FR2421888A1 - Amides d'alkylene-diamines et leur application en therapeutique - Google Patents

Amides d'alkylene-diamines et leur application en therapeutique

Info

Publication number
FR2421888A1
FR2421888A1 FR7803175A FR7803175A FR2421888A1 FR 2421888 A1 FR2421888 A1 FR 2421888A1 FR 7803175 A FR7803175 A FR 7803175A FR 7803175 A FR7803175 A FR 7803175A FR 2421888 A1 FR2421888 A1 FR 2421888A1
Authority
FR
France
Prior art keywords
therapeutics
application
alkylene diamine
amides
diamine amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7803175A
Other languages
English (en)
Other versions
FR2421888B1 (fr
Inventor
Philippe Michel Jacque Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7803175A priority Critical patent/FR2421888A1/fr
Priority to FR7836819A priority patent/FR2445323A2/fr
Priority to IL56578A priority patent/IL56578A/xx
Priority to AU43895/79A priority patent/AU521524B2/en
Priority to NZ189553A priority patent/NZ189553A/xx
Priority to BE0/193248A priority patent/BE873909A/fr
Priority to DK046079A priority patent/DK159316C/da
Priority to ZA79455A priority patent/ZA79455B/xx
Priority to GR50581A priority patent/GR66846B/el
Priority to FI790369A priority patent/FI66861C/fi
Priority to PT7969178A priority patent/PT69178A/fr
Priority to LU80880A priority patent/LU80880A1/fr
Priority to SE7900987A priority patent/SE449360B/sv
Priority to ES477457A priority patent/ES477457A1/es
Priority to IE210/79A priority patent/IE47812B1/en
Priority to AT0084279A priority patent/AT365176B/de
Priority to JP54012737A priority patent/JPS6023114B2/ja
Priority to IT19908/79A priority patent/IT1192347B/it
Priority to CH112079A priority patent/CH637122A5/fr
Priority to NO790358A priority patent/NO151463C/no
Priority to CA320,864A priority patent/CA1102330A/fr
Priority to DE2904445A priority patent/DE2904445C2/de
Priority to NLAANVRAGE7900917,A priority patent/NL181482C/xx
Priority to GB79403279A priority patent/GB2013679B/en
Priority to MX10092979U priority patent/MX5062E/es
Priority to FR7924373A priority patent/FR2466462A2/fr
Priority to BE0/197895A priority patent/BE879730R/fr
Publication of FR2421888A1 publication Critical patent/FR2421888A1/fr
Priority to US06/099,622 priority patent/US4315007A/en
Application granted granted Critical
Publication of FR2421888B1 publication Critical patent/FR2421888B1/fr
Priority to NL930043C priority patent/NL930043I2/nl
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Amides d'alkylène-diamines répondant à la formule générale :
FR7803175A 1978-02-06 1978-02-06 Amides d'alkylene-diamines et leur application en therapeutique Granted FR2421888A1 (fr)

Priority Applications (29)

Application Number Priority Date Filing Date Title
FR7803175A FR2421888A1 (fr) 1978-02-06 1978-02-06 Amides d'alkylene-diamines et leur application en therapeutique
FR7836819A FR2445323A2 (fr) 1978-02-06 1978-12-29 Amides d'alkylenediamines et leur application en therapeutique
AU43895/79A AU521524B2 (en) 1978-02-06 1979-02-02 Quinazoline derivatives
NZ189553A NZ189553A (en) 1978-02-06 1979-02-02 N1-acyl-n2-(4-amino-6,7-dimethoxyquinazolin-2-yl)alkylenediamines
BE0/193248A BE873909A (fr) 1978-02-06 1979-02-02 Derives d'alkylenediamines
DK046079A DK159316C (da) 1978-02-06 1979-02-02 Analogifremgangsmaade til fremstilling af terapeutisk aktive 4-amino-6,7-dimethoxyquinazolinderivater eller farmaceutisk acceptable syreadditionssalte heraf
ZA79455A ZA79455B (en) 1978-02-06 1979-02-02 Alkylenediamine derivatives
GR50581A GR66846B (fr) 1978-02-06 1979-02-02
IL56578A IL56578A (en) 1978-02-06 1979-02-02 Quinazoline derivatives,their preparation and pharmaceutical compositions containing them
AT0084279A AT365176B (de) 1978-02-06 1979-02-05 Verfahren zur herstellung neuer amide und ihrer saeureadditionssalze
LU80880A LU80880A1 (fr) 1978-02-06 1979-02-05 Derives d'alkylenediamines
SE7900987A SE449360B (sv) 1978-02-06 1979-02-05 Alkylendiaminderivat, forfarande for dess framstellning samt farmaceutisk komposition innehallande denna
ES477457A ES477457A1 (es) 1978-02-06 1979-02-05 Procedimiento de preparacion de amidas de alcohilendiaminas.
IE210/79A IE47812B1 (en) 1978-02-06 1979-02-05 Alkylenediamine derivatives
FI790369A FI66861C (fi) 1978-02-06 1979-02-05 Foerfarande foer framstaellning av n,n2-disubstituerade propylendiaminer med antihypertensiv verkan
JP54012737A JPS6023114B2 (ja) 1978-02-06 1979-02-05 アルキレンジアミンアミド誘導体
IT19908/79A IT1192347B (it) 1978-02-06 1979-02-05 Derivati di alchilendiamine
CH112079A CH637122A5 (fr) 1978-02-06 1979-02-05 Amides d'alkylenediamines.
NO790358A NO151463C (no) 1978-02-06 1979-02-05 Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater
CA320,864A CA1102330A (fr) 1978-02-06 1979-02-05 Procede d'obtention de derives d'alkylenediamine
PT7969178A PT69178A (fr) 1978-02-06 1979-02-05 Procede de preparation de derives de alkylenediamines
NLAANVRAGE7900917,A NL181482C (nl) 1978-02-06 1979-02-06 Werkwijze ter bereiding van een geneesmiddel met een cardiovasculaire werking op basis van een chinazolinederivaat, en het daarbij toe te passen chinazolinederivaat.
GB79403279A GB2013679B (en) 1978-02-06 1979-02-06 Alkylenediamine derivatives
MX10092979U MX5062E (es) 1978-02-06 1979-02-06 Procedimiento para preparar amidas de alquilendiaminas
DE2904445A DE2904445C2 (de) 1978-02-06 1979-02-06 N↓1↓-(4-Amino-6.7-dimethoxy-2-chinazolyl)-N↓1↓-methyl-N↓2↓-(2-tetrahydrofuroyl)-1.3-propandiamin, seine Herstellung und seine pharmazeutische Verwendung
FR7924373A FR2466462A2 (fr) 1978-02-06 1979-10-01 Derives d'alkylenediamines, leur preparation et leur application en therapeutique
BE0/197895A BE879730R (fr) 1978-02-06 1979-10-30 Derives d'alkylenediamines
US06/099,622 US4315007A (en) 1978-02-06 1979-12-10 4-Amino-6,7-dimethoxyquinazol-2-yl alkylenediamines
NL930043C NL930043I2 (nl) 1978-02-06 1993-05-28 Werkwijze ter bereiding van een geneesmiddel met een cardiovasculaire werking op basis van een chinazolinederivaat, en het daarbij toe te passen chinazolinederivaat.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7803175A FR2421888A1 (fr) 1978-02-06 1978-02-06 Amides d'alkylene-diamines et leur application en therapeutique
FR7836819A FR2445323A2 (fr) 1978-02-06 1978-12-29 Amides d'alkylenediamines et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2421888A1 true FR2421888A1 (fr) 1979-11-02
FR2421888B1 FR2421888B1 (fr) 1980-09-26

Family

ID=26220430

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7803175A Granted FR2421888A1 (fr) 1978-02-06 1978-02-06 Amides d'alkylene-diamines et leur application en therapeutique
FR7836819A Granted FR2445323A2 (fr) 1978-02-06 1978-12-29 Amides d'alkylenediamines et leur application en therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7836819A Granted FR2445323A2 (fr) 1978-02-06 1978-12-29 Amides d'alkylenediamines et leur application en therapeutique

Country Status (23)

Country Link
US (1) US4315007A (fr)
JP (1) JPS6023114B2 (fr)
AT (1) AT365176B (fr)
AU (1) AU521524B2 (fr)
BE (1) BE873909A (fr)
CA (1) CA1102330A (fr)
CH (1) CH637122A5 (fr)
DE (1) DE2904445C2 (fr)
DK (1) DK159316C (fr)
ES (1) ES477457A1 (fr)
FI (1) FI66861C (fr)
FR (2) FR2421888A1 (fr)
GB (1) GB2013679B (fr)
GR (1) GR66846B (fr)
IE (1) IE47812B1 (fr)
IL (1) IL56578A (fr)
IT (1) IT1192347B (fr)
LU (1) LU80880A1 (fr)
NL (2) NL181482C (fr)
NO (1) NO151463C (fr)
NZ (1) NZ189553A (fr)
PT (1) PT69178A (fr)
SE (1) SE449360B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570275A1 (fr) * 1984-09-14 1986-03-21 Synthelabo Compositions pharmaceutiques a base de diltiazem et d'alfusozine
EP0189336A1 (fr) * 1985-01-18 1986-07-30 Synthelabo Compositions pharmaceutiques contenant un alpha-bloquant et un antagoniste du calcium
FR2577804A1 (fr) * 1985-02-26 1986-08-29 Synthelabo Compositions pharmaceutiques a base de verapamil et d'alfuzosine
FR2577803A1 (fr) * 1985-02-26 1986-08-29 Synthelabo Compositions pharmaceutiques a base de nifedipine et d'alfuzosine
FR2606635A1 (fr) * 1986-11-19 1988-05-20 Oreal Composition pour induire et stimuler la croissance des cheveux et diminuer la chute a base de derives d'alkylene diamino quinazoline
WO2001068615A1 (fr) * 2000-03-13 2001-09-20 Chemrx Advanced Technologies, Inc. Synthese de la quinazoline

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2466462A2 (fr) * 1978-02-06 1981-04-10 Synthelabo Derives d'alkylenediamines, leur preparation et leur application en therapeutique
DE3380093D1 (en) * 1982-09-30 1989-07-27 William John Louis 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
JPS6093016A (ja) * 1983-10-25 1985-05-24 Natl House Ind Co Ltd クランプ搬送装置
FR2582513B1 (fr) * 1985-05-28 1988-08-05 Synthelabo Compositions pharmaceutiques contenant de l'alfuzosine
YU70890A (en) * 1989-04-21 1992-05-28 Egyt Gyogyszervegyeszeti Gyar Process for obtaining quinazoline derivatives
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
FR2694495B1 (fr) * 1992-08-05 1994-09-23 Synthelabo Préparation pharmaceutique transdermique contenant de l'alfuzosine.
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
FR2717388B1 (fr) * 1994-03-21 1996-11-22 Synthelabo Formes galéniques à libération prolongée du chlorhydrate d'alfuzosine.
US6313294B1 (en) 1998-02-04 2001-11-06 Development Center For Biotechnology Process for preparing amides
EP1604653A1 (fr) 1998-09-30 2005-12-14 Takeda Pharmaceutical Company Limited Inhibiteurs de l'acetylcholinestérase pour améliorer la puissance excrétorique de la vessie
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
PT1572173E (pt) 2002-12-13 2010-05-10 Warner Lambert Co Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
CA2451267A1 (fr) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Utilisations pharmaceutiques de ligands alpha2delta
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
PL1789412T3 (pl) * 2004-09-16 2008-10-31 Hetero Drugs Ltd Krystaliczna zasada alfuzosyny
EP1863484A1 (fr) * 2005-03-21 2007-12-12 Pfizer Limited Derives de triazole substitues utilises en tant qu'antagonistes d'oxytocine
DE602006003416D1 (de) * 2005-03-21 2008-12-11 Pfizer Ltd Substituierte triazolderivate als oxytocinantagonisten
EP1917257A1 (fr) * 2005-08-10 2008-05-07 Pfizer Limited Derives de triazole substitues en tant qu'antagonistes d'oxytocine
US20070066824A1 (en) * 2005-09-22 2007-03-22 Anumula Raghupathi R Preparation of alfuzosin
US20070105880A1 (en) * 2005-11-08 2007-05-10 Torrent Pharmaceuticals Limited Process for the preparation of alfuzosin
US20090069562A1 (en) * 2005-12-26 2009-03-12 Joseph Prabahar Koilpillai Process for the preparation of alfuzosin
CN101190890B (zh) 2006-11-30 2011-04-27 江苏豪森药业股份有限公司 5-[(2r)-[2-[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2-甲氧基苯磺酰胺
US20100092556A1 (en) * 2006-12-11 2010-04-15 Kristin Arnold Alfuzosin formulations, methods of making, and methods of use
WO2008073388A2 (fr) * 2006-12-11 2008-06-19 Mutual Pharmaceutical Company, Inc. Formulations d'alfuzosine, procédés de fabrication et procédés d'utilisation de celles-ci
US20100174073A1 (en) * 2007-05-04 2010-07-08 Actavis Group Ptc Ehf Process for the preparation of alfuzosin and salts thereof
WO2009001369A1 (fr) * 2007-06-22 2008-12-31 Alembic Limited Procédé perfectionné pour la préparation de chlorhydrate d'alfuzosine
WO2009007987A1 (fr) * 2007-07-11 2009-01-15 Alembic Limited Procédé amélioré pour la préparation d'alfuzosine et de son nouveau polymorphe
JP2010535185A (ja) * 2007-08-02 2010-11-18 シプラ・リミテッド アルフゾシン塩酸塩の製造方法
US20090076043A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched alfuzosin
WO2010083360A2 (fr) * 2009-01-16 2010-07-22 Mutual Pharmaceutical Company, Inc. Préparations à libération contrôlée
CN107998090A (zh) * 2017-12-30 2018-05-08 威海贯标信息科技有限公司 一种阿夫唑嗪片组合物
CN113801069B (zh) * 2020-06-15 2024-03-15 鲁南制药集团股份有限公司 一种盐酸阿夫唑嗪中间体化合物
CN114573569B (zh) * 2022-03-30 2023-07-04 邦恩泰(山东)生物医药科技集团股份有限公司 一种异喹啉类化合物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7704979A (nl) * 1976-05-07 1977-11-09 Synthelabo Werkwijze ter bereiding van een geneesmiddel, zo gevormd geneesmiddel en werkwijze ter bereiding van daartoe geschikte actieve componenten.
FR2362630A1 (fr) * 1976-08-24 1978-03-24 Synthelabo Derives d'alkylenediamines

Family Cites Families (5)

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US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
FR2350101A1 (fr) * 1976-05-07 1977-12-02 Synthelabo Nouvelles guanidines cyclisees
FR2389613A2 (en) * 1977-05-05 1978-12-01 Synthelabo Antihypertensive 4-amino-6,7-di:methoxy-quinazolyl alkylene di:amine - prepd. from a 2-halo-quinazoline and an alkylene di:amine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7704979A (nl) * 1976-05-07 1977-11-09 Synthelabo Werkwijze ter bereiding van een geneesmiddel, zo gevormd geneesmiddel en werkwijze ter bereiding van daartoe geschikte actieve componenten.
FR2362630A1 (fr) * 1976-08-24 1978-03-24 Synthelabo Derives d'alkylenediamines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570275A1 (fr) * 1984-09-14 1986-03-21 Synthelabo Compositions pharmaceutiques a base de diltiazem et d'alfusozine
EP0178961A1 (fr) * 1984-09-14 1986-04-23 Synthelabo Compositions pharmaceutiques à base de diltiazem et d'alfuzosine
EP0189336A1 (fr) * 1985-01-18 1986-07-30 Synthelabo Compositions pharmaceutiques contenant un alpha-bloquant et un antagoniste du calcium
FR2577804A1 (fr) * 1985-02-26 1986-08-29 Synthelabo Compositions pharmaceutiques a base de verapamil et d'alfuzosine
FR2577803A1 (fr) * 1985-02-26 1986-08-29 Synthelabo Compositions pharmaceutiques a base de nifedipine et d'alfuzosine
FR2606635A1 (fr) * 1986-11-19 1988-05-20 Oreal Composition pour induire et stimuler la croissance des cheveux et diminuer la chute a base de derives d'alkylene diamino quinazoline
BE1000621A3 (fr) * 1986-11-19 1989-02-21 Oreal Composition pour induire et stimuler la croissance des cheveux et diminuer la chute a base de derives d'alkylene diamino quinazoline.
WO2001068615A1 (fr) * 2000-03-13 2001-09-20 Chemrx Advanced Technologies, Inc. Synthese de la quinazoline

Also Published As

Publication number Publication date
FI66861C (fi) 1984-12-10
DE2904445A1 (de) 1979-08-16
DK46079A (da) 1979-08-07
NL7900917A (nl) 1979-08-08
GB2013679B (en) 1982-09-02
CA1102330A (fr) 1981-06-02
IT1192347B (it) 1988-03-31
JPS6023114B2 (ja) 1985-06-05
GR66846B (fr) 1981-05-05
DK159316C (da) 1991-03-04
DE2904445C2 (de) 1986-10-30
CH637122A5 (fr) 1983-07-15
AT365176B (de) 1981-12-28
NZ189553A (en) 1981-05-01
AU4389579A (en) 1979-08-16
FR2421888B1 (fr) 1980-09-26
FI66861B (fi) 1984-08-31
FI790369A (fi) 1979-08-07
FR2445323A2 (fr) 1980-07-25
NL930043I1 (nl) 1993-08-02
NO790358L (no) 1979-08-07
LU80880A1 (fr) 1980-09-24
GB2013679A (en) 1979-08-15
FR2445323B2 (fr) 1981-11-27
PT69178A (fr) 1979-03-01
ES477457A1 (es) 1979-10-16
NO151463B (no) 1985-01-02
NL930043I2 (nl) 1993-11-16
IL56578A0 (en) 1979-05-31
US4315007A (en) 1982-02-09
SE449360B (sv) 1987-04-27
IT7919908A0 (it) 1979-02-05
BE873909A (fr) 1979-08-02
NL181482C (nl) 1987-09-01
DK159316B (da) 1990-10-01
JPS54117487A (en) 1979-09-12
SE7900987L (sv) 1979-08-07
ATA84279A (de) 1981-05-15
NO151463C (no) 1985-04-17
IE790210L (en) 1979-08-06
IE47812B1 (en) 1984-06-27
AU521524B2 (en) 1982-04-08
IL56578A (en) 1983-02-23
NL181482B (nl) 1987-04-01

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