PE20000058A1 - Nueva forma de la sal del acido maleico 5-[4-[2-(n-metil-n-(2-piridil)amino)-etoxi]bencil]tiazolidin-2,4-diona - Google Patents
Nueva forma de la sal del acido maleico 5-[4-[2-(n-metil-n-(2-piridil)amino)-etoxi]bencil]tiazolidin-2,4-dionaInfo
- Publication number
- PE20000058A1 PE20000058A1 PE1998001233A PE00123398A PE20000058A1 PE 20000058 A1 PE20000058 A1 PE 20000058A1 PE 1998001233 A PE1998001233 A PE 1998001233A PE 00123398 A PE00123398 A PE 00123398A PE 20000058 A1 PE20000058 A1 PE 20000058A1
- Authority
- PE
- Peru
- Prior art keywords
- etoxy
- diona
- thiazolidin
- pyridyl
- benzyl
- Prior art date
Links
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title abstract 3
- -1 N-METHYL-N- (2-PYRIDYL) AMINO Chemical class 0.000 title abstract 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title abstract 2
- 239000011976 maleic acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- HAFWELDDNUXLCK-ODZAUARKSA-N (z)-but-2-enedioic acid;hydrate Chemical compound O.OC(=O)\C=C/C(O)=O HAFWELDDNUXLCK-ODZAUARKSA-N 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 238000005481 NMR spectroscopy Methods 0.000 abstract 1
- 238000001069 Raman spectroscopy Methods 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN HIDRATO DE LA SAL DEL ACIDO MALEICO DE 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]TIAZOLIDIN-2,4-DIONA QUE SE CARACTERIZA a)POR SU CONTENIDO DE AGUA ENTRE 0,4% A 2,5% p/p; b)SU ESPECTRO INFRAROJO; c)SU PATRON DE DIFRACCION DE RAYOS X; d)POR SU ESPECTRO RAMAN; e)POR SU ESPECTRO DE RESONANCIA MAGNETICA NUCLEAR EN ESTADO SOLIDO. EL HIDRATO SE PRESENTA EN FORMA AISLADA, PURA, CRISTALINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE SE CARACTERIZA POR LA CRISTALIZACION DE LA SAL DE ACIDO MALEICO DE 5-[4-[2-PIRIDIL)AMINO)-ETOXI]BENCIL]TIAZOLIDIN-2,4-DIONA EN ETANOL QUE CONTIENE DE 15% A 25% EN VOLUMEN DE AGUA. EL HIDRATO TIENE ACTIVIDAD HIPOGLICEMICA E HIPOLIPIDEMICA Y PUEDE SER UTIL PARA EL TRATAMIENTO Y PROFILAXIS DE LA DIABETES MELLITUS, CONDICIONES ASOCIADAS A LA DIABETES MELLITUS Y COMPLICACIONES DE LAS MISMAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726566.4A GB9726566D0 (en) | 1997-12-16 | 1997-12-16 | Novel pharmaceutical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000058A1 true PE20000058A1 (es) | 2000-02-26 |
Family
ID=10823692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001233A PE20000058A1 (es) | 1997-12-16 | 1998-12-16 | Nueva forma de la sal del acido maleico 5-[4-[2-(n-metil-n-(2-piridil)amino)-etoxi]bencil]tiazolidin-2,4-diona |
Country Status (35)
| Country | Link |
|---|---|
| EP (2) | EP1661895A1 (es) |
| JP (1) | JP2002508373A (es) |
| KR (1) | KR100549142B1 (es) |
| CN (3) | CN1281453A (es) |
| AP (1) | AP1365A (es) |
| AR (1) | AR017214A1 (es) |
| AU (1) | AU1967999A (es) |
| BG (1) | BG64988B1 (es) |
| BR (1) | BR9813600A (es) |
| CA (1) | CA2314107A1 (es) |
| CO (1) | CO4980880A1 (es) |
| CZ (1) | CZ299965B6 (es) |
| DZ (1) | DZ2681A1 (es) |
| EA (1) | EA004260B1 (es) |
| EG (1) | EG22337A (es) |
| GB (1) | GB9726566D0 (es) |
| HR (1) | HRP20000408B1 (es) |
| HU (1) | HUP0100509A3 (es) |
| IL (1) | IL136424A (es) |
| IN (1) | IN192487B (es) |
| MA (1) | MA26580A1 (es) |
| MY (1) | MY135612A (es) |
| NO (1) | NO317254B1 (es) |
| OA (1) | OA11766A (es) |
| PE (1) | PE20000058A1 (es) |
| PL (1) | PL341146A1 (es) |
| RS (1) | RS50126B (es) |
| SA (1) | SA99191115B1 (es) |
| SK (1) | SK286618B6 (es) |
| TR (2) | TR200001799T2 (es) |
| TW (1) | TW509690B (es) |
| UA (1) | UA72198C2 (es) |
| UY (2) | UY25304A1 (es) |
| WO (1) | WO1999031095A1 (es) |
| ZA (1) | ZA9811506B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| GB9909041D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| CN1167702C (zh) * | 1999-04-23 | 2004-09-22 | 史密丝克莱恩比彻姆有限公司 | 5-[4-[2-n-甲基-n-(2-吡啶基)氨基]乙氧基]苄基]噻唑烷-2,4-二酮马来酸盐的多晶型物 |
| EA003031B1 (ru) * | 1999-04-23 | 2002-12-26 | Смитклайн Бичам Плс | Новый фармацевтический препарат |
| CN1426402A (zh) * | 2000-04-25 | 2003-06-25 | 杏林制药株式会社 | 噻唑烷二酮衍生物的新颖的稳定晶体及其制法 |
| GB0014005D0 (en) * | 2000-06-08 | 2000-08-02 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021784D0 (en) * | 2000-09-05 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021978D0 (en) * | 2000-09-07 | 2000-10-25 | Smithkline Beecham Plc | Novel pharmaceutical |
| AU9123201A (en) * | 2000-09-26 | 2002-04-08 | Reddy S Res Foundation | Novel polymorphic forms of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione maleate and process for their preparation |
| KR20030082541A (ko) * | 2000-09-26 | 2003-10-22 | 닥터 레디스 레보러터리즈 리미티드 | 5-[4-[2-[엔-메틸-엔-(2-피리딜)아미노]에톡시]벤질]티아졸리딘 4-디온 말레이트의 신규의 다형상 및 그제조방법 |
| GB0129876D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0129872D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| AU2002350965A1 (en) * | 2001-12-13 | 2003-06-23 | Smithkline Beecham Plc | Toluenesulfonate hydrates of a thiazolidinedione derivative |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| SG47100A1 (en) * | 1994-02-10 | 1998-03-20 | Smithkline Beecham Plc | Use of insulin sensitisers for treating renal diseases |
-
1997
- 1997-12-16 GB GBGB9726566.4A patent/GB9726566D0/en not_active Ceased
-
1998
- 1998-12-14 IL IL13642498A patent/IL136424A/xx unknown
- 1998-12-14 HR HR20000408A patent/HRP20000408B1/xx not_active IP Right Cessation
- 1998-12-14 WO PCT/EP1998/008155 patent/WO1999031095A1/en not_active Ceased
- 1998-12-14 RS YUP-363/00A patent/RS50126B/sr unknown
- 1998-12-14 TR TR2000/01799T patent/TR200001799T2/xx unknown
- 1998-12-14 OA OA1200000178A patent/OA11766A/en unknown
- 1998-12-14 KR KR1020007006515A patent/KR100549142B1/ko not_active Expired - Fee Related
- 1998-12-14 BR BR9813600-3A patent/BR9813600A/pt not_active Application Discontinuation
- 1998-12-14 EP EP05077331A patent/EP1661895A1/en not_active Withdrawn
- 1998-12-14 SK SK917-2000A patent/SK286618B6/sk not_active IP Right Cessation
- 1998-12-14 JP JP2000539019A patent/JP2002508373A/ja not_active Withdrawn
- 1998-12-14 CZ CZ20002204A patent/CZ299965B6/cs not_active IP Right Cessation
- 1998-12-14 CN CN98812089A patent/CN1281453A/zh active Pending
- 1998-12-14 CA CA002314107A patent/CA2314107A1/en not_active Abandoned
- 1998-12-14 MA MA25389A patent/MA26580A1/fr unknown
- 1998-12-14 HU HU0100509A patent/HUP0100509A3/hu unknown
- 1998-12-14 AP APAP/P/2000/001831A patent/AP1365A/en active
- 1998-12-14 PL PL98341146A patent/PL341146A1/xx not_active Application Discontinuation
- 1998-12-14 EA EA200000654A patent/EA004260B1/ru not_active IP Right Cessation
- 1998-12-14 CN CNA200810087031XA patent/CN101381367A/zh active Pending
- 1998-12-14 CN CNA2008100870305A patent/CN101302215A/zh active Pending
- 1998-12-14 UA UA2000063485A patent/UA72198C2/uk unknown
- 1998-12-14 EP EP98964510A patent/EP1040110A1/en not_active Withdrawn
- 1998-12-14 AU AU19679/99A patent/AU1967999A/en not_active Abandoned
- 1998-12-15 UY UY25304A patent/UY25304A1/es unknown
- 1998-12-15 AR ARP980106370A patent/AR017214A1/es unknown
- 1998-12-15 ZA ZA9811506A patent/ZA9811506B/xx unknown
- 1998-12-15 EG EG155698A patent/EG22337A/xx active
- 1998-12-15 MY MYPI98005674A patent/MY135612A/en unknown
- 1998-12-15 DZ DZ980291A patent/DZ2681A1/xx active
- 1998-12-15 UY UY25308A patent/UY25308A1/es not_active IP Right Cessation
- 1998-12-16 PE PE1998001233A patent/PE20000058A1/es not_active Application Discontinuation
- 1998-12-16 TR TR1998/02625A patent/TR199802625A3/tr unknown
- 1998-12-16 IN IN3772DE1998 patent/IN192487B/en unknown
- 1998-12-16 TW TW087121121A patent/TW509690B/zh not_active IP Right Cessation
- 1998-12-16 CO CO98074834A patent/CO4980880A1/es unknown
-
1999
- 1999-02-27 SA SA99191115A patent/SA99191115B1/ar unknown
-
2000
- 2000-06-15 NO NO20003069A patent/NO317254B1/no not_active IP Right Cessation
- 2000-07-13 BG BG104603A patent/BG64988B1/bg unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20000058A1 (es) | Nueva forma de la sal del acido maleico 5-[4-[2-(n-metil-n-(2-piridil)amino)-etoxi]bencil]tiazolidin-2,4-diona | |
| PE20000057A1 (es) | Hidrato de la sal del acido maleico de la 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona | |
| MY125398A (en) | Drive unit using shape memory alloy | |
| UY25309A1 (es) | Procedimiento para la preparación de un hidrato de un derivado de tiazolidin-2,4-diona | |
| PE20010040A1 (es) | Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona | |
| NO952573L (no) | Blandinger for behandling av diabetiske komplikasjoner | |
| PE20010045A1 (es) | Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidin-2,4-diona | |
| PE20000059A1 (es) | Cristales de peptido-1 semejantes a glucagon | |
| WO2001053237A3 (en) | Production of monocycloalkyl aromatic compounds | |
| JP2002508373A5 (es) | ||
| BG105485A (en) | New crystal modification n of torasemide | |
| SG36092G (en) | Towel dispenser and process for operating it | |
| PE20010047A1 (es) | Monohidrato de hidrocloruro de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidina-2,4-diona | |
| YU40202A (sh) | Novi derivati tiazolidindiona kao antidijabetički agensi | |
| AR045230A1 (es) | Forma de dosificacion oral que comprende 5-[4-[2-(n-metil-n-(2- piridil)-amino)-etoxi]-bencil]-tiazolidino-2,4-diona y otro agente antidiabetico adicional; procedimiento para su preparacion y uso de 5-[4-[2-(metil-n-(2-piridil)-amino)-etoxi]- bencil]- tiazolidino-2,4-diona y otro agente antidiabetic | |
| UY25101A1 (es) | Método para el tratamiento de la diabetes mellitus y las condiciones asociadas | |
| UY25048A1 (es) | Composiciones para el tratamiento de la diabetes mellitus | |
| ES2135353A1 (es) | Utilizacion del 17beta-estradiol, sus analogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones. | |
| CN221786651U (zh) | 一种临床取石装置 | |
| Ivanuša et al. | Age-related differences in presentation and in-hospital outcome of patients with acute myocardial infarction. | |
| EA200300005A1 (ru) | Соль тиазолидиндиона для лечения сахарного диабета | |
| TH58462A (th) | สารผสมต่อต้านเบาหวานชนิดใหม่ และการรักษา | |
| Yan et al. | X-ray powder diffraction data and Rietveld refinement for NdCoGe sub 3 | |
| CA2388957A1 (en) | Aromatic di-keto derivatives as glucose-6-phosphate translocase inhibitors | |
| RU2000127372A (ru) | Способ получения микроволокон диоксида циркония |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |