JP2005516035A5 - - Google Patents

Info

Publication number

JP2005516035A5

JP2005516035A5 JP2003561625A JP2003561625A JP2005516035A5 JP 2005516035 A5 JP2005516035 A5 JP 2005516035A5 JP 2003561625 A JP2003561625 A JP 2003561625A JP 2003561625 A JP2003561625 A JP 2003561625A JP 2005516035 A5 JP2005516035 A5 JP 2005516035A5

Authority

JP

Japan

Prior art keywords

melagatran

medicament

kit

pharmaceutically acceptable

insulin

Prior art date

2003-01-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 16
• DKWNMCUOEDMMIN-PKOBYXMFSA-N melagatran Chemical compound C1=CC(C(=N)N)=CC=C1CNC(=O)[C@H]1N(C(=O)[C@H](NCC(O)=O)C2CCCCC2)CC1 DKWNMCUOEDMMIN-PKOBYXMFSA-N 0.000 claims 15
• 210000004027 cell Anatomy 0.000 claims 13
• 239000003814 drug Substances 0.000 claims 13
• 229960002137 melagatran Drugs 0.000 claims 12
• 102000004877 Insulin Human genes 0.000 claims 8
• 108090001061 Insulin Proteins 0.000 claims 8
• 229940125396 insulin Drugs 0.000 claims 8
• 238000004519 manufacturing process Methods 0.000 claims 6
• 239000002243 precursor Substances 0.000 claims 6
• 239000000651 prodrug Substances 0.000 claims 6
• 229940002612 prodrug Drugs 0.000 claims 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
• 210000004153 islets of langerhan Anatomy 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• -1 n- propyl Chemical group 0.000 claims 4
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 210000000130 stem cell Anatomy 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 238000011260 co-administration Methods 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000028709 inflammatory response Effects 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1