AR008269A1 - Derivados de insulina con unión a zinc incrementada, un complejo, una composición farmacéutica y proinsulina. - Google Patents

Derivados de insulina con unión a zinc incrementada, un complejo, una composición farmacéutica y proinsulina.

Info

Publication number
AR008269A1
AR008269A1 ARP970103352A ARP970103352A AR008269A1 AR 008269 A1 AR008269 A1 AR 008269A1 AR P970103352 A ARP970103352 A AR P970103352A AR P970103352 A ARP970103352 A AR P970103352A AR 008269 A1 AR008269 A1 AR 008269A1
Authority
AR
Argentina
Prior art keywords
proinsulin
complex
pharmaceutical composition
insulin derivatives
zinc binding
Prior art date
Application number
ARP970103352A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of AR008269A1 publication Critical patent/AR008269A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de insulina con unión de zinc incrementada en donde Z representa un resto histidina o un péptido con 2 a 35 restos aminoácidos genéticamentecodificables, que contiene 1 a 5 restos histidina, se adecúa para la producción de preparadosfarm acéuticos para el tratamiento de diabetes. Las insulinas dela fórmula I forman con zinc complejos que contienen un hexámero de insulina y aproximadamente 5 a 9 moles de zinc por hexámero.
ARP970103352A 1996-07-26 1997-07-24 Derivados de insulina con unión a zinc incrementada, un complejo, una composición farmacéutica y proinsulina. AR008269A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19630242 1996-07-26

Publications (1)

Publication Number Publication Date
AR008269A1 true AR008269A1 (es) 1999-12-29

Family

ID=7800962

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103352A AR008269A1 (es) 1996-07-26 1997-07-24 Derivados de insulina con unión a zinc incrementada, un complejo, una composición farmacéutica y proinsulina.

Country Status (25)

Country Link
US (1) US6221837B1 (es)
EP (1) EP0821006B1 (es)
JP (1) JP4046388B2 (es)
KR (1) KR100547922B1 (es)
CN (2) CN1158305C (es)
AR (1) AR008269A1 (es)
AT (1) ATE264871T1 (es)
AU (1) AU725201B2 (es)
BR (1) BR9704117B1 (es)
CA (1) CA2207078C (es)
CZ (1) CZ292274B6 (es)
DE (1) DE59711533D1 (es)
DK (1) DK0821006T3 (es)
ES (1) ES2218622T3 (es)
HK (1) HK1048125A1 (es)
HU (1) HU224591B1 (es)
IL (2) IL121381A (es)
NO (1) NO317666B1 (es)
NZ (1) NZ328421A (es)
PL (1) PL188617B1 (es)
PT (1) PT821006E (es)
RU (1) RU2176646C2 (es)
TR (1) TR199700685A2 (es)
TW (1) TW474944B (es)
ZA (1) ZA976645B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
CA2452044A1 (en) * 2001-08-28 2003-03-13 Eli Lilly And Company Pre-mixes of glp-1 and basal insulin
MXPA04003569A (es) * 2001-10-19 2004-07-23 Lilly Co Eli Mezclas bifasicas de glp-1 e insulina.
KR100769183B1 (ko) * 2001-12-28 2007-10-23 엘지.필립스 엘시디 주식회사 면발광 램프
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
EP1660531A2 (en) * 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
EP2626368B1 (en) * 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
DK1969004T3 (da) 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
EP2049149B1 (en) * 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
PT2074141T (pt) * 2006-09-22 2016-11-10 Novo Nordisk As Análogos de insulina resistentes a proteases
US9387176B2 (en) * 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
KR20100017667A (ko) * 2007-06-01 2010-02-16 노보 노르디스크 에이/에스 안정한 비-수성의 약학 조성물
US9034818B2 (en) * 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
BRPI0818004B8 (pt) * 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
US9260502B2 (en) * 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
PL2254906T3 (pl) 2008-03-18 2017-04-28 Novo Nordisk A/S Stabilizowane względem proteaz, acylowane analogi insuliny
CA2738615A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
EP3554534B1 (en) 2016-12-16 2021-06-23 Novo Nordisk A/S Insulin containing pharmaceutical compositions
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (fi) * 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DE3526995A1 (de) 1985-07-27 1987-02-05 Hoechst Ag Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
DE3541856A1 (de) 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3636903A1 (de) 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
DE3805150A1 (de) 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3739347A1 (de) 1987-11-20 1989-06-01 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
DE3921447A1 (de) * 1989-06-30 1991-01-17 Hoechst Ag Verfahren zur herstellung von n-alkyl-halogenanilinen
GR1005153B (el) 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
AU3272695A (en) * 1994-08-12 1996-03-07 Immunomedics Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells

Also Published As

Publication number Publication date
CN1158305C (zh) 2004-07-21
JP4046388B2 (ja) 2008-02-13
AU725201B2 (en) 2000-10-05
BR9704117B1 (pt) 2009-08-11
DE59711533D1 (de) 2004-05-27
HU224591B1 (hu) 2005-11-28
IL121381A (en) 2004-09-27
RU2176646C2 (ru) 2001-12-10
IL121381A0 (en) 1998-01-04
BR9704117A (pt) 1998-12-29
HUP9701299A3 (en) 2001-04-28
CZ292274B6 (cs) 2003-08-13
US6221837B1 (en) 2001-04-24
NO973438D0 (no) 1997-07-25
HU9701299D0 (en) 1997-09-29
KR980009281A (ko) 1998-04-30
EP0821006B1 (de) 2004-04-21
CA2207078C (en) 2008-01-29
AU3017197A (en) 1998-02-05
IL121382A0 (en) 1998-01-04
PL188617B1 (pl) 2005-03-31
PL321343A1 (en) 1998-02-02
CA2207078A1 (en) 1998-01-26
CZ237097A3 (cs) 1998-02-18
KR100547922B1 (ko) 2006-06-22
EP0821006A3 (de) 2001-11-28
ATE264871T1 (de) 2004-05-15
JPH1072496A (ja) 1998-03-17
TR199700685A3 (tr) 1998-02-21
DK0821006T3 (da) 2004-08-16
TR199700685A2 (xx) 1998-02-21
ZA976645B (en) 1998-01-26
ES2218622T3 (es) 2004-11-16
PT821006E (pt) 2004-09-30
HUP9701299A1 (hu) 1998-11-30
EP0821006A2 (de) 1998-01-28
CN1172811A (zh) 1998-02-11
NO317666B1 (no) 2004-11-29
NO973438L (no) 1998-01-27
NZ328421A (en) 1998-12-23
CN1362417A (zh) 2002-08-07
HK1048125A1 (zh) 2003-03-21
TW474944B (en) 2002-02-01
MX9705667A (es) 1998-07-31

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Legal Events

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