warner-Lambert Company Novel substituted cyclic amino acids as pharmaceutical agents
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
KR100491282B1 (ko) * 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
ATE361909T1 (de) 1996-10-23 2007-06-15 Warner Lambert Co Substituierte gamma-aminobuttersäurederivate als arzneimittel
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
HRP980342A2 (en) * 1997-06-25 1999-02-28 Warner Lambert Co Anti-inflammatory method
WO1999008670A1 (en) * 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
DE69834204T2 (de) 1997-10-27 2007-03-29 Warner-Lambert Co. Llc Zyklische aminosäuren und deren derivate als arzneimittel
WO1999031075A1 (en) 1997-12-16 1999-06-24 Warner-Lambert Company 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
JP2002508361A (ja) 1997-12-16 2002-03-19 ワーナー−ランバート・カンパニー （（シクロ）アルキル置換）−γ−アミノ酪酸誘導体（＝ＧＡＢＡ類似体）、それらの製造および神経学的疾患の治療における使用
HRP20000407A2 (en) 1997-12-16 2000-10-31 Pfizer Prod Inc Combination effective for the treatment of impotence
KR20010033153A (ko) 1997-12-16 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도
US5945117A (en) * 1998-01-30 1999-08-31 Pentech Pharmaceuticals, Inc. Treatment of female sexual dysfunction
WO1999061424A1 (en) * 1998-05-26 1999-12-02 Warner-Lambert Company Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel
JP2002520277A (ja) * 1998-07-09 2002-07-09 ワーナー−ランバート・カンパニー 不眠症を治療する方法
US5945424A (en) * 1998-07-31 1999-08-31 G & H Associates, Inc. Treatment of periodic limb movement syndrome
NZ510145A (en) * 1998-09-14 2003-02-28 Warner Lambert Co Branched alkyl pyrrolidine-3-carboxylic acids useful in protective action against cardiazole cramp and cerebral conditions such as epilepsy, hypokinesia and cranial traumas
AU779262B2 (en) * 1999-04-08 2005-01-13 Warner-Lambert Company Method for the treatment of incontinence
AU4307800A (en) * 1999-04-30 2000-11-17 Merab Lomia New indication for use of antiepileptic agents and medicines
WO2000067742A2 (en) * 1999-05-05 2000-11-16 Warner-Lambert Company Use of gaba analogues for the modulation of substance p
JP3904452B2 (ja) 1999-06-10 2007-04-11 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー モノ−およびジ置換３−プロピルガンマ−アミノ酪酸
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
MXPA02004829A (es) * 1999-12-08 2003-10-14 Warner Lambert Co Metodo para la sintesis estereoselectiva de aminoacidos ciclicos.
DE60127098T2 (de) * 2000-01-31 2007-11-29 Genaera Corp. Inhibitoren der mucin-synthese
GB0007884D0 (en) * 2000-03-31 2000-05-17 Pfizer Ltd Diphenyl ether compounds useful in therapy
MXPA02010764A (es) * 2000-05-31 2003-03-10 Warner Lambert Co Combinaciones de un antagonista del receptor endotelina y un compuesto antiepileptico que tiene propiedades para aliviar el dolor o analgesico.
MXPA02010668A (es) * 2000-06-26 2003-03-10 Warner Lambert Co Analogos de gabapentina para alteraciones del sueno.
GB2365425A (en) 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
AU1497802A (en) 2000-09-14 2002-03-26 Gruenenthal Chemie Ss-thio-amino acids
CA2356829A1 (en) * 2000-09-22 2002-03-22 Warner-Lambert Company Method for treating asthma using pregabalin
AR034160A1 (es) 2000-09-30 2004-02-04 Gruenenthal Gmbh Sulfonilguanidinas, medicamentos que contienen estos compuestos y el uso de sulfonilguanidinas
DE10048715A1 (de) 2000-09-30 2004-05-19 Grünenthal GmbH Verwendung von Aminosäure zur Behandlung von Schmerz
EP1343805A4 (en) 2000-10-06 2005-07-20 Xenoport Inc COMPOUNDS DERIVED FROM GALLENIC ACIDS FOR THE PROVISION OF CONTINUING SYSTEMIC CONCENTRATIONS OF MEDICINAL PRODUCTS AFTER ORAL ADMINISTRATION
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
GB2368579A (en) 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
AU2002239257A1 (en) 2000-11-17 2002-06-03 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
AP2001002360A0 (en) * 2000-11-30 2001-12-31 Pfizer Prod Inc Combination of gaba agonists and sorbitol dehydrogenase inhibitors.
EA006396B1 (ru) 2001-04-19 2005-12-29 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си Конденсированные бициклические аминокислоты
DE60213592T2 (de) * 2001-05-25 2007-08-09 Warner-Lambert Co. Llc Flüssige pharmazeutische zusammensetzung
WO2002100347A2 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.

Similar Documents

Publication Publication Date Title
JP2006515587A5 (enExample)
RU2306309C2 (ru) Производное 8-азапростагландина, фармацевтическая композиция, агент для профилактики заболеваний
ES2544532T3 (es) Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso
JP2001521020A5 (enExample)
RU2008106058A (ru) Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона
CN105120866B (zh) 与毒性醛相关的疾病和治疗
JP2021176846A (ja) スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用
JPWO2023099592A5 (enExample)
US20100004481A1 (en) L-threonine derivatives of high therapeutic index
JP2009524675A5 (enExample)
CA2514384A1 (en) 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases
RU2012121577A (ru) Замещенные 3-фенилпропионовые кислоты и их применение
JP2005531516A5 (enExample)
JP2006143737A5 (enExample)
JP2004501189A5 (enExample)
WO2008054454A2 (en) Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
JP2018524304A5 (enExample)
JP2003503449A5 (enExample)
JP2010090149A5 (enExample)
JP2006504738A5 (enExample)
JP2009517411A5 (enExample)
JP2004532828A5 (enExample)
CA2589744A1 (en) Pyrrolinidium derivatives as m3 muscarinic receptors
JP2005516035A5 (enExample)
JPS61257967A (ja) ２−ピロリドン誘導体