UY25050A1 - Metodo de tratamiento para diabetes mellitus - Google Patents
Metodo de tratamiento para diabetes mellitusInfo
- Publication number
- UY25050A1 UY25050A1 UY25050A UY25050A UY25050A1 UY 25050 A1 UY25050 A1 UY 25050A1 UY 25050 A UY25050 A UY 25050A UY 25050 A UY25050 A UY 25050A UY 25050 A1 UY25050 A1 UY 25050A1
- Authority
- UY
- Uruguay
- Prior art keywords
- diabetes mellitus
- treatment
- compound
- insulin
- mammal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un método para el tratamiento de diabetes mellitus y procesos asociados a la diabetes mellitus en un mamífero, cuyo método comprende administrar una cantidad eficaz, no tóxica y farmacéuticamente eficaz de 5-(4-(2-(N-metil-N-(2-piridil)amino)etoxi)bencil)tiazolidin-2,4-diona (compuesto (I)) e insulina a un mamífero con necesidad de ello. Preferiblemente, la cantidad de compuesto (I) administrado es de hasta 12 mg, especialmente cuando se administra diariamente. El método comprende o bien la co-administración de compuesto (I) e insulina, o su administración secuencial. Está indicado que el efecto particularmente beneficioso sobre le control de la glucemia proporcionado por el tratamiento de la invención es un efecto sinérgico relativo al control esperado para la suma de los efectos de los agentes activos individuales. En un aspecto preferido, el nivel de dosificación de cada uno de los agentes activos, cuando se utiliza de acuerdo con el tratamiento de la invención, será menor de lo que habría sido necesario considerando un efecto puramente aditivo sobre le control de la glucemia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9712866.4A GB9712866D0 (en) | 1997-06-18 | 1997-06-18 | Novel method of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25050A1 true UY25050A1 (es) | 2000-09-29 |
Family
ID=10814527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25050A UY25050A1 (es) | 1997-06-18 | 1998-06-18 | Metodo de tratamiento para diabetes mellitus |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0999837A1 (es) |
| JP (1) | JP2002504138A (es) |
| KR (1) | KR20010013843A (es) |
| CN (1) | CN1133431C (es) |
| AP (1) | AP1287A (es) |
| AR (2) | AR012997A1 (es) |
| AU (1) | AU8216398A (es) |
| BG (1) | BG104059A (es) |
| BR (1) | BR9810444A (es) |
| CA (1) | CA2294141A1 (es) |
| CO (1) | CO4940454A1 (es) |
| DZ (1) | DZ2521A1 (es) |
| EA (1) | EA004800B1 (es) |
| GB (1) | GB9712866D0 (es) |
| HU (1) | HUP0003260A3 (es) |
| ID (1) | ID23951A (es) |
| IL (1) | IL133143A0 (es) |
| IN (1) | IN189723B (es) |
| MA (1) | MA26511A1 (es) |
| NO (1) | NO996265L (es) |
| OA (1) | OA11517A (es) |
| PE (1) | PE104499A1 (es) |
| PL (1) | PL343123A1 (es) |
| SK (1) | SK179399A3 (es) |
| TR (1) | TR199903095T2 (es) |
| TW (1) | TW587937B (es) |
| UA (1) | UA70299C2 (es) |
| UY (1) | UY25050A1 (es) |
| WO (1) | WO1998057636A1 (es) |
| ZA (1) | ZA985237B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291495B1 (en) * | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| TWI249401B (en) | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| TR200103061T2 (tr) | 1999-04-23 | 2002-05-21 | Smithkline Beecham P.L.C. | Yeni farmasötik madde. |
| WO2000078333A2 (en) | 1999-06-21 | 2000-12-28 | Eli Lilly And Company | Synergetic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat non-insulin dependant diabetes |
| EP1196189A2 (en) | 1999-06-25 | 2002-04-17 | Medtronic MiniMed, Inc. | Multiple agent diabetes therapy |
| US6468507B1 (en) * | 2000-05-01 | 2002-10-22 | Aeropharm Technology, Inc. | Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer |
| GB0023970D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| WO2002067969A2 (en) | 2001-02-21 | 2002-09-06 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| US6531461B1 (en) | 2001-06-04 | 2003-03-11 | Louis Obyo Obyo Nelson | Medicament for the treatment of diabetes |
| US20020198203A1 (en) * | 2001-06-07 | 2002-12-26 | Wyeth | Combination of a PTPase inhibitor and a thiazolidinedione agent |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| MXPA05004743A (es) | 2002-11-08 | 2005-08-03 | Hoffmann La Roche | Derivados 4-alcoxioxazol sustituidos como agonistas ppar. |
| US7264813B2 (en) | 2003-09-24 | 2007-09-04 | Nikken Sohonsha Corporation | Therapeutic uses of Dunaliella powder |
| CN102389427A (zh) * | 2011-10-10 | 2012-03-28 | 成都恒瑞制药有限公司 | 含有罗格列酮和盐酸西替利嗪的固体口服制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0719140B1 (en) * | 1993-09-15 | 2007-10-31 | Daiichi Sankyo Company, Limited | Use of thiazolidinediones to prevent or delay onset of niddm |
| SK16498A3 (en) * | 1995-08-10 | 1999-03-12 | Warner Lambert Co | A method of reducing the amount of exogenous insulin administered to a patient having noninsulin-dependent diabetes mellitus |
| KR19990045756A (ko) * | 1995-09-18 | 1999-06-25 | 윌리암 엘. 레스페스 | Ｒｘｒ 작용제를 이용하는 ｎｉｄｄｍ 치료 방법 |
-
1997
- 1997-06-18 GB GBGB9712866.4A patent/GB9712866D0/en active Pending
-
1998
- 1998-06-15 WO PCT/EP1998/003692 patent/WO1998057636A1/en not_active Application Discontinuation
- 1998-06-15 HU HU0003260A patent/HUP0003260A3/hu unknown
- 1998-06-15 ID IDW991627A patent/ID23951A/id unknown
- 1998-06-15 JP JP50375799A patent/JP2002504138A/ja not_active Ceased
- 1998-06-15 EP EP98932169A patent/EP0999837A1/en not_active Withdrawn
- 1998-06-15 BR BR9810444-6A patent/BR9810444A/pt not_active IP Right Cessation
- 1998-06-15 UA UA99126881A patent/UA70299C2/uk unknown
- 1998-06-15 CN CNB988062232A patent/CN1133431C/zh not_active Expired - Fee Related
- 1998-06-15 AP APAP/P/1999/001718A patent/AP1287A/en active
- 1998-06-15 KR KR1019997011864A patent/KR20010013843A/ko not_active Application Discontinuation
- 1998-06-15 EA EA200000042A patent/EA004800B1/ru not_active IP Right Cessation
- 1998-06-15 IL IL13314398A patent/IL133143A0/xx unknown
- 1998-06-15 CA CA002294141A patent/CA2294141A1/en not_active Abandoned
- 1998-06-15 TR TR1999/03095T patent/TR199903095T2/xx unknown
- 1998-06-15 AU AU82163/98A patent/AU8216398A/en not_active Abandoned
- 1998-06-15 PL PL98343123A patent/PL343123A1/xx unknown
- 1998-06-15 SK SK1793-99A patent/SK179399A3/sk unknown
- 1998-06-17 AR ARP980102883A patent/AR012997A1/es not_active Application Discontinuation
- 1998-06-17 ZA ZA9805237A patent/ZA985237B/xx unknown
- 1998-06-17 DZ DZ980131A patent/DZ2521A1/xx active
- 1998-06-17 MA MA25122A patent/MA26511A1/fr unknown
- 1998-06-17 TW TW087109619A patent/TW587937B/zh not_active IP Right Cessation
- 1998-06-17 AR ARP980102886A patent/AR015894A1/es not_active Application Discontinuation
- 1998-06-18 CO CO98034654A patent/CO4940454A1/es unknown
- 1998-06-18 UY UY25050A patent/UY25050A1/es unknown
- 1998-06-18 PE PE1998000535A patent/PE104499A1/es not_active Application Discontinuation
- 1998-06-18 IN IN1698DE1998 patent/IN189723B/en unknown
-
1999
- 1999-12-17 OA OA9900296A patent/OA11517A/en unknown
- 1999-12-17 NO NO996265A patent/NO996265L/no not_active Application Discontinuation
-
2000
- 2000-01-06 BG BG104059A patent/BG104059A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW587937B (en) | 2004-05-21 |
| CO4940454A1 (es) | 2000-07-24 |
| PL343123A1 (en) | 2001-07-30 |
| CN1260715A (zh) | 2000-07-19 |
| AU8216398A (en) | 1999-01-04 |
| SK179399A3 (en) | 2000-11-07 |
| EA004800B1 (ru) | 2004-08-26 |
| BR9810444A (pt) | 2000-09-05 |
| CA2294141A1 (en) | 1998-12-23 |
| CN1133431C (zh) | 2004-01-07 |
| KR20010013843A (ko) | 2001-02-26 |
| AP1287A (en) | 2004-06-26 |
| AP9901718A0 (en) | 1999-12-31 |
| NO996265D0 (no) | 1999-12-17 |
| ID23951A (id) | 2000-06-08 |
| NO996265L (no) | 1999-12-17 |
| BG104059A (en) | 2000-10-31 |
| WO1998057636A1 (en) | 1998-12-23 |
| IN189723B (es) | 2003-04-19 |
| OA11517A (en) | 2004-02-04 |
| HUP0003260A3 (en) | 2001-12-28 |
| AR012997A1 (es) | 2000-11-22 |
| MA26511A1 (fr) | 2004-12-20 |
| HUP0003260A2 (hu) | 2001-05-28 |
| ZA985237B (en) | 2000-02-17 |
| EP0999837A1 (en) | 2000-05-17 |
| JP2002504138A (ja) | 2002-02-05 |
| GB9712866D0 (en) | 1997-08-20 |
| DZ2521A1 (fr) | 2003-02-08 |
| AR015894A1 (es) | 2001-05-30 |
| PE104499A1 (es) | 2000-01-13 |
| IL133143A0 (en) | 2001-03-19 |
| UA70299C2 (en) | 2004-10-15 |
| TR199903095T2 (xx) | 2000-08-21 |
| EA200000042A1 (ru) | 2000-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ABAN | Application deemed to be withdrawn (no publication fee paid) |
Effective date: 20090526 |