ES8504456A1 - Procedimiento para preparar una suspension de un derivado de insulina - Google Patents

Procedimiento para preparar una suspension de un derivado de insulina

Info

Publication number
ES8504456A1
ES8504456A1 ES534488A ES534488A ES8504456A1 ES 8504456 A1 ES8504456 A1 ES 8504456A1 ES 534488 A ES534488 A ES 534488A ES 534488 A ES534488 A ES 534488A ES 8504456 A1 ES8504456 A1 ES 8504456A1
Authority
ES
Spain
Prior art keywords
treatment
diabetes mellitus
denotes
pharmaceutical formulation
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534488A
Other languages
English (en)
Other versions
ES534488A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8504456A1 publication Critical patent/ES8504456A1/es
Publication of ES534488A0 publication Critical patent/ES534488A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA SUSPENSION DE UN DERIVADO DE INSULINA, DE PH 5-8,5.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UNA SOLUCION ACUOSA DE UN DERIVADO DE INSULINA DE FORMULA GENERAL (I) Y SE FILTRA DE MODO ESTERIL; SEGUNDA, SE AN/ADE A UNA SOLUCION ACUOSA DE UN TAMPON FISIOLOGICAMENTE COMPATIBLE, DE PH 5,0 A 8,5, QUE CONTIENE UN AGENTE DE ISOTONIA, EVENTUALMENTE IONEZ ZN, UN AGENTE CONSERVANTE, UN ESTABILIZANTE O UNA SUSTANCIA DE ACCION RETARDADA, Y SE FILTRA DE UN MODO ESTERIL; Y POR ULTIMO, SE REUNEN CON AGITACION EN UN RECIPIENTE AMBAS SOLUCIONES PREPARADAS Y SE AJUSTA EL PH DE LA SUSPENSION OBTENIDA.
ES534488A 1983-07-22 1984-07-20 Procedimiento para preparar una suspension de un derivado de insulina Granted ES534488A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833326473 DE3326473A1 (de) 1983-07-22 1983-07-22 Pharmazeutisches mittel zur behandlung des diabetes mellitus

Publications (2)

Publication Number Publication Date
ES8504456A1 true ES8504456A1 (es) 1985-05-01
ES534488A0 ES534488A0 (es) 1985-05-01

Family

ID=6204661

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534488A Granted ES534488A0 (es) 1983-07-22 1984-07-20 Procedimiento para preparar una suspension de un derivado de insulina

Country Status (19)

Country Link
US (1) US4608364A (es)
EP (1) EP0132769B1 (es)
JP (1) JPS6042334A (es)
AT (1) ATE31625T1 (es)
AU (1) AU564648B2 (es)
CA (1) CA1236012A (es)
DE (2) DE3326473A1 (es)
DK (1) DK172456B1 (es)
ES (1) ES534488A0 (es)
FI (1) FI79786C (es)
GR (1) GR81550B (es)
HU (1) HUT34889A (es)
IE (1) IE57690B1 (es)
IL (1) IL72468A (es)
NO (1) NO167187C (es)
NZ (1) NZ208960A (es)
PH (1) PH21328A (es)
PT (1) PT78941A (es)
ZA (1) ZA845621B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
AU612141B2 (en) * 1987-02-25 1991-07-04 Novo Nordisk A/S Novel insulin derivatives
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US6875589B1 (en) 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
ES2061797T3 (es) * 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
YU66892A (sh) * 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
DE59209745D1 (de) * 1991-11-29 1999-10-21 Hoechst Ag Peptide mit insulinartiger Wirkung
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
SE520392C2 (sv) 1996-09-27 2003-07-01 Creative Peptides Sweden Ab C Specifika peptider för behandling av diabetes mellitus
DE19649350A1 (de) * 1996-11-28 1998-06-04 Hoechst Ag Inositolglykane mit insulinartiger Wirkung
BR9813111A (pt) 1997-10-24 2000-08-15 Lilly Co Eli Composições de insulina insolúveis
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
ATE251466T1 (de) * 1999-04-08 2003-10-15 Genentech Inc Zusammensetzung auf basis gegensätzlich geladener polypeptide
AU2002248464A1 (en) 2001-02-21 2002-09-12 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
GB0323979D0 (en) 2003-10-13 2003-11-19 Creative Peptides Sweden Ab Therapeutic applications for c-peptide
GB0601950D0 (en) * 2006-01-31 2006-03-15 Creative Peptides Sweden Ab Compositions and methods of treating diabetes
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
US8680263B2 (en) 2008-09-19 2014-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
KR101939557B1 (ko) 2008-10-17 2019-01-17 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
US8410049B2 (en) 2009-10-28 2013-04-02 Cebix Methods and kits for preventing hypoglycemia
CN107308442B (zh) 2009-11-13 2022-10-18 赛诺菲-安万特德国有限公司 包含glp-1激动剂、胰岛素和甲硫氨酸的药物组合物
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
LT2611458T (lt) 2010-08-30 2016-12-27 Sanofi-Aventis Deutschland Gmbh Ave0010 panaudojimas gaminant vaistą, skirtą 2 tipo cukrinio diabeto gydymui
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
MX370264B (es) 2011-08-29 2019-12-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2.
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
SI3229828T1 (sl) 2014-12-12 2023-06-30 Sanofi-Aventis Deutschland Gmbh Formulacija s fiksnim razmerjem inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10689430B2 (en) * 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1176158A (en) * 1981-08-27 1984-10-16 Ronald E. Chance Pharmaceutical formulations comprising human insulin and human c-peptide
DOP1982004086A (es) * 1981-08-27 1988-03-22 Lilly Co Eli Formula farmaceutica que comprende insulina humana y proinsulina humana
CH650680A5 (de) * 1981-08-27 1985-08-15 Lilly Co Eli Pharmazeutisches mittel aus human-insulin, human-c-peptid und human-proinsulin.
ZW17382A1 (en) * 1981-08-27 1982-11-17 Lilly Co Eli Human proinsulin pharmaceutical formulations
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.

Also Published As

Publication number Publication date
DK358384D0 (da) 1984-07-20
FI79786B (fi) 1989-11-30
ZA845621B (en) 1985-02-27
CA1236012A (en) 1988-05-03
ATE31625T1 (de) 1988-01-15
DK172456B1 (da) 1998-08-24
NO167187B (no) 1991-07-08
FI79786C (fi) 1990-03-12
DE3326473A1 (de) 1985-01-31
NO842978L (no) 1985-01-23
DK358384A (da) 1985-01-23
IL72468A (en) 1989-08-15
JPS6042334A (ja) 1985-03-06
EP0132769B1 (de) 1988-01-07
FI842915A (fi) 1985-01-23
IL72468A0 (en) 1984-11-30
DE3468323D1 (en) 1988-02-11
AU3091784A (en) 1985-01-24
NO167187C (no) 1991-10-16
PH21328A (en) 1987-10-13
EP0132769A1 (de) 1985-02-13
AU564648B2 (en) 1987-08-20
IE57690B1 (en) 1993-03-10
NZ208960A (en) 1989-02-24
JPH0469128B2 (es) 1992-11-05
HUT34889A (en) 1985-05-28
FI842915A0 (fi) 1984-07-19
ES534488A0 (es) 1985-05-01
IE841890L (en) 1985-01-22
PT78941A (de) 1984-08-01
GR81550B (es) 1984-12-11
US4608364A (en) 1986-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916