JP2002508373A5 - - Google Patents
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- Publication number
- JP2002508373A5 JP2002508373A5 JP2000539019A JP2000539019A JP2002508373A5 JP 2002508373 A5 JP2002508373 A5 JP 2002508373A5 JP 2000539019 A JP2000539019 A JP 2000539019A JP 2000539019 A JP2000539019 A JP 2000539019A JP 2002508373 A5 JP2002508373 A5 JP 2002508373A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrate according
- hydrate
- diabetes
- exhibits
- complications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 238000000634 powder X-ray diffraction Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000001237 Raman spectrum Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000000279 solid-state nuclear magnetic resonance spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- NQLCBKFSQDRLKI-UAIGNFCESA-N O.C(\C=C/C(=O)O)(=O)O.S1C(NC(C1)=O)=O Chemical compound O.C(\C=C/C(=O)O)(=O)O.S1C(NC(C1)=O)=O NQLCBKFSQDRLKI-UAIGNFCESA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726566.4A GB9726566D0 (en) | 1997-12-16 | 1997-12-16 | Novel pharmaceutical |
| GB9726566.4 | 1997-12-16 | ||
| PCT/EP1998/008155 WO1999031095A1 (en) | 1997-12-16 | 1998-12-14 | 5-[4-[2- (n-methyl-n- (2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508373A JP2002508373A (ja) | 2002-03-19 |
| JP2002508373A5 true JP2002508373A5 (enExample) | 2006-02-09 |
Family
ID=10823692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539019A Withdrawn JP2002508373A (ja) | 1997-12-16 | 1998-12-14 | 医薬としての５−［４−［２−（ｎ−メチル−ｎ−（２−ピリジル）アミノ）エトキシ］ベンジル］チアゾリジン−２，４−ジオン・マレイン酸塩水和物 |
Country Status (35)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| GB9909041D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| CN1167702C (zh) * | 1999-04-23 | 2004-09-22 | 史密丝克莱恩比彻姆有限公司 | 5-[4-[2-n-甲基-n-(2-吡啶基)氨基]乙氧基]苄基]噻唑烷-2,4-二酮马来酸盐的多晶型物 |
| EA003031B1 (ru) * | 1999-04-23 | 2002-12-26 | Смитклайн Бичам Плс | Новый фармацевтический препарат |
| CN1426402A (zh) * | 2000-04-25 | 2003-06-25 | 杏林制药株式会社 | 噻唑烷二酮衍生物的新颖的稳定晶体及其制法 |
| GB0014005D0 (en) * | 2000-06-08 | 2000-08-02 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021784D0 (en) * | 2000-09-05 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021978D0 (en) * | 2000-09-07 | 2000-10-25 | Smithkline Beecham Plc | Novel pharmaceutical |
| AU9123201A (en) * | 2000-09-26 | 2002-04-08 | Reddy S Res Foundation | Novel polymorphic forms of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione maleate and process for their preparation |
| KR20030082541A (ko) * | 2000-09-26 | 2003-10-22 | 닥터 레디스 레보러터리즈 리미티드 | 5-[4-[2-[엔-메틸-엔-(2-피리딜)아미노]에톡시]벤질]티아졸리딘 4-디온 말레이트의 신규의 다형상 및 그제조방법 |
| GB0129876D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0129872D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| AU2002350965A1 (en) * | 2001-12-13 | 2003-06-23 | Smithkline Beecham Plc | Toluenesulfonate hydrates of a thiazolidinedione derivative |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| SG47100A1 (en) * | 1994-02-10 | 1998-03-20 | Smithkline Beecham Plc | Use of insulin sensitisers for treating renal diseases |
-
1997
- 1997-12-16 GB GBGB9726566.4A patent/GB9726566D0/en not_active Ceased
-
1998
- 1998-12-14 IL IL13642498A patent/IL136424A/xx unknown
- 1998-12-14 HR HR20000408A patent/HRP20000408B1/xx not_active IP Right Cessation
- 1998-12-14 WO PCT/EP1998/008155 patent/WO1999031095A1/en not_active Ceased
- 1998-12-14 RS YUP-363/00A patent/RS50126B/sr unknown
- 1998-12-14 TR TR2000/01799T patent/TR200001799T2/xx unknown
- 1998-12-14 OA OA1200000178A patent/OA11766A/en unknown
- 1998-12-14 KR KR1020007006515A patent/KR100549142B1/ko not_active Expired - Fee Related
- 1998-12-14 BR BR9813600-3A patent/BR9813600A/pt not_active Application Discontinuation
- 1998-12-14 EP EP05077331A patent/EP1661895A1/en not_active Withdrawn
- 1998-12-14 SK SK917-2000A patent/SK286618B6/sk not_active IP Right Cessation
- 1998-12-14 JP JP2000539019A patent/JP2002508373A/ja not_active Withdrawn
- 1998-12-14 CZ CZ20002204A patent/CZ299965B6/cs not_active IP Right Cessation
- 1998-12-14 CN CN98812089A patent/CN1281453A/zh active Pending
- 1998-12-14 CA CA002314107A patent/CA2314107A1/en not_active Abandoned
- 1998-12-14 MA MA25389A patent/MA26580A1/fr unknown
- 1998-12-14 HU HU0100509A patent/HUP0100509A3/hu unknown
- 1998-12-14 AP APAP/P/2000/001831A patent/AP1365A/en active
- 1998-12-14 PL PL98341146A patent/PL341146A1/xx not_active Application Discontinuation
- 1998-12-14 EA EA200000654A patent/EA004260B1/ru not_active IP Right Cessation
- 1998-12-14 CN CNA200810087031XA patent/CN101381367A/zh active Pending
- 1998-12-14 CN CNA2008100870305A patent/CN101302215A/zh active Pending
- 1998-12-14 UA UA2000063485A patent/UA72198C2/uk unknown
- 1998-12-14 EP EP98964510A patent/EP1040110A1/en not_active Withdrawn
- 1998-12-14 AU AU19679/99A patent/AU1967999A/en not_active Abandoned
- 1998-12-15 UY UY25304A patent/UY25304A1/es unknown
- 1998-12-15 AR ARP980106370A patent/AR017214A1/es unknown
- 1998-12-15 ZA ZA9811506A patent/ZA9811506B/xx unknown
- 1998-12-15 EG EG155698A patent/EG22337A/xx active
- 1998-12-15 MY MYPI98005674A patent/MY135612A/en unknown
- 1998-12-15 DZ DZ980291A patent/DZ2681A1/xx active
- 1998-12-15 UY UY25308A patent/UY25308A1/es not_active IP Right Cessation
- 1998-12-16 PE PE1998001233A patent/PE20000058A1/es not_active Application Discontinuation
- 1998-12-16 TR TR1998/02625A patent/TR199802625A3/tr unknown
- 1998-12-16 IN IN3772DE1998 patent/IN192487B/en unknown
- 1998-12-16 TW TW087121121A patent/TW509690B/zh not_active IP Right Cessation
- 1998-12-16 CO CO98074834A patent/CO4980880A1/es unknown
-
1999
- 1999-02-27 SA SA99191115A patent/SA99191115B1/ar unknown
-
2000
- 2000-06-15 NO NO20003069A patent/NO317254B1/no not_active IP Right Cessation
- 2000-07-13 BG BG104603A patent/BG64988B1/bg unknown
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