MX9705667A - Derivados de insulina con union a zinc incrementada. - Google Patents

Derivados de insulina con union a zinc incrementada.

Info

Publication number
MX9705667A
MX9705667A MX9705667A MX9705667A MX9705667A MX 9705667 A MX9705667 A MX 9705667A MX 9705667 A MX9705667 A MX 9705667A MX 9705667 A MX9705667 A MX 9705667A MX 9705667 A MX9705667 A MX 9705667A
Authority
MX
Mexico
Prior art keywords
union
insulin
insulin derivatives
zinc
increased zinc
Prior art date
Application number
MX9705667A
Other languages
English (en)
Other versions
MXPA97005667A (es
Inventor
Johann Ertl
Paul Habermann
Karl Geisen
Gerhard Seipke
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9705667A publication Critical patent/MX9705667A/es
Publication of MXPA97005667A publication Critical patent/MXPA97005667A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Derivados de insulina con union de zinc incrementada en donde Z representa un resto histidina o un péptido con 2 a 35 restos aminoácidos genéticamente codificables, que contiene 1 a 5 restos histidina, se adecua para la produccion de preparados farmacéuticos para el tratamiento de diabetes. Las insulinas de la formula I forman con zinc complejos que contienen un hexámetro de insulina y aproximadamente 5 a 9 moles de zinc por hexámero.
MXPA/A/1997/005667A 1996-07-26 1997-07-25 Derivados de insulina con union a zinc incrementada MXPA97005667A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19630242 1996-07-26
DE19630242.0 1996-07-26

Publications (2)

Publication Number Publication Date
MX9705667A true MX9705667A (es) 1998-07-31
MXPA97005667A MXPA97005667A (es) 1998-11-09

Family

ID=

Also Published As

Publication number Publication date
NO973438D0 (no) 1997-07-25
PT821006E (pt) 2004-09-30
PL321343A1 (en) 1998-02-02
AU3017197A (en) 1998-02-05
CZ237097A3 (cs) 1998-02-18
CN1158305C (zh) 2004-07-21
AR008269A1 (es) 1999-12-29
HUP9701299A1 (hu) 1998-11-30
DK0821006T3 (da) 2004-08-16
NO317666B1 (no) 2004-11-29
ATE264871T1 (de) 2004-05-15
ZA976645B (en) 1998-01-26
EP0821006B1 (de) 2004-04-21
HUP9701299A3 (en) 2001-04-28
KR100547922B1 (ko) 2006-06-22
IL121381A (en) 2004-09-27
IL121381A0 (en) 1998-01-04
US6221837B1 (en) 2001-04-24
CZ292274B6 (cs) 2003-08-13
DE59711533D1 (de) 2004-05-27
CA2207078A1 (en) 1998-01-26
HU224591B1 (hu) 2005-11-28
AU725201B2 (en) 2000-10-05
CA2207078C (en) 2008-01-29
HU9701299D0 (en) 1997-09-29
JP4046388B2 (ja) 2008-02-13
ES2218622T3 (es) 2004-11-16
BR9704117A (pt) 1998-12-29
CN1172811A (zh) 1998-02-11
NZ328421A (en) 1998-12-23
JPH1072496A (ja) 1998-03-17
PL188617B1 (pl) 2005-03-31
KR980009281A (ko) 1998-04-30
TR199700685A2 (xx) 1998-02-21
TR199700685A3 (tr) 1998-02-21
RU2176646C2 (ru) 2001-12-10
EP0821006A3 (de) 2001-11-28
HK1048125A1 (zh) 2003-03-21
BR9704117B1 (pt) 2009-08-11
TW474944B (en) 2002-02-01
IL121382A0 (en) 1998-01-04
EP0821006A2 (de) 1998-01-28
NO973438L (no) 1998-01-27
CN1362417A (zh) 2002-08-07

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