PE20000059A1 - Cristales de peptido-1 semejantes a glucagon - Google Patents

Cristales de peptido-1 semejantes a glucagon

Info

Publication number
PE20000059A1
PE20000059A1 PE1998001225A PE00122598A PE20000059A1 PE 20000059 A1 PE20000059 A1 PE 20000059A1 PE 1998001225 A PE1998001225 A PE 1998001225A PE 00122598 A PE00122598 A PE 00122598A PE 20000059 A1 PE20000059 A1 PE 20000059A1
Authority
PE
Peru
Prior art keywords
glp
crystals
zinc
refers
procedure
Prior art date
Application number
PE1998001225A
Other languages
English (en)
Inventor
Ronald Norbert Hermeling
Chakravarthy Narasimhan
James Arthur Hoffmann
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20000059A1 publication Critical patent/PE20000059A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR CRISTALES INDIVIDUALES EN FORMA DE VARILLAS PLANAS TETRAGONALES O SEMEJANTES A PLACAS DE MOLECULAS RELACIONADAS CON EL PEPTIDO-1 SEMEJANTE A GLUCAGON (GLP), QUE COMPRENDE PREPARAR UNA SOLUCION DE CRISTALIZACION QUE CONTIENE a)ENTRE 1 mg/ml Y 10 mg/ml DE GLP EL QUE SE SELECIONA DE GLP-1, DERIVADO DE GLP-1, GLP PROTEGIDO CONTRA LA DIPEPTIDIL-PEPTIDASA-IV (DPP-IV), ANALOGO PEPTIDICO DE GLP-1, ANALOGO BIOSINTETICO DE GLP-1; b) ENTRE 10 nM A 50 nM DE UN AGENTE TAMPONANTE A UN pH DE 6-7, EL QUE SE SELECCIONA ENTRE TRIS, ACETATO AMONICO, ACETATO SODICO; c)UN ALCOHOL, MONO O DISACARIDO LOS QUE SE SELECCIONAN DE METANOL, ETANOL, PROPANOL, GLICEROL, TREHALOSA, MANITOL, GLUCOSA, ERITROSA, ENTRE OTROS Y d)OPCIONALMENTE 1% DE SULFATO DE AMONIO O ZINC. EL ZINC TOTAL ESTA EN UNA RELACION MOLAR DE 0,5 A 1,7 CON RESPECTO AL GLP-1. TAMBIEN SE REFIERE A UN PROCEDIMIENTO QUE COMPRENDE ADEMAS SUMERGIR LOS CRISTALES DE GLP EN UNA SOLUCION QUE CONTIENE CINC. EL CRISTAL DE GLP-1 ESTIMULA LA SECRECION DE INSULINA PRESENTA UNA ACCION PROLONGADA IN VIVO Y PUEDE SER UTIL EN EL TRATAMIENTO DE LA DIABETES, OBESIDAD, AFECCIONES RELACIONADAS
PE1998001225A 1997-12-16 1998-12-15 Cristales de peptido-1 semejantes a glucagon PE20000059A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6972897P 1997-12-16 1997-12-16

Publications (1)

Publication Number Publication Date
PE20000059A1 true PE20000059A1 (es) 2000-02-09

Family

ID=22090845

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001225A PE20000059A1 (es) 1997-12-16 1998-12-15 Cristales de peptido-1 semejantes a glucagon

Country Status (24)

Country Link
US (3) US6380357B2 (es)
EP (1) EP0926159A3 (es)
JP (1) JP2002508332A (es)
KR (1) KR20010033146A (es)
CN (1) CN1281369A (es)
AR (1) AR019806A1 (es)
AU (1) AU1821899A (es)
BR (1) BR9813658A (es)
CA (1) CA2315243A1 (es)
CO (1) CO5040043A1 (es)
CZ (1) CZ20002104A3 (es)
EA (1) EA200000652A1 (es)
HR (1) HRP20000409A2 (es)
HU (1) HUP0100046A2 (es)
ID (1) ID25534A (es)
IL (1) IL136377A0 (es)
NO (1) NO20003081L (es)
NZ (1) NZ505182A (es)
PE (1) PE20000059A1 (es)
PL (1) PL341210A1 (es)
SV (1) SV1998000147A (es)
TR (1) TR200001726T2 (es)
WO (1) WO1999030731A1 (es)
ZA (1) ZA9811466B (es)

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Also Published As

Publication number Publication date
EP0926159A3 (en) 2003-11-26
JP2002508332A (ja) 2002-03-19
US20030045464A1 (en) 2003-03-06
AR019806A1 (es) 2002-03-20
US20010014666A1 (en) 2001-08-16
HUP0100046A2 (hu) 2001-05-28
US6380357B2 (en) 2002-04-30
NZ505182A (en) 2002-05-31
AU1821899A (en) 1999-07-05
BR9813658A (pt) 2000-10-10
NO20003081L (no) 2000-08-08
KR20010033146A (ko) 2001-04-25
IL136377A0 (en) 2001-06-14
EA200000652A1 (ru) 2000-12-25
SV1998000147A (es) 1999-08-18
NO20003081D0 (no) 2000-06-15
CA2315243A1 (en) 1999-06-24
CZ20002104A3 (cs) 2001-08-15
HRP20000409A2 (en) 2000-10-31
TR200001726T2 (tr) 2000-10-23
PL341210A1 (en) 2001-03-26
CO5040043A1 (es) 2001-05-29
US6555521B2 (en) 2003-04-29
CN1281369A (zh) 2001-01-24
EP0926159A2 (en) 1999-06-30
USRE41133E1 (en) 2010-02-16
ZA9811466B (en) 2000-06-14
ID25534A (id) 2000-10-12
WO1999030731A1 (en) 1999-06-24

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